Genome-scale CRISPR screen identifies TMEM41B as a multi-function host factor required for coronavirus replicationResearch Article Published on 2021-12-062022-10-29 Journal: PLoS Pathogens [Category] COVID-19, [키워드] Anti-viral approach Cell contribute contributed coronavirus Coronavirus replication CoV CoV infection CoV replication CoVs CRISPR CRISPR screen Critical disease disease pathogenesis effort Evidence Factor gastroenteritis Health highly pathogenic CoVs Host host gene identification identify Infection inhibit involved kidney performed potential therapeutic target progression Protein provide regulate Replication required reveal RNA virus RNA viruses susceptibility TGEV therapeutic target Tmem41b Vesicle viral infection virus virus replication [DOI] 10.1371/journal.ppat.1010113 PMC 바로가기 [Article Type] Research Article
Re-emergence of invasive pneumococcal disease (IPD) and increase of serotype 23B after easing of COVID-19 measures, Switzerland, 2021COVID-19 조치 완화 이후 침습성 폐렴구균 질환(IPD)의 재발과 23B 혈청형 증가, 스위스, 2021Letter Published on 2021-12-042022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, SARS, 폐렴구균 감염증, [키워드] COVID-19 COVID-19 pandemic COVID-19 restrictions decrease invasive pneumococcal disease isolate Measures non-susceptibility to penicillin pneumococcal pneumococcal conjugate vaccine (PCV) reduced serotype Streptococcus pneumoniae Surveillance susceptibility Switzerland [DOI] 10.1080/22221751.2021.2000892 PMC 바로가기 [Article Type] Letter
Diabetes in COVID-19 patients: challenges and possible management strategiesReviews Published on 2021-12-042022-10-31 Journal: The Egyptian Journal of Bronchology [Category] COVID-19, [키워드] Abstract ACE2 ACE2 expression blood glucose Comorbidities Comorbidity coronavirus disease correlation COVID-19 COVID-19 patient Diabetes Mellitus Diabetes mellitus (DM) Diabetic diabetic patient drug effective healthy Hospitalized immune system indicated infected with COVID-19 less Malfunction management metabolic activity pandemic potential risk problems researcher SARS-CoV-2 severity of COVID-19 Stress susceptibility the patient viral clearance rate [DOI] 10.1186/s43168-021-00099-2 PMC 바로가기 [Article Type] Reviews
How immunity from and interaction with seasonal coronaviruses can shape SARS-CoV-2 epidemiology404 Published on 2021-12-032022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] 95% CI acute respiratory syndrome affected age Alter children circulating contribute coronavirus Coronaviruses COVID-19 cross-protection determine distribution early phase England Epidemics explain First wave Frequency human coronavirus Immunity infections Interaction magnitude mathematical pandemic projection reduced SARS-CoV-2 SARS-CoV-2 epidemiology SARS-COV-2 infection SARS-CoV-2 transmission seasonal coronavirus seasonal coronaviruses Significance surveillance data susceptibility Testing Transmission Transmission model [DOI] 10.1073/pnas.2108395118 PMC 바로가기 [Article Type] 404
Excess Body Mass—A Factor Leading to the Deterioration of COVID-19 and Its Complications—A Narrative Review과도한 체질량-Covid-19의 악화 및 그 합병증으로 이어지는 요인-서술 검토Review Published on 2021-12-032022-09-01 Journal: Viruses [Category] SARS, 진단, [키워드] acute infections Acute kidney injury acute respiratory distress acute respiratory distress syndrome Body body mass Cardiomyopathy Coagulation complications complications of COVID-19 Course COVID-19 COVID-19 complication COVID-19 complications COVID-19 positive patient database Deterioration Disseminated intravascular coagulation dyslipidaemia Endothelial dysfunction excess excess body mass Factor Google Scholar Health influence intravascular coagulation leading leukoencephalopathy lung lesion lung lesions metabolic syndrome narrative Nasopharyngeal swab obese obese patients obesity outcome Patient physiopathology positive positive patients Prevalence respiratory distress review Ribonucleic acid SARS-CoV-2 searched severity of COVID-19 shown significantly stroke subjects susceptibility syndrome thromboembolic Web of Science [DOI] 10.3390/v13122427 PMC 바로가기 [Article Type] Review
