antagonists
[용어속성] Enzyme
Reduced Serological Response to COVID-19 Vaccines in Patients with IBD is Further Diminished by TNF Inhibitor Therapy; Early Results of the VARIATION study [VAriability in Response in IBD Against SARS-COV-2 ImmunisatiON]
Article
[키워드] Affect
Against
antagonists
anti-SP IgG
Anti-spike
anti-TNF
anti-tumour necrosis factor antagonists.
Antibody Response
booster vaccination
bowel
Cohort
Complete
COVID-19
COVID-19 vaccination
determine
Diagnosis
diminished
healthy control
highlight
IBD
Immunoglobulin
Impaired
Inflammatory bowel disease
inhibitor
investigated
medication
mRNA vaccine
Necrosis
Patient
Protein
Quantitative
receiving
recruited
response
response to vaccination
Result
SARS-CoV-2 vaccination
seroconvert
seroconverted
serological response
significantly lower
therapy
TNF
TNF antagonist
Treatment
vaccination
vaccination against COVID-19
Vaccine
vaccine response
were assessed
[DOI] 10.1093/ecco-jcc/jjac029 PMC 바로가기
[DOI] 10.1093/ecco-jcc/jjac029 PMC 바로가기
Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport
Research
[키워드] accessory protein
Acidic
addition
antagonistic
antagonists
binding
blockade
C-terminal
cells
Community
complex
crystal structure
expression
hydrophobic
identify
immunosuppressive
in vitro
Interaction
interferon
interferon antagonism
International
methionine
molecular basis
mRNA
Mutagenesis
mutated
Mutation
ORF6
Orf9b
peptide
residue
reveal
salt-bridge
SARS-CoV
SARS-CoV-2
SARS-CoV-2 variant
Stat1
the binding affinity
the spike protein
Transport
VOCs
[DOI] 10.1038/s41467-022-32489-5 [Article Type] Research
[DOI] 10.1038/s41467-022-32489-5 [Article Type] Research
Neuropilin (NRPs) Related Pathological Conditions and Their Modulators
뉴로필린(NRP) 관련 병리학적 상태 및 조절인자
Review
Published on
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종,
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종,
[키워드] ACE2
addition
Analysis
antagonists
Cancer
clinical disease
Community
computer-aided drug design
condition
COVID-19
COVID-19 research
Diversity
foci
form
homologous
human body
in silico
in silico drug design
joint
Last
Ligand
ligands
modulator
neuropathic
neuropathic pain
neuropilin
neuropilins
NRP1
Pain
pathological
pathological conditions
pathological role
peptidomimetics
physiological
receptor
receptor modulator design
small molecule
small-molecule antagonists.
splice
the SARS-CoV-2
therapeutic
tissue
transmembrane glycoprotein
variant
variety
vertebrates
viral entry
[DOI] 10.3390/ijms23158402 PMC 바로가기 [Article Type] Review
[DOI] 10.3390/ijms23158402 PMC 바로가기 [Article Type] Review
Use of Tumor Necrosis Factor-α Antagonists Is Associated With Attenuated IgG Antibody Response Against SARS-CoV-2 in Vaccinated Patients With Inflammatory Bowel Disease
종양 괴사 인자-α 길항제의 사용은 염증성 장 질환이 있는 백신 접종 환자에서 SARS-CoV-2에 대한 약화된 IgG 항체 반응과 관련이 있습니다
Observational Study
[키워드] Against
age
antagonist
antagonists
anti-SARS-CoV-2 antibody
anti-SARS-CoV-2 vaccination
antibody
Antibody concentrations
Antibody titer
Antibody titers
Biologicals
Blood
blood sampling
bowel
Characteristics
clinical
Clinical characteristics
Combination
completion
Concentration
COVID-19
Crohn's disease
defined
demonstrated
detectable
disease
Effect
elapsed
geometric
geometric mean
IBD
IgG
IgG antibodies
IgG antibody
IgG antibody titer
IgG antibody titers
immune response
immunoassay
immunomodulating
Immunosuppressive medication
immunosuppressive medications
increased risk
independent
independent of
