Allogeneic – Page 5 – Communicable Diseases Research

Platform Incorporating Patient Navigation, Preparative Guidelines, and Hospital at Home May Improve COVID-19 Outcomes for Patients with Myeloid Malignancies

Conference abstract

Published on 2021-11-242022-10-05
Journal: Blood [Category] 유전자 메커니즘,

Gilteritinib for Relapsed Acute Myeloid Leukaemia with FLT3 Mutation during the COVID-19 Pandemic: Real World Experience from the UK National Health Service

Conference abstract

Published on 2021-11-232022-10-05
Journal: Blood [Category] 변종,

[키워드] 95%CI Administered Allogeneic AML approved ASXL1 board Cell Chemotherapy clinically clinician collected Complete COVID-19 COVID-19 pandemic criteria curative database de novo disease domain dose download duplication education effective ELN European experience figure FLT3 Follow-up funding Gilteritinib haematological disorder healthcare hospital Hospital admission IDH1 IDH2 immunosuppressive infected with SARS-CoV-2 information inhibitor Intensive Jazz less majority male median median age Morphological Mortality Most patient mutated Mutation mutations myeloid National Health Service network neutropenia NHS nosocomial not differ NPM1 outcome pandemic Patient patients performance status Physicians proceed reached reducing Registered reported resource resources response Result risk RUNX1 Sequencing significantly speaker Support survival Takeda the median therapy Toxicity TP53 Transmission Treatment tyrosine United Kingdom
[DOI] 10.1182/blood-2021-150169 [Article Type] Conference abstract

Repeated vaccination against SARS-CoV-2 elicits robust polyfunctional T cell response in allogeneic stem cell transplantation recipients

SARS-CoV-2에 대한 반복 백신 접종은 동종 줄기 세포 이식 수혜자에서 강력한 다기능 T 세포 반응을 이끌어냅니다

Article

Published on 2021-11-082022-09-12
Journal: Cancer cell [Category] MERS, SARS, 진단,

[키워드] Allogeneic elicit recipient robust SARS-CoV-2 Stem cell transplantation T cell response vaccination
[DOI] 10.1016/j.ccell.2021.10.002 PMC 바로가기 [Article Type] Article

Development of T-cell immunity in a liver and hematopoietic stem cell transplant recipient following coronavirus disease 2019 infection

2019년 코로나바이러스 감염에 따른 간 및 조혈모세포 이식 수혜자의 T세포 면역 발달

Case Reports

Published on 2021-11-012022-09-12
Journal: Cytotherapy [Category] MERS, SARS, 진단,

[키워드] 229E affected Allogeneic antibody Antigen antigens Cell cellular immunity CMV comparable comprehensive analysis coronavirus disease Coronaviruses COVID-19 COVID-19 infection development EBV HCoV HCoVs healthy donor High-risk patients highlight HKU1 human coronavirus immunological protection Immunosuppression Immunotherapy in vitro Infection initial less liver Liver transplantation membrane Mild NL63 OC43 organ Organ transplant outbreak Patient patients with comorbidities Peripheral blood Post-infection reactivity recipient Reinfection responses against retained risk stratification robust SARS-CoV2 SCT spike survivor T cell T cell assay T cell memory T cells T-cell immunity the patient Transplant umbilical upper respiratory symptom viruses
[DOI] 10.1016/j.jcyt.2021.05.005 PMC 바로가기 [Article Type] Case Reports

Predictors of neutralizing antibody response to BNT162b2 vaccination in allogeneic hematopoietic stem cell transplant recipients

Research

Published on 2021-10-242022-10-29
Journal: Journal of Hematology & Oncology [Category] COVID-19,

[키워드] administration Adults affecting Allogeneic Analysis anti-RBD binding antibody binding domain BNT162b2 BNT162b2 mRNA vaccine CD4 Cell chronic chronic GVHD comparable correlated COVID-19 Cytometry cytometry analysis detectable Factor first vaccination Flow follicular GVHD healthy help helper T cell Hematopoietic cell transplantation identify immunization indicated marker memory B cell mRNA vaccination mRNA vaccine multivariate analyses Neutralizing Neutralizing antibody response Patient patients peripheral blood cell plasmacytoid dendritic cells postvaccination predictor RBD recipient reduced Registered response responses Result risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor significantly lower Stem cell transplantation supplementary material Switched B cells T cell T-SNE therapy vaccination Vaccine was performed were assessed wild type
[DOI] 10.1186/s13045-021-01190-3 PMC 바로가기 [Article Type] Research

