SARS-CoV-2 Spike- and Nucleoprotein-Specific Antibodies Induced After Vaccination or Infection Promote Classical Complement Activation예방 접종 또는 감염 후 유도된 SARS-CoV-2 스파이크 및 핵단백질 특이적 항체는 고전적 보체 활성화를 촉진합니다Article Published on 2022-07-042022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] activated Activation antibodies antibody Antibody responses Antigen binding C1q C1q binding C3b cascade classical classical pathway complement Complement activation Complement cascade complement components Complement pathway component components convalescent COVID-19 COVID-19 patient COVID-19 patients deposition disease status downstream Effect ELISA assay groups hospitalised IgG1 induced median N antigen NHC non-hospitalised non-infected not differ nucleocapsid presence of antibody protective role Protein Protein binding response responses SARS-CoV-2 SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins sera severe COVID-19 specific antigen spike spike glycoprotein subject the disease vaccination Vaccine vaccinees Variability Viral Viral antigen viral antigens [DOI] 10.3389/fimmu.2022.838780 PMC 바로가기 [Article Type] Article
Virology and immune dynamics reveal high household transmission of ancestral SARS-CoV-2 strain바이러스 및 면역 역학은 조상 SARS-CoV-2 균주의 높은 가정 전염을 나타냅니다Article Published on 2022-07-012022-09-11 Journal: Pediatric allergy and immunology : official public [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] acute phase Adults age antibodies Antibody Response Antibody responses attack rate Blood characterized children coronavirus COVID-19 Ct values determine family members feature generate highlight household household transmission Households immune immunological immunology index case Infection IQR Isolation key factor Local measure Melbourne Melbourne, Australia mucosal nasopharyngeal Nasopharyngeal swab Neutralizing antibodies Novel coronavirus NPs nucleocapsid protein participant PCR PCR positivity PCR testing plasma antibody positive provide respiratory respiratory sample Respiratory samples response Saliva SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 variants SARS-CoV-2 viral load SARS-CoV-2-specific antibodies SARS-CoV-2, household transmission secondary attack rate secondary transmission specific antibodies spike Stool tested Transmission transmission of SARS-CoV-2 Viral Virology [DOI] 10.1111/pai.13824 PMC 바로가기 [Article Type] Article
Do the Kinetics of Antibody Responses Predict Clinical Outcome in Hospitalized Patients With Moderate-to-Severe COVID-19?항체 반응의 역학은 중등도에서 중증의 COVID-19로 입원한 환자의 임상 결과를 예측합니까?Observational Study Published on 2022-07-012022-09-11 Journal: In vivo (Athens, Greece) [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody antibody kinetics Antibody Response Antibody responses association Chain Reaction clinical Clinical deterioration Clinical outcome clinical outcomes clinical risk factor Complication consecutive patient coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 infection COVID-19-related complication COVID-19-related complications diabetes diagnosed discharged dyslipidemia follow-up period Hospitalization Hospitalized hospitalized patient hospitalized patients hospitals IgG IgG positivity IgM Immunoglobulin Immunoglobulin G immunoglobulin M Infection intensive care unit Intubated Kinetics Logistic regression analysis males median median age median time moderate-to-severe COVID-19 observational study onset of symptoms Patient patients died polymerase chain polymerase chain reaction predict Predictive prospective observational study qualitative detection Rapid Rapid test respiratory response SARS-CoV-2 SARS-CoV-2 antibody Seroconversion serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity symptomatic time interval time intervals Univariate logistic regression analysis was performed with COVID-19 [DOI] 10.21873/invivo.12916 PMC 바로가기 [Article Type] Observational Study
Features of antibody responses after SARS-COV-2 infection in healthcare workers in the first wave of COVID-19 pandemic in Mexico City멕시코시티 COVID-19 전염병의 첫 번째 물결에서 의료 종사자의 SARS-COV-2 감염 후 항체 반응의 특징Article Published on 2022-07-012022-09-11 Journal: The Journal of international medical research [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] age Analysis Antibody Response Antibody responses Antibody titre COVID COVID-19 COVID-19 pandemic cross-sectional cross-sectional study elicited Factor First wave HCW HCWs healthcare healthcare worker Healthcare workers hospital identify IgG IgG antibodies IgG antibody IgM Immunoglobulin inch Infection intensity involved Isolation lateral flow mandatory measure men men and women Mexico City no differences old age Participants produced recovering from COVID-19 risk of infection SARS-CoV-2 SARS-COV-2 infection semiquantitatively Seroprevalence severe cases significantly higher spread of COVID-19 Symptom the antibody response virus women [DOI] 10.1177/03000605221099458 PMC 바로가기 [Article Type] Article
