Applying heat and humidity using stove boiled water for decontamination of N95 respirators in low resource settingsResearch Article Published on 2021-09-302022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, SARS, [키워드] ambient Applying approach Asia Care Degradation demonstrated Efficiency filtration heat hydrogen peroxide Masks Mumbai N95 respirator Particle performed profile provide remained repeated resource reuse sealed South surgical temperature Treatment vessel [DOI] 10.1371/journal.pone.0255338 PMC 바로가기 [Article Type] Research Article
An atomistic model of the coronavirus replication-transcription complex as a hexamer assembled around nsp15Research Article Published on 2021-09-232022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, MERS, SARS, [키워드] 5′-UTR Applying binding complex coronavirus CTD, C-terminal domain docking dsRNA EndoN, endonuclease exonuclease function generate GTase, guanylyltransferase indicate involved MD, molecular dynamics MHV, murine hepatitis virus molecular Molecular modeling mRNA mRNA transcripts MST, microscale thermophoresis MTase, methyltransferase N, nucleocapsid nsp, nonstructural viral protein nsp13 nsp14 Nsp15 NTD, N-terminal domain NTPase, nucleoside triphosphatase nucleocapsid polymerase Proofreading Protein protein structure question recruit Replication replication-transcription complex responsible RNA RTC, replication-transcription complex SARS-CoV-2 Structure structure model subunit switching Transcription trimer TRS-B, body TRS TRS-L TRS-L, leader TRS TRS, transcription regulatory sequence viral genome Viral protein viral replication Viral RNA viral transcription while [DOI] 10.1016/j.jbc.2021.101218 PMC 바로가기 [Article Type] Research Article
Development of a model-inference system for estimating epidemiological characteristics of SARS-CoV-2 variants of concern관심 SARS-CoV-2 변이체의 역학적 특성 추정을 위한 모델-추론 시스템 개발Article Published on 2021-09-222022-09-10 Journal: Nature Communications [Category] SARS, 변종, [키워드] 95% CI Applying ascertainment B.1.1.7 B.1.351 Characteristics Computational biology and bioinformatics COVID-19 pandemic develop development disease Efficacy epidemiological Epidemiology highlight immune Immune escape incidence infections Infectious diseases lead mass Model mortality data new SARS-CoV-2 P.1 pandemic preventive measures SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spread Support this system Transmissibility Vaccine variants variants of concern wild-type [DOI] 10.1038/s41467-021-25913-9 PMC 바로가기 [Article Type] Article
Addressing Gaps for Health Systems Strengthening: A Public Perspective on Health Systems’ Response towards COVID-19Article Published on 2021-08-272022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] adaptive analysed Analysis Applying approach block blocks complex interaction conducted COVID-19 develop Effects effort Epidemic Gap Health health system health systems building blocks Health systems strengthening help identify improvement Malaysia mapped opinion outbreak Perspective Public question response System systems thinking understanding WHO [DOI] 10.3390/ijerph18179047 PMC 바로가기 [Article Type] Article
Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8 + T cellsSARS-CoV-2에 의한 인간 소장 감염은 활성화된 CD8 + T 세포에 의한 점막 침윤이 특징입니다.Article Published on 2021-08-212022-09-10 Journal: Mucosal Immunology [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] accumulation activated addition analyzed Apoptosis Applying biopsies biopsy caused CD8 change characterized claimed complex COVID-19 COVID-19 patients Cytometry demonstrated direct infection disease duodenal epithelial epithelial cells epithelium Evidence Gastrointestinal symptom gastrointestinal symptoms gastrointestinal tract Human immune activation immunohistochemistry infected individuals Infection infiltration intestinal intestinal cell intestinal cells intestinal epithelial cell intestinal epithelial cells lung modulation mucosa mucosal mucosal immune nucleocapsid protein proliferation qRT-PCR regenerative SARS-CoV-2 SARS-CoV-2 infected individuals SARS-CoV-2 pandemic SARS-CoV-2 RNA small intestine subsequent Symptom T cell T cells the SARS-CoV-2 upper airway upper airways Viral viral tropism with COVID-19 [DOI] 10.1038/s41385-021-00437-z PMC 바로가기 [Article Type] Article
