Molecular targets and system biology approaches for drug repurposing against SARS-CoV-2Review Published on 2020-11-192022-10-28 Journal: Bulletin of the National Research Centre [Category] COVID-19, [키워드] approach can be used COVID-19 COVID-19 disease creating drug drug candidate Drug repurposing drug target drug targets drugs help host cell surface identify information Interaction network network analysis network biology non-structural protein pandemic provide receptors SARS-CoV-2 System biology target targets Virtual screening virus WHO [DOI] 10.1186/s42269-020-00444-3 PMC 바로가기 [Article Type] Review
Hydroxychloroquine in COVID-19 Patients: Pros and ConsPharmacology Published on 2020-11-192022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] anti-inflammatory properties approach Autoimmune caused cellular and molecular Chloroquine COVID-19 derivative disease Diseases distress Drug discovery Drug repurposing Effect effective Effects Evidence HCQ Hydroxychloroquine in vitro in vivo Initially life-threatening malaria management mechanism Mild neurological pandemic pandemic of COVID-19 potential therapy Pro Prophylaxis reported SARS-CoV-2 Side effects therapeutic effect therapy treat treating COVID-19 patient Treatment use of hydroxychloroquine [DOI] 10.3389/fphar.2020.597985 PMC 바로가기 [Article Type] Pharmacology
Direct inhibitory effect on viral entry of influenza A and SARS‐CoV‐2 viruses by azithromycin아지트로마이신에 의한 인플루엔자 A 및 SARS-CoV-2 바이러스의 바이러스 침입에 대한 직접적인 억제 효과Original Article Published on 2020-11-192022-09-10 Journal: Cell Proliferation [Category] SARS, 신약개발, 치료제, [키워드] A549 cell alkalinization antiviral agent Antiviral agents Antiviral effect Azithromycin azithromycin treatment binding Caco2 cells cell line Direct Drug repurposing drugs effective inhibitor Emergency evaluate expression fusion IAV impair in vitro independent independent of Infection Influenza influenza A influenza A virus inhibit inhibited inhibitory effect interferon internalization lead luciferase reporter gene lysosomal material membrane fusion membranes objective pseudotyped Pseudotyped virus pseudovirus reported reporter reporter gene Result SARS‐CoV‐2 SARS‐CoV‐2 virus SARS‐CoV‐2 screened spike mutations Strains subtype Treatment vacuolar Vesicle vesicles Viral viral entry viral replication virions virus was used [DOI] 10.1111/cpr.12953 PMC 바로가기 [Article Type] Original Article
Target-Centered Drug Repurposing Predictions of Human Angiotensin-Converting Enzyme 2 (ACE2) and Transmembrane Protease Serine Subtype 2 (TMPRSS2) Interacting Approved Drugs for Coronavirus Disease 2019 (COVID-19) Treatment through a Drug-Target Interaction Deep Learning Model인간 안지오텐신 전환 효소 2(ACE2) 및 막관통 프로테아제 세린 아형 2(TMPRSS2) 상호 작용에 대한 표적 중심 약물 용도 변경 예측Article Published on 2020-11-182022-08-31 Journal: Viruses [Category] SARS, 신약개발, [키워드] ACE ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approval approved drug AT1R candidate clinically Control coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 daclatasvir deep deep learning drug Drug repurposing drug-target drugs enalaprilat eprosartan FDA FDA approved drug food gene expression profile HCV Host host cell Human inhibit inhibitor inhibitory potency Interaction learning less lisuride Model molecule Neuropsychiatric ombitasvir overcome overlapped paritaprevir portal predict predicted prediction protease receptor Remdesivir Replication reported repurposing respiratory SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 spike Serine serine 2 severe acute respiratory syndrome Coronavirus subtype target TMPRSS2 TMPRSS2 inhibitors transmembrane transmembrane protease serine 2 Treatment Viral viral entry virus [DOI] 10.3390/v12111325 PMC 바로가기 [Article Type] Article
