Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19Article Published on 2021-08-252022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] 4-hydroxynonenal 4-hydroxynonenal (HNE) Admission aggression Aggressive antioxidant antioxidants approach blood vessel blood vessels COVID-19 Critical care Critically ill patient Deceased Detection limit died finding Free radicals HNE-ELISA immunohistochemistry in both groups Inflammation Inflammatory diseases involved laboratory parameter lethal limitation Lipid lipid peroxidation lung Lungs Major majority mechanism no difference outcome oxidative stress oxidative stress response Patient patients Peroxidation peroxides pilot study plasma Pneumonia Prevent product Protein reactive oxygen species (ROS) Research SARS-CoV-2 sera Seven shown survivor Survivors total antioxidant capacity variations [DOI] 10.3390/antiox10091341 PMC 바로가기 [Article Type] Article
Inhibition of elastase enhances the adjuvanticity of alum and promotes anti–SARS-CoV-2 systemic and mucosal immunity엘라스타제의 억제는 명반의 면역증강을 강화하고 항-SARS-CoV-2 전신 및 점막 면역을 촉진합니다.423 Published on 2021-08-242022-09-12 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 진단, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjuvant adjuvanticity alum alum adjuvant antibodies antibody Antibody Response Antibody responses Antigen Blood bloodstream blunt CD4 Cell-mediated immunity coronavirus COVID-19 patients Efficacy Elastase ENhance epitope Epitopes follicular help identify IgA antibodies IgA antibody IL-1 Immunity immunization Immunoglobulin IMPROVE induce inhibition inhibitor injected innate response interleukin investigated lack magnitude mice mucosal mucosal immunity mucosal route mucosal secretion mucosal tissue mucosal tissues myeloid cells neutrophil Neutrophil elastase neutrophil elastase inhibitor Neutrophils pharmacological promote protective antibodies Protective antibody Protein Protein subunit protein-based vaccine recruitment regulate response responses SARS-CoV-2 SARS-CoV-2 spike protein sera Serine serine protease serum antibody serum IgG severe acute respiratory syndrome Coronavirus SIgA Significance Spike protein stimulate subunit Support suppression T cell T cell responses T helper Tfh Th1 Th2 the spike protein vaccination Vaccine Vaccines [DOI] 10.1073/pnas.2102435118 PMC 바로가기 [Article Type] 423
The Rise and Fall of a Local SARS-CoV-2 Variant with the Spike Protein Mutation L452RArticle Published on 2021-08-232022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Alpha variant Critical Delta demonstrated disease spread effort Epsilon independent individual Infection L452R Lineage Local Mutation neutralization neutralization capacity outbreak Prevent pseudoviruses reduction in SARS-CoV-2 SARS-CoV-2 variant Sequencing sera shown Surveillance the Spike vaccination variant wild-type strain [DOI] 10.3390/vaccines9080937 PMC 바로가기 [Article Type] Article
Recombinant Antigens Based on Non-Glycosylated Regions from RBD SARS-CoV-2 as Potential Vaccine Candidates against COVID-19Article Published on 2021-08-202022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] animal model antibody Antigen candidate candidate vaccine controls coronavirus 2 COVID-19 COVID-19 patients determine Escherichia coli expressed glycosylated glycosylation glycosylation site highlight Host immune response Hypothesis IgG antibody immunized immunogenic potential limit mice Neutralizing activity neutralizing antibody not carry Patient polyclonal antibody Potential Prokaryotic expression Protein protein region purified raise RBD Receptor binding domain recombinant Region Research residue respiratory S-RBD SARS-CoV-2 selected sera serum Spike protein strong immune response the Spike Vaccine viral glycosylation [DOI] 10.3390/vaccines9080928 PMC 바로가기 [Article Type] Article
Development and Evaluation of a Set of Spike and Receptor Binding Domain-Based Enzyme-Linked Immunosorbent Assays for SARS-CoV-2 Serological TestingArticle Published on 2021-08-202022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] anti-SARS-CoV-2 IgG approval collected conducted COVID-19 development ELISA plates IgG IgG isotypes IgG titer IgG1 IgG2 IgG3 IgG4 implementation individual individuals Infectious disease MOST onset of symptoms positive positive COVID-19 RBD protein reported reporters RT-PCR SARS-CoV-2 secondary antibody sensitivity sera Seroconversion Serological assay serological diagnostics serum sample specificity spike Testing UDITEST-V2G® viral infection were used [DOI] 10.3390/diagnostics11081506 PMC 바로가기 [Article Type] Article
