Development and Evaluation of Quantitative Immunoglobulin G Enzyme-Linked Immunosorbent Assay for the Diagnosis of Coronavirus Disease 2019 Using Truncated Recombinant Nucleocapsid Protein as Assay Antigen분석 항원으로 절단된 재조합 뉴클레오캡시드 단백질을 사용한 코로나바이러스 질병 2019 진단을 위한 정량적 면역글로불린 G 효소 연결 면역흡착 분석법의 개발 및 평가Article Published on 2021-09-132022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibodies Antigen applied can be used causative agent collected complementary conserved conserved region coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis cross-reactive cross-reactive antibodies cross-reactive antibody deleted demonstrated development Diagnosis E. coli ELISA evaluate full-length gold IgG IgG ELISA IgG indirect ELISA Immunoglobulin Immunoglobulin G less N protein negative control neutralization test nucleocapsid protein plaque reduction neutralization Plaque reduction neutralization test prevalent PRNT Protein protein expression real-time RT-PCR recombinant respiratory RT-PCR SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 N SARS-CoV-2 N protein SARS-CoV-2 spike protein sensitivity sera Serological assay serological assays severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specificity spike IgG Spike protein Surveillance [DOI] 10.3390/ijerph18189630 PMC 바로가기 [Article Type] Article
Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents무증상 또는 경증의 증상이 있는 SARS-CoV-2 감염은 소아 및 청소년에서 지속적인 중화 항체 반응을 유발합니다Research Article Published on 2021-09-082022-09-10 Journal: JCI Insight [Category] SARS, 진단, 치료기술, [키워드] acute infection Adaptive immunity All participants Antibody Response Antibody responses Asymptomatic children comparable contribute detectable elicit evaluated generate humoral immune response humoral immune responses IgA IgG IgM immune response immune responses immunology Infectious disease Mild Neutralizing activity Neutralizing antibody response Participants populations question Reinfection robust SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection sera Spread strength symptomatic infection symptomatic SARS-CoV-2 infection virus-neutralizing [DOI] 10.1172/jci.insight.150909 PMC 바로가기 [Article Type] Research Article
Prevalence of SARS-CoV-2 IgG antibodies and their association with clinical symptoms of COVID-19 in Estonia (KoroSero-EST-1 study)SARS-CoV-2 IgG 항체의 유병률 및 에스토니아에서 COVID-19의 임상 증상과의 연관성(KoroSero-EST-1 연구)Article Published on 2021-09-072022-09-12 Journal: Vaccine [Category] MERS, SARS, 진단, [키워드] 95% CI 95% confidence interval absence acute respiratory illness age Analysis analyzed antibody concentration Antibody concentrations assays association chest pain clinical symptom Concentration cough COVID-19 cumulative determine diagnosis of SARS-CoV-2 diarrhea difficulty breathing Epidemic Estonia Estonian European country Factor fatality Fatality rate Fever First wave Focusing Hospitalization hotspot IgG incidence individual Infection Infection fatality rate majority Multiple linear regression neutralizing antibody participant PCR practitioners Prevalence random recruited regions required respiratory symptom SARS-CoV-2 SARS-CoV-2 IgG antibody selected sera seropositive subject Seroprevalence Shortness of breath stratified susceptible Symptom Symptoms Tallinn Total [DOI] 10.1016/j.vaccine.2021.07.093 PMC 바로가기 [Article Type] Article
Assessment of avidity related to IgG subclasses in SARS-CoV-2 Brazilian infected patientsSARS-COV-2 브라질 감염 환자의 IgG 서브 클래스와 관련된 열성 평가Clinical Trial Published on 2021-09-032022-08-13 Journal: Scientific Reports [Category] SARS, 임상, 진단, 치료기술, [키워드] analyzed anti-RBD Anti-RBD IgG anti-RBD IgG4 antibody Antibody avidity antibody levels Antibody Response Applied immunology assessment association avidity avidity range Brazil COVID-19 detectable Diagnostic markers died disease effort elicit ELISA exacerbated Follow-up form Health highlighting hospitalized patient hospitalized patients house IgG IgG antibody IgG subclasse IgG1 IgG3 IgG4 Immunological response Immunological techniques indicate infected patient Laboratory less life-threatening Mild Mild disease Most patients outcome Patient predict protective immunity RBD RBD IgG RBD IgG-ELISA RBD protein resulting reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD sensibility sera severe COVID-19 specificity study period symptomatic patient Symptomatic patients symptoms onset the disease Vaccine development with COVID-19 with mild disease [DOI] 10.1038/s41598-021-95045-z PMC 바로가기 [Article Type] Clinical Trial
Monitoring Specific IgM and IgG Production Among Severe COVID-19 Patients Using Qualitative and Quantitative Immunodiagnostic Assays: A Retrospective Cohort Study정성적 및 정량적 면역진단 분석을 사용하여 중증 COVID-19 환자 중 특정 IgM 및 IgG 생산 모니터링: 후향적 코호트 연구Immunology Published on 2021-09-032022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, 치료법, [키워드] Abbott acute respiratory syndrome analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibody production Architect assays association Cohen’s kappa coefficient Combination Concentration concentrations confirmed COVID-19 patients coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 patient develop Diagnosis early phase form humoral immune response IgG IgG and IgM IgG test IgM IgM and IgG IgM antibody IgM seroconversion immunoassays immunoglobulins MONITOR monitoring Mortality Patient Pearson correlation coefficient performed positive positive relationship processed Production Qualitative Quantitative respiratory robust SARS-CoV-2 SARS-CoV-2 IgG Saudi Arabia sera seroconversion rate seroconversion rates Serological testing serum severe severe COVID-19 severity of COVID-19 Specific test results tested [DOI] 10.3389/fimmu.2021.705441 PMC 바로가기 [Article Type] Immunology
