The risk of transmission of the novel coronavirus (SARS-CoV-2) with human heart valve transplantation: evaluation of cardio-vascular tissues from two consecutive heart donors with asymptomatic COVID-19인간 심장 판막 이식으로 신종 코로나바이러스(SARS-CoV-2) 전파 위험: 무증상 COVID-19가 있는 2명의 연속 심장 기증자의 심혈관 조직 평가Case Reports Published on 2021-12-012022-09-11 Journal: Cell and tissue banking [Category] SARS, 치료기술, [키워드] ACE2 Allograft Aortic valve Asymptomatic Asymptomatic COVID-19 Cardiomyopathy clinically coronavirus COVID-19 cytoplasmic dilated cardiomyopathy donation Donor donors eosinophilic myocarditis heart Heart transplantation Heart valves hearts Homograft hypertrophic hypertrophic cardiomyopathy immunostaining life-threatening LIGHT light microscopy living donors Microscopy Mild mitral mitral valve myocarditis Myocardium Novel coronavirus nucleus Obstructive performed positive Presence pulmonary Pulmonary valve receiving Research risk risk of transmission RT-PCR SARS-CoV-2 SARS-CoV-2 test tested tissue Tissue banking Tissue Transplantation tissues Transmission tricuspid tricuspid valve Viral transmission virus virus transmission wall [DOI] 10.1007/s10561-021-09913-z PMC 바로가기 [Article Type] Case Reports
Treatment of COVID-19 in pregnant women: A systematic review and meta-analysisReview article Published on 2021-12-012022-10-05 Journal: European journal of obstetrics, gynecology, and re [Category] Coronavirus, SARS, 임상, 치료법, [키워드] 95% CI Abstract Admission adverse outcome anaesthesia APGAR score Appendix association authors China clinical clinically CNKI collected Comparative Complication country COVID-19 Critical database death defined Diagnosis ECMO Effect effective eligibility eligibility criteria eligible estimate excluded expected General population hospital Hospital admission ICU ICU admission include Infrastructure Interpretation Intervention involved mechanical ventilation Meta-analysis Neonatal Neonatal COVID-19 NICU admission objective outcome outcomes performed pharmacological Pneumonia positive Pregnancy pregnant pregnant women Preterm birth Prevalence prospective cohort provided Randomised controlled trials researcher Result retrospective cohort screened selected Stillbirth Study design Symptom symptomatic systematic literature search systematic review the disease Treatment Trial was performed WHO with COVID-19 women World Health Organization [DOI] 10.1016/j.ejogrb.2021.10.007 [Article Type] Review article
Humoral protection to SARS-CoV2 declines faster in patients on TNF alpha blocking therapiesSARS-CoV2에 대한 체액 보호는 TNF 알파 차단 요법을 받는 환자에서 더 빨리 감소합니다Article Published on 2021-12-012022-09-11 Journal: RMD Open [Category] 변종, 진단, [키워드] Anti-spike anti-Spike IgG anti-TNF Antigen appearance Arthritis blockade booster booster vaccination booster vaccinations CD4+ T cell CD4+ T-cell chronic inflammatory disease chronic inflammatory diseases clinically Cohort controls COVID-19 Critical Decline declined Efficacy faster Frequency greater groups healthy controls healthy individual humoral immune response Humoral response humoral responses IgA level IgA levels IgG immune responses Inflammatory diseases lack mRNA vaccination Necrosis neutralization Neutralizing antibodies no differences pandemic Patient patients persistence receiving regimens response SARS-CoV2 second vaccination significantly T cell therapy TNF TNF alpha Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor inhibitors vaccination vaccine response vaccine responses variants while [DOI] 10.1136/rmdopen-2021-002008 PMC 바로가기 [Article Type] Article
Relationship between serum soluble endothelial protein C receptor level and COVID-19 findings혈청 용해성 내피 단백질 C 수용체 수치와 코로나19 소견과의 관계Article Published on 2021-12-012022-09-11 Journal: Blood coagulation & fibrinolysis : an internationa [Category] SARS, 바이오마커, 치료기술, [키워드] activated Admission anti-inflammatory activity Anticoagulant association biochemical blood specimen blood specimens Chain Reaction clinically Coagulation coagulation cascade Coagulopathy collected Complication Computed tomography Course COVID-19 COVID-19 patient detect diagnosed e parameters endothelial enrolled EPCR GGO ground-glass opacity group Inflammation inflammatory process laboratory parameter Laboratory parameters laboratory-confirmed leads member negative patients no difference onset of symptom parameter Patient PCR positive Protein protein C qPCR test receptor reduce related disease relationship reported reverse transcription RT-qPCR RT-qPCR test serum shown significantly higher Symptoms Thorax thrombosis was performed [DOI] 10.1097/MBC.0000000000001070 PMC 바로가기 [Article Type] Article
Longitudinal respiratory subphenotypes in patients with COVID-19-related acute respiratory distress syndrome: results from three observational cohortsObservational Study Published on 2021-12-012022-10-05 Journal: The Lancet. Respiratory Medicine [Category] SARS, 임상, [키워드] 28-day mortality 95% CI acute respiratory distress Analysis approaches ARDS association baseline clinically Cohort cohorts Compliance COVID-19 data-driven died evaluate facilitate heterogeneous population homogenous ICU ICUs identify independent intensive care unit Invasive mechanical ventilation invasive ventilation investigator-initiated IQR latent class longitudinal Mechanical power mechanical ventilation median minute ventilation Mortality multicentre National Netherlands not differ Observational cohort study Older PaO parameter Patient positive RT-PCR Prognostic value provided Registered Replication Respiratory system Sample size syndrome temporal dynamics thrombotic event trajectory translation USA variable venous ventilator-free day ventilatory [DOI] 10.1016/S2213-2600(21)00365-9 PMC 바로가기 [Article Type] Observational Study
