Immunogenic amino acid motifs and linear epitopes of COVID-19 mRNA vaccinesCOVID-19 mRNA 백신의 면역 원성 아미노산 모티프 및 선형 에피토프Research Article Published on 2021-09-092022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 변종, 진단, [키워드] Adults Amino acid approach Bacterial C-terminal domain coronavirus COVID-19 COVID-19 mRNA vaccine Critical Effectiveness elicit epitope Epitopes expressed healthy homology human coronavirus identify identity IgG Immune escape immunization immunogenic immunoprecipitate in vitro individual linear epitope linear epitopes mapped motif mRNA vaccine natural infection peptide peptides Post-vaccine primary sequence random recipients response S1 and S2 SARS-CoV SARS-CoV-2 neutralization SARS-CoV-2 spike protein Spike protein subset subunit target the SARS-CoV-2 therapy vaccination Vaccine variants were used [DOI] 10.1371/journal.pone.0252849 PMC 바로가기 [Article Type] Research Article
Degenerate CD8 Epitopes Mapping to Structurally Constrained Regions of the Spike Protein: A T Cell-Based Way-Out From the SARS-CoV-2 Variants Storm스파이크 단백질의 구조적으로 제한된 영역에 매핑되는 CD8 에피토프 변성: SARS-CoV-2 변이체 폭풍으로부터의 T 세포 기반 탈출구Review Published on 2021-09-082022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] Analysis analyzed arising B cell responses can not candidate CD8 CD8 T cell CD8 T cell epitopes CD8 T cell responses CD8 T cells CD8 T-cell Cell-mediated immunity compensated conserved COVID-19 vaccines cross-neutralization degenerate Efficacy ENhance epitope Epitopes Evolution expected HLA HLA class I HLA class I molecules immune response immune responses immunization immunodominant impairing inactivation limit maintain mapping mutate mutations Neutralizing antibodies Perspective Population Protective protective immunity Region response S-protein SARS-CoV-2 SARS-CoV-2 vaccines SARS-CoV-2 variants spike region stimulatory storm T cell T cell epitopes T cells the SARS-CoV-2 the Spike translational vaccination Vaccination strategies Vaccination strategy Vaccine Vaccines variant variants variants of concern Viral viral escape viral variant Viral variants [DOI] 10.3389/fimmu.2021.730051 PMC 바로가기 [Article Type] Review
Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variantsSARS-COV-2 수용체 결합 도메인 항체 인식의 구조적 및 에너지 프로파일 링 및 순환 변이체의 영향Research Article Published on 2021-09-072022-09-10 Journal: PLoS Computational Biology [Category] SARS, 변종, 진단, [키워드] affected Alpha Analysis antibody atomic Author B.1.1.7 B.1.617.2 binding binding domain circulating variant Clustering Community complex computational modeling Contact COVID-19 pandemic dataset Delta described determinant disrupt epitope epitope conservation evade feature group high resolution highlight identify immune response immune responses less molecular monoclonal antibodies monoclonal antibody Mutation mutations natural infection Neutralizing antibodies performed predicted Protective antibody protective antibody responses RBD Receptor binding domain Research residue residues SARS-CoV-2 pandemic SARS-CoV-2 receptor SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus spike glycoprotein Spread Structural analysis Structure structures target the SARS-CoV-2 the SARS-CoV-2 virus therapeutic Unsupervised clustering Vaccine Vaccine design Vaccines variants Viral viral variant Viral variants was used [DOI] 10.1371/journal.pcbi.1009380 PMC 바로가기 [Article Type] Research Article
Quantifying T Cell Cross-Reactivity: Influenza and CoronavirusesReview Published on 2021-09-072022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Adaptive immune response bipartite bipartite network Cell competition process condition Coronaviruses cross-reactive cross-reactivity epitope Epitopes heterologous infection homeostasis immunodominant epitope immunodominant epitopes Infection Influenza mathematical modeling overlap pattern Population pre-existing immunity Quantitative Re-infection recognize strain T cell T cell receptor viral strain [DOI] 10.3390/v13091786 PMC 바로가기 [Article Type] Review
Multiepitope Proteins for the Differential Detection of IgG Antibodies against RBD of the Spike Protein and Non-RBD Regions of SARS-CoV-2Article Published on 2021-09-032022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] absence Analysis analyzed antibodies approach Asymptomatic carrier benefit chimeric contributed coronavirus COVID-19 COVID-19 pandemic de novo De novo design detection Diagnostic method diagnostic tests Diseases ELISA epitope generate identify IgG immunological linear B cell epitopes non-specific offer pathogen platform populations produced Protein RBD reactivity Region SARS-CoV-2 sequence serodiagnostic serological test similarity spread to target the RBD the receptor-binding domain the Spike the spike protein Transmission virus while Wuhan, China [DOI] 10.3390/vaccines9090986 PMC 바로가기 [Article Type] Article
