Antibody Responses to BNT162b2 Vaccination in Japan: Monitoring Vaccine Efficacy by Measuring IgG Antibodies against the Receptor-Binding Domain of SARS-CoV-2Research Article Published on 2022-01-192022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, COVID19(2023년), SARS, [키워드] acute respiratory syndrome age analyzed antibody antibody isotype antibody production Antibody Response BNT162b2 BNT162b2 vaccine cause clinical setting Cohort coronavirus coronavirus disease correlated correlation COVID-19 detect determine dose Efficacy enzyme enzyme-linked immunosorbent Factors female Gender high correlation hypertension IgA IgG IgG level IgM immunoassay individual individuals information Japan Japanese Laboratory levels of antibodies males mass vaccination MONITOR monitoring mRNA vaccine negative correlation Neutralizing activity of BNT162b2 powerful tool predict provide RBD reported response SARS-CoV-2 SARS-CoV-2 vaccination second dose second vaccination sera Serological assay significantly significantly higher the receptor-binding domain vaccinated individual vaccination Vaccination strategy Vaccine was measured were measured [DOI] 10.1128/spectrum.01181-21 PMC 바로가기 [Article Type] Research Article
The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19β-NGF/TrkA 신호 전달 경로는 회복기 COVID-19에서 항핵단백질 IgG의 생산과 관련이 있습니다Immunology Published on 2022-01-142022-09-12 Journal: Frontiers in Immunology [Category] 진단, [키워드] β-NGF age analysed antibody antibody production Asymptomatic CD4 convalescent correlated COVID-19 Cytokines defined discrepancy ELISPOT expressed Factor First wave flow cytometry high variability Host IC50 IFN-γ IgG IgG level IL-1α Infection Inflammation mild SARS-CoV-2 infection molecular mechanism neutralising antibody pandemic pathway PBMC PCR-confirmed peptides positive positive correlation Production receptor Regulation reported Result SARS-CoV-2 SARS-COV-2 infection selected serum severe COVID-19 shown significantly specific antibody subject subjects T cell T cells titre undetectable virus-specific T cell Volunteer was determined were measured while [DOI] 10.3389/fimmu.2021.813300 PMC 바로가기 [Article Type] Immunology
Prolonged viral shedding of SARS-CoV-2 and related factors in symptomatic COVID-19 patients: a prospective studyResearch Published on 2021-12-272022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] 95% CI Admission antibody antibody production average clinical information collected contribute COVID-19 COVID-19 patient COVID-19 patients declined enrolled Factor female female gender highest hospital Hospital admission identify IgM antibody initial median time multivariate Cox regression nasopharyngeal negativity Older Older age outbreak Patient population level progression Prolonged prolonged viral shedding Prospective Study quantified quantitative PCR remained respiratory sample Result risk factor RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral load significant effect significantly significantly higher supplementary material symptom onset symptomatic symptomatic patient transcriptase viral kinetics Viral load viral shedding Wuhan, China [DOI] 10.1186/s12879-021-07002-w PMC 바로가기 [Article Type] Research
Absent antibody production following COVID19 vaccination with mRNA in patients under immunosuppressive treatments면역억제 치료를 받는 환자에서 mRNA로 COVID19 백신 접종 후 항체 생성 없음Article Published on 2021-12-172022-09-11 Journal: Vaccine [Category] MERS, SARS, 진단, 치료기술, [키워드] administration Analysis antibody antibody production Antibody testing B-cell booster vaccinations cellular coronavirus coronavirus disease COVID COVID19 depleting detectable dose evaluated fingolimod Immunosuppressed immunosuppressed patient immunosuppressed patients Immunosuppressive treatment Infection Inflammatory inhibit lymphocyte maintain Measures metabolic disease Metabolic diseases mRNA ongoing therapies ongoing therapy Patient patients recipients respond responsiveness risk SARS-CoV-2 spike SARS-CoV-2 virus second dose solid organ solid organ transplant specific antibodies subunit T cell T cell proliferation tacrolimus the SARS-CoV-2 virus therapy vaccination Vaccine were measured [DOI] 10.1016/j.vaccine.2021.10.068 PMC 바로가기 [Article Type] Article
Perspective of HLA-G Induced Immunosuppression in SARS-CoV-2 InfectionImmunology Published on 2021-12-062022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome antibody production antiviral immune response Apoptosis B cell caused CD8 Cell Cellular immune response coronavirus COVID-19 COVID-19 disease dendritic cell disease disease severity expression HLA-G Host Human identify immune attack Immune cell immune inhibitory Immune receptor immune responses Immune suppression immunopathological induce induced inhibit inhibitory receptor Interaction KIR knowledge leukocyte Ligand macrophages maturation natural killer NK cell outcomes patients with COVID-19 progression provoke public health receptors regulatory cell SARS-CoV-2 SARS-COV-2 infection T cell the disease transcript upregulated viral clearance viral infections [DOI] 10.3389/fimmu.2021.788769 PMC 바로가기 [Article Type] Immunology
Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization불 활성화 된 SARS-COV-2 바이러스 면역 후 감마 및 제타 변이체에 대한 보호 면역Article Published on 2021-12-042022-09-01 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] addition anti-S antibody antibody production cellular response circulation conducted COVID-19 cross-protection cross-reactive demonstrated evade evaluated follow-up study Gamma Gamma variant histopathological IgG IL-6 IL-6 expression immune response immune system Immunity immunization immunized immunized mice inactivated Inactivated vaccine increase individual induce Infection levels of antibody Lungs mice mice immunization Neutralizing activity outcome pathological outcome pathological outcomes performed produced Production reduced reduced viral loads reducing robust SARS-CoV-2 SARS-CoV-2 vaccine Serum Neutralization significantly TNF vaccinated individuals vaccination variant variants Viral viral infection viral loads viral variant WT SARS-CoV-2 Zeta variant [DOI] 10.3390/v13122440 PMC 바로가기 [Article Type] Article
The Humoral Immune Response to BNT162b2 Vaccine Is Associated With Circulating CD19+ B Lymphocytes and the Naïve CD45RA to Memory CD45RO CD4+ T Helper Cells Ratio in Hemodialysis Patients and Kidney Transplant RecipientsImmunology Published on 2021-12-032022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] alteration analyzed anti-SARS-CoV2 antibodies antibody production Antibody Response Antibody titer association B cell B cells B lymphocyte baseline BNT162b2 CD19+ CD19+ B lymphocytes CD4+ CD45RA CD45RO Cellular immune response circulating correlation dose first dose flow cytometry fraction helper Hemodialysis humoral Immunosuppressed in both group in both groups kidney transplant recipient kidney transplant recipients lymphocyte material memory memory CD4+CD45RO+ T helper cells naïve CD4+CD45RA+ T helper cells naïve Patient positive correlation provide Ratio recipient response Result SARS-CoV-2 vaccination SARS-CoV2 second dose seronegative seropositive subpopulation T cell T helper cell Transplant vaccination vaccination efficacy vaccine dose vaccine-induced antibody response [DOI] 10.3389/fimmu.2021.760249 PMC 바로가기 [Article Type] Immunology
Secretory IgA and T cells targeting SARS-CoV-2 spike protein are transferred to the breastmilk upon mRNA vaccinationReport Published on 2021-12-022022-10-31 Journal: Cell Reports Medicine [Category] COVID-19, SARS, [키워드] Abstract Affect anti-RBD Anti-spike antibody antibody production Antibody titer BNT162b2 breastmilk breastmilk T cells circulating Combination Concentration controls COVID-19 cumulative determine effective evaluated Frequency functional IgA IgG immune protection immune response immune transfer induce lactating women mammary maternal vaccination memory B cell memory B cells milk-transferred SARS-CoV-2 protection milk-transferred spike-reactive T cells Moderna mRNA vaccination mRNA vaccine mRNA-1273 vaccine mucosa neutralization capacity neutralize Neutralizing neutralizing capacity occur Pfizer plasmablasts Protective RBD SARS-CoV-2 SARS-CoV-2 spike protein secretory secretory IgA SIgA spike SIgA transfer transferred vaccination [DOI] 10.1016/j.xcrm.2021.100468 PMC 바로가기 [Article Type] Report
The Immunomodulatory Function of Vitamin D, with Particular Reference to SARS-CoV-2Review Published on 2021-12-022022-10-30 Journal: Medicina [Category] COVID-19, SARS, [키워드] antibody production attenuate circulating common cold complementary COVID-19 Effectiveness Efficacy function immunomodulation immunomodulatory activity increase Influenza morbidity Mutation Particular Patient pro-inflammatory cytokine recent reduce reference SARS-CoV-2 SARS-COV-2 infection vaccination Vaccine virus infection Vitamin D [DOI] 10.3390/medicina57121321 PMC 바로가기 [Article Type] Review
Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopeniaChAdOx1 nCoV-19 백신 유도 면역 혈전성 혈소판 감소증에 대한 통찰력Article Published on 2021-12-022022-09-11 Journal: Blood [Category] SARS, 유전자 메커니즘, 진단, [키워드] abundance activated addition Adverse reaction aggregate Analysis antibody antibody production antigenic AstraZeneca Autoimmune B-cell response Biomarkers cause ChAdOx1 ChAdOx1 nCoV-19 complex complexes component determinant determinants dissemination DNA EDTA elevated ethylenediaminetetraacetic acid HEK293 heparin heparin-induced thrombocytopenia immune immune responses immunohistochemistry insight mechanism mice Microscopy Mouse models NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils Pathogenesis pathologic Patient patients PF4 Platelet platelet factor 4 platelet surface Platelets polyphosphate procoagulant proinflammatory Protein proteomics reaction resulting SARS-CoV-2 serum stimulate stimulated Support thrombocytopenia thromboembolic thrombosis thrombotic Thrombotic thrombocytopenia Trigger Vaccine vascular leakage virus [DOI] 10.1182/blood.2021013231 PMC 바로가기 [Article Type] Article