The potential of COVID-19 patients’ sera to cause antibody-dependent enhancement of infection and IL-6 productionCOVID-19 환자의 혈청의 잠재력은 감염 및 IL-6 생산의 항체 의존적 향상을 유발합니다.Article Published on 2021-12-092022-09-01 Journal: Scientific Reports [Category] SARS, 진단, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADE Antibody-dependent enhancement cell line clone cloned coronavirus COVID-19 demonstrated dengue virus evaluate host cell host cells IL-6 immortalized Infection infection with SARS-CoV-2 infections initiated myeloid cell neutralizing antibody other coronavirus other coronaviruses productivity respiratory resulting SARS-CoV-2 SARS-COV-2 infection screened sera severe acute respiratory syndrome Coronavirus severe COVID-19 patient severe COVID-19 patients stimulate susceptibility TMPRSS2 vaccination Vaccine development vaccine trial virus infections [DOI] 10.1038/s41598-021-03273-0 PMC 바로가기 [Article Type] Article
ACE2, TMPRSS2, and L-SIGN Expression in Placentae From HIV-Positive Pregnancies Exposed to Antiretroviral Therapy-Implications for SARS-CoV-2 Placental InfectionSARS-CoV-2 태반 감염에 대한 항레트로바이러스 요법에 노출된 HIV 양성 임신의 태반에서 ACE2, TMPRSS2 및 L-SIGN 발현Article Published on 2021-12-082022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus AIDS angiotensin Antiretroviral therapy ART binding Black race Chain Reaction coexpressed contribute coronavirus COVID-19 detrimental expression female groups HIV HIV infection HIV protease inhibitors HIV-uninfected hyperinflammation infant sex L-SIGN lower expression mRNA level mRNA levels Neonate Placenta placental polymerase chain polymerase chain reaction pregnant women priming protease Protease inhibitor protease TMPRSS2 Quantitative quantitative polymerase chain reaction race receptor receptor ACE2 reduced Renin renin-angiotensin system SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 SIGN significantly significantly higher Spike protein susceptibility the spike protein TMPRSS2 TMPRSS2 level TMPRSS2 levels viral entry with HIV women [DOI] 10.1093/infdis/jiab166 PMC 바로가기 [Article Type] Article
The effect of renin–angiotensin–aldosterone system inhibitors on organ-specific ace2 expression in zebrafish and its implications for COVID-19Article Published on 2021-12-082022-10-04 Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, 치료법, [키워드] ACE2 Affect Animal physiology baseline levels benefit Brain cellular entry clinical decision condition COVID-19 death examined expression expression level Gene Expression Human hypertension implication information inhibitor inhibitors intestine kidney knowledge liver olmesartan organ-specific pathway Patient performed pharmacogenetics potential risk Protein provide qRT-PCR analysis RAAS rodent SARS-CoV-2 SARS-COV-2 infection significantly significantly increased susceptibility treated Treatment while zebrafish [DOI] 10.1038/s41598-021-03244-5 PMC 바로가기 [Article Type] Article
Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO StudyArticle Published on 2021-12-072022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] APOE added Analysis ApoE association available data characterization chromosomal region confirmed case Control COVID-19 COVID-19 disease COVID-19 prognosis COVID-19 severity Dementia disease disease severity Factor Genetic Genome-wide association study GR@ACE/DEGESCO GWAS Host implicated individual initiative involved locus LZTFL1 Meta-analysis outcome performed SARS-CoV-2 SARS-COV-2 infection sensitivity analysis SLC6A20 statistically significant stratified suggested susceptibility TYK2 with COVID-19 [DOI] 10.3390/jpm11121318 PMC 바로가기 [Article Type] Article
IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 AxisImmunology Published on 2021-12-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] ACE2 Affect axis COVID-19 effort favor GATA2 Host IL1β IL1β indicated Inflammatory Inflammatory cytokine investigated modulating molecular mechanism p38 pandemic pro-inflammatory progression regulate Research SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis susceptibility the disease the SARS-CoV-2 TMPRSS2 TMPRSS2 expression [DOI] 10.3389/fimmu.2021.781352 PMC 바로가기 [Article Type] Immunology
