Paper-Based Point-of-Care Testing of SARS-CoV-2Bioengineering and Biotechnology Published on 2021-11-292022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] acute infection can be used clinically COVID-19 diagnostics COVID-19 pandemic CRISPR develop Diagnosis diagnostic test diagnostics disease identify immunoassay Laboratory limitation paper-based platform POC POC test point-of-care Research researcher SARS-CoV-2 Testing the disease the patient [DOI] 10.3389/fbioe.2021.773304 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
Successful treatment of prolonged COVID-19 with Bamlanivimab in a patient with severe B-Cell aplasia due to treatment with an anti-CD20 monoclonal antibody: A case reportCase report Published on 2021-11-292022-10-05 Journal: Respiratory Medicine Case Reports [Category] 치료법, [키워드] administration anti-CD20 Antibiotic therapy B-cell B-Cell aplasia bamlanivimab Case report clinically COVID-19 demonstrated Dexamethasone female high affinity immunodeficiency IMPROVE Inflammatory marker monoclonal monoclonal antibodies monoclonal antibody Patient Pneumonia RT-PCR SARS-CoV2 Spike protein the patient the receptor-binding domain the SARS-CoV-2 Treatment viral shedding virus-neutralizing worsening worsening respiratory failure [DOI] 10.1016/j.rmcr.2021.101560 [Article Type] Case report
Development of a PROTAC-Based Targeting Strategy Provides a Mechanistically Unique Mode of Anti-Cytomegalovirus ActivityArticle Published on 2021-11-272022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] activity addition Adenovirus analyzed Antiviral antiviral activity antiviral drugs antiviral therapy antivirals applicability approach CDK1 CDK2 CDK7 CDK9 Chimera Clinical symptoms clinically Combined Concentration current Degradation demonstrated development Direct-acting antivirals Efficacy elements HCMV help host-directed antivirals Human Human Cytomegalovirus human/animal pathogenic viruses IMPROVE indicated inhibitor investigated kinase inhibitors mode murine new drug qualities pathogenic prevalent PROTAC-based targeting strategy PROteolysis TArgeting Chimeras required SARS-CoV-2 replication strain Strategy target targeting varicella variety virus Zika virus [DOI] 10.3390/ijms222312858 PMC 바로가기 [Article Type] Article
Ameliorated immunity elicited by intradermal inoculation in individuals vaccinated with inactivated SARS-CoV-2 vaccine비활성화된 SARS-CoV-2 백신 접종을 받은 개인의 피내 접종으로 유도된 개선된 면역Article Published on 2021-11-262022-09-11 Journal: Vaccine [Category] MERS, SARS, 진단, 치료기술, [키워드] activated anti-S antibody antibody Antigen Antigen inoculation clinical trials clinically effective elicited eliminated ELISA IgGs immune response Immunity immunization immunized inactivated individual inflammatory reactions inoculation Intradermal Intradermal immunization neutralizing antibody participant Participants persistence problem protective effect redness SARS-CoV-2 SARS-CoV-2 vaccine short duration swelling the antibody [DOI] 10.1016/j.vaccine.2021.10.043 PMC 바로가기 [Article Type] Article
Preliminary study of coronavirus disease 2019 on pets in pandemic in Denpasar, Bali, IndonesiaResearch Article Published on 2021-11-262022-10-29 Journal: Veterinary World [Category] COVID-19, [키워드] acute respiratory syndrome assumed Asymptomatic caused clinically close contact collected coronavirus disease Coronavirus disease 2019 Coronavirus-2 correlation COVID-19 Critical epidemiological eyes genetic material hospital Hospitalization Hospitalized Host Human humans individual Indonesia infected individual Infection limit material nasopharyngeal sample pandemic Patient patients with COVID-19 PCR product pets positive processed required Respiratory disease respiratory droplet resulting RNA isolation RNA samples RT-PCR SARS-CoV-2 SARS-COV-2 infection Seven severe acute respiratory syndrome coronavirus-2 Spread Swab swab sample swab samples tested the disease threshold through contact Transmission transmitted understanding Viral detection virus wild animal World Health Organization zoonotic transmission [DOI] 10.14202/vetworld.2021.2979-2983 PMC 바로가기 [Article Type] Research Article
Beware of the ambiguous enemy of multisystem inflammatory syndrome in adult (MIS‐A) following Covid‐19 infection or vaccinationCase Report Published on 2021-11-262022-11-01 Journal: Clinical Case Reports [Category] COVID-19, [키워드] Activation addition Admission biochemically C‐reactive protein children clinically commenced Course COVID 19 COVID‐19 COVID‐19 Critical care Cytokine storm demonstrated described deteriorate diagnoses Diagnosis disease dysfunction Evidence examination Extensive female ferritin Fever function Hypoxemia Infection infective Inflammation Inflammatory Laboratory lymph nodes management Measures Methylprednisolone Mild MIS‐A Neck pain negative test outcomes pandemic Patient presenting raised reduced resolution of symptom Safe SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 Sepsis steroid Support supportive care syndrome the patient vaccination Vaccine Ventilation ventricular was done [DOI] 10.1002/ccr3.5138 PMC 바로가기 [Article Type] Case Report