Immuno-Endocrinology of COVID-19: The Key Role of Sex HormonesCOVID-19의 면역 내분비학: 성 호르몬의 주요 역할Review Published on 2021-12-022022-09-11 Journal: Frontiers in Endocrinology [Category] SARS, 유전자 메커니즘, [키워드] Adaptive immune response androgen Clinical studies clinical study coronavirus coronavirus 2019 disease COVID-19 COVID-19 pathogenesis COVID-19 severity Cytopathic effect disease severity element Estrogen Evidence Factor Factors fatality Gender Gene regulation hormone hyper-inflammatory response identify immune response immune responses immuno-endocrinology include Infection Injury involved mechanism optimization Pathogenesis personalised regulated Regulation role SARS-CoV2 severity Sex sex hormone Sex hormones susceptibility target targets therapeutic intervention tissue injury tissue specific Treatment outcome Trial [DOI] 10.3389/fendo.2021.726696 PMC 바로가기 [Article Type] Review
Microbiological characteristics of bacteremias among COVID-19 hospitalized patients in a tertiary referral hospital in Northern Greece during the second epidemic waveResearch Article Published on 2021-12-022022-11-01 Journal: Fems Microbes [Category] COVID-19, [키워드] Acinetobacter antibiotic Antibiotic resistance average Bacteremia Bacteria Bacterial pathogens bacterial specy Bloodstream infections Characteristics Co-infection cocci confirmed case COVID-19 COVID-19 epidemic COVID-19 pandemic COVID-19 patient Enterococcus faecium Epidemic epidemic wave Epidemiology Frequency Gram-negative bacteria Greece handling hospital Hospitalization hospitalized COVID-19 patient hospitalized patient ICU in-hospital mortality Klebsiella pneumoniae MDR microorganism nosocomial occurred organism pandemic pathogen Patient patients hospitalized profile silent Surveillance susceptibility tertiary referral hospital [DOI] 10.1093/femsmc/xtab021 PMC 바로가기 [Article Type] Research Article
Does prior exposure to immune checkpoint inhibitors treatment affect incidence and mortality of COVID-19 among the cancer patients: The systematic review and meta-analysisResearch article Published on 2021-12-012022-10-05 Journal: International immunopharmacology [Category] 치료법, [키워드] 95% CI 95% confidence interval Affect Antiviral effect bioRxiv Cancer cancer patient Cancer patients Controlled COVID-19 COVID-19 pandemic database Immune checkpoint inhibitor Immune checkpoint inhibitors incidence incidence of COVID-19 increased risk indicated Infection inflammatory storm inhibitor ISI material medRxiv meta-analyses Meta-analysis meta-regression analysis Mortality no significant difference Patient Primary outcome Prospective Study recent reduce Result retrospective risk SARS-CoV2 infection searched secondary outcome selected shown subsequent susceptibility systematic review T cells Treatment [DOI] 10.1016/j.intimp.2021.108242 [Article Type] Research article
IFN-γ + cell response and IFN-γ release concordance after in vitro SARS-CoV-2 stimulation시험관 내 SARS-CoV-2 자극 후 IFN-γ + 세포 반응 및 IFN-γ 방출 일치Article Published on 2021-12-012022-09-11 Journal: European Journal of Clinical Investigation [Category] SARS, 치료법, [키워드] Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody case-control study CD4 T-cell CD8 CD8 T-cell Cell cellular Cellular immune response cellular response Concordance convalescent COVID-19 cross-sectional determine ELISA exposed healthcare workers. flow cytometry greater HCW HCWs healthcare healthcare worker Healthcare workers IFN-γ immune in vitro increased risk individual Infection less magnitude proportion protective immunity quantification SARS-CoV-2 SARS-CoV-2-infected patients Stimulation susceptibility Symptoms T cell T cells T-cell Response uninfected Viral protein Viral proteins [DOI] 10.1111/eci.13636 PMC 바로가기 [Article Type] Article
Role of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers고도로 노출되었지만 감염되지 않은 의료 종사자 사이에서 SARS-CoV-2에 대한 감수성에서 ACE2 유전적 다형성의 역할Article Published on 2021-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] SARS, 변종, [키워드] A allele ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 COVID-19 COVID-19 patients drug target evaluate Evaluating Genetic Genetic polymorphism Genetic variant genetic variants healthcare worker help hospitalized patient identify increased risk individual polymorphism role SARS-CoV-2 SARS-COV-2 infection selected single-nucleotide single-nucleotide polymorphism SNP susceptibility susceptible T allele uninfected variant with COVID-19 [DOI] 10.1080/22221751.2021.1902755 PMC 바로가기 [Article Type] Article