Thermostable designed ankyrin repeat proteins (DARPins) as building blocks for innovative drugs
Research Article
[키워드] abicipar pegol
Ala
antibody
block
clinical development
clinically
DARPin
DARPins, designed ankyrin repeat proteins
designed ankyrin repeat protein
domain
domains
drug
Drug development
drug engineering
electrostatic repulsion
endothelial
ensovibep
FIVE
flexible
growth
HER2, human epidermal growth factor receptor 2
hGABP, human guanine-adenine-binding protein
HSA, human serum albumin
Ile
IMPROVE
improvement
in silico analysis
inhibitor
IR, internal repeat
less
molecular dynamics
Molecular dynamics simulation
Mutation
N-terminal
N-terminal capping repeat
Protein
reduce
replaced
responsible
SARS-CoV-2 entry
temperature
thermostability
thermostable
Thr
transferred
Val
Vascular
VEGF, Vascular endothelial growth factor
was increased
[DOI] 10.1016/j.jbc.2021.101403 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1016/j.jbc.2021.101403 PMC 바로가기 [Article Type] Research Article