Successful COVID-19 rescue therapy by extra-corporeal membrane oxygenation (ECMO) for respiratory failure: a case reportCase Report Published on 2020-05-082022-10-28 Journal: Patient Safety in Surgery [Category] COVID-19, [키워드] acute respiratory syndrome Antiviral treatment bilateral pneumonia Care Case report cohort of patients compassionate use coronavirus Course COVID-19 Critical care decannulated deteriorate discharged ECMO Extra-corporeal membrane oxygenation extracorporeal membrane oxygenation female Future healthy high mortality rate hospital initiated Lung injury nitric oxide novel coronavirus disease outcome Patient patient with COVID-19 positive prone positioning rehabilitation Remdesivir Remdesivir treatment Respiratory failure SARS-CoV-2 severe COVID-19 disease significantly therapy transferred treated Treatment Ventilation Wuhan, China [DOI] 10.1186/s13037-020-00245-7 PMC 바로가기 [Article Type] Case Report
Considerations for Postacute Rehabilitation for Survivors of COVID-19Viewpoint Published on 2020-05-082022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome asked Care caused cognitive Comorbidities Complication coronavirus COVID-19 discharge disease Effect geriatric help hospital Infection Infectious disease inpatient rehabilitation intensive care intubation mental health neurological outcomes pathology Patient patient outcome patients with COVID-19 public health Quality of life question recovery rehabilitation reported Respiratory system SARS-CoV-2 second subacute care suggested survivor Survivors therapy Treatment virus [DOI] 10.2196/19462 PMC 바로가기 [Article Type] Viewpoint
Towards treatment planning of COVID-19: Rationale and hypothesis for the use of multiple immunosuppressive agents: Anti-antibodies, immunoglobulins, and corticosteroidsArticle Published on 2020-05-082022-10-04 Journal: International immunopharmacology [Category] MERS, SARS, 임상, 치료법, [키워드] accelerate anti-IL6 antibody benefit cell entry Characteristics clinical benefit Controlled clinical trial correlated Corticosteroid Corticosteroids COVID-19 COVID-19-related death cytokine essential element fatal disease humans Hypothesis IL6 immune system Immunoglobulin immunoglobulins immunosuppressive IMPROVE Inflammation interleukin 6 monoclonal antibody Novel coronavirus outcomes Patient patients with COVID-19 pro-inflammatory cytokine Prognosis prognosis of patient rationale reduce SARS-CoV2 severe COVID-19 severity shown target targeted therapy therapeutic option therapy Treatment use of corticosteroid Viral load with COVID-19 [DOI] 10.1016/j.intimp.2020.106560 PMC 바로가기 [Article Type] Article
Cell Versus Cytokine – Directed Therapies for Hemophagocytic Lymphohistiocytosis (HLH) in Inborn Errors of ImmunityReview Published on 2020-05-082024-09-02 Journal: Frontiers in immunology [Category] 대상포진, [키워드] cytokine hemophagocytic lymphohistiocytosis HSCT inborn errors of immunity Inflammation Pathogenesis therapy [DOI] 10.3389/fimmu.2020.00808 PMC 바로가기 [Article Type] Review
Glycyrrhetinic acid alleviates hepatic inflammation injury in viral hepatitis disease via a HMGB1-TLR4 signaling pathwayArticle Published on 2020-05-082022-11-01 Journal: International immunopharmacology [Category] Coronavirus, [키워드] Activation alleviate anti-inflammatory agent antibody clinical setting cured cytokine deficiency disease downstream Glycyrrhetinic acid glycyrrhizic acid hepatic injury Hepatitis HMGB1 HMGB1 release human disorder hydrolysis immunological in viral Infection Infectious disease Inflammation Inflammatory Inflammatory diseases Inflammatory response ingredient inhibit inhibited injection Injury involved licorice mechanism MHV mice murine murine hepatitis virus Neutralizing neutralizing antibody occur provide Regulation reported Signaling signaling pathway significantly TCM the cytokine storm therapy TLR4 Treatment triggered variety Viral hepatitis viral-induced [DOI] 10.1016/j.intimp.2020.106578 PMC 바로가기 [Article Type] Article
