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[키워드] 95% CI 95% confidence interval ACE2 Admission Analysis BALF Bronchoalveolar lavage fluid BTK C-reactive protein Cell cell interaction COVID-19 COVID-19 patient COVID-19 patients disease severities disease severity elevated expression furin hazard ratio Hospital admission Hospitalization ICU identify immune immune response immune responses individual Infectious diseases Inflammatory biomarker Inflammatory marker inflammatory markers intensive care intensive care unit Interaction likelihood Macrophage macrophages male mechanism moderate Molecular medicine monocyte mononuclear cell mononuclear cells Mortality nasal network analysis neutrophil–lymphocyte ratio NRP1 observation offer outcome Patient Patient care PBMCs Peripheral blood Peripheral blood mononuclear cells potential molecular procalcitonin profile reveal SARS-CoV-2 entry factors SARS-COV-2 infection SARS-CoV-2 positivity scRNA-seq Sequencing sera severe COVID-19 severity Sex difference single-cell Single-cell RNA-sequencing sputum samples squamous cells susceptibility Systems biology targeted intervention TLR7 TMPRSS2 Toll-like receptor toll-like receptor 7 transcriptional activation tyrosine Viral viral infection with COVID-19
[DOI] 10.1038/s41392-021-00709-x PMC 바로가기 [Article Type] Clinical Trial