Clinical trials during pandemics and beyond: time for a more efficient pharmacological strategy팬데믹 기간 및 그 이후의 임상 시험: 보다 효율적인 약리학적 전략이 필요한 시점Article Published on 2021-08-122022-09-11 Journal: Journal of Antimicrobial Chemotherapy [Category] SARS, 비임상, 임상, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal animal model Antiviral Applying approach breath clinical clinical trial clinical trials conducted coronavirus dosage drug Drug efficacy Efficacy implementation in vitro information International money National pandemic Pandemics pharmacological Research SARS-CoV-2 severe acute respiratory syndrome Coronavirus symptomatic target therapeutic Trial [DOI] 10.1093/jac/dkab190 PMC 바로가기 [Article Type] Article
Identification of potent human neutralizing antibodies against SARS-CoV-2 implications for development of therapeutics and prophylacticsSARS-CoV-2에 대한 강력한 인간 중화 항체의 식별이 치료제 및 예방 개발에 미치는 영향Article Published on 2021-08-092022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Administered Analysis angiotensin anti-SARS-CoV-2 Anti-viral treatment antibodies antibody Applying Candidates coronavirus detectable determinate Diseases domain drug Economy effective drug effective drugs Emerging infectious diseases epitope Epitopes Fab germline global public health hACE2 high affinity human Angiotensin-converting enzyme identification identify Impact implication infected patient infected patients Infectious diseases Lung injury maturation mechanism mice monoclonal antibodies monoclonal antibody naïve neutralize Neutralizing Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibodies neutralizing monoclonal antibody Novel coronavirus platform Prophylactic prophylactically RBD reduce respiratory reveal SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein the RBD the SARS-CoV-2 therapeutic Vaccines Viral viral infection viral titer [DOI] 10.1038/s41467-021-25153-x PMC 바로가기 [Article Type] Article
Exploring Changes to the Actionability of COVID-19 Dashboards Over the Course of 2020 in the Canadian Context: Descriptive Assessment and Expert Appraisal StudyOriginal Paper Published on 2021-08-062022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, SARS, [키워드] Applying appraisal assessment Canada Care change changed communication conducted COVID-19 Dashboard dashboards data-driven Decision-making defined development dynamic early stage effort element elements evaluated Evolution expert feature Health health information management improvement include information involved lack management Medical informatics objective over pandemic performance measures Public public health public reporting of health care data qualitative research remained reported Result Seven specificity Support Surveillance widespread [DOI] 10.2196/30200 PMC 바로가기 [Article Type] Original Paper
The Determinants of Telehealth Provision: Empirical Evidence from OECD CountriesArticle Published on 2021-08-052022-10-30 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] Ageing applied Applying cooperation country COVID-19 pandemic determinant development E-health elevated estimation exceeded Factor Health Health Service IMPROVE increase in individual logistic regression model organization outcome parameter per capita GDP Population proportion provided reached Research resource telehealth threshold turn variables [DOI] 10.3390/ijerph18168288 PMC 바로가기 [Article Type] Article
Infection prevention and control (IPC) implementation in low-resource settings: a qualitative analysisResearch Published on 2021-07-312022-10-28 Journal: Antimicrobial Resistance and Infection Control [Category] COVID-19, [키워드] Analysis Applying approach association build coded component conducted coronavirus country COVID-19 Critical demonstrated develop effective elements Evidence example explain feasible HAI Health health system implementation IMPROVE Infection prevention Infection prevention and control Infectious disease initial interview Local low-resource settings National offer pandemic positive professional promote Qualitative evidence questionnaire regions resources Result robust Standard supplementary material the WHO thematic analysis Threats transcript Validity WHO WHO core components World Health Organization [DOI] 10.1186/s13756-021-00962-3 PMC 바로가기 [Article Type] Research