A prospective study of the impact of glycaemic status on clinical outcomes and anti-SARS-CoV-2 antibody responses among patients with predominantly non-severe COVID-19주로 심각하지 않은 COVID-19 환자에서 혈당 상태가 임상 결과 및 항 SARS-CoV-2 항체 반응에 미치는 영향에 대한 전향적 연구Article Published on 2022-03-012022-09-12 Journal: Diabetes research and clinical practice [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] Admission age anti-SARS-CoV-2 antibody antibodies association C-reactive protein (CRP Care carried clinical Clinical deterioration Clinical outcome clinically comparable COVID-19 COVID-19 patient COVID-19 patients COVID-19 vaccination programme CRP defined deteriorate Deterioration diabetes Diabetes Mellitus elevated lactate dehydrogenase evaluate immune system interferon treatment neutralising antibody not differ Older age oxygen Patient Prediabetic state. predicted Prospective Study radiological Rate response responses severe inflammation survivor symptomatic titre titres Viral load viral loads [DOI] 10.1016/j.diabres.2022.109232 PMC 바로가기 [Article Type] Article
Cross-sectional cycle threshold values reflect epidemic dynamics of COVID-19 in MadagascarResearch article Published on 2022-03-012022-10-05 Journal: Epidemics [Category] SARS, 바이오마커, [키워드] Africa approach Biomarker can be used Course COVID-19 cross-sectional Cross-sectional data cycle threshold Cycle threshold value distribution Epidemic epidemic wave epidemiological estimate extension febrile illness growth growth rate incidence Infection Laboratory Laboratory testing LMIC madagascar National offer platform processed real time Region regions resource RT-qPCR SEIR statistically significant Surveillance trajectory viral kinetics Viral load [DOI] 10.1016/j.epidem.2021.100533 [Article Type] Research article
A thermostable Cas12b from Brevibacillus leverages one-pot discrimination of SARS-CoV-2 variants of concernBrevibacillus의 열안정성 Cas12b는 우려되는 SARS-CoV-2 변이체의 원팟 식별을 활용합니다.Article Published on 2022-03-012022-09-11 Journal: EBioMedicine [Category] SARS, 변종, 치료기술, [키워드] Accuracy activity Alicyclobacillus Alpha amplification applied B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Breast Breast cancer Cas12b center clinical samples college Complete Control COVID-19 CRISPR Ct value current Delta detection system diagnostics differential scanning fluorimetry disease control dissemination Dual-detection Engineering facilitate foundation fraction Gamma guide RNA high viral load house implementation isothermal amplification lack landscape Loop-mediated isothermal amplification Medicine Negative predictive value NIAID offer office omicron One-pot detection overcome P.1 Palindromic Pathogens platform point-of-care positive Predictive value President prevention primer Protein purified qPCR reaction reagent Real-time monitoring reverse transcription robust RT-LAMP S gene SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 variant Science sensitivity Sequencing SPADE specificity technology the SARS-CoV-2 Thermophillic university variants variants of concern veterinary medicine vice Vice President Viral load VoC VOCs were expressed [DOI] 10.1016/j.ebiom.2022.103926 PMC 바로가기 [Article Type] Article
Transmission dynamics and epidemiological characteristics of SARS-CoV-2 Delta variant infections in Guangdong, China, May to June 20212021년 5월~6월 중국 광둥성 SARS-CoV-2 Delta 변종 감염의 전파 역학 및 역학적 특성Article Published on 2022-03-012022-09-11 Journal: Eurosurveillance [Category] SARS, 변종, [키워드] accounted adjusted odds ratio association attack rate Characteristics China close contact collected Complete confirmed COVID-19 case Contact credible interval Delta delta variant Diseases emerging or re-emerging diseases. epidemiological estimate estimation evaluated Guangdong had more higher risk Incubation period index index cases indicated Infection occurred outbreak parameters Patient pre-symptomatic predominant reproduction numbers SARS-CoV-2 secondary secondary attack rate symptom onset Transmission Transmission dynamics transmissions vaccination Viral load viral loads wild type wild-type SARS-CoV-2 [DOI] 10.2807/1560-7917.ES.2022.27.10.2100815 PMC 바로가기 [Article Type] Article
Short-chain fatty acid acetate triggers antiviral response mediated by RIG-I in cells from infants with respiratory syncytial virus bronchiolitis짧은 사슬 지방산 아세테이트는 호흡기 세포융합 바이러스 세기관지염이 있는 유아의 세포에서 RIG-I에 의해 매개되는 항바이러스 반응을 유발합니다Article Published on 2022-03-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 치료제, [키워드] A549 A549 cell A549 cells Acetate Admission animal animals antiviral response Bronchiolitis Cell clinical clinical isolates code COVID-19 demonstrated disease severity duration of fever Effect epithelial cell epithelial cells examined expression faster fatty fecal gut microbiota Hospitalized IFNB1 Impact in vitro Increased increased expression Infant Infants Infection interferon interferon-stimulated gene interferon-stimulated genes intranasally ISG ISG15 ISGs isolate isolates lung MAVS mice microbial modulation mouse model OAS1 oxygen oxygen saturation Patient PROTECT receptor reduce reduced reduction in respiratory respiratory cell respiratory epithelial cell respiratory epithelial cells respiratory syncytial virus RIG-I RSV SARS-CoV-2 infected patient SARS-CoV-2 infected patients severity significantly Stool strain Strains treated Treatment Trigger Viral load virus virus recognition [DOI] 10.1016/j.ebiom.2022.103891 PMC 바로가기 [Article Type] Article
