SARS-CoV-2 vaccines strategies: a comprehensive review of phase 3 candidatesReview Article Published on 2021-02-222022-10-04 Journal: NPJ Vaccines [Category] 임상, [키워드] ACE-2 receptor antibody appear approval candidate cause caused China COVID-19 disease deaths Disadvantages disease effective induce Infection Laboratory morbidity and mortality neutralizing antibody new SARS-CoV-2 pandemic phase Phase 3 presenting Prevent receiving reduce RNA vaccines RNA virus SARS-CoV-2 vaccine sequenced Spread tested the Coronaviridae the spike protein Vaccine vaccine candidate vaccine candidates Vaccine development vaccine platform viral infection virus [DOI] 10.1038/s41541-021-00292-w PMC 바로가기 [Article Type] Review Article
Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody단량체, 서브나노몰 친화성 나노바디에 의한 SARS-CoV-2 D614 및 G614 변이체의 임상 분리물의 강력한 중화Article Published on 2021-02-082022-09-01 Journal: Scientific Reports [Category] MERS, 변종, 진단, [키워드] ACE-2 receptor alpaca antibody Antiviral antiviral agent applicability Bacterial bind binding Biochemistry Biotechnology Cell Biology centrifugation Critical D614G variant density gradient density gradient centrifugation develop Diagnosis E. coli G614 variant global effort health systems IC50 immunization immunology include isolate Isolation Molecular biology monomeric nanobodies nanobody neutralization neutralize potent prophylactic measure prophylactic measures Protein RBD reduce regimen required S RBD SARS-CoV-2 SARS-CoV-2 spike protein selected situation spike Spike protein the SARS-CoV-2 therapeutic Treatment wild type [DOI] 10.1038/s41598-021-82833-w PMC 바로가기 [Article Type] Article
Targeting Lipid Rafts as a Strategy Against CoronavirusCell and Developmental Biology Published on 2021-02-042022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE-2 ACE-2 receptor acute respiratory syndrome Affect affecting Against Alpha angiotensin-converting enzyme-2 Antiviral compounds approach autophagic bind binding Bioavailability characterized cholesterol clearance complexes component coronavirus Coronavirus-2 Coronaviruses cyclodextrins domain downstream drug functional host cell host cell membrane host cell surface impairing Inclusion involved Lipid Lipid rafts main receptor membrane N-terminal Necrosis pharmacological platform proinflammatory molecule raft reducing Region Remdesivir SARS-CoV-2 selective sialic acid sphingolipids Spike protein statins Strategy targeting the SARS-CoV-2 the spike protein these compound TNF-α viral envelope viral replication virus infectivity viruses [DOI] 10.3389/fcell.2020.618296 PMC 바로가기 [Article Type] Cell and Developmental Biology
Guillain-Barre Syndrome Associated With COVID-19 Infection: A Case Report With Review of LiteratureNeurology Published on 2021-02-032022-10-31 Journal: Cureus [Category] COVID-19, [키워드] ACE-2 receptor Acute motor axonal neuropathy Affect binding bloodstream Brain co-morbidities Contact COVID-19 COVID-19 infection criteria disease Effects endothelial Guillain-Barré syndrome Immune-mediated Infection literature nervous system occur olfactory pandemic PCR polymerase chain positive Prevent progression receptors report review syndrome Treatment variant with COVID-19 [DOI] 10.7759/cureus.13096 PMC 바로가기 [Article Type] Neurology
Insights of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) pandemic: a current reviewReview Published on 2021-02-012022-10-27 Journal: Biological Procedures Online [Category] COVID-19, [키워드] ACE-2 ACE-2 receptor ancestor antiviral drugs approaches approval Arbidol Azithromycin cause causes China chlorpromazine coronavirus country COVID-19 COVID-19 pandemic development domain drug Drug repurposing Evolution gastrointestinal systems group HCQ Health Organization Human human Angiotensin-converting enzyme insight Lopinavir membranes Novel coronavirus Oritavancin pandemic pandemic era rapid test kit receptors recommendation Research resource respiratory RT-PCR SARS-CoV-2 Support Treatment Trial Vaccine virulent WHO [DOI] 10.1186/s12575-020-00141-5 PMC 바로가기 [Article Type] Review
