SARS-CoV-2 spike – Page 41 – Communicable Diseases Research

Targeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication

Article

Published on 2021-05-242022-10-04
Journal: Cell Discovery [Category] 신약개발, 치료제,

Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization

다가 나노 입자 기반 백신은 단일 예방 접종 후 SARS-CoV-2로부터 햄스터를 보호합니다.

Article

Published on 2021-05-192022-09-10
Journal: Communications Biology [Category] SARS, 진단, 치료기술,

Clonal analysis of immunodominance and cross-reactivity of the CD4 T cell response to SARS-CoV-2

SARS-CoV-2에 대한 CD4 T 세포 반응의 면역우세 및 교차 반응성의 클론 분석

Report

Published on 2021-05-182022-09-10
Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, 치료법,

HLA class I-associated expansion of TRBV11-2 T cells in multisystem inflammatory syndrome in children

어린이의 다기관 염증 증후군에서 TRBV11-2 T 세포의 HLA 클래스 I 관련 확장

Article

Published on 2021-05-172022-09-11
Journal: The Journal of Clinical Investigation [Category] SARS, 유전자 메커니즘,

Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells

Article

Published on 2021-05-132022-11-01
Journal: Cell Reports [Category] COVID-19, SARS,

[키워드] Abstract acute respiratory syndrome Analysis Antigen Antigen presentation antigen processing CD4 complex glycan coronavirus cross-protective dendritic cell dendritic cells dentritic cells Epitopes facilitate glycan glycopeptides glycoslyation glycosylated glycosylation highlight HLA class II HLA-DR HLA-II human leukocyte antigen identify immunogenicity data immunopeptidomics infected individual LC-MS leukocyte mapping observé peptide protective immune response Protein receptor binding motif receptor-binding motif recipient regions reported residue response responses Result reveal SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein spike the S protein the SARS-CoV-2 understanding unique Vaccine Vaccine design
[DOI] 10.1016/j.celrep.2021.109179 PMC 바로가기 [Article Type] Article

Vaccination strategy and anti – SARS-CoV-2 S titers in healthcare workers of the INT – IRCCS “Fondazione Pascale” Cancer Center (Naples, Italy)

Research Article

Published on 2021-05-122022-10-30
Journal: Infectious Agents and Cancer [Category] COVID-19,

[키워드] administration age anti-RBD anti-SARS-CoV-2 vaccination anti-spike serology Antibody Response Antibody titer Beads-based linear serology calculated Cancer institute center change Cohort contract the virus coronavirus 2 coronavirus disease COVID-19 disease domain dose Efficacy Elecsy evaluated FDA first dose fold Fold change geometric mean titer glycoprotein healthcare worker humoral immune response immune response immunoassay individual Infection INT IRCCS Italy limit mRNA vaccine naïve subjects Naples Older Post-COVID-19 single dose vaccine. pre-vaccination respiratory Result resulting Roche SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2-infected individual second dose serum sample shown significantly higher spread to statistically significant subject subjects susceptibility the SARS-CoV-2 trimeric spike Vaccine vaccine administration vaccine doses vaccinees
[DOI] 10.1186/s13027-021-00375-2 PMC 바로가기 [Article Type] Research Article

The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

중화 항체 LY-CoV555는 비인간 영장류에서 SARS-CoV-2 감염을 예방합니다

Research Article

Published on 2021-05-122022-09-12
Journal: Science Translational Medicine [Category] MERS, SARS, 비임상, 진단,

