Neutralizing Antibody Responses After SARS-CoV-2 Infection in End-Stage Kidney Disease and Protection Against ReinfectionClinical Research Published on 2021-04-282022-10-04 Journal: Kidney International Reports [Category] 비임상, [키워드] absence Abstract acute respiratory syndrome Against anti-N IgG antibody Asymptomatic Asymptomatic disease baseline coronavirus COVID-19 detectable determine develop ELISA enzyme-linked immunosorbent ESKD evaluate evaluated functional Hemodialysis humoral immune response Humoral immunity IgG level immune response individual Infection infectious complication investigated Kidney disease median NAb Neutralization assay Neutralizing activity neutralizing antibody outcome Patient patients polymerase chain protection pseudotype renal Repeat response responses Result retained risk factor S1 subunit SARS-CoV-2 SARS-CoV-2 spike seroconvert seroconverted seroconverted patient serum sample susceptibility [DOI] 10.1016/j.ekir.2021.03.902 PMC 바로가기 [Article Type] Clinical Research
Effects of SARS-CoV-2 on Cardiovascular System: The Dual Role of Angiotensin-Converting Enzyme 2 (ACE2) as the Virus Receptor and Homeostasis Regulator-ReviewReview Published on 2021-04-262022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE inhibitor ACE-2 ACE2 ACE2 expression ACEi/ARB acute respiratory distress acute respiratory syndrome ADAM17 age alveolar Angiotensin II appear ARBs ARDS blocker cardiovascular cardiovascular disease cardiovascular system Cell cleavage Comorbidities Comorbidity coronavirus disease-2019 Coronavirus-2 COVID-19 COVID-19 mortality COVID-19 vaccine CVD domain driven by ectodomain Effect entry receptor enzyme excessive immune response expressed gastrointestinal tract Gender genetics homeostatic host cell humans immune response immune systems Interaction Leydig cell Lung epithelial cells multi-organ failure pandemic Patient priming Protein provide RAS renal tubular epithelium renin-angiotensin system required resulting role SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike spike glycoprotein syndrome TMPRSS2 transmembrane Treatment turn type I Vaccines vascular endothelial cells [DOI] 10.3390/ijms22094526 PMC 바로가기 [Article Type] Review
Editorial: SARS-CoV-2 mRNA Vaccines and the Possible Mechanism of Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT)사설: SARS-CoV-2 mRNA 백신과 백신 유발 면역 혈전성 혈소판 감소증(VITT)의 가능한 메커니즘Editorial Published on 2021-04-262022-09-11 Journal: Medical science monitor : international medical jo [Category] SARS, 유전자 메커니즘, 임상, [키워드] antibody AstraZeneca Autoimmune cavernous sinus cavernous sinus thrombosis ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine clinical trials collaboration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-react death rate editorial Efficacy global pandemic heparin heparin-induced thrombocytopenia Hope morbidity mRNA mRNA vaccine Oxford Platelet platelet factor 4 Prevent safety profile SARS-CoV-2 SARS-CoV-2 spike Science Sinus thrombosis Spread syndrome the SARS-CoV-2 thrombocytopenia thrombosis thrombotic thrombotic event Thrombotic events University of Oxford vaccination virus women [DOI] 10.12659/MSM.932899 PMC 바로가기 [Article Type] Editorial
SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formationSARS-CoV-2는 바이러스 진입 및 병리학적 합포체 형성을 위해 콜레스테롤을 필요로 합니다Research Article Published on 2021-04-232022-09-10 Journal: eLife [Category] MERS, SARS, 변종, 진단, [키워드] ACE2 approaches caused Cell Cell Biology cell-cell fusion cell-cell fusion assay cholesterol co-culture Contact coronavirus COVID-19 COVID-19 patient COVID-19 patients Culture drug expressing facilitate Host immune response Human human cell human cells identify induce intercellular intercellular contacts isolates lung Lungs mechanism membrane membrane fusion membrane fusion event membrane fusion events Microscopy molecular basis multinucleated cell multinucleated cells outcome positive producing Quantitative receptor ACE2 regions Replication replication-competent SARS-CoV-2 reported reveal SARS-CoV-2 SARS-CoV-2 spike Screen spike spike variants statins Syncytia syncytia formation Therapeutics thought Viral viral entry virus viruses [DOI] 10.7554/eLife.65962 PMC 바로가기 [Article Type] Research Article
