Antibody and Memory B-Cell Immunity in a Heterogeneously SARS-CoV-2-Infected and -Vaccinated PopulationArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] accumulating acute respiratory syndrome Adenovirus antibody B-cell B.1.1.529 Combination coronavirus correlated country determine distribution elicited FIVE help heterogeneous immune immune evasion immune response Immunity individuals Infection less Level majority memory B memory B cells memory B-cell mRNA Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody titers Omicron variant platform Population population immunity prefusion recipient SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant single vaccine spike trimer the vaccine undetectable vaccination Vaccine [DOI] 10.1128/mbio.00840-22 PMC 바로가기
Immune modulation as a consequence of SARS-CoV-2 infectionArticle Published on 2022-08-302022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] adaptive Alter alteration B cells CD3 CD8 Clinical severity clinically COVID-19 COVID-19 pathogenesis Cytokine storm D-dimer levels Decreased detrimental effects diagnosed elevated Elevation enrolled Frame healthy controls IFN-γ IgA level IgG IL-10 IL-6 IL-8 ILCs immune immune response Immunity Mild moderate modulated modulation negative correlation NK cell NK cells Patient Plasma cell pro-inflammatory cytokine Protective reduced reduction SARS-CoV-2 SARS-COV-2 infection Serum level severe COVID-19 disease Severe patient severe patients significantly subset T cell T cells the disease TNF-α [DOI] 10.3389/fimmu.2022.954391 PMC 바로가기
A Booster Dose of CoronaVac Increases Neutralizing Antibodies and T Cells that Recognize Delta and Omicron Variants of ConcernArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] SARS, 변종, 진단, [키워드] active against addition Adults anti-SARS-CoV-2 anti-SARS-CoV-2 immune responses approved booster booster dose Brazil CD4 cellular Chilean China clinical trial concern CoronaVac COVID-19 Delta dose doses Emergency use healthy healthy volunteers homologous humoral immune response Immunity immunized IMPROVE inactivated Inactivated vaccine increase interferon neutralizing antibody not significantly different omicron phase phase III clinical trial. previous study reached reduced reported SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2-specific T cell second dose secretion shown significant increase significantly T cell T cell activation T cell response the vaccine these cell Turkey vaccination schedule Vaccine variants of concern VoC VOCs were assessed WHO World Health Organization [DOI] 10.1128/mbio.01423-22 PMC 바로가기
Effectiveness, safety, and immunogenicity of half dose ChAdOx1 nCoV-19 COVID-19 Vaccine: Viana projectArticle Published on 2022-08-292022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] adverse event age and sex analyzed anti-SARS-CoV-2 baseline Biomarker booster dose ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine chemiluminescence chemokines Concentration Controlled trial COVID-19 Cytokines death dose effective Effectiveness evaluated exclusion first dose Fractional dose Frequency geometric mean Growth factors healthcare worker Hospitalization immune response immunization immunoassay immunogenic immunogenicity incidence incidence rate increase in indicate individual individuals multiplex neutralizing antibody non-inferiority non-randomized plaque reduction neutralization plasma pre-immune primary endpoint PRNT Protein quantified RBD Receptor binding domain Registered reported RT-PCR Safe Safety second dose Serious Adverse Event seroconversion rate seronegative seropositive seropositive subject SUS Vaccine Vaccines [DOI] 10.3389/fimmu.2022.966416 PMC 바로가기
Heterogenous CD8+ T Cell Maturation and ‘Polarization’ in Acute and Convalescent COVID-19 PatientsArticle Published on 2022-08-282022-11-15 Journal: Viruses [Category] SARS, 진단, 치료기술, 치료제, [키워드] acute COVID-19 acute phase adaptive analyzed antibody antiviral immune response CD3+CD8+ CD57 CD8+ CD8+ T cell CD8+ T cells Cell cells chemokine chemokine receptors collected convalescent correlated COVID-19 COVID-19 convalescent CXCR5 dendritic cells described detectable elevated expressed expressing expression flow cytometry Frequency healthy volunteer homing IgG antibody IL-27 immune response Interaction lung tissue majority memory memory CD8+ T cells Memory cells mucosal naïve Patient patient group patients Peripheral blood sample polarization Post-COVID-19 syndrome post-symptom onset SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein senescent serum subject subjects subset syndrome Tc1 Tc17 Tc2 TEMRA TEMRA cell Th1 cell tissue upregulated [DOI] 10.3390/v14091906 PMC 바로가기