Novel Coronavirus Infection (COVID-19) Related Thrombotic and Bleeding Complications in Critically Ill Patients: Experience from an Academic Medical CenterArticle Published on 2021-11-302022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Admission age anticoagulation association baseline characteristics bleeding bleeding event bleeding mortality center clinically coagulation parameter Coagulation parameters Cohort Comorbidity Complication complications convalescent serum COVID-19 COVID-19 patient COVID-19 patients COVID19 Critically ill described died dose event experience ICU Ill incidence INR intensive care unit intermediate dose Intubated IQR major bleeding major bleeding event majority male mechanical ventilation median median age Median BMI Mortality novel Novel coronavirus infection outcome P -value Patient patients Platelet Prophylactic question raised Remdesivir retrospective risk SARS-CoV-2 secondary Sex significantly statistically significant Steroids subject suffered therapeutic anticoagulation thrombosis thrombotic thrombotic event Thrombus Treatment was performed [DOI] 10.3390/jcm10235652 PMC 바로가기 [Article Type] Article
TCR meta-clonotypes for biomarker discovery with tcrdist3 enabled identification of public, HLA-restricted clusters of SARS-CoV-2 TCRstcrdist3를 사용한 바이오마커 발견을 위한 TCR 메타 클론형으로 SARS-CoV-2 TCR의 공개 HLA 제한 클러스터 식별 가능Research Article Published on 2021-11-302022-09-10 Journal: eLife [Category] MERS, SARS, 바이오마커, 치료기술, 치료제, [키워드] Amino acid Analysis Antigen antigen exposure biochemically Biomarker Biomarkers can be used clinically Cluster cohorts complicate COVID-19 patient COVID-19 patients epitope Epitopes Evidence evidence of expressed facilitate false discovery rate feature flexible framework Genotype group HLA HLA allele Human human leukocyte antigen immune repertoire independent individuals information leukocyte open-source software Patient reflect restriction SARS-CoV-2 SARS-CoV-2 antigen Sequencing Software T cell receptor T-cell receptor T-Cell Receptors TCR TCRs the SARS-CoV-2 utility [DOI] 10.7554/eLife.68605 PMC 바로가기 [Article Type] Research Article
Avascular Necrosis Bone Complication after Active COVID-19 Infection: Preliminary Results활성 COVID-19 감염 후 무혈성 괴사 골 합병증: 예비 결과Article Published on 2021-11-302022-09-12 Journal: Medicina [Category] MERS, SARS, 진단, [키워드] adverse effect Analysis arising Autoimmune Avascular Necrosis avascular necrosis bone bone changes changes in Characteristics clinically Complication coronavirus correlation Corticosteroids Course COVID-19 COVID-19 disease COVID-19 infection COVID-19 virus degeneration degenerative disease IgG antibodies Infarction Infection Inflammatory joint joints locomotor majority material Necrosis normalized observation Occurrence osteonecrosis Pain Patient patients Research Respiratory system Result risk factor SARS-CoV-2 SARS-CoV-2 infections severe symptoms spine Steroids study group Symptom the study group tissue Treatment viral infection [DOI] 10.3390/medicina57121311 PMC 바로가기 [Article Type] Article
Acute estradiol and progesterone therapy in hospitalised adults to reduce COVID-19 severity: a randomised control trialRandomized Controlled Trial Published on 2021-11-302022-10-05 Journal: BMJ Open [Category] SARS, 임상, [키워드] addition Admission adverse events Anti-inflammatory antibody production approved drug Biology center clinically Corticosteroids COVID-19 death determine disease severity double blind drug Efficacy Ethical approval Ethics evaluate food general endocrinology Hospital stay hospitalised Hospitalised patients HRT HRT. immune response immune tolerance include Infectious diseases Inflammatory biomarker intramuscular mechanical ventilation Medicine mitigate New New Orleans Occurrence Oestradiol outcome Participants Patient peer-reviewed Phase 2 Placebo placebo-controlled primary endpoint Primary outcome progesterone proportion randomised readmission reduce reducing Result Sample size secondary Sex sex steroids & Sponsor Standard of care steroid subjects submitted the WHO therapeutic option therapy Trial university USA was obtained WHO ordinal scale [DOI] 10.1136/bmjopen-2021-053684 PMC 바로가기 [Article Type] Randomized Controlled Trial
SARS-CoV-2 Among Migrants Recently Arrived in Europe From Low- and Middle-Income Countries: Containment Strategies and Special Features of Management in Reception CentersPublic Health Published on 2021-11-302022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] activate activities adopted Analysis Arrived asylum seekers and migrant Asymptomatic center clinically Community concerning Contact contagious disease Containment Containment strategy COVID-19 described distribution epidemiological Europe European global health Health implementation IMPROVE Infection prevention and control Isolation Italian knowledge limit management measure migrant reception center outbreak Outbreaks pandemic pauci-symptomatic positive public health quarantine reported risk Risk assessment SARS-CoV-2 SARS-CoV-2 transmission Significant social distancing Strategy Surveillance the SARS-CoV-2 Topic [DOI] 10.3389/fpubh.2021.735601 PMC 바로가기 [Article Type] Public Health