Discovery and Use of Long dsRNA Mediated RNA Interference to Stimulate Antiviral Protection in Interferon Competent Mammalian Cells인터페론 유능한 포유동물 세포에서 항바이러스 보호를 자극하기 위한 긴 dsRNA 매개 RNA 간섭의 발견 및 사용Article Published on 2022-05-062022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] Antiviral Antiviral effect antiviral response antiviral responses cell line cells cellular cleaved comparable competent complementary Concentration cornerstone CoV dependent on Dicer dsRNA Evidence explanation expressing fluorescent functional gene targeting generate green fluorescent protein HCoV HCoV-229E human coronavirus human coronaviruses IFN immune defense induce inducer inhibit Interference interferons knockdown Lineage Long long dsRNA mammalian mammalian cell mammalian cells Mediated mRNA pathway platform preventing infection produced protection Protein provide required responsible retained RISC RNA RNA interference RNA-induced silencing complex RNAi RNAi pathway SARS-CoV-2 replication sequence shown significantly siRNA siRNAs stimulate stomatitis suppress therapeutic These cells threshold type I interferon vesicular stomatitis vesicular stomatitis virus viral inhibition virus VSV-GFP [DOI] 10.3389/fimmu.2022.859749 PMC 바로가기 [Article Type] Article
Evaluation of Antiviral Effect against SARS-CoV-2 Propagation by Crude Polysaccharides from Seaweed and Abalone Viscera In Vitro해조류 및 전복 내장의 조다당류에 의한 SARS-CoV-2 증식에 대한 시험관내 항바이러스 효과 평가Article Published on 2022-04-272022-09-11 Journal: Marine Drugs [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] Abalone abalone viscera addition Antiviral antiviral activity Antiviral effect COVID-19 discus Effect evaluated expression level followed by Haliotis immunofluorescence assay inhibit SARS-CoV-2 inhibited inhibitory effect Interference nucleocapsid Nucleocapsid proteins plaque Plaque titration polysaccharide polysaccharides Propagation Quantitative Replication RNA copies RNA copy RT-PCR analysis Sargassum SARS-CoV-2 SARS-CoV-2 propagation SARS-CoV-2 replication SARS-CoV-2 spikes seaweed seaweed. Treatment Vero E6 VERO E6 cells viral entry viral infection viscera western blot [DOI] 10.3390/md20050296 PMC 바로가기 [Article Type] Article
Clofazimine derivatives as potent broad-spectrum antiviral agents with dual-target mechanism이중 표적 기전을 가진 강력한 광범위 항바이러스제로서의 클로파지민 유도체Article Published on 2022-04-152022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral antiviral activity antiviral agent Antiviral effect binding broad-spectrum Candidates Clofazimine Clofazimine analogues comparable Compound derivative derivatives evaluated inhibit inhibited lead mechanism membrane fusion nsp13 Protein provided rabies Rabies virus Raby S protein SARS-CoV-2 Structure–activity relationship. [DOI] 10.1016/j.ejmech.2022.114209 PMC 바로가기 [Article Type] Article
Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor인터페론 자극 유전자에 대한 유도성 CRISPR 활성화 스크린은 OAS1을 SARS-CoV-2 제한 인자로 식별합니다Article Published on 2022-04-142022-09-11 Journal: PLoS Pathogens [Category] Coronavirus, COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] Activation activities Antiviral Antiviral effect approach catalytic activity cDNA cell line complementary confounding effect CRISPR described exhibited experiments expression Factors function Genetic identify interferon interferon-stimulated gene interferon-stimulated genes interferons ISG ISGs mechanism OAS1 platform required respond restrict restriction factor Result SARS-CoV-2 specificity subset [DOI] 10.1371/journal.ppat.1010464 PMC 바로가기 [Article Type] Article