Evaluation of Factors that Affect the Performance of COVID-19 Molecular Assays Including Presence of Symptoms, Number of Detected Genes and RNA Extraction Type증상 유무, 검출된 유전자 수, RNA 추출 유형 등 코로나19 분자 분석 성능에 영향을 미치는 요인 평가Article Published on 2022-03-012022-09-11 Journal: Molecular diagnosis & therapy [Category] MERS, SARS, 진단, 치료기술, [키워드] Affect amplified Asymptomatic BGI center Cepheid collected Coronavirus disease 2019 COVID-19 cycle threshold Direct evaluated extraction Factor focus Genomics greater highest Including Laboratory limitation lowest material Mitigation molecular nasopharyngeal sample nCoV number pandemic participant performance positive result Presence Rapid rapid assay rapid assays reagent RNA RT-PCR Sample SARS-CoV-2 SARS-CoV-2 test sensitivity symptomatic participant symptomatic participants System Test tested Traditional Type Viral viral genome Viral load [DOI] 10.1007/s40291-021-00574-y PMC 바로가기 [Article Type] Article
The impact of COVID-19 epidemic phase and changes in mean viral loads: implications for SARS-CoV-2 testing strategiesCOVID-19 전염병 단계의 영향 및 평균 바이러스 부하의 변화: SARS-CoV-2 테스트 전략에 대한 영향Article Published on 2022-03-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] SARS, 치료기술, [키워드] average changed changes in collected COVID-19 epidemic Diagnosis diagnostic methods diagnostic test diagnostic tests early phase highest implication lowest marker pandemic Patient peaked phase population level Public health intervention question reduced RT-PCR SARS-CoV-2 SARS-CoV-2 testing SARS-CoV-2 viral load SARS-CoV-2 viral loads sensitivity threshold Viral load [DOI] 10.1016/j.diagmicrobio.2021.115598 PMC 바로가기 [Article Type] Article
Standardization of a high-performance RT-qPCR for viral load absolute quantification of influenza AArticle Published on 2022-03-012023-06-23 Journal: Journal of virological methods [Category] 신종인플루엔자, [키워드] Absolute quantification influenza A MIQE Standard Viral load [DOI] 10.1016/j.jviromet.2021.114439
Evaluation of methylene blue based photodynamic inactivation (PDI) against intracellular B-CoV and SARS-CoV2 viruses under different light sources in vitro as a basis for new local treatment strategies in the early phase of a Covid19 infectionCovid19 감염 초기 단계의 새로운 국소 치료 전략의 기초로서 시험관 내 다양한 광원에서 세포 내 B-CoV 및 SARS-CoV2 바이러스에 대한 메틸렌 블루 기반 광역학 불활화(PDI) 평가Article Published on 2022-03-012022-09-11 Journal: Photodiagnosis and photodynamic therapy [Category] SARS, 치료기술, [키워드] Antiviral aPDT (antimicrobial photodynamic therapy). approach Cell Concentration Corona viruses dark dose early phase experiment Extracellular in vitro inactivation Incubation infected cell infected cells Infection intensity Laser Local logarithmic reduction low dose Methylene Methylene blue nose and throat PDI PDI (photodynamic inactivation) phenothiazine Phenothiazine dye in aPDT photodynamic inactivation photodynamic therapy photosensitizer Prognosis radiation intensity reducing reduction SARS-CoV-2 SARS-CoV-2 inactivation SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV2 sensitizer substitute therapy treated treatment strategy Vero E6 Viral load virus was reduced [DOI] 10.1016/j.pdpdt.2021.102642 PMC 바로가기 [Article Type] Article
Neutralizing antibody: a savior in the Covid-19 disease중화항체: 코로나19의 구세주Review Published on 2022-03-012022-09-11 Journal: Molecular biology reports [Category] MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단, [키워드] ACE2 angiotensin Angiotensin converting enzyme-2 (ACE2) receptor antibody binding clinical trial combating Community community health components Convalescent plasma transfer (CPT) coronavirus COVID-19 COVID-19 disease COVID-19 infection Defense defense mechanism diagnostic disease enzyme Health Health Organization human lung cells humoral immune immune surveillance immune system immunogenic Infection Infectious disease Infectious diseases interact life mechanism monoclonal antibodies monoclonal antibody MOST Neutralizing antibodies neutralizing antibody outbreak pandemic plasma Plasma cell Plasma cells plasma therapy Protein RBD receptor Receptor-binding domain Receptor-binding domain (RBD) recognize reduce secreted shown Spike protein Surveillance the receptor-binding domain the spike protein therapeutic therapy transfer Vaccine development Viral Viral load virus WHO World Health Organization [DOI] 10.1007/s11033-021-07020-6 PMC 바로가기 [Article Type] Review