Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes심각하고 치명적인 COVID-19에서 사이토카인 상승: 신속한 체계적인 검토, 메타 분석 및 다른 염증 증후군과의 비교Meta-Analysis Published on 2020-12-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] Fulltext, MERS, 바이오마커, [키워드] 95% CI acute respiratory distress acute respiratory distress syndrome antagonists anti-cytokine anti-cytokine therapies comparator comparison Concentration COVID-19 Critical Critical disease cytokine Cytokine release syndrome Cytokine storm description elevated feature group illness immune Inflammatory interleukin-6 Meta-analysis organ dysfunction Patient patients patients with COVID-19 question Rapid reported respiratory distress review Sepsis serum syndrome systematic review the disease Treatment Trial were recorded [DOI] 10.1016/S2213-2600(20)30404-5 PMC 바로가기 [Article Type] Meta-Analysis
Design, Synthesis and In Vitro Experimental Validation of Novel TRPV4 Antagonists Inspired by Labdane DiterpenesArticle Published on 2020-10-182022-10-30 Journal: Marine Drugs [Category] Coronavirus, MERS, SARS, [키워드] acute respiratory syndrome amide amides/esters antagonist antagonists assays bioactive diterpenes biological activity cellular Compound coronavirus COVID-19 Critical determinant diterpene flexible Infection Labdane labdane scaffold novel nucleus organism oxidized pharmacological pharmacological target plants receptor respiratory diseases SARS-CoV-2 sclareolide selective Structure-activity relationships synthesis terrestrial TRPV1 TRPV4 TRPV4 channel validation variety were assessed widespread [DOI] 10.3390/md18100519 PMC 바로가기 [Article Type] Article
No Time to Waste: Real-World Repurposing of Generic Drugs as a Multifaceted Strategy Against COVID-19Viewpoint Published on 2020-09-302022-10-29 Journal: Jmirx Med [Category] COVID-19, [키워드] absence Against antagonists Anti-inflammatory anticoagulation antiplatelet Antiviral bezafibrate Cimetidine COVID-19 COVID-19 crisis COVID-19 pandemic Dipyridamole drug drug candidate Drug repurposing drugs example expand Famotidine Fenofibrate Fibrates Generic histamine type-2 receptor antagonists inhibitor off-label pathophysiology patients patients with COVID-19 physician public health receptor Repository repurposing Safe Sildenafil Strategy Support supported time Treatment [DOI] 10.2196/19583 PMC 바로가기 [Article Type] Viewpoint
Cellular and Molecular Pathways of COVID-19 and Potential Points of Therapeutic InterventionPharmacology Published on 2020-07-292022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 Alpha alveolar cell antagonists Apoptosis AT1 biological marker blockade blockers capillary leakage CDK9 Cell cellular and molecular chemotactic clinical feature clinical marker contribute COVID-19 COVID-19 immune response CRP cytokine release Cytokine storm Cytokines cytoplasmic Defense Degradation Dexamethasone differentiation Diffuse alveolar damage downstream signaling pathway doxycycline element elevated elevated lactate dehydrogenase entry of SARS-CoV-2 epithelial estrogen receptor expression IL-17 IL-6 immune immune response Immunity include infiltration Inflammatory Inflammatory cytokine inflammatory cytokine production inflammatory signaling inhibitor initial Injury interferon response Intervention Ivermectin Jak kinase inhibitors LDH lung tissue MAPK mechanism melatonin membrane fusion membrane-bound molecular monocyte monocyte-derived macrophage NETosis NETs neutrophil Neutrophil extracellular trap Neutrophil-to-lymphocyte ratio NF-κB NLR p65 pathogenic pathophysiology pathway Platelet Pneumocytes Point Potential pro-inflammatory promote Prophylaxis provoke receptor reduce Remdesivir Research respiratory epithelia respiratory epithelial cells SARS-CoV-2 coronavirus selective Signal transduction skewed subtype T-cell therapeutic interventions therapeutic response Therapeutics thrombosis TNF-α type I interferons type III Vascular Viral load virus [DOI] 10.3389/fphar.2020.01169 PMC 바로가기 [Article Type] Pharmacology
