Bioengineering tools to speed up the discovery and preclinical testing of vaccines for SARS-CoV-2 and therapeutic agents for COVID-19Review Published on 2020-05-272022-10-28 Journal: Theranostics [Category] COVID-19, MERS, SARS, [키워드] accelerate Antiviral antiviral drug bioengineering Cell Cell culture Community coronavirus COVID-19 Culture group identify International mechanism organoids Preclinical Testing provide Research SARS-CoV-2 SARS-COV-2 infection target therapeutic agent tissue Vaccine Vaccines [DOI] 10.7150/thno.47406 PMC 바로가기 [Article Type] Review
Trends and Innovations in Biosensors for COVID‐19 Mass TestingMinireview Published on 2020-05-272022-10-31 Journal: Chembiochem [Category] COVID-19, MERS, SARS, [키워드] accelerate antibody assays benefit Biomarker biosensor Blood circumvent COVID-19 COVID‐19 CRISPR CRISPR Diagnostics Diagnosis diagnostic diagnostics DNA amplification DNA sequencing ENhance equipment immunoassay immunoassays Infectious disease Innovation isothermal isothermal amplification mass molecular molecular diagnostics outbreak pandemic point‐of‐care test polymerase chain Quantitative Rapid test respond reverse transcription sensitivity Sensitivity and specificity serological specificity Swab Testing trend Viral protein Viral RNA virus widespread [DOI] 10.1002/cbic.202000250 PMC 바로가기 [Article Type] Minireview
Research Progress of Coronavirus Based on Bibliometric AnalysisArticle Published on 2020-05-262022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] accelerate Analysis Bibliometrics China clinical trial contributed coronavirus corresponding vaccine COVID-19 database Developing distribution drug Epidemics Hong Kong hotspot International journal Progress proportion provided Research researchers retrieved rising SARS-CoV-2 Support the United State university Virology was used Web of Science were used [DOI] 10.3390/ijerph17113766 PMC 바로가기 [Article Type] Article
Mining the Characteristics of COVID-19 Patients in China: Analysis of Social Media PostsOriginal Paper Published on 2020-05-172022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, SARS, [키워드] accelerate acute respiratory syndrome analyzed ArcGIS asked calculated Characteristics characteristics of patient characterized Chest Chest computed tomography China Chinese city clinical symptom Clustering conducted coronavirus coronavirus disease COVID-19 COVID-19 patient description distribution emergency response epidemiological Fever Government ground-glass opacity Health help high-risk patient hospital human-to-human transmission Identified identify illness onset Infection information IQR laboratory-confirmed lockdown measure media median age median time methodology Most patient objective observation Patient patients platform pneumonia case reported Research Result RT-PCR SARS-CoV-2 seeking Sina Weibo social media Symptom Symptoms the disease the median Transmission Wuhan [DOI] 10.2196/19087 PMC 바로가기 [Article Type] Original Paper
Towards treatment planning of COVID-19: Rationale and hypothesis for the use of multiple immunosuppressive agents: Anti-antibodies, immunoglobulins, and corticosteroidsArticle Published on 2020-05-082022-10-04 Journal: International immunopharmacology [Category] MERS, SARS, 임상, 치료법, [키워드] accelerate anti-IL6 antibody benefit cell entry Characteristics clinical benefit Controlled clinical trial correlated Corticosteroid Corticosteroids COVID-19 COVID-19-related death cytokine essential element fatal disease humans Hypothesis IL6 immune system Immunoglobulin immunoglobulins immunosuppressive IMPROVE Inflammation interleukin 6 monoclonal antibody Novel coronavirus outcomes Patient patients with COVID-19 pro-inflammatory cytokine Prognosis prognosis of patient rationale reduce SARS-CoV2 severe COVID-19 severity shown target targeted therapy therapeutic option therapy Treatment use of corticosteroid Viral load with COVID-19 [DOI] 10.1016/j.intimp.2020.106560 PMC 바로가기 [Article Type] Article
SARS-CoV-2 RNA polymerase as target for antiviral therapyCommentary Published on 2020-05-052022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, MERS, SARS, [키워드] accelerate acute respiratory syndrome antiviral drug antiviral therapy approved clinical trial coronavirus drug effective Infection pandemic Pandemics parasite polymerase positive-sense RdRP RNA virus RNA viruses SARS-CoV-2 SARS-CoV-2 RNA significant difference Specific the SARS-CoV-2 Treatment virus WHO Wuhan, China zoonotic [DOI] 10.1186/s12967-020-02355-3 PMC 바로가기 [Article Type] Commentary
Umifenovir treatment is not associated with improved outcomes in patients with coronavirus disease 2019: a retrospective studyArticle Published on 2020-04-252022-11-01 Journal: Clinical microbiology and infection : the official [Category] COVID-19, SARS, [키워드] accelerate acute respiratory syndrome Admission antiviral drug antiviral intervention Arbidol Care caused China clinical trial comparable control group corona virus disease 2019 coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient death defined Effectiveness Efficacy Hospital stay ICU IMPROVE in both groups Influenza interquartile range IQR laboratory characteristics median time negative test negativity non-ICU patients nucleic acid objective onset of symptom outcome Patient Pharyngeal swab polymerase chain Prognosis Randomized Result Retrospective study RT-PCR Russia SARS-CoV-2 SARS-CoV-2 clearance severe adverse reaction specimens tested treat Treatment turn two groups umifenovir virus was performed [DOI] 10.1016/j.cmi.2020.04.026 PMC 바로가기 [Article Type] Article
In silico identification of vaccine targets for 2019-nCoVResearch Article Published on 2020-04-142022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus 2019-nCoV accelerate Adaptive immunity Algorithm aligned binding can be used candidate characterized China Chinese conducted coronavirus curated database de novo death develop European population experimental validation Health HLA allele IEDB Immune Epitope Database immunogenic immunogenic peptide immunogenicity in silico nCoV NetMHCpan peptide peptides predicted Predictive model proteome provide resource SARS CoV second similarity T cell assays T cell cross-reactivity target TCR Treatment Vaccine Vaccine development [DOI] 10.12688/f1000research.22507.2 PMC 바로가기 [Article Type] Research Article
Reverse Logistics Network Design for Effective Management of Medical Waste in Epidemic Outbreaks: Insights from the Coronavirus Disease 2019 (COVID-19) Outbreak in Wuhan (China)Article Published on 2020-03-092022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] accelerate analyses available data China conducted coronavirus disease COVID-19 COVID-19 outbreak disease disease spread effective Effectiveness Epidemic Epidemic logistics epidemic outbreak experiment information insight knowledge logistics management Medical waste network network design operations research outbreak Outbreaks patients Quantitative recommendation Research reverse logistics risk Spread treat treated waste Wuhan Wuhan, China [DOI] 10.3390/ijerph17051770 PMC 바로가기 [Article Type] Article
The N-Terminal Domain of Spike Protein Is Not the Enteric Tropism Determinant for Transmissible Gastroenteritis Virus in PigletsArticle Published on 2019-03-302022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] accelerate affected approach Bacterial Cas9 cDNA Cell chromosome Clinical sign clone coronavirus CRISPR/Cas9 demonstrated determinant enteric enteric tropism experiment full-length gastroenteritis genetics growth help Mortality mutant N-terminal domain PK-15 platform Protein rescued Research Respiratory Coronavirus reverse genetics spike spike gene Spike protein survival TGEV transmissible gastroenteritis virus tropism Vaccine virulence virus [DOI] 10.3390/v11040313 PMC 바로가기 [Article Type] Article