immune responses – Page 47 – Communicable Diseases Research

Humoral responses to SARS-CoV-2 mRNA vaccines: Role of past infection

SARS-COV-2 mRNA 백신에 대한 체액 반응 : 과거 감염의 역할

Research Article

Published on 2021-11-082022-09-10
Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술,

Pathogenic Basis of Thromboinflammation and Endothelial Injury in COVID-19: Current Findings and Therapeutic Implications

COVID-19에서 혈소판 염증 및 내피 손상의 병원성 근거: 현재 연구 결과 및 치료적 시사점

Review

Published on 2021-11-082022-09-10
Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 유전자 메커니즘, 치료제,

[키워드] activities acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Atypical B cell responses Basis cardiovascular risk factors cause caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 current dry cough dysregulated dysregulated immune responses Endothelial dysfunction endothelial injury exacerbated Fever finding global pandemic high mortality highlight immune evasion immune responses Inflammation interferon interferon signaling interstitial pneumonia knowledge leads mechanisms morbidity Most patients multiple organ failure Organ failure Pathogenesis pathogenesis of COVID-19 pathogenic patients platelet activation platelet hyperactivation public health respiratory respiratory distress resulting SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe cases suppression symptoms of COVID-19 syndrome T cell therapeutic strategy Therapeutics Thromboembolism Thromboinflammation thrombosis
[DOI] 10.3390/ijms222112081 PMC 바로가기 [Article Type] Review

Quercetin for COVID-19 and DENGUE co-infection: a potential therapeutic strategy of targeting critical host signal pathways triggered by SARS-CoV-2 and DENV

COVID-19 및 DENGUE 동시 감염에 대한 케르세틴: SARS-CoV-2 및 DENV에 의해 유발되는 중요한 숙주 신호 경로를 표적으로 하는 잠재적 치료 전략

Article

Published on 2021-11-052022-09-11
Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘,

[키워드] alleviate Analysis bioinformatics biological function Biological functions CCL-2 Clinical characteristics clinical consequence clinical consequences Co-infection Computational biology COVID-19 Critical current CXCL8 Cytokines cytokines release Dengue drug drug trial evaluate Evidence excessive immune response functional Host IL-17 immune responses indicated Inflammation inflammatory pathway inhibit Intervention mechanism mechanisms NF-κB overlapping pathway patients pharmacological pharmacological target potential molecular PPI protein-protein interaction public health quercetin SARS-CoV-2 shown signaling pathways target targets therapeutic therapeutic strategy TNFα Toll-like receptor toll-like receptor signaling Treatment treatment of COVID-19 triggered upstream virus
[DOI] 10.1093/bib/bbab199 PMC 바로가기 [Article Type] Article

COVID-19 mRNA Vaccination in Lactation: Assessment of Adverse Events and Vaccine Related Antibodies in Mother-Infant Dyads

수유에서의 Covid-19 mRNA 백신 접종 : 마시어-영향 다이어드에서의 부작용 및 백신 관련 항체의 평가

Immunology

Published on 2021-11-032022-08-13
Journal: Frontiers in Immunology [Category] MERS, SARS, 임상,

[키워드] addition Adverse adverse event age anti-RBD anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG antibodies antibodies antibody assessment automated Blood blood sample Blood samples BNT162b2 Breastfeeding Cohort collected COVID-19 COVID-19 mRNA Vaccination COVID-19 mRNA vaccine diagnosed with COVID-19 dose dyad ELISA first vaccination generate human milk IgA IgA level IgG antibodies IgG antibody IgM immune response immune responses immunoassay individual Infant Infants lactating lactation maternal plasma milk mother mRNA mRNA vaccine mRNA vaccines mRNA-1273 mRNA-based vaccine mRNA-based vaccines passive immunity PEGylated protein PEGylated proteins plasma prospective cohort Pylon 3D Questionnaires reported Result robust SARS-CoV-2 severe adverse event severe adverse events significant level significantly increased study period subset Symptom the vaccine transfer vaccination were assessed were measured
[DOI] 10.3389/fimmu.2021.777103 PMC 바로가기 [Article Type] Immunology

