Artificial Intelligence Predicts Severity of COVID-19 Based on Correlation of Exaggerated Monocyte Activation, Excessive Organ Damage and Hyperinflammatory Syndrome: A Prospective Clinical Study인공 지능, 과장된 단핵구 활성화, 과도한 장기 손상 및 과염증 증후군의 상관 관계를 기반으로 COVID-19의 심각도 예측: 전향적 임상 연구Immunology Published on 2021-08-272022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단, [키워드] Accuracy Admission Alanine alanine aminotransferase Algorithms ALT Analysis analyzed applied artificial artificial intelligence aspartate Aspartate aminotransferase AST biochemical analyses Biomarker C-reactive protein C-reactive protein (CRP chemokine chemokines clinical COVID-19 COVID-19 patient COVID-19 patients creatinine CT scan CT scans cytokine Cytokines D-dimer damage develop eight fibrinogen forest gamma interferon Glucose healthy control HMGB1 hospitalized COVID-19 patient identify IL-6 intelligence interferon Laboratory Lactate lactate dehydrogenase LDH Logistic regression Lungs Macrophage macrophage derived cytokine management mDC methodology MIG moderate moderate disease monocyte monokine objective on admission parameter predict prediction prediction models predictor Prognostic factor Prognostic factors Prognostic value Prospective provide Random forest reduce mortality Result severe disease severely ill patient severely ill patients severity severity of COVID-19 significantly higher support vector machine the disease the patient [DOI] 10.3389/fimmu.2021.715072 PMC 바로가기 [Article Type] Immunology
ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker강력하고 광범위한 코로나바이러스 차단제로서의 ACE2 표적 단클론항체Article Published on 2021-08-252022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, 진단, 치료제, [키워드] ACE2 affecting Alanine angiotensin B.1.1.7 B.1.351 B.1.617.1 binding blocked CDR3 clinical development coronavirus Coronaviruses COVID-19 cryo cryo-EM D614G domain Drug development entry receptor epitope Evolution HCoV HCoV-NL63 heavy chain human ACE2 human Angiotensin-converting enzyme in vitro Infection Infectious diseases live SARS-CoV-2 management mice monoclonal antibody multiple coronaviruses mutant non-human primate non-human primates P.1 physiological activities physiological activity Prophylactic provided residue SARS-CoV SARS-CoV-2 SARS-COV-2 infection Toxicity variant virus [DOI] 10.1038/s41392-021-00740-y PMC 바로가기 [Article Type] Article
Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 in people living with and without HIV in South Africa: an interim analysis of a randomised, double-blind, placebo-controlled, phase 1B/2A trial남아프리카에 HIV가 있거나없는 사람들의 SARS-COV-2에 대한 Chadox1 NCOV-19 (AZD1222) 백신의 안전성 및 면역 원성 : 무작위, 이중 맹검, 위약 대조, Phase 1B/2A 시험의 중간 분석Clinical Trial Published on 2021-08-172022-08-13 Journal: The Lancet. HIV [Category] MERS, SARS, 변종, 임상, 진단, [키워드] 1:1 1B/2A trial 95% CI adverse event adverse events African Alanine alanine aminotranferase allocation concealment Antibody Response Antibody Units Antiretroviral therapy Asp614Gly wild-type AZD1222 B.1.351 baseline Beta Beta variant binding antibodies binding antibody unit booster booster response both groups ChAdOx1 ChAdOx1 nCov 19 ChAdOx1 nCoV-19 clinical COV005 criteria cross-reactive binding antibodies cross-reactive binding antibody cross-reactivity D614G demonstrated died domain dose double-blind elevated eligibility criteria enrolled enrolment Fever finding FIVE foundation full-length funding geometric mean geometric mean concentration GMC high responder high responders High-level binding antibody HIV HIV-negative hospital IgG responses immunogenicity in both groups increased risk individual individuals Innovation interim analysis Intervention less Medical Research Council Melinda Gate Melinda Gates n=36 nCoV neutralisation Neutralising activity outcome Pan participant Participants people with HIV person with HIV Placebo placebo-controlled plasma Primary immunogenicity analyses Primary immunogenicity analysis prime-boost regimen priming priming dose randomised Randomly reactogenicity receive Receptor-binding domain Registered registry responses responses against retained rising Safety SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens Serious Adverse Events seronegative seropositive serum IgG Seven severe COVID-19 South South Africa titre Trial unlikely Vaccine vaccine dose Viral Viral load wild-type wild-type Wuhan-1 Asp614Gly with HIV [DOI] 10.1016/S2352-3018(21)00157-0 PMC 바로가기 [Article Type] Clinical Trial