Inflammatory
Inflammatory bowel disease
medication
Microparticle
monotherapy
Most patients
mRNA
mRNA vaccines
mRNA-based vaccine
mRNA-based vaccines
Multivariable models
Patient
patient age
patients
patients treated
prospective observational cohort
quantitative determination
RBD
receive
receiving
Receptor-binding domain
regimen
response
S1 subunit
sampling
SARS-CoV-2
SARS-COV-2 infection
Seroconversion
serological response
significantly lower
Spike protein
the receptor-binding domain
the S1 subunit
the spike protein
titer
TNF-α-antagonists
treated
Treatment
Tumor
ulcerative colitis
vaccination
Vaccine
vector
was used
were measured
were recorded
[DOI] 10.3389/fimmu.2022.920333 PMC 바로가기 [Article Type] Observational Study
[DOI] 10.3389/fimmu.2022.920333 PMC 바로가기 [Article Type] Observational Study
High-throughput drug screening allowed identification of entry inhibitors specifically targeting different routes of SARS-CoV-2 Delta and Omicron/BA.1
고용량 약물 스크리닝을 통해 SARS-CoV-2 Delta 및 Omicron/BA.1의 다양한 경로를 구체적으로 표적으로 하는 진입 억제제 식별 가능
Article
Published on
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘,
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘,
[키워드] acute respiratory syndrome coronavirus
Alpha
antagonist
antagonists
applied
BA.1
Beta
Caco2 cells
Cathepsin-L
cell entry
cells
cellular entry
chlorpromazine
Combination
Compound
D614G
Delta
drug
Drug repurposing
Drug screening
Entry inhibitor
FDA-approved drugs
G protein
G protein coupled receptor antagonist
G-protein
help
highest
identify
Infection route
inhibit
inhibitors
lentiviral
Lentiviral vector
lentiviral vectors
mechanism
membrane fusion
omicron
pathway
phenothiazine
preference
pseudotyped
pseudovirus
pseudoviruses
receptor
receptor antagonist
Receptor binding
receptors
respiratory
responsible
resulting
SARS-CoV-2
several variant
several variants
Severe acute respiratory syndrome
specific inhibitors
spike variant
synergistic
targets
TMPRSS2
variant
variant of concern
viral entry
VoC
VOCs
[DOI] 10.1016/j.biopha.2022.113104 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.biopha.2022.113104 PMC 바로가기 [Article Type] Article
Angiotensin type-1 receptor and ACE2 autoantibodies in Parkinson´s disease
Research
[키워드] ACE2
administration
agonists
angiotensin
angiotensin-converting enzyme 2
antagonists
ARBs
AT1
autoantibodies
autoantibody
Autoimmunity
blocker
Brain
candesartan
cerebrospinal fluid
contribute
controls
correlated
CSF
cultures
Cytokines
disease
dysregulation
Effect
Factor
increasingly
Inflammatory
inhibited
involved
mechanism
member
neurodegeneration
Neuroinflammation
observation
Parkinson’s disease
Patient
patients
progression
RAS
receptor
renin-angiotensin system
serum
substantia
suggested
Support
TNFSF14
Treatment
Tumor
[DOI] 10.1038/s41531-022-00340-9 [Article Type] Research
[DOI] 10.1038/s41531-022-00340-9 [Article Type] Research
Clinical update on COVID-19 for the emergency and critical care clinician: Medical management
응급 및 중환자 진료의를 위한 COVID-19에 대한 임상 업데이트: 의료 관리
Review
Published on
Journal: The American journal of emergency medicine [Category] COVID19(2023년), SARS, 임상, 치료제,
Journal: The American journal of emergency medicine [Category] COVID19(2023년), SARS, 임상, 치료제,
[키워드] 2019
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
addition
Admitted Patient
antagonists
antivirals
Aspirin
Care
caused
Chloroquine
clinical
clinician
Clinicians
Colchicine
concerning
convalescent plasma
coronavirus
