High-level expression of the monomeric SARS-CoV-2 S protein RBD 320-537 in stably transfected CHO cells by the EEF1A1 -based plasmid vectorEEF1A1 기반 플라스미드 벡터에 의한 안정적으로 형질감염된 CHO 세포에서 단량체 SARS-CoV-2 S 단백질 RBD 320-537의 고수준 발현Research Article Published on 2021-02-022022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, [키워드] Accuracy acute respiratory syndrome Alpha amplification analyzed Antigen antigenic antigenic determinants C-terminal Cell culture cell line Chinese hamster CHO cell condition coronavirus coronavirus 2 Coronaviruses described determinant domain EEF1A1 elongation factor exceeded except for expression gel gel filtration Genetic Genome glycans glycosylation Host immune response inducer mammalian mass spectrometry methotrexate monomeric N-glycosylation peptide performed Plasmid PNGase F polyacrylamide polyacrylamide gel produced Protein purification RBD RBD protein recombinant Recombinant SARS-CoV-2 RBD reducing regulatory sequence regulatory sequences respiratory S protein S proteins SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 S protein selected serological serological test Serological tests severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signal peptide subunit Subunit vaccine the S protein transfected cells translation unique Vaccine variant Viral viral envelope viral signal was obtained [DOI] 10.1371/journal.pone.0242890 PMC 바로가기 [Article Type] Research Article
A multiplex chemiluminescent immunoassay for serological profiling of COVID-19-positive symptomatic and asymptomatic patientsCOVID-19 양성 증상 및 무증상 환자의 혈청학적 프로파일링을 위한 다중 화학발광 면역분석Article Published on 2021-02-022022-09-10 Journal: Nature Communications [Category] MERS, 바이오마커, 진단, 치료기술, [키워드] Affect antibodies antibody profiling Antibody Response Antibody responses Antimicrobial responses Asymptomatic individuals binding domain Biomarker chemiluminescent immunoassay children Cohort COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 PCR test Critical deaths detect Detection limit develop Diagnostic markers disease severity greater IgA IgA response IgA responses IgG IgG response IgG responses IgM IgM response IgM responses immune response initial large cohort Mild-to-moderate multiplex Multiplex assay multiplex serology participant Participants Patient PCR test risk robust SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2-specific antibodies serological serology significantly increased Symptom symptom onset symptomatic and asymptomatic symptomatic participant symptomatic participants the antibody response Viral viral infection Viral transmission with COVID-19 [DOI] 10.1038/s41467-021-21040-7 PMC 바로가기 [Article Type] Article
Experience of clinical screening for COVID-19 among patients undergoing elective orthopedic surgeries: an alternative proposalObservational Study Published on 2021-02-022022-10-04 Journal: Journal of Orthopaedic Surgery and Research [Category] MERS, 임상, [키워드] acute respiratory syndrome affected age average cohort of patient Contact coronavirus coronavirus disease COVID-19 COVID-19 pandemic death diagnostic tests early stage epidemiological Evidence experience female Hospitalized implementation incidence of COVID-19 involved Isolation Level molecular Mortality multicenter orthopedic Orthopedic procedures Outpatient surgical procedures pandemic Patient patients died performed physical Physical examination positive result postoperative protocol recorded Result retrospective RT-PCR test SARS-CoV-2 serological Support Surgical Procedure Symptom Symptoms symptoms of COVID-19 tested the disease with COVID-19 [DOI] 10.1186/s13018-021-02217-8 PMC 바로가기 [Article Type] Observational Study
Vi-specific serological correlates of protection for typhoid fever비특이적 장티푸스 예방을 위한 혈清학적 상관관계Article Published on 2021-02-012022-10-29 Journal: The Journal of Experimental Medicine [Category] COVID-19, 살모넬라증, [키워드] addition Analysis antibody applied approach assist Bacteria both groups children Combination component correlated develop disease severity Endemic enrolled feature Fever functional human infection humoral identify IgA IgG response increases in Infection innate immune cell marker multivariate neutrophil participant phagocytosis polyclonal predicted Protective reduced regions responses Salmonella serological serology shown typhoid used to evaluate Vaccine vaccine availability Vaccines [DOI] 10.1084/jem.20201116 PMC 바로가기 [Article Type] Article
T cell and antibody responses to SARS-CoV-2: Experience from a French transplantation and hemodialysis center during the COVID-19 pandemicSARS-CoV-2에 대한 T 세포 및 항체 반응: COVID-19 전염병 동안 프랑스 이식 및 혈액 투석 센터의 경험Article Published on 2021-02-012022-09-11 Journal: American journal of transplantation : official jou [Category] MERS, 바이오마커, 진단, [키워드] Adaptive immune response antibody Antibody Response Antibody responses Antiviral COVID-19 COVID-19 diagnosis COVID-19 pandemic COVID-19 patient differential diagnosis evaluate experience exposure to form French healthy control Hemodialysis immune response immune responses Immunity immunobiology Immunosuppressed immunosuppressive immunosuppressive therapy Infection infection and infectious agents - viral infectious agent infectious agents involved kidney kidney transplantation / nephrology monitoring: immune Nephrology Patient progression reactivity reduction Research responses risk RT-PCR SARS-CoV-2 serological seronegative severe forms of COVID-19 T cell T cell response T cell responses T cells the disease therapy translational translational research / science. Transplant virus [DOI] 10.1111/ajt.16348 PMC 바로가기 [Article Type] Article
