antibody cocktail – Page 5 – Communicable Diseases Research

Development and application of therapeutic antibodies against COVID-19

COVID-19에 대한 치료 항체의 개발 및 적용

Review

Published on 2021-04-102022-09-12
Journal: International Journal of Biological Sciences [Category] MERS, SARS, 진단,

Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016

Report

Published on 2021-04-052022-10-31
Journal: Cell Reports Medicine [Category] COVID-19,

Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice

Research

Published on 2021-03-252022-10-05
Journal: Nature [Category] SARS, 변종, 유전자 메커니즘,

Prospective mapping of viral mutations that escape antibodies used to treat COVID-19

COVID-19를 치료하는 데 사용되는 항체를 벗어나는 바이러스 돌연변이의 전향적 매핑

Report

Published on 2021-02-192022-09-10
Journal: Science (New York, N.y.) [Category] Fulltext, MERS, 변종, 진단,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Amino acid antibodies antibody Antibody binding antibody cocktail antibody treatment binding circulating Complete consequence coronavirus COVID-19 disrupt domain Epitopes explain help host receptor human population identify in vitro Interpretation mapped mapping maps monoclonal antibody Mutation Patient potential therapy predict Prospective RBD Receptor binding domain Regeneron REGN-CoV2 REGN-COV2 cocktail REGN10933 REGN10987 respiratory risk SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 strains Science selected severe acute respiratory syndrome Coronavirus single antibody single mutation Surveillance susceptible the antibody the SARS-CoV-2 therapy treat treated variant Viral viral escape viral evolution viral mutation Viral mutations virus yeast
[DOI] 10.1126/science.abf9302 PMC 바로가기 [Article Type] Report

REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

Clinical Trial

Published on 2021-01-212022-10-04
Journal: The New England Journal of Medicine [Category] MERS, SARS, 변종, 임상, 진단,

[키워드] 95% CI 95% confidence interval acute respiratory syndrome adverse event antibody cocktail assigned authority average baseline characterized cocktail Complication coronavirus coronavirus disease death Department development dose double-blind end point greater group Human hypersensitivity reactions immune response in viral initiated interim analysis investigated log mean difference mutant virus neutralizing monoclonal antibody outcome Outpatient Patient patients percentage Placebo placebo group Randomly Reactions receive recent reduce reduced Regeneron Pharmaceutical REGN-CoV2 reported risk Safety SARS-CoV-2 serum Spike protein the patient the placebo group Trial Viral load viral loads
[DOI] 10.1056/NEJMoa2035002 PMC 바로가기 [Article Type] Clinical Trial

Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape

SARS-CoV-2 탈출을 방지하는 항체 칵테일을 위한 분자 결정인자 및 메커니즘

Article

Published on 2021-01-202022-09-10
Journal: Nature Communications [Category] 변종, 유전자 메커니즘, 진단,

[키워드] antibodies antibody antibody cocktail antibody combination approach candidate Candidates cocktail cocktails Combination conserved Critical determinant determinants epitope Epitopes identify in vitro Interaction mechanism mice multiple neutralizing antibodies Mutation Neutralizing neutralizing antibody non-overlapping epitope non-overlapping epitopes Prevent PROTECT protein folding RBD RBD protein RBD-ACE2 Receptor binding Receptor-binding domain residue SARS-CoV SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody the receptor-binding domain treating COVID-19 Viral viral challenge viral escape
[DOI] 10.1038/s41467-020-20789-7 PMC 바로가기 [Article Type] Article

Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections

SARS-CoV-2 감염 치료를 위한 2-MAb 칵테일의 개발 및 구조적 기초

Article

Published on 2021-01-112022-09-12
Journal: Nature Communications [Category] 변종, 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered antibody antibody cocktail Antiviral effect binding caused characterization complex complexes conformational coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cryo-EM structure cryo-EM structures determine development drug Drug development epitope Epitopes exhibit expressed Fab groups humanized IC50 identify in vitro information inhibitory concentration Interaction mAbs mice Microbiology monoclonal antibodies monoclonal antibody mouse model neutralize Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibody option pandemic Post-infection Prophylaxis Protein RBD Receptor-binding domain representing respiratory S trimer SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus Spike protein structural biology the receptor-binding domain the SARS-CoV-2 therapeutic treat treating COVID-19 treating SARS-CoV-2 infection trimeric S protein two group two groups
[DOI] 10.1038/s41467-020-20465-w PMC 바로가기 [Article Type] Article

Structure-based development of human antibody cocktails against SARS-CoV-2

SARS-CoV-2에 대한 인간 항체 칵테일의 구조 기반 개발

Letter to the Editor

Published on 2020-12-012022-09-12
Journal: Cell Research [Category] MERS, SARS, 진단,

[키워드] antibody cocktail Cryoelectron microscopy Molecular biology SARS-CoV-2
[DOI] 10.1038/s41422-020-00446-w PMC 바로가기 [Article Type] Letter to the Editor

Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection

Pan-SARS-CoVs 보호를 제공하기 위해 여러 기능을 배치하는 인간 항체 칵테일의 합리적인 개발

Article

Published on 2020-12-012022-09-12
Journal: Cell Research [Category] MERS, SARS, 진단,

REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters

REGN-COV2 항체는 붉은털 원숭이와 햄스터의 SARS-CoV-2 감염을 예방하고 치료합니다.

Report

Published on 2020-11-272022-09-12
Journal: Science (New York, N.y.) [Category] Fulltext, MERS, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered administration antibody antibody cocktail benefit clinical trials cocktail convalescent coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 decrease described disease effective therapy Efficacy effort Epitopes evaluate evaluated Evidence evidence of golden hamster golden hamsters greatly reduce hamster hamsters host cells Human humanized in vivo limit lung titer lung titers Lungs mice Mild Mild disease Neutralizing antibodies neutralizing antibody nonoverlapping epitope nonoverlapping epitopes pandemic Pneumonia Prevent prophylactically provided REGN-CoV2 REGN10933 REGN10987 respiratory rhesus rhesus macaque rhesus macaques SARS-CoV-2 SARS-COV-2 infection Science severe acute respiratory syndrome Coronavirus severe disease severe symptoms Spike protein target therapeutic potential Therapeutics treat upper airway upper airways virus virus load weight loss
[DOI] 10.1126/science.abe2402 PMC 바로가기 [Article Type] Report