sera – Page 43 – Communicable Diseases Research

Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants

SARS-COV-2 변이체에 대한 mRNA-1273의 혈청 중화 활성

Clinical Trial

Published on 2021-09-222022-08-13
Journal: Journal of Virology [Category] MERS, SARS, 변종, 임상, 진단,

Epitope Profiling Reveals the Critical Antigenic Determinants in SARS-CoV-2 RBD-Based Antigen

Immunology

Published on 2021-09-212022-11-01
Journal: Frontiers in Immunology [Category] COVID-19,

[키워드] analyzed antibodies Antibody Response Antigen B-cell epitope binding caused characterized conserved COVID-19 COVID-19 pandemic cross-reactive antibody determinant diagnostic domain effort epitope facilitate globe humoral IFA immunization immunized immunodominant immunodominant epitope immunogenic in viral Infection information linear mapped mice monoclonal antibody neutralization activity Neutralizing antibodies peptide peptides Profiling Protein public health crisis RBD RBM receptor binding motif Result SARS-CoV SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 S trimer SARS-CoV-2 spike SARS-CoV-2 strains SARS-CoV-2 vaccine sera Spike protein Structural analysis the antibody response the RBD
[DOI] 10.3389/fimmu.2021.707977 PMC 바로가기 [Article Type] Immunology

Coronavirus induces diabetic macrophage-mediated inflammation via SETDB2

420

Published on 2021-09-212022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS,

[키워드] “cytokine storm” acute respiratory syndrome administration affected binding site blockade contribute coronavirus Coronavirus infection COVID-19 COVID-19 pandemic Cytokine storm decrease develop diabetes Diabetic diabetic patient enzyme epigenetics expression Hepatitis Hyperinflammatory IFNβ increase in induce Infection Inflammation Inflammatory inflammatory cytokine production Inflammatory cytokines Inflammatory response innate immune cell interferon beta lysine mechanism methyltransferase MHV-A59 mice monocyte monocyte/macrophage morbidity and mortality murine murine model NFkB obesity pathologic pathway Patient patients with comorbidities potential mechanism promote promoters regulate regulated responsible reverse inflammation reversed robust SARS-CoV-2 sera SETDB2 severe COVID-19 shown Signaling Significance T2D the cytokine storm therapeutic targeting Transcription type 2 diabete type 2 diabetes with COVID-19
[DOI] 10.1073/pnas.2101071118 PMC 바로가기 [Article Type] 420

SAS: A Platform of Spike Antigenicity for SARS-CoV-2

Cell and Developmental Biology

Published on 2021-09-202022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

[키워드] antigenic antigenic resistance antigenic sites antigenic variants antigenicity assays B.1.351 carried circulating complement Coverage Effectiveness epitope Epitopes experiments GISAID include mAb mAbs monoclonal antibody mutant mutants mutated outbreak Perspective platform predicted Protein provided reactivity reduce Region SARS-CoV-2 SARS-CoV-2 antibody SAS sera shown South Africa spike Spike protein Strains the vaccine unique Vaccine variant variants
[DOI] 10.3389/fcell.2021.713188 PMC 바로가기 [Article Type] Cell and Developmental Biology

Sex Differences in the Evolution of Neutralizing Antibodies to Severe Acute Respiratory Syndrome Coronavirus 2

중화항체가 중증 급성 호흡기 증후군으로 발전하는 과정에서 성별 차이 코로나바이러스 2

Article

Published on 2021-09-172022-09-11
Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age anti-N antibodies anti-N antibody anti-S Anti-spike antibodies antibody association BMI body mass body mass index Chain Reaction collected coronavirus coronavirus 2 COVID-19 declined difference Evolution faster healthcare worker humoral Humoral response independent independent of individuals male participant male participants men Mild disease Neutralizing antibodies neutralizing antibody nucleoprotein participant polymerase chain polymerase chain reaction positive Quantitative respiratory SARS-CoV-2 sera severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Sex Sex-related differences sex-related differences. symptom onset timepoint with mild disease women
[DOI] 10.1093/infdis/jiab127 PMC 바로가기 [Article Type] Article

SARS-CoV-2 spike linear epitope scanning via a peptide microarray through sera profiling

혈청 프로파일링을 통한 펩타이드 마이크로어레이를 통한 SARS-CoV-2 스파이크 선형 에피토프 스캐닝

Article

Published on 2021-09-172022-09-12
Journal: STAR protocols [Category] SARS, 진단,

A bioluminescent and homogeneous SARS-CoV-2 spike RBD and hACE2 interaction assay for antiviral screening and monitoring patient neutralizing antibody levels

항 바이러스 스크리닝 및 모니터링 환자 중화 항체 수준에 대한 생물 발광 및 균질 한 SARS-COV-2 스파이크 RBD 및 HACE2 상호 작용 분석