Anurans against SARS-CoV-2: A review of the potential antiviral action of anurans cutaneous peptidesArticle Published on 2022-04-142022-10-04 Journal: Virus research [Category] COVID19(2023년), SARS, 치료제, [키워드] Abstract addition antimicrobial peptide Antiviral antiviral action Antiviral actions Antiviral effect Anuran's skin caused China Clinical sign COVID-19 disease drug effective effort etiology identify identifying Image in silico literature review natural antiviral pandemic Patient peptide peptides Pneumonia Prevent reported SARS-CoV-2 secreted Sequencing Symptom tested the SARS-CoV-2 virus therapeutic agent therapeutic agents treat Treatment triggered viral infectious diseases virus viruses World Health Organization [DOI] 10.1016/j.virusres.2022.198769 PMC 바로가기 [Article Type] Article
Anti-Inflammatory and Antiviral Effects of Cannabinoids in Inhibiting and Preventing SARS-CoV-2 InfectionSARS-CoV-2 감염을 억제하고 예방하는 칸나비노이드의 항염 및 항바이러스 효과Review Published on 2022-04-102022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] adenosine Anti-inflammatory Antiviral Antiviral effect assumed cannabidiol cannabinoid cannabinoids cannabis Cannabis sativa cause caused CBD complex Compound Course COVID-19 COVID-19 pandemic Effect examination excessive immune response glycine GPR55 inflammatory cascade Interaction knowledge Mitigation pandemic Preventing receptors regulate researcher SARS-CoV-2 SARS-CoV-2 virus scientist shown signaling pathways subject Symptoms terpene the disease the SARS-CoV-2 virus therapeutic options Treatment treatment of COVID-19 Trigger TRPV1 Web of Science [DOI] 10.3390/ijms23084170 PMC 바로가기 [Article Type] Review
Interaction of surface glycoprotein of SARS-CoV-2 variants of concern with potential drug candidates: A molecular docking studyArticle Published on 2022-04-072022-11-15 Journal: F1000Research [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] antiviral drug Antiviral effect arising B.1.1.7 B.1.351 B.1.351 variant B.1.617.2 Baricitinib binding binding affinity change conducted COVID-19 determine Dexamethasone drug Drug repurposing experiments Favipiravir Genetic variant investigated mitigate molecular docking molecular dynamics Mutation outbreak Previous studies public health Receptor binding domain Remdesivir residue SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant several variant Surface glycoprotein the SARS-CoV-2 virus Transmission treat virulence VOCs Wuhan, China [DOI] 10.12688/f1000research.109586.1 PMC 바로가기
RNAi to treat SARS-CoV-2-variant proofing the next generation of therapies차세대 치료법을 입증하는 SARS-CoV-2 변이체를 치료하는 RNAiArticle Published on 2022-04-072022-09-11 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] animals Antiviral Antiviral effect approach approved effective Efficacy eliminating market Medicine molnupiravir Older pathology Paxlovid reducing RNA RNAi SARS-CoV-2 siRNAs therapy treat Treatment variant Viral viral replication [DOI] 10.15252/emmm.202215811 PMC 바로가기 [Article Type] Article
Recombinant human interferon-α1b inhibits SARS-CoV-2 better than interferon-α2b in vitro재조합 인간 인터페론-α1b는 시험관 내에서 인터페론-α2b보다 SARS-CoV-2를 더 잘 억제합니다Article Published on 2022-04-012022-09-11 Journal: Virologica Sinica [Category] COVID19(2023년), SARS, 치료제, [키워드] anti-SARS-CoV-2 Antiviral effect Calu-3 comprehensive evaluation drug immunofluorescence in vitro inhibit qPCR recombinant SARS-CoV-2 shown TCID therapy Vero [DOI] 10.1016/j.virs.2022.01.031 PMC 바로가기 [Article Type] Article
Serum zinc levels in pediatric patients with COVID-19Observational Study Published on 2022-04-012022-10-05 Journal: European journal of pediatrics [Category] COVID19(2023년), SARS, 임상, [키워드] Adults Analysis Antiviral effect association children conducted control group correlation COVID-19 Critical cut-off deficiency defined determine diagnosed with COVID-19 disease disease severity Factor growth Hospitalization hospitalizations Immunity incidence IQR living environment median median age neurologic participated Patient patients with COVID-19 Pediatric patient performed prospective observational study SARS-CoV-2 serum severity of COVID-19 Sex significantly higher significantly lower SPSS the median to define Variation window with COVID-19 Zinc [DOI] 10.1007/s00431-021-04348-w PMC 바로가기 [Article Type] Observational Study