[키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus airway airways angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-spike antibody Antigen antigen-specific B cell Antigen-specific B cells B cells bamlanivimab binding characterized clearance clinical testing Clinical use collected conducted convalescent patient coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 demonstrated evaluated functional high-affinity binding Hospitalized in vitro in vivo indications individual infected with SARS-CoV-2 Infection Interaction Jone Jones less Lower respiratory tract LY-CoV555 mAb mAbs monoclonal monoclonal antibodies monoclonal antibody neutralize Neutralizing activity Neutralizing antibodies neutralizing antibody offer patients with COVID-19 pharmacokinetic Population prevented prophylactic dose prophylactic doses prophylactic treatment PROTECT public health threat Receptor-binding domain reduced respiratory distress Respiratory distress syndrome rhesus rhesus macaque SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike severe acute respiratory distress syndrome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spectrum Spike protein Support syndrome tested the receptor-binding domain therapeutic therapeutic agent therapeutic option Therapeutics These data Treatment upper and lower respiratory tract upper and lower respiratory tracts vaccination viral replication widespread
[DOI] 10.1126/scitranslmed.abf1906 PMC 바로가기 [Article Type] Research Article

Dual nature of human ACE2 glycosylation in binding to SARS-CoV-2 spike

408

Published on 2021-05-112022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS,

[키워드] ACE2 ACE2 receptor bind binding Cell cells complex conserved contribute docking Effect epitope glycan glycosylated glycosylation host cells human ACE2 human ACE2 receptor human Angiotensin-converting enzyme human cells infect Infection inhibitors interact Interaction interfere MD simulation molecular molecular dynamics N322 N90 Neutralizing antibodies neutralizing antibody opposite PROTECT RBD receptor Receptor binding domain receptor protein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 virus Significance Spike protein sugar sugars susceptibility the RBD the SARS-CoV-2 the spike protein translocation Trigger virus Virus-host interaction
[DOI] 10.1073/pnas.2100425118 PMC 바로가기 [Article Type] 408

Neutralizing antibody responses to SARS-CoV-2 in symptomatic COVID-19 is persistent and critical for survival

증상이 있는 COVID-19에서 SARS-CoV-2에 대한 항체 반응 중화는 지속되고 생존에 중요합니다

Article

Published on 2021-05-112022-09-10
Journal: Nature Communications [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, 진단, 치료기술,

[키워드] age antibody Antibody Response Antibody responses Antibody titer Antibody titers Antigen antigens Antimicrobial responses best beta-coronavirus Care co-morbidities Cohort common cold conditions COVID-19 COVID-19 patient COVID-19 symptomatic patient Critical detectable Disease progression eight flu H1N1 hemagglutinin Heterologous Humoral immunity IgG immune response immune responses Immunity increased risk Infection Influenza lack majority morbidities neutralization Neutralizing antibodies neutralizing antibody neutralizing antibody titers neutralizing capacity not affected nucleoprotein outcome Patient care Planning recognizing recovered patient recovered patients S2 antigen SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralization SARS-CoV-2 spike SARS-CoV-2 spike antigen SARS-CoV-2 spike protein seasonal coronavirus seasonal coronaviruses severe COVID-19 Spike protein survival Swab symptom onset symptomatic symptoms onset the antibody response the SARS-CoV-2 Therapeutic approach therapeutic approaches therapy understanding vaccination viral infection virus worsening
[DOI] 10.1038/s41467-021-22958-8 PMC 바로가기 [Article Type] Article

A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation

SARS-CoV-2 항체는 바이러스 뉴클레오캡시드 단백질 유도 보체 과활성화를 억제합니다

Article

Published on 2021-05-112022-09-10
Journal: Nature Communications [Category] SARS, 변종, 진단, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allosteric regulation Analysis antibodies antibody Antibody Response binding affinity binding domain changes in complement Complement cascade complex convalescent patient coronavirus coronavirus disease Coronavirus disease-19 COVID-19 COVID-19 patients crystal structure dominant elicited epitope Epitopes foundation functional highest binding affinity Hyperactivation Infection mAb mAbs monoclonal antibodies monoclonal antibody morbidity morbidity and mortality N protein nucleocapsid Protein Regulation respiratory reveal risk factor RNA S protein SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 N protein SARS-CoV-2 S protein SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus the N protein the SARS-CoV-2 while X-ray crystallography
[DOI] 10.1038/s41467-021-23036-9 PMC 바로가기 [Article Type] Article