Clinical evaluation of commercial automated SARS-CoV-2 immunoassays상용 자동화된 SARS-CoV-2 면역분석의 임상 평가Article Published on 2021-02-012022-09-11 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단, 치료기술, [키워드] antibody Antibody detection assays automated Automated SARS-CoV-2 antibody detection clinical Control COVID-19 infection diagnostic diagnostic sensitivities Diagnostic specificities diagnostic specificity DiaSorin epitope Euroimmun excluded facilitate four groups High throughpu testing IgA IgG IgM IgM/IgG immunoassay Infection involved laboratory-confirmed lack lead Longitudional monitoring of antibody development negative control negative controls number of samples Numerous pandemic control Patient performed positive qRT-PCR released reproducibility retrospective Roche SARS-CoV-2 SARS-CoV-2 antibody sensitivity sera Seroconversion serological serological assays serological result Serpprevalence. significantly SNIBE specificity the disease validation [DOI] 10.1016/j.ijid.2020.12.003 PMC 바로가기 [Article Type] Article
Evaluating SARS-CoV-2 spike and nucleocapsid proteins as targets for antibody detection in severe and mild COVID-19 cases using a Luminex bead-based assayLuminex 비드 기반 분석을 사용하여 중증 및 경증 COVID-19 사례에서 항체 검출을 위한 표적으로 SARS-CoV-2 스파이크 및 뉴클레오캡시드 단백질 평가Article Published on 2021-02-012022-09-11 Journal: Journal of virological methods [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody Antibody detection Antibody test Antigen assays Bead-based assay Combination coronavirus COVID-19 case domain ELISA Evaluating FIVE IgA antibodies IgA antibody IgA response IgG IgG antibody IgM include Infection Luminex antibody test Mild mild case mild cases multiple antigen multiple antigens Multiplexing neutralization neutralization test neutralizing antibody nucleocapsid nucleocapsid protein offer Pathogens RBD RDTs Receptor-binding domain Recombinant nucleocapsid protein respiratory SARS-CoV-2 SARS-CoV-2 spike sera serological serological test Serological tests Serosurveillance severe cases significantly lower specificity Support symptom onset target threshold titers virus neutralization assays virus neutralization test while [DOI] 10.1016/j.jviromet.2020.114025 PMC 바로가기 [Article Type] Article
Antibody dynamics to SARS-CoV-2 in asymptomatic COVID-19 infections무증상 COVID-19 감염에서 SARS-CoV-2에 대한 항체 역학Article Published on 2021-02-012022-09-12 Journal: Allergy [Category] MERS, SARS, 진단, [키워드] analyzed antibodies antibody Antibody dynamics Asymptomatic Asymptomatic carrier Asymptomatic COVID-19 asymptomatic individual asymptomatic infections Biomarker Combination condition controls COVID-19 demonstrated Detection sensitivity Diagnosis diagnostic did not produce dynamics of antibody Enrollment epidemiologically healthy individual Humoral immunity IgM and IgG IgM antibody IgM responses immunization strategies implication individual Infection infections knowledge Microarray microarray analysis mild patient N protein Neutralization assay neutralizing antibody nucleic acid pandemic peaked produced profile Protein proteome Pseudotyped virus public health raise recruited SARS-CoV-2 SARS-CoV-2 proteome screened sensitivity serological serological survey Serological testing serum significantly symptoms onset the NAT [DOI] 10.1111/all.14622 PMC 바로가기 [Article Type] Article
Lessons learned from COVID-19 pandemic in Italy – A commentaryCommentary Published on 2021-02-012022-10-27 Journal: Bosnian Journal of Basic Medical Sciences [Category] COVID-19, Fulltext, MERS, [키워드] Admission affected country COVID-19 COVID-19 outbreak COVID-19 pandemic COVID-19 patients deaths early diagnosis Europe health-care Home isolation hospital indication Infection Italy lesson management outbreak pandemic prevention reducing SARS-CoV-2 serological Spread stimulate Swab therapy [DOI] 10.17305/bjbms.2020.4847 PMC 바로가기 [Article Type] Commentary
Dynamic anti-spike protein antibody profiles in COVID-19 patientsCOVID-19 환자의 동적 스파이크 방지 단백질 항체 프로필Article Published on 2021-02-012022-09-12 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단, [키워드] Admission Analysis anti-S Anti-spike antibody C-terminal domain CD4 CD8 clinical collected COVID-19 COVID-19 patient COVID-19 patients CTD decrease Decreased discharge dynamic Dynamics elevated ELISA assay exhibited FIVE full-length S glycoprotein highlight Humoral response IgG IgG and IgM immune protection immunoassay immunoreactivity In-patients less Lymphocytes N-terminal domain NTD plasma positive rate profile Protein Proteins recovered patient rehabilitation rehabilitation patient response SARS-CoV-2 SARS-COV-2 infection semi-quantitative serological simple spike spike glycoprotein stages T cell T cells was determined [DOI] 10.1016/j.ijid.2020.12.014 PMC 바로가기 [Article Type] Article