Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targetsArticle Published on 2021-12-092022-10-04 Journal: Nature cell biology [Category] 바이오마커, [키워드] ACE ACE2 Ago2 Alzheimer’s disease app Biomarker Cancer Cancer models cardiovascular disease Cell Biology Cellular imaging circulating clinically decrease disease Diseases Enzymes Extracellular extracellular vesicle functional GPC1 greater hepatic lipid Host human diseases identify in vivo intense investigation involved Lactate majority mass spectrometry MET morphologically PCSK9 prognostic Protein RNA secretion TGFBI therapeutic therapeutic target transfer unique Vesicle [DOI] 10.1038/s41556-021-00805-8 PMC 바로가기 [Article Type] Article
COVID-19: A New Horizon in Congenital Heart DiseasesPediatrics Published on 2021-12-082022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] 95% CI ACE ACE inhibitor addition analyzed angiotensin receptor blocker cardiac disorder Cardiac surgery CHD Chest CT children collected congenital congenital heart disease coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic demographics demonstrated died discharged disease enzyme female heart high risk Horizon ICU admission Infection infections inhibitor intensive care IQR lung involvement median age median interval myocarditis New not different Odds ratio pandemic participant Patient pediatric Physical examination positive prevalence of COVID-19 previous study pulmonary hypertension recruited reported risk RT-PCR significantly higher surgical susceptible suspicious patient symptomatic the healthy the patient Two patient worsening [DOI] 10.3389/fped.2021.582043 PMC 바로가기 [Article Type] Pediatrics
ACE and ACE2: insights from Drosophila and implications for COVID-19Review article Published on 2021-12-072022-10-05 Journal: Heliyon [Category] 변종, [키워드] accelerated ACE ACE2 Acer acute respiratory syndrome addition Ance Biochemistry Cardiovascular function catalytically cellular entry conserved coronavirus coronavirus disease COVID-19 COVID-19 pandemic Drosophila Drosophila melanogaster enzyme function functional highlight homologue homology identify implication in vivo knowledge mammalian organism orthologue pathogenicity peptides provide raise recent receptor renin-angiotensin system Research responsible SARS-CoV-2 therapeutic intervention unique utility Vaccine variants various coronaviruses Vasoactive Virus-host interaction [DOI] 10.1016/j.heliyon.2021.e08555 [Article Type] Review article
SARS-CoV-2 neutralizing antibodies after one or two doses of Comirnaty (BNT162b2, BioNTech/Pfizer): Kinetics and comparison with chemiluminescent assaysComirnaty(BNT162b2, BioNTech/Pfizer) 1회 또는 2회 투여 후 SARS-CoV-2 중화 항체: 동역학 및 화학발광 분석과의 비교Article Published on 2021-12-012022-09-12 Journal: Clinica chimica acta; international journal of cli [Category] MERS, SARS, 진단, [키워드] 2019-nCoV ACE age antibody assays BNT162b2 BNT162b2 vaccine Chemiluminescent assay circulating antibody CLIA Comirnaty correlated correlation COVID-19 cut-off difference dose Elecsy elicit evaluated FIVE Gender HCW healthcare worker IgG immune immunoassay immunoassays Immunological response Interaction Kinetics NAb titer neutralizing antibody no significant difference plaque reduction neutralization PRNT Protective S-RBD SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 vaccine serology seropositive subjects threshold [DOI] 10.1016/j.cca.2021.10.028 PMC 바로가기 [Article Type] Article
Association of hypertension with mortality in patients hospitalised with COVID-19Observational Study Published on 2021-12-012022-10-05 Journal: Open Heart [Category] 임상, [키워드] 95% CI ACE ACE inhibitor adjusted age analysed angiotensin receptor blocker ARB ARBs association baseline Cardiomyopathy Chronic kidney disease chronic obstructive clinical Comorbidity consecutive patient COVID-19 enrolled evaluate had no heart failure hospitalisation hospitalised hospitals hypertension in-hospital mortality increased mortality independent independent risk factor inhibitor male Mortality multivariable model Observational cohort study Patient patients with comorbidity Pharmacology predictor prevalent pulmonary disease registry Treatment were excluded with COVID-19 [DOI] 10.1136/openhrt-2021-001853 PMC 바로가기 [Article Type] Observational Study
Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic interventionCOVID-19 질병의 발병기전에서 ACE-2 수용체의 역할 이해: 치료적 개입을 위한 잠재적 접근Review Published on 2021-12-012022-09-11 Journal: Pharmacological Reports [Category] SARS, 변종, [키워드] ACE ACE gene ACE-2 receptor ACE2 ACE2 receptor ACE2 receptors acute lung injury acute respiratory distress syndrome aldosterone angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 approach cardiovascular system Cell correlation COVID-19 COVID-19 pathogenesis disorders distress enzyme genomic variant homologue human cells hypertension intake lung Lung injury manifestation medications molecular pandemic of COVID-19 pathogenesis of COVID-19 pathophysiology pathway persistence Proteins question raised raising receptor Renin renin-angiotensin-aldosterone system researcher respiratory distress Respiratory distress syndrome rhACE2 SARS-CoV-2 SARS-CoV-2-infected patients therapeutic intervention these viruses understanding viral particle virus [DOI] 10.1007/s43440-021-00303-6 PMC 바로가기 [Article Type] Review
Cirrhosis-Associated RAS-Inflammation-Coagulation Axis Anomalies: Parallels to Severe COVID-19Article Published on 2021-12-012022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] abnormal coagulation abnormality ACE acute respiratory distress acute respiratory distress syndrome Angiotensin-converting enzyme Antigen axis C-reactive protein characterized cirrhosis coagulation parameter correlated COVID patient COVID-19 COVID-19 patients CRP D-dimer Endothelial dysfunction exhibited fibrinolysis healthy subject IL-6 Increased increased risk Inflammation interleukin-6 investigated Liver disease Mild nine parameter Patient patients patients with COVID-19 portal hypertension RAS RAS activity renin-angiotensin-system severe COVID-19 severity significantly syndrome systemic inflammation upregulation venous vWF [DOI] 10.3390/jpm11121264 PMC 바로가기 [Article Type] Article
Traditional Uses, Pharmacological Effects, and Molecular Mechanisms of Licorice in Potential Therapy of COVID-19Pharmacology Published on 2021-11-262022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE analyzed Anti-inflammation Antiviral binding Cell Characteristics Chinese clinical symptom clinical trials component Coronavirus disease 2019 COVID-19 dry cough Effects expected Fever glycyrrhizin immunomodulatory effects IMPROVE Inflammatory factor inflammatory mediator inhibit interfere licorice mechanism of action mechanisms Mild moderate molecular mechanism outbreak pandemic pathogenesis of COVID-19 pathway Patient pharmacological Pharmacological Effects Potential Prevent respiratory diseases Shortness of breath significant difference significantly stimulated suggested Symptoms target therapeutic Topic Traditional traditional uses treat Treatment type I interferon Vaccine virus spike protein [DOI] 10.3389/fphar.2021.719758 PMC 바로가기 [Article Type] Pharmacology
Posttraumatic Stress Symptoms Among Chinese College Students During the COVID-19 Pandemic: A Longitudinal StudyCOVID-19 팬데믹 기간 동안 중국 대학생의 외상 후 스트레스 증상: 종단 연구Public Health Published on 2021-11-252022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 치료기술, 치료제, [키워드] ACE ACEs childhood China Chinese Chinese college students collected college COVID-19 declined descriptive survey study enrolled finding information longitudinal Longitudinal assessment longitudinal study outbreak Posttraumatic Stress predict predicted predictor Prevalence PTSS remained Resilience Result risk factor Risk factors self-compassion significantly socioeconomic status student Symptom target trauma Treatment vulnerable population Wave while [DOI] 10.3389/fpubh.2021.759379 PMC 바로가기 [Article Type] Public Health
COVID-19 and Rheumatoid Arthritis Crosstalk: Emerging Association, Therapeutic Options and ChallengesReview Published on 2021-11-242022-10-31 Journal: Cells [Category] COVID-19, MERS, SARS, [키워드] ACE ACE2 acute respiratory syndrome Angiotensin-converting enzyme anti-rheumatic drug Anti-rheumatic drugs appear arthralgia Autoimmune disease caused challenge clinical monitoring coronavirus coronavirus disease COVID-19 cytokine Cytokine storm Diseases Evidence exacerbate feature Hyperactivation immune response Inflammation knowledge management manifestation mechanism Musculoskeletal myalgia option outcome overlapping pathway Patient patients pro-inflammatory mediator recommendation resulting Rheumatoid rheumatoid arthritis risk risk of COVID-19 SARS-CoV-2 SARS-COV-2 infection severity Structure therapeutic options [DOI] 10.3390/cells10123291 PMC 바로가기 [Article Type] Review