The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airwaysSARS-CoV-2 및 기타 인간 코로나바이러스 스파이크 단백질은 인간 기도의 온도 및 프로테아제에 맞게 미세 조정됩니다.Research Article Published on 2021-04-222022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 변종, 유전자 메커니즘, [키워드] activate activated Activation of SARS-2-S adaptive mechanism adaptive mechanisms adjusted airway adaptation airways alternative route authentic virus replication Author cathepsin L cathepsin L pathway cathepsin-rich cells caused cell tropism common cold common cold coronavirus contrary contributed coronavirus coronavirus spike protein coronavirus virulence coronaviruses SARS-CoV COVID-19 pandemic Critical D614 variant D614G mutation deletion mutants effective ENhance explain extended loop length feature furin furin recognition motif G614 variant HCoV HCoV-229E high transmissibility of SARS-CoV-2 highly pathogenic human airway human airways human coronaviruses human host human respiratory tract increase indicate intrinsic temperature preference loop deletion mutant loop deletion mutants lower airways mechanism MERS MERS-CoV mild common cold other coronavirus other coronaviruses pathogenic HCoV-229E virus pathology predominant processing produced promote property protease protease condition protease conditions Proteases Protein pseudoviruses pseudoviruses of SARS-CoV-2 replaced Replication respiratory respiratory tract S protein S protein stability S proteins S1/S2 cleavage loop SARS-2-S SARS-2-S-driven entry SARS-CoV SARS-CoV-2 SARS-CoV-2 epidemiology SARS-CoV-2 spike SARS-CoV-2 stability severe pneumonia significantly increased spike activator spike property Spike protein Spike proteins spike stability spike-D614 spike-G614 variant Spread surface protease surface proteases temperature temperature and protease conditions the S protein the SARS-CoV-2 the spike protein TMPRSS13 TMPRSS13 protease TMPRSS2 transmissibility of SARS-CoV-2 upper airways upper or lower airways Usage Viral viral spike protein virulent coronavirus virulent coronaviruses virus virus entry virus preference virus spread virus transmission Zoonotic introduction [DOI] 10.1371/journal.ppat.1009500 PMC 바로가기 [Article Type] Research Article
CpG-adjuvanted stable prefusion SARS-CoV-2 spike protein protected hamsters from SARS-CoV-2 challengeSARS-CoV-2 공격으로부터 햄스터를 보호하는 CpG 보조 안정 예비 융합 SARS-CoV-2 스파이크 단백질Article Published on 2021-04-222022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 진단, 치료기술, [키워드] alum aluminum aluminum hydroxide applied average build clinical development comparable control groups COVID-19 pandemic COVID-19 vaccine CpG Detection limit Diseases dose effective vaccine global public health group hamster hydroxide IgG immunized immunogenic immunogenicity immunology imperative Infection injection intramuscularly intranasally Lung pathology lung viral load Microbiology Neutralizing antibodies neutralizing antibody Neutralizing titer pandemic prefusion produced Protective pseudovirus Rapid reduced S-2P Safe SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein significantly Support the vaccine titers Vaccine vehicle Viral virus weight loss with infection [DOI] 10.1038/s41598-021-88283-8 PMC 바로가기 [Article Type] Article