Flagellin From Pseudomonas aeruginosa Modulates SARS-CoV-2 Infectivity in Cystic Fibrosis Airway Epithelial Cells by Increasing TMPRSS2 ExpressionImmunology Published on 2021-12-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] Activation AEC airway angiotensin-converting enzyme 2 Calu-3 cell calu-3 cells CFTR chronic respiratory disease coronavirus disease Course COVID-19 COVID-19 severity COVID19 Critical Cystic cystic fibrosis deficiency develop epithelial cell Factor fibrosis flagella flagellin Health host protease identify immune response increase Increasing infect Infection Infectivity MAPK modulation P. aeruginosa Patient patients populations protease Protein Pseudomonas aeruginosa receptor recommendation reduce released risk of COVID-19 SARS-CoV-2 SARS-COV-2 infection susceptibility TLR5 TMPRSS2 TMPRSS2 expression transmembrane transmembrane serine protease urgency virus particle [DOI] 10.3389/fimmu.2021.714027 PMC 바로가기 [Article Type] Immunology
Evidence for increased SARS-CoV-2 susceptibility and COVID-19 severity related to pre-existing immunity to seasonal coronavirusesReport Published on 2021-12-072023-07-01 Journal: Cell Reports [Category] SARS, [키워드] antibodies common cold COVID-19 disease severity HCoV Humoral immunity pandemic SARS-CoV-2 seasonal coronaviruses susceptibility [DOI] 10.1016/j.celrep.2021.110169 PMC 바로가기 [Article Type] Report
Porcine Deltacoronavirus Utilizes Sialic Acid as an Attachment Receptor and Trypsin Can Influence the Binding ActivityArticle Published on 2021-12-062022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] acid activity Adsorption alleviate aminopeptidase N atomic attachment binding Can carbohydrate carbohydrates cause Cell cell membrane cells Critical demonstrated dependent on diarrhea distribution ENhance entry receptor facilitate functional in vivo experiments Infection influence Interaction intestine Invasion involved mechanism Microscopy Novel coronavirus Plaque assay Porcine deltacoronavirus promoted provide receptor sialic acid significantly susceptibility trypsin virus western blotting [DOI] 10.3390/v13122442 PMC 바로가기 [Article Type] Article
Association of lipid-lowering drugs with COVID-19 outcomes from a Mendelian randomization study멘델식 무작위 배정 연구에서 지질 저하 약물과 COVID-19 결과의 연관성Research Article Published on 2021-12-062022-09-10 Journal: eLife [Category] 변종, 신약개발, 치료제, [키워드] 95% CI 95% confidence interval Analysis approach association associations benefit Blood calculate carried causal relationship caused cholesterol clinical trial confounding bias COVID-19 COVID-19 hospitalization COVID-19 pandemic death decrease drug drugs eLife estimates Evidence expression expression quantitative trait loci faster fat funding genetic instrument genetic instruments Genetic variant genetic variants Genome-wide association study higher risk HMGCR Hospitalization Hospitalized Human Hypothesis identify in viral infected with SARS-CoV-2 Infection infections LDL cholesterol Lipid lipid metabolism lipid-lowering drugs loci low-density Low-density lipoprotein mendelian randomization Mendelian randomization studies Mendelian randomization study metabolism Mortality MR study NPC1L1 Odds ratio outcome Patient PCSK9 positive protective effect Quantitative reduce reduced risk SARS-CoV-2 SARS-COV-2 infection severe disease SMR statins suggested susceptibility target gene Target genes treating COVID-19 university variable Viral viral infections virus were used with COVID-19 [DOI] 10.7554/eLife.73873 PMC 바로가기 [Article Type] Research Article
Aging-Related Impairments to M Cells in Peyer’s Patches Coincide With Disturbances to Paneth CellsImmunology Published on 2021-12-062022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] ACE2 adverse effect aging Antigen Cell cell differentiation cellular receptor Co-expression analysis data set distribution disturbance down-regulation Effect epithelia expression follicle-associated epithelium functional Gut Immunity IMPROVE include increase increased expression Infection intestine M cells maturation mice morbidity and mortality mucosal Paneth cell Paneth cells pathogen Peyer’s patche Peyer’s patches raise reduced reduction in regenerative respiratory tract suggested susceptibility transcription factor transcriptomics vaccination efficacy virus was increased [DOI] 10.3389/fimmu.2021.761949 PMC 바로가기 [Article Type] Immunology