Cytokine Release Syndrome in COVID-19 Patients, A New Scenario for an Old Concern: The Fragile Balance between Infections and AutoimmunityReview Published on 2020-05-082022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] accompanied Antiviral approach Autoimmunity balance Baricitinib China close monitoring complex cough COVID-19 CRS Cytokine release syndrome disease Dyspnea Effectiveness fatigue Features Fever flu-like symptom health emergency Host Hydroxychloroquine immunomodulation Immunosuppressant immunosuppressive agent increase in induce Infection infection risk initiated life-threatening manifestation New Novel coronavirus Patient patients patients with COVID-19 pro-inflammatory response receiving Release researcher Rheumatic diseases rheumatoid arthritis SARS-CoV-2 scenario sequenced serological severe interstitial pneumonia Spread therapy Tocilizumab Treatment trials Typical [DOI] 10.3390/ijms21093330 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Infection with Different Radiological InsightsCase Report Published on 2020-05-072022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome affected anti-inflammatory drug anticoagulant therapy Antiviral ARDS characterized clinical condition Computed tomography death insight lung lung acute embolism Mild Patient radiological radiological finding SARS-CoV-2 severe acute respiratory syndrome-coronavirus-2 Symptom syndrome therapy viral infection [DOI] 10.3390/diagnostics10050283 PMC 바로가기 [Article Type] Case Report
Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?세포외 HMGB1: 코로나19를 포함한 중증 폐염증 치료 표적?Review Published on 2020-05-072022-08-13 Journal: Molecular Medicine [Category] MERS, SARS, 유전자 메커니즘, [키워드] 2019 novel coronavirus 2019 novel coronavirus disease activated activated innate immunity cells acute respiratory distress acute respiratory distress syndrome Apoptosis ARDS Blood cause cells from males cellular cytosol complexes concentrations coronavirus disease COVID-19 COVID-19-associated inflammation cytokine cytosolic DAMP DAMPs danger molecule Danger molecules detrimental disease Disulfide Disulfide-HMGB1 dying cell dying cells endocytosed endocytosis endogenous damage-associated molecular pattern endolysosomal system endothelial cells expressed expression Extracellular extracellular DNA Extracellular HMGB1 extracellular SARS-CoV-2 RNA female form HMGB1 identify in vivo individuals induce inflammasome activation Inflammation Influenza initiate innate immunity cells lung Lungs lysosome Lysosomes lytic cell death molecular molecule HMGB1 Necrosis Novel coronavirus novel coronavirus disease observation other molecules PAMP PAMPs pathogen pathogen-associated molecular Pathogenesis pathogenic molecule Pathways physiological plasma Pneumonia pro-inflammatory cytokine pro-inflammatory cytokine release proinflammatory receptor pulmonary endothelial cell pulmonary endothelial cells pulmonary inflammation RAGE reduction released respiratory distress Respiratory distress syndrome RNA SARS-CoV-2 secreted syndrome Therapeutic compounds therapeutic target therapy TLR4 TLR4 receptor TLR4 receptors transfer transported Trigger triggers venous venous blood [DOI] 10.1186/s10020-020-00172-4 PMC 바로가기 [Article Type] Review
Is the use of RAS inhibitors safe in the current era of COVID-19 pandemic?Review Published on 2020-05-072022-10-31 Journal: Clinical Hypertension [Category] COVID-19, [키워드] 2019 novel coronavirus ACE inhibitor ACE2 ACE2 expression angiotensin receptor blocker Antihypertensive drug antihypertensive drugs blockade cell membrane COVID-19 COVID-19 infection cytoplasm death enzyme Evidence exacerbated facilitate homeostasis hypertension Infection maintain mechanism nervous system pandemic Protein RAS RAS inhibitor respiratory Safe SARS SARS-CoV-2 Sepsis shown sodium balance subject subjects therapy viral entry viral surface virus [DOI] 10.1186/s40885-020-00144-0 PMC 바로가기 [Article Type] Review
Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19Review Published on 2020-05-062022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] activity acute respiratory syndrome affected antioxidant articles caused China Clinical management Clinical studies clinically Complication Controlled clinical trial coronavirus COVID-19 disease Effect effective experimental model expression homeostasis IL-1β IL-6 Inflammation Inflammatory diseases Keap1/Nrf2/ARE pathway management mechanism of action modulation molecular mechanism NF-κB Nrf2 organ organ damage outbreak oxidative stress ozone therapy 1 pathway peer-reviewed physiological Potential Research SARS-CoV-2 shown Support systemic therapy tissue damage viral infection viral infections [DOI] 10.3390/antiox9050389 PMC 바로가기 [Article Type] Review