Culture-Based Virus Isolation To Evaluate Potential Infectivity of Clinical Specimens Tested for COVID-19Virology Published on 2020-06-092022-10-30 Journal: Journal of Clinical Microbiology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome addition Amplicon cause characterized clinical coronavirus coronavirus disease correlation COVID-19 culturability Culture detect detectable examined Genome genome copy genome integrity Infectivity linear log lowest N genes Nasopharyngeal swab nine Nsp12 performed positive Potential real-time RT-PCR Region regions required reverse transcription-PCR RT-PCR SARS-CoV-2 SARS-CoV-2 RNA specimen specimens sputum viral genome Viral RNA virus virus isolation was determined [DOI] 10.1128/JCM.01068-20 PMC 바로가기 [Article Type] Virology
Effect of Cancer on Clinical Outcomes of Patients With COVID-19: A Meta-Analysis of Patient DataReview Articles Published on 2020-06-082022-10-31 Journal: JCO Global Oncology [Category] COVID-19, SARS, [키워드] 95% CI absence Admission age all-cause mortality article Asia calculated Cancer clinical Clinical outcome clinician comparable COVID-19 death Effect Elderly patient Europe Evidence Health ICU ICU admission identify increased risk infected with COVID-19 intensive care Meta-analysis Mortality observational study Patient patients Patients with cancer patients with COVID-19 prespecified subgroup analysis Prognosis random-effects model Registered risk ratio searched systematic review the United State those without cancer with COVID-19 worse prognosis [DOI] 10.1200/GO.20.00225 PMC 바로가기 [Article Type] Review Articles
Evaluation of Chemical Protocols for Inactivating SARS-CoV-2 Infectious SamplesBrief Report Published on 2020-06-082022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] biosafety Chemical clinical clinical sample collected Contact coronavirus coronavirus disease COVID-19 COVID-19 patients diagnostic effective European evaluated extraction buffer French inactivation Infectious virus Laboratory less log lysis buffer molecular nasopharyngeal sample Patient protocol reduce reduction risk RNA extraction Sample SARS-CoV-2 supernatant tested were used [DOI] 10.3390/v12060624 PMC 바로가기 [Article Type] Brief Report
Subcutaneous administration of interferon beta-1a for COVID-19: A non-controlled prospective trialArticle Published on 2020-06-072022-10-04 Journal: International immunopharmacology [Category] MERS, SARS, 임상, [키워드] administration Adverse drug reaction age Antiviral clearance clinical Clinical symptoms Combination coronavirus country COVID-19 death demographic dose Effect Epidemic evaluate Hospitalization Hydroxychloroquine imaging immunomodulatory effects include infected cells interferon Interferon beta-1a interferons management maturation New coronavirus Patient patients previous study Prospective trial protein synthesis Pulmonary infection recorded resolved Result Seven shown significant decrease Spread subcutaneous administration subcutaneously Support susceptible Symptom the patient therapeutic effect therapy Trial Trial registration viral replication virological clearance virus [DOI] 10.1016/j.intimp.2020.106688 PMC 바로가기 [Article Type] Article
Clinical Perspective on 2019 Novel Coronavirus Pneumonia: A Systematic Review of Published Case ReportsInternal Medicine Published on 2020-06-072022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 2019 novel coronavirus 2019-nCoV acute respiratory distress antiviral drug ARDS Case report clinical Clinical improvement clinical trial conducted Corona pandemic COVID-19 pneumonia COVID-2019 death disease effective High-risk patients hospital IMPROVE interstitial pneumonia Isolation Laboratory management management guideline Mild mild illness moderate multi-viral pneumonia novel novel corona virus outcome pandemic pathology Patient Pneumonia randomized clinical trial RCTs reducing mortality Remdesivir report review severe pneumonia shown supportive care syndrome systematic review Transmission Treatment treatment guideline Wuhan, China [DOI] 10.7759/cureus.8488 PMC 바로가기 [Article Type] Internal Medicine
Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 PatientsPerspective Published on 2020-06-072022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory distress caused clinical clinical setting clinical testing clinical trial coronavirus COVID-19 Cytokine storm drug candidate effective evaluate expected function global pandemic global public health Host IL-6 immune Infection Inflammatory cytokine inhibitor interferon Jak limit lymphopenia mechanism monoclonal antibody novel coronavirus SARS-CoV-2 Open-label Patient predicted provide Randomized reduce Remdesivir replication/transcription machinery responses RNA-dependent RNA polymerase senescence severe COVID-19 Signaling silibinin Spain STAT3 storm syndrome T-cell targeting the cytokine storm therapeutic efficacy Viral load virus replication [DOI] 10.3390/jcm9061770 PMC 바로가기 [Article Type] Perspective
SARS-Cov2 Clinical Diagnostics: Academic Scientists Take on the COVID-19 PandemicArticle Published on 2020-06-062022-10-05 Journal: Med (New York, N.Y.) [Category] SARS, 진단, [키워드] clinical COVID-19 diagnostic hospital Regulatory SARS-CoV-2 testing scientist [DOI] 10.1016/j.medj.2020.06.002 [Article Type] Article
Challenges amid COVID-19 times – Review of the changing practices in a clinical chemistry laboratory from a developing countryReview Article Published on 2020-06-062022-10-04 Journal: Annals of Medicine and Surgery [Category] 유전자 메커니즘, [키워드] Care challenge challenges Chemistry China clinical Corona country COVID-19 COVID-19 outbreak diagnostic disease Health highlight Iran Karachi Laboratory lessons Like measure National outbreak Pakistan pandemic resource response review university variety widespread [DOI] 10.1016/j.amsu.2020.06.004 PMC 바로가기 [Article Type] Review Article
COVID-19: Specific and Non-Specific Clinical Manifestations and Symptoms: The Current State of KnowledgeReview Published on 2020-06-052022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory distress acute respiratory syndrome Affect age Asymptomatic carriers atypical symptom chest pain clinical clinical manifestation clinical manifestations Complication confirmed case coronavirus Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) Coronavirus-2 country COVID-19 COVID-19 patients current death Diagnosis dry cough Epidemic epidemiological Gustatory include Infant manifestation Manifestations Mild neurological occur olfactory ophthalmic outbreak Pandemics Patient Pediatric patients Pneumonia prevalent public health reported RNA SARS-CoV-2 SARS-COV-2 infection Specific specific symptom spread to state Symptoms syndrome the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) typical symptom viral disease weakness [DOI] 10.3390/jcm9061753 PMC 바로가기 [Article Type] Review
Norwegian Coronavirus Disease 2019 (NO COVID-19) Pragmatic Open label Study to assess early use of hydroxychloroquine sulphate in moderately severe hospitalised patients with coronavirus disease 2019: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-06-052022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 1:1 7-point ordinal scale accelerate activities activity acute respiratory syndrome adaptive addition administration Admission airway Akershus allocation sequence Analysis anticipated approach automatically baseline Biochemistry Biomarker blinded Blinding Blood C-reactive protein cardiac troponin Chloroquine clinical Clinical outcome Clinical practice clinical status clinical symptom collected condition coronavirus coronavirus disease COVID-19 Culture database Department disease dissemination early treatment element Endpoint examined excluded extracorporeal membrane oxygenation Good harmonization hepatic injury history hospital Hospital admission hospitalisation hospitalised hospitalised patient Hospitalized Hydroxychloroquine Hypothesis In-hospital include independent Inpatient intensive care intensive care unit International Conference Intervention intervention arm Invasive mechanical ventilation Laboratory marker Microbiology Mortality nasopharyngeal NEWS2 non-invasive ventilation Norway number Nurse objective open label Oropharyngeal Oropharyngeal sampling outcome oxygen participant Patient patients peptide Placebo polymerase chain polymerase chain reaction positive Practice Pragmatic pragmatic trial primary endpoint profile Prolonged Protein protocol QT interval randomisation randomised randomised controlled randomised controlled trial randomization Randomized Randomized controlled trial recruited recruitment Registered renal requiring supplemental oxygen resource responsible RT-PCR Safe Sample size SARS-CoV-2 SARS-CoV-2 viral load score secondary Seven standard care statistical analyses status Study protocol subjects Surveillance therapy transcriptase Treatment treatment allocation Trial Two-arm university use of hydroxychloroquine Viral load virological clearance viruses vital signs website [DOI] 10.1186/s13063-020-04420-0 PMC 바로가기 [Article Type] Letter