Serological Detection of SARS-CoV-2 Antibodies in Naturally-Infected Mink and Other Experimentally-Infected Animals자연 감염 밍크 및 기타 실험적으로 감염된 동물에서 SARS-COV-2 항체의 혈청 학적 검출Brief Report Published on 2021-08-192022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] animal animal reservoir antibody Antibody detection bat calculation Cohen’s kappa detection diagnostic discrimination examined ferrets FIVE hamster hamsters Human immunized immunoassay infect LIPS luciferase Luciferase immunoprecipitation system luciferase immunoprecipitation systems mink negative sample neutralization nucleocapsid nucleocapsid protein Nucleocapsid proteins Other positive purified rabbit S proteins SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 N sera serological surveillance serum samples Spearman spike Spike protein statistical analyses statistical analysis tested the SARS-CoV-2 Viral viral antibodies viral antibody virus Virus neutralization was used were used wild animal wild animals [DOI] 10.3390/v13081649 PMC 바로가기 [Article Type] Brief Report
Influenza Virus-like Particle (VLP) Vaccines Expressing the SARS-CoV-2 S Glycoprotein, S1, or S2 DomainsArticle Published on 2021-08-182022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] activities activity acute respiratory syndrome antibody approved binding Cell characterized consequence Coronavirus-2 COVID-19 Effective vaccines effort elicited Emergency use expressing full length generate glycoprotein IgG IgG2a immune immunization Influenza inhibit mice naïve neutralization pandemic Particle predominant Protein SARS-CoV-2 sera TEM the SARS-CoV-2 transmission electron microscopy Vaccine Virus-like particle virus-neutralizing VLP VLPs while [DOI] 10.3390/vaccines9080920 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Serologic Assays Dependent on Dual-Antigen Binding Demonstrate Diverging Kinetics Relative to Other Antibody Detection Methods이중 항원 결합에 의존하는 SARS-CoV-2 혈청학적 분석은 다른 항체 검출 방법에 비해 발산하는 역학을 보여줍니다Article Published on 2021-08-182022-09-11 Journal: Journal of Clinical Microbiology [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus anti-SARS-CoV-2 Anti-SARS-CoV-2 S antibodies antibody Antibody detection Antibody titer Antibody titers Antigen assays binding Cohort convalescent COVID-19 patients convalescent plasma coronavirus Course COVID-19 cross-sectional demonstrated Dependent dependent on detection Donor drug dual-antigen binding assays eight Elecsy Elecsys electrochemiluminescence immunoassay Emergency use authorization food humoral humoral immune response Humoral response immunoassays implication Kinetics lack longitudinal Longitudinal studies majority Neutralizing nucleocapsid Other Patient populations profile relative respiratory Roche Roche Diagnostics SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody sera serologic serologic assay serologic assays serology study period symptom onset while [DOI] 10.1128/JCM.01231-21 PMC 바로가기 [Article Type] Article
Humoral Responses to Single-Dose BNT162b2 mRNA Vaccination in Dialysis Patients Previously Infected With SARS-CoV-2Medicine Published on 2021-08-172022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] age Analysis Anti-S1 antibody antibody reactivity BNT162b2 BNT162b2 mRNA cohort study COVID-19 dialysis dose epitope group healthy controls Hemodialysis Humoral response IgG immune response infected individual infected patients Infection IQR median Neutralizing antibodies neutralizing antibody neutralizing capacity Patient patients PCR-confirmed COVID-19 performed response SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 spike protein SARS-CoV-2 vaccination second vaccination sera Seven significantly higher single vaccine vaccination were measured [DOI] 10.3389/fmed.2021.721286 PMC 바로가기 [Article Type] Medicine
Antibodies against type I interferon: detection and association with severe clinical outcome in COVID‐19 patientsShort Communication Published on 2021-08-172022-10-31 Journal: Clinical & Translational Immunology [Category] COVID-19, [키워드] addition admitted to ICU antibody antiviral immune response association autoantibodies autoantibody circulating Clinical characteristics Clinical course Clinical outcome Cohort Concentration COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 Critical Critically ill critically ill patients Deleterious evaluate explained France higher risk hospice ICU IFN Immunity impairment IMPROVE intensive care unit majority Mild neutralising Neutralising activity neutralize no significant difference objective outcome pandemic progresses Patient positive Prevalence quantification reported Result SARS‐CoV‐2 virus sera serum subset subtype the disease Thermo Fisher type I Type I IFN type I interferon viral infection was determined [DOI] 10.1002/cti2.1327 PMC 바로가기 [Article Type] Short Communication