Immune Response of Neonates Born to Mothers Infected With SARS-CoV-2

SARS-CoV-2에 감염된 산모에게서 태어난 신생아의 면역 반응

Observational Study

Published on 2021-11-032022-09-10
Journal: JAMA Network Open [Category] MERS, SARS, 임상, 진단, 치료기술,

[키워드] 48 hour 48 hours age antibody antibody production arbitrary unit association Birth breastmilk children Clinical outcome cohort study enrolled enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated explain exposure exposure to finding Follow-up gestational age IgA IgA antibodies IgA antibody IgG antibodies IgM antibodies IgM antibody immune complex Immune complexes immune response immune responses immune system Importance in utero Infant Infants infected with SARS-CoV-2 Infection infection with SARS-CoV-2 information investigated IQR Italy life male Maternal maternal age measure mother mucosal mucosal immune Neonatal Neonate Newborn objective occurred offspring participant parturition passive immunity Point positive Pregnancy pregnant women prospective cohort study PROTECT provided Receptor binding Receptor binding domain Relevance response Result Rome Saliva salivary SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 spike secretory IgA serum setting significantly higher significantly increased specific antibodies specific antibody specific IgG antibodies spike-specific antibodies Spike-specific antibody spike-specific IgG stimulate systemic immune response systemic immune responses tested transfer Transmission Umberto vertical transmission vertical virus transmission virus Virus spike virus transmission
[DOI] 10.1001/jamanetworkopen.2021.32563 PMC 바로가기 [Article Type] Observational Study

COVID-19-Associated acute respiratory distress syndrome (CARDS): Mechanistic insights on therapeutic intervention and emerging trends

Article

Published on 2021-11-032022-10-04
Journal: International immunopharmacology [Category] MERS, SARS, 신약개발, 임상, 치료제,

[키워드] Abstract acute respiratory distress antiviral effects ARDS Attention caused Clinical effect clinical trial Complication Coronavirus disease 2019 COVID-19 COVID-19-associated ARDS COVID-19-associated ARDS (CARDS) COVID‐19 current database decrease develop distress drug target effective therapy Effectiveness Effects Elsevier evaluated examined expected feature help immune responses material modulating molecular Molecular drug targets morbidity Mortality Numerous outcomes pathophysiological mechanism pathophysiology Patient pharmacological treatment respiratory SARS-COV-2 infection Significance syndrome systematic review targets Therapeutic approach therapeutic intervention therapeutic option Treatment
[DOI] 10.1016/j.intimp.2021.108328 PMC 바로가기 [Article Type] Article

Peritoneal Administration of a Subunit Vaccine Encapsulated in a Nanodelivery System Not Only Augments Systemic Responses against SARS-CoV-2 but Also Stimulates Responses in the Respiratory Tract

나노 전달 시스템에 캡슐화 된 서브 유닛 백신의 복막 투여 SARS-COV-2에 대한 체계적인 반응을 강화 할뿐만 아니라 호흡기에서의 반응을 자극합니다.

Article

Published on 2021-11-022022-09-01
Journal: Viruses [Category] MERS, SARS, 진단,

[키워드] activated addition adjuvant delivery particles administration Antibody Response Bronchoalveolar lavage chitosan circulating COVID-19 pandemic COVID-19 vaccine demonstrated disease elicited global health Health herd immunity IgA IgG immune responses Immunity immunization immunized mice immunogenicity investigated lung homogenate lung homogenates mass vaccination mice mucosal mucosal immunity neutralizing capacity Particle peritoneal immunization receiving respiratory respiratory tract response SARS-CoV-2 SARS-CoV-2 spike glycoprotein SARS-CoV-2-infected patients SARS-CoV-2-specific IgG SARS-CoV-2-specific immune response SARS-CoV-2-specific immune responses spike glycoprotein spike-specific T cell Spread stimulate stimulated subunit Subunit vaccine System systemic T cell tract vaccination vaccine candidate
[DOI] 10.3390/v13112202 PMC 바로가기 [Article Type] Article