Evidence supporting the use of peptides and peptidomimetics as potential SARS-CoV-2 (COVID-19) therapeuticsReview Published on 2020-07-162022-10-31 Journal: Future Medicinal Chemistry [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme-2 antagonists clinical setting coronavirus COVID-19 develop disease drugs entry pathway help Host identify Interaction overcome peptide peptide-based peptidomimetics Protein proteolytic receptor researcher SARS-CoV SARS-CoV-2 Spike protein target Therapies use of peptide viral entry [DOI] 10.4155/fmc-2020-0180 PMC 바로가기 [Article Type] Review
Immunopathology of SARS-CoV-2 Infection: Immune Cells and Mediators, Prognostic Factors, and Immune-Therapeutic ImplicationsReview Published on 2020-07-062022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] “cytokine storm” Activation alteration Analysis antagonists blockers Blood purification cellular characterized Chloroquine Critical Cytokine storm Cytokines drugs Evolution glucocorticoid humoral IFN lambda IL-1 IL-6 immune Immune cell immune change immune reaction immune response immunoglobulins immunopathology Infection inflammatory parameters inhibitor inhibitors leukocyte lymphocyte mononuclear macrophage pathogen Prognostic factor Prognostic marker proliferation recruitment resistance mechanisms SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patients stem cells subpopulations T lymphocyte the disease therapy TNF Tocilizumab variety virus [DOI] 10.3390/ijms21134782 PMC 바로가기 [Article Type] Review
SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonistsResearch Article Published on 2020-06-202022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] activities Amino acid antagonist antagonists caused Characteristics contribute Coronavirus disease 2019 COVID-19 deaths demonstrated deubiquitinase Health Immune suppression Infection interferon interferon antagonist intranasal novel SARS-CoV-2 virus nsp13 nsp14 Nsp15 ORF6 outbreak PLPro protease SARS-CoV SARS-CoV-2 SARS-COV-2 infection sequence similarity suppress the SARS-CoV-2 unique Vaccine viral pathogenesis Viral proteins [DOI] 10.1080/22221751.2020.1780953 PMC 바로가기 [Article Type] Research Article
A Review: Does Complement or the Contact System Have a Role in Protection or Pathogenesis of COVID-19?Review Published on 2020-05-132022-10-28 Journal: Pulmonary Therapy [Category] COVID-19, [키워드] ACE2 acute respiratory distress Angiotensin receptors antagonists anti-IL-6 antiviral therapy approval ARDS benefit bradykinin complement Contact contact system convalescent plasma coronavirus coronavirus pathogenesis Corticosteroids COVID-19 cytokine Cytokine storm death defined edema effective enzyme etiology Evidence Human Hydroxychloroquine include increase in Intervention investigated knockout mice less Lung disease manuscript mice mouse model office Pathogenesis Pneumonia Potential treatment protection Protective Pulmonary edema receptor Result risk role SARS-CoV SARS-CoV-2 searched syndrome System the disease therapeutic intervention Treatment viruses wild-type [DOI] 10.1007/s41030-020-00118-5 PMC 바로가기 [Article Type] Review
COVID-19, immune system response, hyperinflammation and repurposing antirheumatic drugsArticle Published on 2020-04-212022-10-29 Journal: Turkish Journal of Medical Sciences [Category] COVID-19, SARS, [키워드] “cytokine storm” acute respiratory distress acute respiratory syndrome adaptive antagonists anti-inflammatory treatments antiinflammatory association betacoronaviruses caused China coronavirus COVID-19 Cytokine storm disease drug feature Host immune response Hydroxychloroquine hyperinflammation IL-1 immune system Immunity Inflammation information life-threatening Lower respiratory tract membrane nonstructural proteins Novel coronavirus nucleocapsid outcome pandemic pathophysiology Proinflammatory cytokine responsible rheumatology RNA SARS-CoV-2 severe COVID-19 severe disease severity shown single-stranded positive-sense Spike protein structural proteins syndrome the cytokine storm Treatment viral infection viral infectivity Wuhan [DOI] 10.3906/sag-2004-168 PMC 바로가기 [Article Type] Article