Signaling pathways in the regulation of cytokine release syndrome in human diseases and intervention therapy

Review Article

Published on 2021-10-202022-10-04
Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 바이오마커, 치료제,

[키워드] adverse event Allogeneic Autoimmune diseases CAR-T Characteristics characterized chimeric antigen receptor circulating clinical feature clinical manifestations clinically COVID-19 CRS cytokine cytokine levels Cytokine release syndrome described disease disorder Efficacy elevated feature Fever Host human disease hyperinflammation Immunological disorders Immunotherapy incidence Infectious diseases Influenza Intervention life-threatening management mechanism organ dysfunction Pandemics pathway potential mechanism Regulation SARS-CoV signaling pathways Symptom syndrome systemic inflammatory therapy Toxicity
[DOI] 10.1038/s41392-021-00764-4 PMC 바로가기 [Article Type] Review Article

The COVID-19 mRNA BNT163b2 Vaccine Was Well Tolerated and Highly Immunogenic in Young Adults in Long Follow-Up after Haematopoietic Stem Cell Transplantation

Article

Published on 2021-10-192022-10-28
Journal: Vaccines [Category] COVID-19,

A phase I/II dose-escalation multi-center study to evaluate the safety of infusion of natural killer cells or memory T cells as adoptive therapy in coronavirus pneumonia and/or lymphopenia: RELEASE study protocol

코로나바이러스 폐렴 및/또는 림프구감소증에서 자연살해세포 또는 기억 T 세포 주입의 안전성을 평가하기 위한 1/2상 용량 증량 다기관 연구: RELEASE 연구 프로토콜

Study Protocol

Published on 2021-10-022022-09-10
Journal: Trials [Category] MERS, SARS, 임상,

[키워드] 1:1 administration Allogeneic alloreactivity ARMS assigned Biology can be used Cell clinical trial convalescent Coronavirus pneumonia COVID-19 COVID-19 patient determine Donor dose dose-escalation dysregulated Efficacy evaluate facilitate HLA immune system Immunotherapy lymphopenia mechanical ventilation memory memory T memory T cell memory T cells nasal nasal cannula natural killer natural killer cell NK cell NK cells Open-label oxygen Oxygen requirement oxygen supplementation Patient patients Phase 2 Phase I Pneumonia protocol Randomized receive Safety SOC Standard of care Study protocol supplementary material T cell T cell lymphopenia T cells T-lymphocyte the patient therapeutic window therapy Tolerability treat Treatment Trial Trial registration Viral
[DOI] 10.1186/s13063-021-05625-7 PMC 바로가기 [Article Type] Study Protocol

Serologic Responses following a Single Dose of SARS-Cov-2 Vaccination in Allogeneic Stem Cell Transplantation Recipients

동종 줄기 세포 이식 환자에서 SARS-Cov-2 백신 1회 접종 후 혈청학적 반응

Article

Published on 2021-10-012022-09-12
Journal: Transplantation and cellular therapy [Category] MERS, SARS, 진단,

Humoral and Cellular Vaccination Responses against SARS-CoV-2 in Hematopoietic Stem Cell Transplant Recipients

Article

Published on 2021-09-252022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] Allogeneic allogeneic hematopoietic stem cell transplantation analyzed antibodies antibody Antibody Response antigens Cell cellular immunity cellular response Changing Control controls COVID ELISPOT female healthy control help hematopoietic HSCT HSCT patient HSCT recipient humoral IgG ELISA Immunity impaired antibody response Infection male median Oxford Patient positive post vaccination reached recipient reduced response SARS-CoV-2 SARS-CoV-2 IgG antibody SARS-CoV-2 vaccination second vaccination Seven Sex sex-dependency significantly significantly higher STEM tested the vaccine Transplant vaccination vaccine responses were assessed
[DOI] 10.3390/vaccines9101075 PMC 바로가기 [Article Type] Article