Self-collection of capillary blood using Tasso-SST devices for Anti-SARS-CoV-2 IgG antibody testingAnti-SARS-CoV-2 IgG 항체 검사를 위한 Tasso-SST 장치를 이용한 모세혈관 자가 채혈Research Article Published on 2021-09-022022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] Accuracy administration anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 S1 IgG Blood blood sample Blood samples capillary capillary blood Care clinical laboratory component components Concordance condition COVID-19 demonstrated extreme healthy control IgG antibodies IgG antibody include Laboratory limitation Medical care medical supervision Participants reliability Result SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies SARS-CoV-2 pandemic sera summer tested venipuncture venous venous blood was collected was obtained widespread [DOI] 10.1371/journal.pone.0255841 PMC 바로가기 [Article Type] Research Article
Operational characteristics of 30 lateral flow immunoassays used to identify COVID-19 immune responseCOVID-19 면역 반응을 식별하는 데 사용되는 30가지 측면 유동 면역 측정법의 작동 특성Observational Study Published on 2021-09-012022-09-10 Journal: Journal of Immunological Methods [Category] SARS, 임상, 진단, 치료기술, [키워드] 2019 2019-nCoV Algorithm antibody Antibody test antibody tests approval approved Boson BSS cassette cassettes Characteristics Control coronavirus coronavirus 2 COVID-19 COVID-19 immune response detect evaluated highlight identify IgG IgG and IgM IgM immunochromatography Immunoglobulin Immunoglobulin G immunoglobulin M implementation Infection lateral flow immunoassay Lateral flow immunoassays Lateral flow test Lateral flow tests majority National nCoV negative novel Novel coronavirus Orient Patient performance plasma point-of-care produced reported required respiratory SARS CoV SARS CoV-2 SARS CoV-2 infection SARS-CoV2 sensitivities sensitivity sera serological serology serum Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 shape Specificities specificity specimen tested Volume [DOI] 10.1016/j.jim.2021.113096 PMC 바로가기 [Article Type] Observational Study
High rate of clinically unrecognized SARS-CoV-2 infections in pediatric palliative care patients소아 완화 치료 환자에서 임상적으로 인식되지 않는 높은 SARS-CoV-2 감염 비율Clinical Trial Published on 2021-09-012022-09-12 Journal: European journal of pediatrics [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] acute respiratory syndrome analyzed children Clinical course clinically close contact Comorbidities Comorbidity condition conditions coronavirus COVID-19 cross-sectional Frequency Infection life-limiting outcome Palliative care Patient patients pediatric Pediatric patient Pediatric patients pediatrics Prevalence reported risk risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections sera seronegative patient seropositive severe disease course significant difference silent Symptom tested treated Trial was determined [DOI] 10.1007/s00431-021-04242-5 PMC 바로가기 [Article Type] Clinical Trial
Association between the nasopharyngeal microbiome and metabolome in patients with COVID-19Research article Published on 2021-09-012022-10-05 Journal: Synthetic and Systems Biotechnology [Category] 바이오마커, 유전자 메커니즘, [키워드] Analysis anti-SARS-CoV-2 association bacterial metabolite Blood characterized Cohort commensal bacteria COVID-19 COVID-19 patient COVID-19 patients disease enrolled feature identify infect information Interaction lactic acid Leptotrichia Local metabolome metabolomic analysis metagenomic Microbiome microbiota nasopharyngeal Nasopharyngeal microbiome Nasopharyngeal swab Non-COVID-19 Non-COVID-19 patients Patient patients with COVID-19 pharyngeal Prevotella provide reduced respiratory tract Result SARS-CoV-2 sera serum significantly Streptococcus susceptibility Urine were used [DOI] 10.1016/j.synbio.2021.06.002 [Article Type] Research article
The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serumSARS-CoV-2 회복기 혈청의 중화 활성 및 RBD 결합에 대한 스파이크 N501Y 돌연변이의 영향Article Published on 2021-09-012022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 변종, 진단, [키워드] 95% CI Amino acid amino acids ANOVA Anti-RBD IgG Anti-S1 antibody Antibody binding assays B.1.1.7 B.1.351 binding binding domain clinician collected convalescent sera convalescent serum COVID-19 COVID-19 patient determine enzyme immunoassay evaluated geometric geometric mean geometric mean titer GMT Hong Kong IgG isolates K417N Lineage mean difference Michael microneutralization N501Y N501Y mutation neutralization Neutralizing activity neutralizing antibody Neutralizing antibody Spike protein receptor binding domain NSP2 one-way ANOVA Patient positive Protein RBD RBD binding Receptor binding Receptor binding domain recovered COVID-19 patient reduced Richard SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 lineage SARS-CoV-2 N501Y variant B.1.1.7 sensitivity sera serum service significantly spike Spike protein Spike receptor binding domain Spread statistically susceptibility symptom onset tested variant variants virus virus variant virus variants viruses VoC VOC. was determined wild-type [DOI] 10.1016/j.ebiom.2021.103544 PMC 바로가기 [Article Type] Article