Structural Dissection of Viral Spike-Protein Binding of SARS-CoV-2 and SARS-CoV-1 to the Human Angiotensin-Converting Enzyme 2 (ACE2) as Cellular ReceptorArticle Published on 2021-08-182022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] ACE2 ACE2 protein ACE2 sequence acute respiratory syndrome amino acid residue Betacoronavirus binding Binding interface cellular receptor complexes COVID-19 Dissection evidenced experimental structure Host host cells Human human ACE2 implication in silico analysis Interaction Invasion K417 molecular interaction Mutagenesis N-terminal new coronavirus SARS-CoV-2 outbreak outcome R426 RBD Receptor-binding domain (RBD) reported residue SARS-CoV-1 SARS-CoV-2 Spread Support viral spike-protein [DOI] 10.3390/biomedicines9081038 PMC 바로가기 [Article Type] Article
ACE2 protein expression within isogenic cell lines is heterogeneous and associated with distinct transcriptomes동종 세포주 내 ACE2 단백질 발현은 이질적이며 별개의 전사체와 연관됩니다.Article Published on 2021-08-052022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] ACE2 ACE2 expression ACE2 gene ACE2 protein angiotensin angiotensin-converting enzyme 2 antibodies application approach Cell cell line cells cellular cellular receptor daughter cells detectable enrichment enzyme Epigenetic expression fixed Gene regulation heterogeneity heterogeneous HUH7 cells identify initiated membrane protein Membrane proteins mRNA abundance mRNA level multiple cell line multiple cell lines pathway promoter protein level proximal Regulation Renin renin-angiotensin system RNA-Seq SARS-CoV-2 SARS-CoV-2 virus single cells specificity subset Support the SARS-CoV-2 virus transcript transcription factor Transcriptome transcriptomes transcripts [DOI] 10.1038/s41598-021-95308-9 PMC 바로가기 [Article Type] Article
Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility임신에서 ACE2의 역할과 COVID-19 감수성에 대한 잠재적 영향Review Published on 2021-08-022022-09-11 Journal: Clinical Science (London, England : 1979) [Category] MERS, SARS, 바이오마커, [키워드] ACE ACE2 ACE2 protein acute respiratory syndrome angiotensin angiotensin converting enzyme 2 Angiotensin-converting enzyme cardiovascular disease cells changes in children circulation coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 susceptibility Critical deplete disease manifestation disorder during pregnancy Effect Evidence evidence of feature Follow-up hemodynamic impair implication IMPROVE indicate Infection information Kinin knowledge main receptor management mechanism molecular mother organ physiological system physiological systems Placenta placental biology placentation pregnancies Pregnancy Protective RAS renin–angiotensin system Replication respiratory risk role SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome Significant Stratification Transmission vertical transmission Viral viral entry viral infection with COVID-19 [DOI] 10.1042/CS20210284 PMC 바로가기 [Article Type] Review
Efficient machine learning model for predicting drug-target interactions with case study for Covid-19COVID-19에 대한 사례 연구와 약물-표적 상호 작용을 예측하기위한 효율적인 기계 학습 모델Article Published on 2021-08-012022-08-31 Journal: Computational biology and chemistry [Category] MERS, SARS, 신약개발, 치료기술, 치료제, [키워드] Accuracy ACE2 protein affected Algorithm amino-acid amino-acid sequence applied can be used case study chemical properties computational method Corona virus Corona viruses COVID-19 COVID-19 infection cross dataset datasets Deep-learning develop drug drug treatment drug treatments drug-target interaction Drug-target interactions DrugBank drugs Effect effective efficient Ensemble learning experiment Experimental result experimental results f-score feature Infection input Interaction interactions labor labor-intensive Laboratory LINE machine machine learning performed physical physical and chemical properties predict predicted prediction Protein protein sequence protein sequences Proteins Structure structures System target time-consuming viruses [DOI] 10.1016/j.compbiolchem.2021.107536 PMC 바로가기 [Article Type] Article
A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infectionRBD를 표적으로 하는 합성 나노바디는 SARS-CoV-2 감염으로부터 햄스터를 보호합니다Article Published on 2021-07-302022-09-12 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료제, [키워드] ACE2 protein animal model animal models antibody bind binding Bioavailability biochemical candidate Candidates causative agent Clinical sign Clinical signs COVID-19 domain feature form hamster hamsters high affinity high stability host cell in vitro inhibited Interaction Live virus llama mechanism medical intervention nanobodies nanobody neutralization activity Neutralizing Neutralizing antibodies offer outbreak PROTECT pseudoviruses RBD RBD-ACE2 Receptor-binding domain reduce SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudoviruses single dose storage structure-based design sybodies sybody synthetic nanobodies synthetic nanobody therapeutic therapeutic activity Viral RNA viral RNA load virus X-ray crystallography [DOI] 10.1038/s41467-021-24905-z PMC 바로가기 [Article Type] Article
Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection인간 ACE2의 돌연변이는 SARS-CoV 및 SARS-CoV-2 스파이크 매개 감염을 차등적으로 촉진합니다Research Article Published on 2021-07-162022-09-10 Journal: PLoS Pathogens [Category] SARS, 변종, [키워드] abrogated abundance ACE2 ACE2 protein ACE2 sequence Affect allele bind binding biochemical Cell cell line cell surface cells change coding coronavirus coronavirus spike proteins correlated CoV spike proteins Cross-species transmission Cytopathic effect cytopathic effects determine Effect Efficiency engage events exomes expressed expression fraction Genetic genomic integration HEK 293T Human human ACE2 human Ace2 protein implication infect cells Infection inhibited Interaction Missense missense mutants Modification mutant mutants N501Y Non-linear relationship nucleotide overlapping parental promote Protein pseudotyped lentivirus pseudovirus entry pseudovirus infection Quantitative receptor protein reduced reducing reference sequence SARS-CoV SARS-CoV entry SARS-CoV-2 SARS-CoV-2 RBD binding SARS-CoV-2 replication SARS-CoV-2 spike SARS-CoV-2 spike proteins SARS-CoV-2 spike variants SARS-like coronavirus SARS-like coronaviruses sequence single nucleotide Spike protein Spike proteins susceptibility susceptibility to infection target cell target cells the cell the spike protein transgenic unique variant variants Viral viral spike virus viruses while zoonotic [DOI] 10.1371/journal.ppat.1009715 PMC 바로가기 [Article Type] Research Article
Mathematical Model of SARS-Cov-2 Propagation Versus ACE2 Fits COVID-19 Lethality Across Age and Sex and Predicts That of SARSMolecular Biosciences Published on 2021-07-122022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE2 ACE2 protein age age and sex binding country COVID-19 Decline Degradation epidemiological fatality Fatality rate high accuracy human ACE2 Hypothesis Inflammatory response lethality Lungs mathematical mathematical model men Model molecular organism parameter predict progression Propagation receptor receptor protein SARS-CoV SARS-CoV-2 the spike protein Variation viral propagation virus women [DOI] 10.3389/fmolb.2021.706122 PMC 바로가기 [Article Type] Molecular Biosciences
ACE2 Is Expressed in Immune Cells That Infiltrate the Placenta in Infection-Associated Preterm BirthArticle Published on 2021-07-082022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] ACE2 ACE2 mRNA ACE2 protein Bacterial infection Birth Blood CCL2 chorioamnionitis circulation collected COVID-19 cytokine Endothelium exhibited Express expression fetal fraction granulocyte greater healthy immune Immune cell incidence Infiltrate Lipopolysaccharide (LPS) LPS lymphocyte M1 M1/M2 macrophage M2 macrophages Macrophage monocyte Monocytes mRNA mRNA expression neutrophil Neutrophils pathway peripheral Placenta placental positive Pregnancy pregnant women Preterm birth Protein PTB risk SARS-CoV-2 SARS-CoV-2 virus second trimester TNFα Transmission treated was collected [DOI] 10.3390/cells10071724 PMC 바로가기 [Article Type] Article
Bioinformatics Analysis of Allele Frequencies and Expression Patterns of ACE2, TMPRSS2 and FURIN in Different Populations and Susceptibility to SARS-CoV-2SARS-CoV-2에 대한 다양한 인구 및 감수성에서 ACE2, TMPRSS2 및 FURIN의 대립유전자 빈도 및 발현 패턴의 생물정보학 분석Article Published on 2021-07-052022-09-10 Journal: Genes [Category] SARS, 변종, [키워드] ACE2 ACE2 protein age analyzed contributing to COVID-19 Critical database differentially expressed eQTLs expression expression level expression pattern expression quantitative trait loci Factor Frequency furin Genetic genetic factors Health Health crisis highlight immune response loci myriad pattern peptidase Population populations priming protease Quantitative receptor responsible retrieved SARS-CoV-2 sequence Serine serine protease shown Spike protein target cells TMPRSS2 TMPRSS2 expression level TMPRSS2 expression levels variant variants Variation variations various tissue various tissues virus [DOI] 10.3390/genes12071041 PMC 바로가기 [Article Type] Article
Expression of ACE2, Soluble ACE2, Angiotensin I, Angiotensin II and Angiotensin-(1-7) Is Modulated in COVID-19 Patients코로나19 환자에서 ACE2, 가용성 ACE2, 안지오텐신 I, 안지오텐신 II 및 안지오텐신-(1-7)의 발현이 조절됨Immunology Published on 2021-06-142022-09-11 Journal: Frontiers in Immunology [Category] MERS, 바이오마커, [키워드] ACE2 ACE2 (Angiotensin Converting Enzyme-2) ACE2 expression ACE2 gene ACE2 mRNA ACE2 protein adverse effect adverse effects Affect alveolar Ang II angiotensin angiotensin I Angiotensin II binding blood cell Blood cells blood pressure blood pressure homeostasis Cell cell types cells circulating Concentration consequence coronavirus COVID-19 COVID-19 patient COVID-19 patients dysregulation enzyme etiological agent Evidence Express expression healthy controls healthy volunteers hypertension less lower expression membrane Monocytes outcome plasma plasma concentration Plasma levels pneumocyte Prevent proteolysis regulator Renin – Angiotensin – Aldosterone System sACE2 SARS – CoV – 2 SARS-CoV-2 SARS-CoV-2-infected patients soluble ACE2 the SARS-CoV-2 These data Trigger Variation variations Viral virus [DOI] 10.3389/fimmu.2021.625732 PMC 바로가기 [Article Type] Immunology