Leveraging coronavirus binding to gangliosides for innovative vaccine and therapeutic strategies against COVID-19COVID-19에 대한 혁신적인 백신 및 치료 전략을 위해 강글리오사이드에 대한 코로나바이러스 결합 활용Article Published on 2021-01-292022-09-12 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 진단, [키워드] ACE-2 receptor analyzed antibody Antibody binding Azithromycin bind binding binding domain binding site blocked cellular convalescent coronavirus COVID-19 Critical epitope explain flat ganglioside Hydroxychloroquine identity Infection Interaction isolate Lipid Lipid raft N-terminal domain neutralizing antibody NTD offer overlap patients plasma membrane RBD Receptor binding domain Respiratory disease S protein S trimer SARS-CoV-2 SARS-CoV-2 neutralization supported the S protein therapeutic therapeutic strategy These data unique Vaccine virus Virus spike [DOI] 10.1016/j.bbrc.2020.10.015 PMC 바로가기 [Article Type] Article
Effect of ambient temperature on respiratory tract cells exposed to SARS-CoV-2 viral mimicking nanospheres-An experimental studySARS-CoV-2 바이러스 모방 나노스피어에 노출된 호흡기 세포에 대한 주변 온도의 영향-실험 연구Article Published on 2021-01-282022-09-12 Journal: Biointerphases [Category] 진단, [키워드] ACE-2 ACE-2 receptor acute respiratory syndrome airway epithelial cell ambient angiotensin-converting enzyme 2 binding bovine Calu-3 caused change coated with Community coronavirus country denaturing Effect fibroblast cell fluctuation had no Host host cell incubated indicated infect Infection Infectious disease Interaction lung epithelia mimicking modulated nonspecific Novel coronavirus occurred pandemic Polymer Protein RBD reached reported respiratory tract respiratory tract cell S protein S-RBD SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 viral seasonal serum Spread stability surface receptor temperature the S protein the SARS-CoV-2 Transmission Viral transmission virus [DOI] 10.1116/6.0000743 PMC 바로가기 [Article Type] Article
Molecular Docking Reveals Ivermectin and Remdesivir as Potential Repurposed Drugs Against SARS-CoV-2Microbiology Published on 2021-01-252022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] ACE-2 ACE-2 receptor addition Against Antiviral antiviral agent bind cause caused Cell Chloroquine chloroquine/hydroxychloroquine clinical trial conducted Consequences coronavirus coronavirus disease COVID-19 docking drug drugs evaluated Favipiravir global pandemic Hydroxychloroquine inhibitors of SARS-CoV-2 Ivermectin M protein mechanism membrane fusion Membrane proteins molecular dynamics nsp14 Potential Proteases RdRP Remdesivir remdesivir (GS-5734) Replication reported Repurposed drugs Respiratory disease RNA RNA polymerase SARS-CoV-2 screened severity Stage surface receptor target target proteins the binding affinity therapeutic agents TMPRSS2 treatment protocols Trigger viral replication viral spike protein was performed Wuhan [DOI] 10.3389/fmicb.2020.592908 PMC 바로가기 [Article Type] Microbiology
The race to treat COVID-19: Potential therapeutic agents for the prevention and treatment of SARS-CoV-2Review Published on 2021-01-122023-07-01 Journal: European journal of medicinal chemistry [Category] SARS, [키워드] 3CL Protease ACE-2 receptor Cathepsin L proteinase coronavirus COVID-19 Inhibitors. contents RdRP SARS-CoV-2 spike glycoprotein TMPRSS2 [DOI] 10.1016/j.ejmech.2021.113157 PMC 바로가기 [Article Type] Review
Compounds of Citrus medica and Zingiber officinale for COVID-19 inhibition: in silico evidence for cues from AyurvedaResearch Published on 2021-01-092022-10-31 Journal: Future Journal of Pharmaceutical Sciences [Category] COVID-19, [키워드] ACE-2 ACE-2 receptor angiotensin-converting enzyme 2 Ayurveda Ayurvedic formulation ciliated cell Citrus Compound contagious contagiousness COVID-19 docking docking study Efficacy Evidence evidenced expressed fevers goblet Herbal Host Human human cell in silico In silico evidence indicated inhibit key factor management mitigate Molecular docking study nasal nasal epithelium nasal passages nasopharynx organism pathogenic Protein Receptor binding reduce reducing reported Respiratory illness Result S protein SARS-CoV-2 SARS-CoV-2 spike protein severity silico study Spike protein the disease these compound Transmission Viral load viral shedding virus Zingiber [DOI] 10.1186/s43094-020-00171-6 PMC 바로가기 [Article Type] Research