The role of A-to-I RNA editing in infections by RNA viruses: Possible implications for SARS-CoV-2 infectionRNA 바이러스 감염에서 A-to-I RNA 편집의 역할: SARS-CoV-2 감염에 대한 가능한 의미Review Published on 2021-05-012022-09-11 Journal: Clinical immunology (Orlando, Fla.) [Category] SARS, 변종, 치료법, [키워드] A-to-I RNA editing ADAR adenosine Affect APOBEC biological process cytosine cytosolic receptor cytosolic receptors Deamination double-stranded RNA double-stranded RNAs Effect enzyme events Evidence forms Future Host Host immune response implication Infection infections Innate innate immune response Innate immunity Inosine majority mapped Mutation mutations nucleotide patients with COVID-19 proliferation recent Recognition RNA RNA virus RNA viruses SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection shown single nucleotide Spike protein Substitution the spike protein uracil viral infections Viral protein viral replication [DOI] 10.1016/j.clim.2021.108699 PMC 바로가기 [Article Type] Review
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking결정학적 스크리닝 및 컴퓨터 도킹을 통해 확인된 SARS-CoV-2의 Nsp3 매크로도메인에 대한 단편 결합Research Article Published on 2021-04-142022-08-13 Journal: Science Advances [Category] Biochemistry, COVID-19, SARS, [키워드] active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenosine adenosine diphosphate Antiviral Antiviral agents antiviral target binding catalytic chemotype chemotypes conformational coronavirus counteract Data collection differential scanning fluorimetry docking effort enzyme Fluorescence foundation fragment heterogeneity homogeneous host-mediated antiviral adenosine diphosphate–ribosylation signaling inhibitor inhibitors isothermal titration calorimetry macrodomain macrodomain-binders massive Mutation nonpathogenic nonstructural protein 3 physiological temperature protein 3 provide respiratory SARS-CoV-2 selected severe acute respiratory syndrome Coronavirus Signaling starting point starting points Structure unique virus viruses X-ray data collection [DOI] 10.1126/sciadv.abf8711 PMC 바로가기 [Article Type] Research Article
Efficacy and Effect of Inhaled Adenosine Treatment in Hospitalized COVID-19 PatientsImmunology Published on 2021-03-182022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] adenosine Antiviral treatment average COVID-19 COVID-19 patients COVID19 patient CRP level Cytokine storm decrease Effect effective response Efficacy high mortality rate Hospitalization immune system IMPROVE Inflammation Inflammatory mediators Inhaled Length of stay modulate NLR PaO parameters positive Prognosis progression reducing reduction reduction in Regulatory Safe SARS-CoV-2 Therapeutic treatment treated patient Treatment viral infection [DOI] 10.3389/fimmu.2021.613070 PMC 바로가기 [Article Type] Immunology
Identification of FDA approved drugs and nucleoside analogues as potential SARS-CoV-2 A1pp domain inhibitor: An in silico study잠재적인 SARS-CoV-2 A1pp 도메인 억제제로서 FDA 승인 약물 및 뉴클레오시드 유사체 식별: 실리코 연구Article Published on 2021-03-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 신약개발, 치료제, [키워드] A1pp domain adenosine adenosine diphosphate Analysis approved binding binding affinity binding free energy biological activity citicholine conserved coronavirus crystal structure demonstrated deviation docking scores domain exhibited FDA FDA approved drug FDA approved Drugs FIVE fluctuation free energy free energy landscape gyration Host human coronavirus hydrogen Hydrogen bond hydrophobic identification in silico infect inhibit inhibitor Interaction intestine macro Macro domain molecular molecular dynamics Molecular dynamics simulation Molecular mechanics nadide nucleoside nucleoside analogue Nucleoside analogues offer Pathogenesis performed phosphatase positive control promote Protein radius radius of gyration reported respiratory tract ribose RMSD RMSF root mean square deviation root mean square fluctuation SARS-CoV-2 solvent stable complex substrate binding site surface area Therapeutic molecule Therapeutics these compound these compounds These viruses these viruses viral infection [DOI] 10.1016/j.compbiomed.2020.104185 PMC 바로가기 [Article Type] Article
Host-directed editing of the SARS-CoV-2 genomeSARS-CoV-2 게놈의 숙주 주도 편집Review Published on 2021-01-292022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 유전자 메커니즘, [키워드] acting ADAR adenosine adenosine deaminase Antiviral APOBEC Apolipoprotein B catalytic Defense defense mechanisms directional Evolution facilitated Genome editing Host implication instance instances mechanisms mRNA Mutation oxygen pandemic Protein reactive oxygen species reactive oxygen specy RNA ROS SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome sequence the SARS-CoV-2 genome Viral viral genome Virus evolution [DOI] 10.1016/j.bbrc.2020.10.092 PMC 바로가기 [Article Type] Review