coronavirus disease
Coronavirus-2019
COVID-19
Critical care
demonstrated
disease
Emergency
Famotidine
help
Hydroxychloroquine
IMPROVE
interleukin
interleukin-6
introduced
Ivermectin
kinase inhibitors
management
mineral
Minerals
monoclonal antibodies
morbidity and mortality
outcomes
Outpatient
outpatients
pandemic
Patient
patients
progressed
prophylactic anticoagulation
provide
Randomized
respiratory
SARS-CoV-2
severe acute respiratory syndrome Coronavirus
severe acute respiratory syndrome coronavirus 2
Steroids
Therapies
therapy
utility
variety
Vitamin
vitamins
with COVID-19
[DOI] 10.1016/j.ajem.2022.03.036 PMC 바로가기 [Article Type] Review
[DOI] 10.1016/j.ajem.2022.03.036 PMC 바로가기 [Article Type] Review
Endogenous opiates and behavior: 2020
Review article
[키워드] Gly-ol(5)-enkephalin
Nme(4)
Acetylcholine
AChAcetylcholine
acid-sensing ion channel
ACLanterior cruciate ligament
ACTHadrenocorticotrophic hormone
adenosine monophosphate
adrenocorticotrophic hormone
agonist
alcohol
AMPadenosine monophosphate
antagonists
anterior cruciate ligament
ARCarcuate nucleus of hypothalamus
arcuate nucleus of hypothalamus
article
ASICacid-sensing ion channel
baso-lateral amygdala
BDNFbrain-derived neurotrophic factor
bed nucleus of the stria terminalis
BENDbeta-endorphin
beta-endorphin
beta-funaltrexamine
BFNAbeta-funaltrexamine
BLAbaso-lateral amygdala
BMIbody mass index
BNSTbed nucleus of the stria terminalis
body mass index
brain-derived neurotrophic factor
Ca(2+)/cAMP responsive element binding protein
cannabinoid
CBcannabinoid
CCIchronic constriction injury
CCKcholecystokinin
CCRchemokine receptor
CFAcomplete Freund’s adjuvant
ChATcholine acetyltransferase
Chemokine receptor
cholecystokinin
choline acetyltransferase
chronic constriction injury
complete Freund’s adjuvant
concerning
conditioned place preference
CPPconditioned place preference
CREBCa(2+)/cAMP responsive element binding protein
CTAPD-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2
D-Ala(2)
D-Arg-Phe-Lys-NH2
D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2
DAdopamine
DALDAD-Arg-Phe-Lys-NH2
DAMGOD-Ala(2)
delta opioid receptor
Deltdeltorphin
deltorphin
Dopamine
DORdelta opioid receptor
dorsal root ganglion
DRGdorsal root ganglion
DYNDynorphin
Dynorphin
Effect
EGFRepidermal growth factor receptor
encephalin
endogenous
Endoplasmic reticulum
Enkencephalin
epidermal growth factor receptor
ERendoplasmic reticulum
ERKextracellular regulated signal kinases
extracellular regulated signal kinases
G protein-coupled receptor kinase
G-protein-coupled receptor
GABAgamma-amino butyric acid
gamma-amino butyric acid
Gastrointestinal
genetic manipulation
GIGastrointestinal
GLPglucagon-like peptide
glucagon-like peptide
GPCRG-protein-coupled receptor
GRKG protein-coupled receptor kinase
heat shock proteifn
hepatic function
HIVhuman immunodeficiency virus
Hormones
HSPheat shock proteifn
Human
Human immunodeficiency virus
ICUIntensive Care Unit
ILInterleukin
Immunological response
inhibitory postsynaptic current
intensive care unit
interleukin
IPSCinhibitory postsynaptic current
JNKJun-N-terminal kinase
Jun-N-terminal kinase
K(+)potassium
kappa opioid receptor
kappa opioid receptor gene
kisspeptin
KNDykisspeptin
knockout
KOknockout
KORkappa opioid receptor
lateral magnocellular nucleus of the anterior nidopallium
LClocus coeruleus
leutinizing hormone
LHleutinizing hormone
lipopolysaccharide
LMANlateral magnocellular nucleus of the anterior nidopallium