Complement Mediated Hemolytic Anemias in the COVID-19 Era: Case Series and Review of the LiteratureImmunology Published on 2021-11-252022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Activation Atypical Autoimmune autoimmune hemolytic anemia benefit CAD carried clinically Cold agglutinin disease complement Complement inhibitor complex Complication condition COVID-19 COVID-19 disease COVID-19 infection COVID19 vaccine disease dose greater Hemodialysis hemolytic hemolytic anemia hemolytic uremic syndrome include Infection inhibitor Laboratory LDH literature manuscript Mediated occur occurred Occurrence paroxysmal nocturnal hemoglobinuria pathophysiologic Patient Patient education patient population plasma Platelet Prophylaxis provided recognize required review Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine Sery severity steroid subject therapeutic intervention Thrombotic complications Treatment Trigger uremic syndrome Vaccine warm [DOI] 10.3389/fimmu.2021.791429 PMC 바로가기 [Article Type] Immunology
An overview of the National COVID-19 Chest Imaging Database: data quality and cohort analysisData Note Published on 2021-11-252022-10-31 Journal: GigaScience [Category] COVID-19, MERS, SARS, [키워드] Analysis Care categories chest X-ray Clinical data clinically cohort analysis Comorbidity Completeness computed tomography scan conditions coronavirus SARS-CoV-2 Coverage COVID-19 COVID-19 pandemic database Diagnosis DICOM disease finding imaging IMPROVE improvement increase machine learning measure Medical imaging offer Patient patients patients hospitalized Prognosis provide researcher resource resources risk risk stratification SARS-CoV2 Severe COVID-19 Infection Sex subset Support thoracic imaging training dataset variety Volume [DOI] 10.1093/gigascience/giab076 PMC 바로가기 [Article Type] Data Note
Evaluation of the Relationship between Clonal Hematopoiesis and Severe COVID-19 Disease in Rhesus MacaquesConference abstract Published on 2021-11-242022-10-05 Journal: Blood [Category] 변종, [키워드] Acquired advanced age age Analysis Asymptomatic autologous Autopsy BAL benefit Blood clinical manifestation clinical symptom clinically co-morbidities cohort study Concentration Control control group controls COVID-19 COVID-19 disease detectable develop died disease Evidence expand Factor Genes group hallmark Hematopoiesis Human Hyperinflammatory IL-6 IL-6 level IL-8 Infection Inflammation inoculated Laboratory LOF loss of function lung tissue macaque MCP-1 Mild MIP-1b Multiorgan mutant Mutation occur pathophysiological pathophysiology phenotype progenitor cell relationship reported Respiratory failure Respiratory samples rhesus macaque risk risk factor robust Sample size SARS-CoV infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA sera severe COVID-19 severe COVID-19 disease severe COVID-19 illness significant difference somatic mutation suggested Symptom TET2 the median therapeutic approaches therapy Vaccine development Viral antigen [DOI] 10.1182/blood-2021-152628 [Article Type] Conference abstract
Clonal Hematopoiesis of Indeterminate Potential Is Associated with Increased Age-Independent Morbidity and Mortality in Patients with COVID-19- the Beyond DNA COVID-19 ProjectConference abstract Published on 2021-11-242022-10-05 Journal: Blood [Category] 변종, [키워드] accounted affected age age and sex allele approved assays association ASXL1 ATAC-seq baseline Blood blueprint carried ChIP clinically collected common Comorbidities comparable Coverage COVID-19 COVID-19 diagnosis COVID-19 disease severity COVID-19 patient CRP CRS cytokine cytokine levels Cytokine release syndrome Cytokines database death defined described Detection limit DNA download elevated ELISA assay entire cohort figure Fisher Follow-up funding Genes grade 3 group had more hazard healthy individual Hematopoiesis Hospitalization hypoxemic hypoxic respiratory failure identify IL6 Increased increased mortality indeterminate indicated individuals Infection Inflammation Inflammatory inflammatory cascade Inflammatory marker IRB male Mayo Clinic MCP-1 median median age mononuclear cell morbidity Mortality MPL Mutation mutations neutropenia no difference observé Older pathophysiology Patient patients patients with COVID-19 PBMC Peripheral blood Potential proteomic study reached regression models remained Research resolved Respiratory failure RNA scale Sequencing severe disease severity Sex SF3B1 Single Cell ssDNA subsequent survival survival analysis TET2 the Kaplan-Meier method the WHO TNF-a TP53 two groups variables variant was performed WHO Wilcoxon rank sum with COVID-19 [DOI] 10.1182/blood-2021-151548 [Article Type] Conference abstract