Safe and effective two-in-one replicon-and-VLP minispike vaccine for COVID-19: Protection of mice after a single immunizationCOVID-19에 대한 안전하고 효과적인 2-in-1 레플리콘 및 VLP 미니스파이크 백신: 단일 면역 후 마우스 보호Research Article Published on 2021-04-212022-09-12 Journal: PLoS Pathogens [Category] MERS, SARS, 진단, [키워드] animals Antigen antigen expression approach Author boost build candidate caused Cell cell surface chimeric classic Complication concern COVID-19 disease COVID-19 patients COVID-19 vaccine Critical disease domain effective Efficiency emergence of virus encoding enhancement envelope expressing expression functional glycoprotein humans immune response immunization immunogen include induce K18-hACE2 mice mice Neutralizing activity Neutralizing antibodies non-infectious Non-neutralizing antibodies outcome Particles pathogenic problem protection protective immune response Protein Rabies virus RBD RBD antigen Receptor binding domain Replication replication-competent virus replication-competent viruses RNA S antigen Safe SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 pandemic SARS-CoV-2 spike secreted sequence Side effect single dose Spread stimulated transgenic transmembrane tropism of SARS-CoV-2 vaccination Vaccine vaccine platform vectors vesicular stomatitis vesicular stomatitis virus viral DNA virus virus propagation Virus-like particle virus-neutralizing antibody VLP VLPs VSV VSVΔG [DOI] 10.1371/journal.ppat.1009064 PMC 바로가기 [Article Type] Research Article
The Impact on Infectivity and Neutralization Efficiency of SARS-CoV-2 Lineage B.1.351 PseudovirusSARS-CoV-2 계통 B.1.351 슈도바이러스의 감염성 및 중화 효율에 미치는 영향Communication Published on 2021-04-072022-09-01 Journal: Viruses [Category] MERS, SARS, 변종, 진단, [키워드] affected antibody B.1.351 Casirivimab D614G E484K E484K mutation E484K mutations Efficacy Efficiency Imdevimab Impact indicated Infectivity investigated K417N K417N and E484K mutation of spike Lineage monoclonal antibodies multiple mutation multiple mutations mutant Mutation N501Y N501Y mutation neutralization neutralized Neutralizing antibodies pseudovirus pseudoviruses raising RBD Receptor-binding domain referred to SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant significantly increased South Africa Strains tested the receptor-binding domain Transmissibility variant of SARS-CoV-2 Viral viral infectivity viral spread Wuhan Wuhan strain [DOI] 10.3390/v13040633 PMC 바로가기 [Article Type] Communication
SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responsesReport Published on 2021-04-052022-10-31 Journal: Cell Reports Medicine [Category] COVID-19, MERS, SARS, [키워드] Abstract antibody Antibody Response Antibody titer boost demonstrated detectable effective elicit exceptional Follow-up health emergency host cells Human human donor immunization macaques magnitude memory B cell mice MONITOR Neutralizing antibodies Neutralizing antibody response Neutralizing antibody titer Neutralizing titer outbreak prefusion conformation Prophylactic Protein protein subunit vaccine response rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein seropositive single dose spike glycoprotein Spike protein Spread stimulate subunit subunit vaccines Support Trimers vaccination Vaccine [DOI] 10.1016/j.xcrm.2021.100252 PMC 바로가기 [Article Type] Report
Computational epitope map of SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질의 전산 에피토프 지도Research Article Published on 2021-04-012022-08-13 Journal: PLoS Computational Biology [Category] Biochemistry, COVID-19, MERS, [키워드] analyses Antibody binding antibody binding site antibody binding sites Author bioinformatics candidate caused characterized COVID-19 vaccine COVID-19 vaccines epitope Epitopes expected flexible full-length glycosylated Health Health crisis highlighting host cell identify immunological impair Infection membrane molecular dynamics Molecular dynamics simulation molecular dynamics simulations patch performed primary antibody Protective Protein rigidity S proteins SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 virus Sequence conservation Spike protein stalk steric Structure structures surface area target targets the SARS-CoV-2 Vaccine design Vaccine development Viral viral entry viral envelope protein viral envelope proteins viral membrane viral surface [DOI] 10.1371/journal.pcbi.1008790 PMC 바로가기 [Article Type] Research Article