Remdesivir: From Ebola to COVID-19렘데시비르: 에볼라에서 코로나19까지Review Published on 2021-01-292022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] 비임상, 치료제, [키워드] acute respiratory syndrome adenosine Adenosine analogues animal coronavirus Animal coronaviruses antiviral activity antiviral drug antiviral drugs antiviral therapy approved candidate changed China clinical study coronavirus Coronavirus infection Coronavirus infections COVID-19 disease double blind drug Ebola Ebola virus Efficacy Epidemic HCoV Health highly pathogenic hospitalized patient hospitalized patients hosts Human human coronavirus human coronaviruses human-to-human transmission in vitro In vitro studies in vitro study inhibit initial initiated MERS Middle East Middle East respiratory syndrome Mild molecular mechanism mortality rate mortality rates nucleotide outbreak Pathogens Patient placebo controlled trial preclinical studies Randomized Remdesivir Replication respiratory Respiratory tract diseases RNA RNA dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 coronavirus Severe acute respiratory syndrome shortening shown syndrome thought Time to recovery treated Treatment Trial upper respiratory tract USA virus zoonotic infection zoonotic infections [DOI] 10.1016/j.bbrc.2020.11.043 PMC 바로가기 [Article Type] Review
Mutational signatures and heterogeneous host response revealed via large-scale characterization of SARS-CoV-2 genomic diversityArticle Published on 2021-01-282022-10-30 Journal: iScience [Category] COVID-19, [키워드] ADAR adenosine affected Analysis APOBEC bioinformatics Clinical outcome Deaminase dissect dN/dS Frequency genetics Genome genomic Genotype heterogeneous highlighting homoplasy Host host response Hypothesis large-scale analysis mechanism MOST Mutation mutational processe nucleotide substitution phylogenetics profile purified respiratory reveal RNA ROS SARS-CoV-2 SARS-CoV-2 infections Specy Support Transmission Transmission dynamics transmitted variant variants [DOI] 10.1016/j.isci.2021.102116 PMC 바로가기 [Article Type] Article
Living in a Hostile World: Inflammation, New Drug Development, and Coronavirus적대적인 세상에서의 생활: 염증, 신약 개발 및 코로나바이러스Review Published on 2021-01-222022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 신약개발, [키워드] adenosine Antigen appear cellular changed Coagulopathy coronavirus COVID-19 patients cytokine Cytokines death Defense development drug drug therapies dysfunction endothelial Evolution excessive inflammation fluid therapy function Health Host host defense immune Immune cell immune cells immune dysfunction immune response immune system Infection Inflammation Inflammatory initiated Injury Intersection intravenous lead lidocaine maintenance mandatory mediators metabolic dysfunction multiple organ failure New patients with COVID-19 Pattern recognition pattern recognition receptor Prevent produced reduce removal repair reported robust Sepsis situation sterile trauma survival therapy tissue damage tissues trauma triggered unique [DOI] 10.3389/fimmu.2020.610131 PMC 바로가기 [Article Type] Review
Off-Target In Vitro Profiling Demonstrates that Remdesivir Is a Highly Selective Antiviral Agent오프 타겟 시험관 내 프로파일링은 렘데시비르가 고도로 선택적인 항바이러스제임을 보여줍니다Article Published on 2021-01-202022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] 치료제, [키워드] 50% effective concentration addition adenosine aerobic agent Anti-SARS-CoV-2 Activity Antiviral Antiviral agents assays biochemical biochemical assay cells cellular cellular respiration Concentration coronavirus COVID-19 cytotoxicity demonstrated DNA DNA and RNA Effect elicit epithelial cells evaluated Filovirus filoviruses GS-5734 human airway human airway epithelial human airway epithelial cells human cell human cell line human cell lines human cells inhibitor Interaction Last MERS MERS-CoV metabolic conditions metabolite Mitochondria mitochondrial mitochondrial DNA mitochondrial respiration nucleoside nucleoside analogs oxygen polymerases primary cells Profiling protein synthesis ranged RDV reactive oxygen species Remdesivir reported resulting safety profile SARS-CoV SARS-CoV-2 selective selectivity indices target tested Toxicity Treatment triphosphate turn Viral Viral RNA [DOI] 10.1128/AAC.02237-20 PMC 바로가기 [Article Type] Article
Purinergic Signaling of ATP in COVID-19 Associated Guillain-Barré SyndromeInvited Review Published on 2021-01-182024-09-04 Journal: Journal of neuroimmune pharmacology : the official [Category] 대상포진, [키워드] adenosine ATP COVID-19 Guillain-Barré syndrome P2X7R [DOI] 10.1007/s11481-020-09980-1 PMC 바로가기 [Article Type] Invited Review