cause – Page 47 – Communicable Diseases Research

Site Density Functional Theory and Structural Bioinformatics Analysis of the SARS-CoV Spike Protein and hACE2 Complex

Article

Published on 2022-01-262022-10-30
Journal: Molecules [Category] COVID-19, SARS,

Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease

Research article

Published on 2022-01-262022-10-05
Journal: Immunity [Category] SARS, 바이오마커,

[키워드] abnormality Activation acute COVID-19 airway airways Apoptosis B cell cause cell death Concentration COVID-19 Cytotoxic T cells dysfunction elevated epithelial Evidence Follow-up greater healthy control healthy individuals hospital discharge immune Immune cell Increased indicated individual Injury Long COVID lung abnormalities Lung disease lymphocyte monocyte Patient patients hospitalized Peripheral blood plasma post-COVID-19 patient Protein proteomes proteomics Regulation resolved Respiratory disease respiratory symptom respiratory tract respiratory viral infection reveal SARS-CoV-2 subset T cells tissue repair tissue-resident memory widespread
[DOI] 10.1016/j.immuni.2022.01.017 [Article Type] Research article

Optimal Deep-Learning-Enabled Intelligent Decision Support System for SARS-CoV-2 Classification

SARS-CoV-2 분류를 위한 최적의 딥러닝 기반 지능형 의사결정 지원 시스템

Research Article

Published on 2022-01-252022-09-10
Journal: Journal of Healthcare Engineering [Category] SARS, 치료기술,

Associated Factors of High Sedative Requirements within Patients with Moderate to Severe COVID-19 ARDS

Article

Published on 2022-01-252022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] acute respiratory distress acute respiratory distress syndrome addition affected age Analysis ARDS cause Combination conditions coronavirus coronavirus disease COVID-19 Critical care Critically ill demonstrated dysfunction enrolled extracorporeal membrane oxygenation Factor global healthcare High dose hypnotics and sedatives intensive care Linear regression model mechanism observation period Organ failure pandemic Patient patients Prone position prone positioning pulmonary ventilation receiving renal required Requirement Sedation sedative severe acute respiratory syndrome coronavirus 2 significantly higher significantly lower statistical analysis syndrome therapy was performed
[DOI] 10.3390/jcm11030588 PMC 바로가기 [Article Type] Article

Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2

Article

Published on 2022-01-252022-10-29
Journal: Scientific Reports [Category] COVID-19,

[키워드] ACE2 acute infection Acute inflammation Affect airway airways alveolar macrophage Alveolar macrophages ambient analyzed Angiotensin-converting enzyme binding cause cellular receptor clinical settings collected correlated dependent on detrimental effect elevated Environmental impact Epidemiology expression expression level health emergency Host host cell host susceptibility individual Infection Interaction lung tissue mice morbidity and mortality Mortality pandemic Pathogenesis priming proportion protease Protein proteolytic respiratory tract SARS-CoV-2 SARS-CoV-2 entry Scientific community serine 2 severe disease severe SARS-CoV-2 severity shown significantly subsequent susceptibility the SARS-CoV-2 TMPRSS2 TMPRSS2 protein transcript transmembrane upregulate upregulated virus while
[DOI] 10.1038/s41598-022-04906-8 PMC 바로가기 [Article Type] Article

Regional excess mortality during the 2020 COVID-19 pandemic in five European countries

Article

Published on 2022-01-252022-10-29
Journal: Nature Communications [Category] COVID-19, SARS,

Clinico-histopathologic and single-nuclei RNA-sequencing insights into cardiac injury and microthrombi in critical COVID-19

중요한 COVID-19에서 심장 손상 및 미세 혈전에 대한 임상 조직 병리학 및 단일 핵 RNA 시퀀싱 통찰력

Clinical Trial

Published on 2022-01-252022-09-10
Journal: JCI Insight [Category] 임상, 진단, 치료기술, 치료제,