Dynamic changes in liver function parameters in patients with coronavirus disease 2019: a multicentre, retrospective study코로나 바이러스 질병 환자의 간 기능 매개 변수의 동적 변화 2019 : 여러 센터, 후 향적 연구Multicenter Study Published on 2021-08-162022-09-10 Journal: BMC Infectious Diseases [Category] MERS, SARS, 바이오마커, 치료기술, [키워드] Aalanine aminotransferase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alanine alanine aminotransferase albumin alkaline phosphatase ALP ALT aspartate Aspartate aminotransferase AST baseline Bilirubin change changes in chronic liver disease coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 decrease died dynamic Dynamic changes Elevation elevations enrolled increase in Injury Inpatient Inpatients lead Liver function Liver function test liver function tests Liver injury multicentre parameter Patient phosphatase reported respiratory Result Retrospective study SARS-CoV-2 SARS-CoV-2 clearance severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant increases in significantly increased total bilirubin Viral viral shedding [DOI] 10.1186/s12879-021-06572-z PMC 바로가기 [Article Type] Multicenter Study
Evaluation of hepatic enzymes activities in COVID-19 patients코로나19 환자의 간효소 활성 평가Article Published on 2021-08-012022-09-11 Journal: International immunopharmacology [Category] 바이오마커, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Alanine alanine aminotransferase alkaline phosphatase ALP ALT analyzed aspartate Aspartate aminotransferase AST Bilirubin Biomarker cause caused Characteristics clinical Clinical characteristics collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CRP disease enzyme activity enzyme tests Enzymes evaluate female hepatic enzyme hepatic enzymes IL-6 Inflammation Inflammatory biomarker inflammatory biomarkers Iraq Laboratory laboratory findings liver liver enzyme Liver function Liver function test male mechanism outbreak P-value Patient patients patients with COVID-19 phosphatase remained respiratory SARS-CoV-2 serum Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly higher Spread statistically statistically significant the patient total bilirubin virus virus replication was collected were measured [DOI] 10.1016/j.intimp.2021.107701 PMC 바로가기 [Article Type] Article
The common risk factors for progression and mortality in COVID-19 patients: a meta-analysisCOVID-19 환자의 진행 및 사망률에 대한 일반적인 위험 요소: 메타 분석Meta-Analysis Published on 2021-08-012022-09-11 Journal: Archives of Virology [Category] MERS, SARS, 바이오마커, [키워드] affected Alanine alanine aminotransferase ALT Bacteria bilateral pneumonia Bilirubin C-reactive protein caused Cerebrovascular disease CHD Chronic kidney disease CKD clinical manifestations Cochrane Library Coinfection Comorbidities Coronary heart disease coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity creatine creatine kinase CRP CVD database death in COVID-19 Deceased defined fungi global public health global public health emergency Health Organization heart disease hemoptysis identify increased risk investigated Kidney disease Laboratory laboratory examinations lymphocyte Lymphocyte count malignancy Meta-analysis Mortality N-terminal neutrophil neutrophil count non-severe group NT-proBNP participant Patient patients patients worldwide peptide Platelet Platelet count Pneumonia progression proportion risk factor Risk factors severe group significantly higher significantly more sputum production survival group total bilirubin was performed WHO World Health Organization [DOI] 10.1007/s00705-021-05012-2 PMC 바로가기 [Article Type] Meta-Analysis
