Severe acute respiratory syndrome coronavirus spike protein counteracts BST2‐mediated restriction of virus‐like particle releaseResearch Article Published on 2019-07-102022-11-01 Journal: Journal of medical virology [Category] Coronavirus, SARS, [키워드] acute respiratory syndrome alleviate Antiviral association BST2 Cell cellular coronavirus coronavirus coronavirus spike protein counteract Degradation determine downregulate downregulating downregulation experiment Factor Factors glycoprotein glycosylation human coronavirus 229E Human immunodeficiency virus immune responses Infection inhibit Innate immunity lysosomal ORF7a Particle Particles pathway Pathways proteasomal reduce reduced reported required SARS Coronavirus Spike protein Support target virion virus virus classification virus replication viruses [DOI] 10.1002/jmv.25518 PMC 바로가기 [Article Type] Research Article
Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4 -transgenic mice infected with MERS-CoVArticle Published on 2018-04-242022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] accompanied activated Activation acute lung injury alleviate antibody treatment Apoptosis blockade C5a cause Cell cells chemokines complement Concentration contribute cytokine dysregulated elevated greater hDPP4 high mortality highly pathogenic Host immune response Inflammatory responses Intervention investigated less lung lung damage lung tissues manifested MERS-CoV MERS-CoV infection mice Middle East observation outcome Pathogenesis promote receptor reduced Respiratory failure respiratory syndrome coronavirus secretion sera spleen spleen tissue T cell tissue damage treated Treatment triggered viral infection viral replication [DOI] 10.1038/s41426-018-0063-8 PMC 바로가기 [Article Type] Article
Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections안지오텐신 전환 효소 2는 치명적인 조류 인플루엔자 A H5N1 감염으로부터 보호합니다Article Published on 2014-05-062022-09-25 Journal: Nature Communications [Category] Fulltext, 신종인플루엔자, 유전자 메커니즘, 진단, [키워드] ACE2 administration alleviate angiotensin-converting enzyme 2 cause death rates develop downregulation enzyme expression flu H5N1 highly pathogenic human ACE2 inactivation Infection Influenza influenza A influenza virus Influenza virus information lung lung failure Lung injury Medical research mice Mouse models outbreak Pandemics Pathologies Patient patients Potential treatment PROTECT Respiratory tract diseases serum Serum level severe lung injury severity supplementary material virus [DOI] 10.1038/ncomms4594 PMC 바로가기 [Article Type] Article
Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Regulates Cell Stress Response and ApoptosisResearch Article Published on 2011-10-202022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] absence activating Activation acute respiratory syndrome addition alleviate Apoptosis apoptotic Author Cell cell metabolism cell stress cells compared contribute contributed control cell different dissemination down-regulated drug drugs E gene E protein elicit envelope enzyme expressing expression Factor Gene Gene Expression homeostasis Host host gene expression identify immunoregulation in vivo increase in Infected Infection Inflammation involved lack mechanisms mutant pathway Pathways potential mechanism proinflammatory Proinflammatory cytokine PROTECT Protein reduced reduction reduction in regulated respiratory respiratory syncytial virus response reversed SARS-CoV SARS-CoV E severe Signal transduction signaling pathway Stress subset Transcription transcription factor treated Treatment unfolded protein response upregulated virus virus production was reduced [DOI] 10.1371/journal.ppat.1002315 PMC 바로가기 [Article Type] Research Article