Human CD4 + T cells specific for dominant epitopes of SARS-CoV-2 Spike and Nucleocapsid proteins with therapeutic potential치료 가능성이 있는 SARS-CoV-2 스파이크 및 뉴클레오캡시드 단백질의 우세한 에피토프에 특이적인 인간 CD4 + T 세포Article Published on 2021-09-012022-09-11 Journal: Clinical and experimental immunology [Category] SARS, 치료법, [키워드] adverse effects Antigen cancer patient Cancer patients CD4 Cell therapy cellular clone clones coronavirus disease COVID-19 COVID-19 patient COVID-19 patients cytokine response develop dominant epitope Efficacy effort epitope epitope. Epitopes examined focus haematopoietic stem cell transplantation Human identify immune response immune responses immunocompromised individuals immunodominant epitope immunodominant epitopes immunological protection long-lasting Neutralizing antibodies neutralizing antibody nine nucleocapsid protein Protective Protein SARS-CoV-2 SARS-CoV-2 virus sensitivity sequence sequencing approach short-lived spike Spread stem cell Stem cell transplantation T cell T cell receptor T cell response T cell responses T cells TCR the SARS-CoV-2 virus therapeutic potential therapy These data Treatment Vaccine while [DOI] 10.1111/cei.13627 PMC 바로가기 [Article Type] Article
GENERATING RESPONSES IMMUNE IN CELLULAR AND HUMORAL TREATMENT WITH EPITOPE SPIKE, EPITOPE ENVELOPE PROTEIN, AND EPITOPE MEMBRANE PROTEIN SARS-COV-2, HONEY, SAUSSUREA LAPPA , AND NIGELLA SATIVAArticle Published on 2021-09-012022-10-27 Journal: African Journal of Infectious Diseases [Category] COVID-19, [키워드] Sausseria lappa administration animal model Cellular immune response cellular immunity clinical trial COVID-19 CPE CTL domination envelope protein epitope evaluated four group four groups Honey humoral immune response Humoral immunity IgG IL-4 immunomodulator Indonesia lung marker material membrane protein mice Nigella Sativa NK cell NK cells organ pandemic PBS Placebo Research Respons immune Spike protein β-defensin [DOI] 10.21010/ajidv15i2S.3 PMC 바로가기 [Article Type] Article
GENERATING RESPONSES IMMUNE IN CELLULAR AND HUMORAL TREATMENT WITH EPITOPE SPIKE, EPITOPE ENVELOPE PROTEIN, AND EPITOPE MEMBRANE PROTEIN SARS-COV-2, HONEY, SAUSSUREA LAPPA , AND NIGELLA SATIVA에피토프 스파이크, 에피토프 봉투 단백질 및 에피토프 막 단백질 SARS-COV-2, Honey, Saussurea Lappa 및 Nigella Sativa로 세포 및 체액 처리에서 면역을 생성합니다.Article Published on 2021-09-012022-09-10 Journal: African Journal of Infectious Diseases [Category] 비임상, [키워드] Sausseria lappa administration animal model breath Cellular immune response cellular immune responses cellular immunity clinical trial COVID-19 CPE CTL domination envelope protein epitope evaluated four group four groups Honey humoral immune response Humoral immunity IgG IL-4 immune responses immunomodulator Indonesia lung marker material membrane protein mice mouth Nigella Sativa NK cell NK cells organ pandemic PBS Placebo Research Respons immune Spike protein TGF-β β-defensin [DOI] 10.21010/ajidv15i2S.3 PMC 바로가기 [Article Type] Article
An in-depth in silico and immunoinformatics approach for designing a potential multi-epitope construct for the effective development of vaccine to combat against SARS-CoV-2 encompassing variants of concern and interest우려 및 관심의 변이를 포함하는 SARS-CoV-2에 대항하는 백신의 효과적인 개발을 위한 잠재적인 다중 에피토프 구성을 설계하기 위한 심층 실리코 및 면역정보학 접근 방식Article Published on 2021-09-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 변종, [키워드] ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Antibody titer antigenicity approach B cell B cell epitope B-cell epitope B.1.1.7 B.1.351 B.1.427 B.1.429 B.1.526 B.1.617.1 B.1.617.2 binding Cell cells coronavirus COVID-19 effective elevated epitope Health immune response Immunity immunoinformatics in silico in vitro linker linkers MEV Multi-epitope vaccine NK cells nucleotide nucleotide sequence ORF1 ORF10 ORF1ab ORF3a ORF6 ORF7a ORF7b ORF8 outbreak P.1 P.2 Pathogens Physicochemical properties polyprotein present Prevent preventive measure receptor S protein SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 T cell T cell epitope T-cell the vaccine TLR2 TLR4 Toll-like receptor Toll-like receptors turn utility Vaccine vaccine construct variants variants of concern variants of interest variants of SARS-CoV-2 viral pathogen were used [DOI] 10.1016/j.compbiomed.2021.104703 PMC 바로가기 [Article Type] Article
Enhancing the Stability of COVID-19 Serological Assay through Metal-Organic Framework Encapsulation금속-유기 프레임워크 캡슐화를 통한 COVID-19 혈청학적 분석의 안정성 향상Article Published on 2021-09-012022-09-11 Journal: Advanced Healthcare Materials [Category] SARS, 진단, 치료기술, [키워드] alleviate among others antibody Antigen antigens approach biospecimens Clinical data complementary condition conformational conformational epitopes COVID-19 COVID-19 patient COVID-19 patients Critical demonstrated diagnostic reagent diagnostic reagents Disease surveillance effective electricity elements elevated temperature encapsulation Enhancing enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays epitope Epitopes framework growth handling IMPROVE inaccessible metal-organic frameworks plasma sample plasma samples preservation quantification refrigeration resource-limited settings. SARS-CoV-2 SARS-CoV-2 antigens serologic assays stability storage conditions Surveillance temperature the disease [DOI] 10.1002/adhm.202100410 PMC 바로가기 [Article Type] Article