Article

Published on 2021-09-162022-09-01
Journal: Scientific Reports [Category] SARS, 변종, 신약개발, 진단, 치료기술, 치료제,

[키워드] ACE2 ACE2 binding Anti-RBD antibodies antibody Antiviral apparent affinity binding affinity Biological techniques bioluminescent Brazil can be used changes in Clinical research COVID-19 demonstrated doses Drug discovery E484K E484K mutation epitope escaped hACE2 homogeneous human ACE2 Immunity immunoassay immunology Infectious diseases inhibitor Interaction methodology miniprotein N501Y mutation NAb NAbs Nanoluc luciferase Neutralizing activity Neutralizing antibodies neutralizing antibody Patient persistence populations positive sample RBD RBD mutation RBD mutations Region Research SARS-CoV-2 SARS-CoV-2 Spike RBD secondary antibodies secondary antibody sera soluble ACE2 spike symptom onset tested the binding affinity USA utility vaccinated individual vaccinated individuals
[DOI] 10.1038/s41598-021-97330-3 PMC 바로가기 [Article Type] Article

Sera Neutralizing Activities Against Severe Acute Respiratory Syndrome Coronavirus 2 and Multiple Variants 6 Months After Hospitalization for Coronavirus Disease 2019

중증 급성 호흡기 증후군 코로나바이러스 2 및 다중 변이체에 대한 혈청 중화 활성 코로나바이러스 질병 2019로 입원 후 6개월

Article

Published on 2021-09-152022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 진단, 치료법,

[키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Admission Against anti-S Anti-spike antibodies antibody B.1.1.7 B.1.351 B.1.351 variant characterized collected coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 D614G effective Efficiency Evolution experiment Hospitalized humoral Humoral response IgG IgG level IgG levels Immunoglobulin Immunoglobulin G initial intensive care unit intensive care units invasive ventilation Level marker Month Multiple neutralization Neutralizing activity neutralizing capacity neutralizing effect occur P.1 variant P.1 variants Patient patients hospitalized performed Postinfection Prospective Study quantified Quantitative respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sera serological Serological assay serological assays severe acute respiratory syndrome Coronavirus severity significantly sustained tested the patient variant with COVID-19
[DOI] 10.1093/cid/ciab308 PMC 바로가기 [Article Type] Article

Infectious SARS-CoV-2 in Exhaled Aerosols and Efficacy of Masks During Early Mild Infection

호기 에어로졸의 전염성 SARS-CoV-2와 경증 초기 감염 시 마스크의 효능

Major Article

Published on 2021-09-142022-09-10
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 치료기술,

[키워드] 95% CI 95% confidence interval aerosol Aerosol generation Aerosols Airborne infection Alpha Alpha variant Anti-spike antibodies binding domain Blood breath collected confounders Control COVID-19 case COVID-19 cases Culture cultured virus enrolled exhaled breath aerosol Face masks Impact increase in Mask Masks not significantly different participant quantified recruited reduced remained Respirator respirators Result Saliva SARS-CoV-2 SARS-CoV-2 epidemiology SARS-CoV-2 RNA SARS-CoV-2 variants sequenced sera seronegative surgical swabs vaccination rate vaccination rates variant variants Viral Viral RNA viruses
[DOI] 10.1093/cid/ciab797 PMC 바로가기 [Article Type] Major Article

Neutralizing Monoclonal Antibodies That Target the Spike Receptor Binding Domain Confer Fc Receptor-Independent Protection against SARS-CoV-2 Infection in Syrian Hamsters

스파이크 수용체 결합 도메인을 표적으로 하는 중화 모노클로날 항체는 시리아 햄스터에서 SARS-CoV-2 감염에 대한 Fc 수용체-독립적 보호를 제공합니다

Research Article

Published on 2021-09-142022-09-12
Journal: mBio [Category] MERS, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered aerosol transmission antibody blocked contribute coronavirus COVID-19 demonstrated elicited epitope Epitopes examined expected hamster hamsters immunization in vitro in vivo Infection inhibitory concentration Interaction lung lung viral load Lungs mAbs mechanism mechanism of action monoclonal antibodies monoclonal antibody nasal turbinate nasal turbinates Neutralizing activity Neutralizing antibodies neutralizing antibody Prophylactic prophylactically PROTECT protection receptor Receptor binding domain recognizing reduced required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections sera severe acute respiratory syndrome Coronavirus Spike protein Support Syrian hamster target the Spike therapeutic Therapeutics transferred Transmission Viral load viral loads virus Virus neutralization weight loss
[DOI] 10.1128/mBio.02395-21 PMC 바로가기 [Article Type] Research Article