[키워드] Acute cardiac injury Analysis antiplatelet association bioinformatics Biomarkers biomarkers of inflammation C-reactive protein cardiac injury Cardiology cardiovascular disease cause clinical factors Cohort conducted controls Corticosteroid corticosteroid treatment COVID-19 Critical enrichment erythrocyte sedimentation erythrocyte sedimentation rate etiology Extracellular matrix Features fibrinolysis fibroblast heart hearts identify In-hospital increased mortality Injury microthrombi Molecular pathology myocarditis Necrosis New York City pathophysiology Patient potential therapeutic target prevalent Prospective Study RNA-sequencing sedimentation rate Sequencing analysis Signaling tested therapeutic anticoagulation Therapies therapy transcriptomic were used
[DOI] 10.1172/jci.insight.154633 PMC 바로가기 [Article Type] Clinical Trial

Case Report: Chronic Cavitatory Pulmonary Aspergillosis after COVID-19

Article

Published on 2022-01-242022-10-28
Journal: The American Journal of Tropical Medicine and Hygi [Category] COVID-19, MERS,

Comprehensive characterization of the antibody responses to SARS-CoV-2 Spike protein finds additional vaccine-induced epitopes beyond those for mild infection

SARS-CoV-2 스파이크 단백질에 대한 항체 반응의 포괄적인 특성화는 경증 감염에 대한 것 이외의 추가 백신 유도 에피토프를 찾습니다.

Comparative Study

Published on 2022-01-242022-09-10
Journal: eLife [Category] 변종, 치료기술, 치료제,

[키워드] Affect affected age Alter Analysis antibodies antibody Antibody binding antibody epitope Antibody Response Antigen Bacteria binding C-terminal domain cause chair changes in complicate Comprehensive computing conserved Control covariate COVID-19 COVID-19 pandemic disease DNA fragment dose education effective epitope Epitopes escape escape mutations experiment exposure to faculty FAM feature finding focus foundation funding fusion peptide genetic code help Howard Hughe Howard Hughes Human Humoral response humoral responses identify immune Immune escape immune system implication individual infect infected individuals Infection Infrastructure interfere Laboratory Lower majority mild infection mRNA vaccination mRNA vaccine mutant Mutation mutations NIH not affect not altered occur offered overlapping pandemic pathway Pathways pattern peptide peptides phage phages population level portion Principal component principal component analysis produced producing PROTECT Protein RBD Region regions Research residue route S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 spike protein Scholar selected severe disease Severe infection shape small molecule Small molecules specific antibodies specific protein spike Spike protein spike-specific antibodies Spike-specific antibody Spread stick subsequent Support supported target the antibody the antibody response the RBD the S1 subunit the SARS-CoV-2 the Spike the spike protein thought triggering unique vaccinated individual vaccinated individuals vaccination Vaccine Vaccine development vaccine-induced antibodies vaccine-induced antibody variant Variation virus was performed while wild-type
[DOI] 10.7554/eLife.73490 PMC 바로가기 [Article Type] Comparative Study

Non-pharmaceutical interventions during the COVID-19 epidemic changed detection rates of other circulating respiratory pathogens in Japan

CovID-19 전염병 중 비 약사 개입은 일본의 다른 순환 호흡기 병원체의 감지율을 변경했습니다.

Research Article

Published on 2022-01-212022-09-10
Journal: PLoS ONE [Category] 치료기술, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus age cause Chain Reaction changed circulating collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 epidemic COVID-19 pandemic detect detection rate disease-associated Diversity Effect FIVE groups hand washing indicated Infection infection control infection with SARS-CoV-2 Intervention Japan majority measure multiplex Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples Older Panel pathogen Pathogens Patient PCR performed polymerase chain polymerase chain reaction Prevalence Quantitative reduced respiratory Respiratory disease respiratory infections respiratory pathogen reverse transcription PCR rhinovirus SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2
[DOI] 10.1371/journal.pone.0262874 PMC 바로가기 [Article Type] Research Article