Anti-SARS-COV-2 specific immunity in HIV immunological non-responders after mRNA-based COVID-19 vaccinationArticle Published on 2022-08-262022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] antibody booster vaccination CD4 cell Cellular immune response Cohort control group correlated COVID-19 COVID-19 vaccination disease FIVE Follow-up healthy individual HIV HIV-1 Human immunodeficiency virus immune immune response immune responses Immunity immunological immunological non-responder (INR) Immunosuppression individual lack mRNA-based non-responder Patient receive receiving SARS-CoV-2 SARS-COV-2 infection vaccinated against COVID-19 Vaccine [DOI] 10.3389/fimmu.2022.994173 PMC 바로가기
Immunogenicity and safety of a SARS-CoV-2 inactivated vaccine (CoronaVac) co-administered with an inactivated quadrivalent influenza vaccine: A randomized, open-label, controlled study in healthy adults aged 18 to 59 years in China비활성화된 4가 인플루엔자 백신과 함께 투여된 SARS-CoV-2 비활성화된 백신(CoronaVac)의 면역원성 및 안전성: 중국에서 18세에서 59세 사이의 건강한 성인을 대상으로 한 무작위, 공개, 대조 연구Randomized Controlled Trial Published on 2022-08-262022-09-12 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] 95% confidence interval administration Adverse reaction antibody assigned China comparable Concomitant Concomitant administration conducted CoronaVac COVID-19 COVID-19 vaccine dose enrolled Evidence feasible first dose GMT groups healthy immune response immunogenicity inactivated Inactivated vaccine Influenza influenza vaccine Mild moderate MOST non-inferiority Occurrence Open-label participant per-protocol randomization Randomized Randomly receive regimen SARS-CoV-2 Seasonal influenza second dose seroconversion rate two-sided Vaccine Zhejiang [DOI] 10.1016/j.vaccine.2022.07.021 PMC 바로가기 [Article Type] Randomized Controlled Trial
Beneficial non-specific effects of live vaccines against COVID-19 and other unrelated infectionsReview article Published on 2022-08-262022-10-05 Journal: The Lancet. Infectious Diseases [Category] 임상, [키워드] Administered analysed Analysis BCG children COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 vaccines Effect effective Effects Endpoint ENhance Health Heterologous host immune system immune response Immunity incidence individual Infection infections Live attenuated vaccine lymphocyte response modify non-specific observational study occur Older overall mortality pandemic Patient Placebo randomised controlled trial receiving researcher respiratory infection revaccination second sequence Severity of infection Sex subgroup analysis to define Trial Vaccine vaccine administration Vaccines View [DOI] 10.1016/S1473-3099(22)00498-4 [Article Type] Review article
Integrated microbiome and metabolome analysis reveals the potential therapeutic mechanism of Qing-Fei-Pai-Du decoction in mice with coronavirus-induced pneumoniaArticle Published on 2022-08-262022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] 유전자 메커니즘, [키워드] 16S rRNA addition affected amino acids Analysis bile acids change China Clinical treatment coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 current Eicosanoids evaluated fatty acids Gut gut microbiota Host Host immune response immune immune function immune response IMPROVE Inflammation lipid metabolism lung tissue mechanism metabolism metabolite metabolome metabolomic analysis mice Microbiome modulating patients with COVID-19 performed Pneumonia Qing-Fei-Pai-Du decoction reduce reveal Sequencing serum severity shown significantly Spearman correlation analysis Staphylococcus therapeutic therapeutic effect Treatment was performed [DOI] 10.3389/fcimb.2022.950983 PMC 바로가기
Reduced Immune Response to Inactivated Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine in a Cohort of Immunocompromised Patients in Chile칠레의 면역 저하 환자 집단에서 비활성화된 중증 급성 호흡기 증후군 코로나바이러스 2 백신에 대한 면역 반응 감소Article Published on 2022-08-242022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] acute respiratory syndrome anti-SARS-CoV-2 antibody Autoimmune Cancer Cell clinical concentrations conducted control group controls CoronaVac coronavirus coronavirus 2 COVID-19 dose Enrollment evaluate groups HIV HIV group Human immunodeficiency virus humoral immune response Immunocompromised Immunocompromised patient immunocompromising condition Immunoglobulin Inactivated vaccine Infection interferon γ median Neutralizing activity not differ not significant participant patients prospective cohort study receiving Red reduce respiratory response rheumatic disease SARS-CoV-2 significantly solid organ transplant solid tumor T cell T-cell Response Trial Vaccination strategy Vaccine vulnerable patients [DOI] 10.1093/cid/ciac167 PMC 바로가기 [Article Type] Article