A Modular Biomaterial Scaffold-Based Vaccine Elicits Durable Adaptive Immunity to Subunit SARS-CoV-2 Antigens

모듈식 생체 재료 스캐폴드 기반 백신은 소단위 SARS-CoV-2 항원에 대한 내구성 있는 적응 면역을 유도합니다

Article

Published on 2021-11-012022-09-11
Journal: Advanced Healthcare Materials [Category] MERS, SARS, 변종, 진단,

[키워드] activate adaptive Adaptive immunity antibodies antibody Antigen antigen-presenting cell antigen-presenting cells APCS biomaterial cellular colony-stimulating factor coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 vaccine cytotoxic cytotoxic T-cells described facilitate generate GM-CSF granulocyte granulocyte-macrophage colony-stimulating factor Humoral response immune responses Immunity in vitro injection lack mesoporous silica rods Monophosphoryl lipid A monophosphoryl lipid A (MPLA) MPLA pandemic Pathogens persistent platform poorly immunogenic Protein protein antigen RBD Receptor binding domain recombinant proteins recruit regimen robust rod Safe SARS-CoV-2 SARS-CoV-2 antigens SARS-CoV-2 variant SARS-CoV-2 viral silica Subunit vaccine subunit vaccines T-cells tested Toll-like receptor toll-like receptor 4 Vaccine vaccine platform Vaccines Viral viral neutralization
[DOI] 10.1002/adhm.202101370 PMC 바로가기 [Article Type] Article

NK cell receptor and ligand composition influences the clearance of SARS-CoV-2

NK 세포 수용체 및 리간드 구성은 SARS-CoV-2의 제거에 영향을 미칩니다

Article

Published on 2021-11-012022-09-11
Journal: The Journal of Clinical Investigation [Category] Coronavirus, SARS, 바이오마커,

[키워드] activity addition Admission CD155 Cell clearance clearance of SARS-CoV-2 Control correlated COVID-19 cytolytic Diversity expressing expression functional host-pathogen interaction host-pathogen interactions Immune cell immune cells immune response immune responses immune system immune systems infected cells Infection influence intensive care intensive care unit Interaction involved Ligand mechanical ventilation modulate natural killer nectin NK cell NK cells pathway Patient platform proteomics receptor receptors SARS-COV-2 infection single-cell subpopulation subset target cell TIGIT Viral viral clearance rate virus-infected cells
[DOI] 10.1172/JCI146408 PMC 바로가기 [Article Type] Article

Mass spectrometric identification of immunogenic SARS-CoV-2 epitopes and cognate TCRs

면역원성 SARS-CoV-2 에피토프 및 동족 TCR의 질량 분석 식별

420

Published on 2021-11-012022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis approach best binding affinities caused cell lines cells cellular immune responses conserved coronavirus COVID-19 COVID-19 infection Critical defined effective elicit epitope Epitopes Evidence expressing glycoprotein histocompatibility complex humoral Humoral response humoral responses immune immune protection immune responses immunogenic immunogenicity In silico method in vitro increasingly Infection infectious kill killing major histocompatibility complex malignant disease malignant diseases mass spectrometric mass spectrometry membrane membrane glycoprotein MGP MHC MHC peptide nsp13 peptide peptides predict processed Protein recognize recognizing Region reported respiratory robust SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 epitope SARS-CoV-2 epitopes SARS-CoV-2 peptide SARS-CoV-2 strains severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Significance specificity T cell T cell epitope T cell epitopes T cell response T cell responses T cells tandem Tandem mass spectrometry target cells TCR TCR-T the disease the SARS-CoV-2 therapy to define Treatment variants
[DOI] 10.1073/pnas.2111815118 PMC 바로가기 [Article Type] 420