Correlation of Viral Load With the Clinical and Biochemical Profiles of COVID-19 PatientsInfectious Disease Published on 2021-07-272022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome Alanine albumin ALP ALT analyzed Aspartate aminotransferase AST Bilirubin biochemical biochemical parameter Biochemical parameters calculated caused chi-square test clinical clinical parameter Clinical severity coronavirus correlated correlation COVID 19 COVID-19 COVID-19 patients cross-sectional CRP cycle threshold D-dimer disease Disease progression disease severity ferritin group IBM Infectious disease lactate dehydrogenase LDH leucocyte load lymphocyte Mild moderate Patient PCT profile Protein Result retrospective RT-PCR SARS-CoV-2 severity shown single-center study SPSS statistically statistically significant the disease three group variations Viral load was done was used with COVID-19 [DOI] 10.7759/cureus.16655 PMC 바로가기 [Article Type] Infectious Disease
Biophysical properties of the isolated spike protein binding helix of human ACE2인간 ACE2의 분리된 스파이크 단백질 결합 나선의 생물물리학적 특성Article Published on 2021-07-202022-09-11 Journal: Biophysical Journal [Category] SARS, 변종, 치료기술, [키워드] ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity Alanine angiotensin binding binding affinity Concentration coronavirus F28 Factor failure Fluorescence correlation spectroscopy high affinity human ACE2 human Angiotensin-converting enzyme human cell human cells hydrophobic hydrophobic residue hydrophobic residues interact lack much lower mutant oligomerization peptide promoter receptor Receptor-binding domain reduce reduced severe acute respiratory syndrome Coronavirus solubility Spike protein the receptor-binding domain the spike protein viral spike protein virus virus detection without affecting β-sheet [DOI] 10.1016/j.bpj.2021.06.017 PMC 바로가기 [Article Type] Article
Natural Transmission of Bat-like Severe Acute Respiratory Syndrome Coronavirus 2 Without Proline-Arginine-Arginine-Alanine Variants in Coronavirus Disease 2019 Patients코로나바이러스 질병 2019 환자에서 프롤린-아르기닌-아르기닌-알라닌 변이체가 없는 박쥐 유사 중증 급성 호흡기 증후군 코로나바이러스 2의 자연 전염Article Published on 2021-07-152022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Alanine arginine Chain Reaction cleavage Cluster Coronaviral coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Coronaviruses COVID-19 COVID-19 patients ENhance Evolution of SARS-CoV-2 Frequency furin furin cleavage PRRA motif hamster hamsters Human humans implication isolates motif Mutation natural natural infection organoids patients polymerase chain polymerase chain reaction Prevalence prevalence rate proline PRRA Quasispecies quasispecy respiratory S1/S2 SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Transmission transmitted upstream variant variants Vero VERO-E6 viral pathogenicity Viral variants virus wild-type zoonotic origin [DOI] 10.1093/cid/ciaa953 PMC 바로가기 [Article Type] Article
Comprehensive Profiling of Inflammatory Factors Revealed That Growth Differentiation Factor-15 Is an Indicator of Disease Severity in COVID-19 Patients염증 인자의 포괄적 인 프로파일 링은 성장 분화 인자 -15가 COVID-19 환자의 질병 중증도의 지표임을 보여 주었다.Immunology Published on 2021-07-152022-08-31 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, [키워드] Admission Alanine alanine aminotransferase analyzed aspartate Aspartate aminotransferase Asymptomatic Bioinformatics analysis Biomarker blood cell candidate CD200 change Comprehensive convalescent COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patient COVID-19 patients Critical differentiation discharge disease severity Elevation ELISA eosinophil eosinophil counts expression level expression levels FABP2 Factor functional GDF15 group groups healthy control identify include Indicator inflammatory factors lymphocyte Mild moderate neutrophil neutrophil count NLR Occurrence Patient patient sera Potential biomarker potential biomarkers predict Prevent Profiling progression Remission Revealed severe COVID-19 severe group severity severity of COVID-19 the disease TRAIL Transferrin VCAM-1 were measured White blood cell white blood cell count [DOI] 10.3389/fimmu.2021.662465 PMC 바로가기 [Article Type] Immunology