Longitudinal variation in SARS-CoV-2 antibody levels and emergence of viral variants: a serological analysisSARS-CoV-2 항체 수준의 종단적 변이와 바이러스 변이체의 출현: 혈청학적 분석Article Published on 2022-07-012022-09-11 Journal: The Lancet. Microbe [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, [키워드] absence Analysis antibody antibody levels Antibody Response Antibody responses Antibody titre assays baseline Clinical practice Cohort correlation correlation analyses COVID-19 vaccine declined detectable Deterioration determine determined by Effect facilitate functional Immunity individual Infection longitudinal MONITOR National Health Service neutralisation activity neutralisation assays neutralising Neutralising activity neutralising antibody titre neutralising antibody titres nucleocapsid participants with SARS-CoV-2 Post-infection predict Predictive Predictive value presence or absence SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection sensitivities sensitivity serological analysis Serological assay serological assays serological measurement serological measurements serological test Serological tests serum sample serum samples Spearman Spike protein Spike protein sequence subsequent Surrogates the spike protein These data threshold timepoint timepoints titres two-tailed variants variants of concern Variation Viral viral variant Viral variants [DOI] 10.1016/S2666-5247(22)00090-8 PMC 바로가기 [Article Type] Article
Antibody response after a booster dose of SARS-CoV-2 vaccine in liver transplant recipients and those with chronic liver diseasesArticle Published on 2022-07-012023-07-08 Journal: Annals of hepatology [Category] COVID19(2023년), [키워드] Antibody responses Chronic Liver Diseases liver transplant recipients. SARS-CoV-2 booster vaccination [DOI] 10.1016/j.aohep.2022.100702 PMC 바로가기
The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopesSARS-CoV-2 Delta 변이체는 주로 클래스 1 및 2 항체 에피토프에 초점을 맞춘 항체 반응을 유도합니다Article Published on 2022-06-292022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] addition antibodies antibody Antibody binding antibody epitope antibody immunity Antibody Response Antibody responses antigenic Beta Beta variant binding class D614G Delta delta variant Effect elicit elicited epitope Epitopes exposure help Impact induce Infection infections K417N mRNA mRNA vaccine Mutation neutralization Neutralizing antibody response polyclonal polyclonal antibody RBD Receptor-binding domain reduce responses SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 variant SARS-CoV-2 variants specificity the RBD the receptor-binding domain vaccination Vaccinations Vaccine variant virus viruses [DOI] 10.1371/journal.ppat.1010592 PMC 바로가기 [Article Type] Article
Development and Implementation of Dried Blood Spot-Based COVID-19 Serological Assays for Epidemiologic Studies역학 연구를 위한 건조혈점 기반 COVID-19 혈청학적 분석의 개발 및 구현Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] addition alternative ambient ambient temperatures antibodies antibody antibody kinetics antibody levels Antibody Response Antibody responses Bay Blood changes in Cohort Community comparable COVID-19 COVID-19 pandemic Critical DBS sample DBS samples detect development dried blood spot Dried blood spots East Effectiveness enzyme enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays estimate estimation Immunity implementation inaccessible Infection Infectious disease Infectious diseases invasive Measures pandemic participant pathogen pathogen-specific phlebotomy Postinfection Prevalence Prevent public health measures Public health responses refrigeration risk factor Risk factors San Francisco SARS-CoV-2 SARS-COV-2 infection serological serological assays serological data serological studies serological surveillance serological survey serology Seroprevalence specific antibodies Spread stability storage study participant Study participants study population Surveillance Traditional vaccination venipuncture venous venous blood [DOI] 10.1128/spectrum.02471-21 PMC 바로가기 [Article Type] Article
ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike ProteinORFeome 파지 디스플레이, SARS-CoV-2 스파이크 단백질의 S2 하위 도메인에 대한 주요 면역원성 에피토프 공개Article Published on 2022-06-172022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Amino acid amino acid sequence anti-SARS-CoV-2 antibodies antibodies antibody Antibody Response Antibody responses applied approved binding binding site blocking cell entry cleave COVID-19 COVID-19 pandemic COVID-19 patients Diseases display Efficacy epitope epitope mapping Epitopes fusion peptide genomic genomic library Host host cell identify immunogenic library Major mechanism monoclonal antibody mutate Mutation neutralization neutralize NGS Open reading frame open reading frames ORFeome ORFs Particle peptide phage phage display RBD RBD region Receptor binding domain representing SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant SARS-CoV-2 variants sequence Serine serine protease serine protease TMPRSS2 spike the cell the RBD the SARS-CoV-2 genome therapeutic therapy TMPRSS2 Vaccine virus variants [DOI] 10.3390/v14061326 PMC 바로가기 [Article Type] Article
Virus-Like Particles Are Efficient Tools for Boosting mRNA-Induced Antibodies바이러스 유사 입자는 mRNA 유도 항체를 강화하기 위한 효율적인 도구입니다Article Published on 2022-06-162022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibodies Antibody Response Antibody responses approved boost COVID-19 economics Efficacy efficient Heterologous heterologous prime-boost heterologous prime-boost vaccination strategies homologous investigated maintain mRNA mRNA-1273 mRNA-1273 vaccine overcome Particle priming reduced regimen SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 variant the antibody response Vaccination strategy Vaccine vaccine candidate Virus-like particle virus-like particles VLP VLPs VOCs were used [DOI] 10.3389/fimmu.2022.864718 PMC 바로가기 [Article Type] Article