Combating the Pandemic COVID-19: Clinical Trials, Therapies and PerspectivesMolecular Biosciences Published on 2020-11-172022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] acute respiratory syndrome addition antiviral drug approach caused claimed clinical Clinical studies clinical trial Convalescent plasma therapy coronavirus Coronavirus disease-19 Coronavirus-2 COVID-19 database Direct drug Drug repurposing Ebola evidenced globe in silico in vitro Infection Influenza measure MERS-CoV pandemic Potential Prophylaxis provide provided Registered RNA virus SARS-CoV SARS-CoV-2 Science systematic review Therapeutic approach therapy Till Treatment treatment strategy unique Vaccine [DOI] 10.3389/fmolb.2020.606393 PMC 바로가기 [Article Type] Molecular Biosciences
Repurposing Known Drugs as Covalent and Non-covalent Inhibitors of the SARS-CoV-2 Papain-Like ProteaseChemistry Published on 2020-11-162022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] absence activity acute respiratory syndrome analyzed Antiviral approved candidate Candidates ChEMBL clinical trial complex coronavirus coronavirus disease costly COVID-19 dataset docked docking scores downloaded drug Drug discovery Drug repurposing effective Health identify in silico in vitro inhibitor Interaction knowledge molecular docking molecular interaction fingerprints pandemic papain-like cysteine protease Papain-like protease Peptide inhibitor PLPro Polypharmacology released repurposing SARS-CoV-2 SARS–CoV–2 similarities Spread the SARS-CoV-2 therapeutic strategy time-consuming Treatment Vaccine Virtual screening [DOI] 10.3389/fchem.2020.594009 PMC 바로가기 [Article Type] Chemistry
Repurposing Sigma-1 Receptor Ligands for COVID-19 Therapy?Pharmacology Published on 2020-11-092022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activate acute respiratory syndrome adaptive Anti-viral Antiviral Antiviral compound antiviral drug approach approaches approved drug benefit cause chaperone clinical development clinical trials coronavirus Course COVID-19 COVID-19 pandemic COVID-19 patients CoVs Drug repurposing drugs Endoplasmic reticulum ER membranes ER stress expected facilitate Health host cell host cell response host protein identify in vitro Infection infections interact Interaction interfere Intervention Ligand mechanism Medicine membrane-bound modulation occur pathway patients potential mechanism Prevent professional protective immune response Proteins provide receptor reduce regulate Repurposed drugs repurposing SARS-CoV-2 SARS-CoV-2 protein sigma-1 receptor Stress targeting the disease therapeutic therapy treat unique upstream viral replication [DOI] 10.3389/fphar.2020.582310 PMC 바로가기 [Article Type] Pharmacology
Exploring the effect of ritonavir and TMC-310911 on SARS-CoV-2 and SARS-CoV main proteases: potential from a molecular perspectiveResearch Article Published on 2020-11-092022-10-31 Journal: Future Science OA [Category] COVID-19, [키워드] Abstract antiretroviral drug binding mechanism cause coronavirus coronavirus disease COVID-19 demonstrated develop disease drug Drug repurposing facilitated implicated Interaction material molecular Perspective Pneumonia Proteases Protein provided residue Ritonavir SARS-CoV SARS-CoV-2 SARS-CoV-2 protein Spread therapeutic activity therapeutic potency TMC-310911 Treatment Vaccines virus [DOI] 10.2144/fsoa-2020-0079 PMC 바로가기 [Article Type] Research Article
Repurposing of FDA-Approved Toremifene to Treat COVID-19 by Blocking the Spike Glycoprotein and NSP14 of SARS-CoV-2Article Published on 2020-11-062023-07-12 Journal: Journal of Proteome Research [Category] SARS, [키워드] COVID-19 Drug repurposing methyltransferase nonstructural protein 14 (NSP14) molecular docking SARS-CoV-2 spike glycoprotein toremifene. [DOI] 10.1021/acs.jproteome.0c00397 PMC 바로가기
Computational drug re-purposing targeting the spike glycoprotein of SARS-CoV-2 as an effective strategy to neutralize COVID-19Article Published on 2020-11-062023-07-02 Journal: European journal of pharmacology [Category] SARS, [키워드] coronavirus COVID-19 Drug repurposing molecular docking SARS-CoV SARS-CoV-2 [DOI] 10.1016/j.ejphar.2020.173720 PMC 바로가기