locus coeruleus
long-term depression
LPSlipopolysaccharide
LTDlong-term depression
MAPKmitogen-activated protein kinase
MeAmedial nucleus of amygdala
medial nucleus of amygdala
medial prefrontal cortex
memory
Menkmet-enkephalin
mental illness
met-enkephalin
mitogen-activated protein kinase
molecular
MORmu opioid receptor
mPFCmedial prefrontal cortex
mu opioid receptor
mu opioid receptor gene
naltrindole
NBNInor-binaltorphamine
neurologic disorder
nitric oxide
nitric oxide synthase
non-steroidal anti-inflammatory drug
NONitric Oxide
nor-binaltorphamine
NOSnitric oxide synthase
NSAIDnon-steroidal anti-inflammatory drug
NTInaltrindole
OFCorbito-frontal cortex
OPRK1kappa opioid receptor gene
OPRM1mu opioid receptor gene
orbito-frontal cortex
ORL-1orphan receptor like receptor
orphan receptor like receptor
Pain
patient controlled analgesia
PCApatient controlled analgesia
PD-1programmed cell death protein-1
PDYNprodynorphin
PENKpre-proenkephalin
peptide
PFCpre-frontal cortex
pharmacological
PKCprotein kinase C
POFQ/Npro-nociceptin
POMCpro-opiomelanocortin
Post-traumatic stress disorder
Potassium
pre-frontal cortex
pre-proenkephalin
Pregnancy
pro-nociceptin
pro-opiomelanocortin
prodynorphin
programmed cell death protein-1
prolonged release
protein kinase C
PRprolonged release
PTSDpost-traumatic stress disorder
receptor
regulators of G-protein signaling
renal
Research
response
RGSregulators of G-protein signaling
rostral ventromedial medulla
RVMrostral ventromedial medulla
Seizure
Single nucleotide polymorphism
SNLspinal nerve ligation
SNPSingle nucleotide polymorphism
SNSubstantia nigra
spinal nerve ligation
Stress
substantia nigra
TDCStranscranial direct current stimulation
Testosterone
THtyrosine hydroxylase
Tolerance
TPtestosterone
Transcranial direct current stimulation
tyrosine hydroxylase
ventral tegmental area
VTAventral tegmental area
[DOI] 10.1016/j.peptides.2022.170752 [Article Type] Review article
[DOI] 10.1016/j.peptides.2022.170752 [Article Type] Review article
Plant-Derived Antiviral Compounds as Potential Entry Inhibitors against Spike Protein of SARS-CoV-2 Wild-Type and Delta Variant: An Integrative in SilicoApproach
SARS-CoV-2 야생형 및 델타 변이체의 스파이크 단백질에 대한 잠재적 진입 억제제로서의 식물 유래 항바이러스 화합물: SilicoApproach의 통합
Article
[키워드] antagonists
Antiviral
Antiviral agents
antiviral drug
antiviral drugs
approach
approaches
binding affinities
binding affinity
binding energy
binding free energies
binding free energy
binding interaction
carried
complexes
Compound
compounds
controls
Corilagin
country
COVID-19
COVID-19 infection
Delta
delta variant
develop
docking
Efficacy
exhibited
experimental validation
explained
FIVE
free energies
glycoprotein
greater
H-bonds
hydrogen
hydrophobic interaction
hydrophobic interactions
Hypericin
in silico
India
lead
Ligand
ligands
Lupeol
molecular
molecular docking
molecular dynamics
molecular dynamics and simulations
Molecular modeling
mutated
phytochemical compounds
plant compound
Potential
Protein
Research
resulting
RMSD
RMSF
S protein
SARS-CoV-2
SARS-CoV-2 spike
SARS-CoV-2 variant
second wave
selected
several variant
several variants
spike
spike glycoprotein
Spike protein
stability
target proteins
therapeutic intervention
Transmissibility
Vaccine
Virtual screening
virulence
was performed
while
wild-type
wild-type SARS-CoV-2
[DOI] 10.3390/molecules27061773 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/molecules27061773 PMC 바로가기 [Article Type] Article