Self-supervised deep learning model for COVID-19 lung CT image segmentation highlighting putative causal relationship among age, underlying disease and COVID-19연령, 기저 질환 및 COVID-19 간의 추정 인과 관계를 강조하는 COVID-19 폐 CT 이미지 분할을 위한 자체 지도 딥 러닝 모델Research Published on 2021-07-262022-09-10 Journal: Journal of Translational Medicine [Category] SARS, 유전자 메커니즘, [키워드] Accuracy age Analysis approach Automatic automatically auxiliary baseline best causal relationship chain Chain Reaction Chest CT image Chest CT images computer vision Computerized tomography consolidation contagious contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis COVID-19 severity COVID-19 testing dataset deep deep learning Diagnosis diagnostic Efficiency evaluate faster feature ground-glass opacity highlighting Image analysis Image segmentation introduced lesion lung Lung CT Lung CT images lung lesions mechanism Mediation analysis Mediation effect phenotype polymerase chain reaction predicted problems provide reaction Result Self-supervised learning severity supplementary material Support underlying disease underlying diseases were used with COVID-19 [DOI] 10.1186/s12967-021-02992-2 PMC 바로가기 [Article Type] Research
Identification of Potential Binding Sites of Sialic Acids on the RBD Domain of SARS-CoV-2 Spike ProteinChemistry Published on 2021-07-222022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] ACE2 acid acute respiratory syndrome Analysis auxiliary binding binding site caused coronavirus COVID-19 determine DPP4 glycoprotein host cell human cells humans identification Interaction MERS-CoV Middle East molecular pandemic Penetrating Potential predominant probe question RBD RBD domain receptor respiratory SARS-CoV-2 sequence sialic acid Site spike Spike protein SPR the RBD the spike protein virus infection viruses [DOI] 10.3389/fchem.2021.659764 PMC 바로가기 [Article Type] Chemistry
Automated Detection of Covid-19 from Chest X-ray scans using an optimized CNN architectureResearch article Published on 2021-06-012022-10-05 Journal: Applied Soft Computing [Category] 치료기술, [키워드] Accuracy adopted affected affecting Algorithm Analysis analyzed automated auxiliary chest X-ray classification clinical setting Clinicians CNN code contribute Correcting COVID-19 dataset detection Diagnosis diagnostic diagnostic capability disease ECOC Ensemble facilitate faster global pandemic Grey GWO healthcare professionals information initial initiated Isolation lack meet network Neural Novel coronavirus optimization output pandemic parameter patients perceptron public health radiologist recent finding Research sensitivity testing Spread SVM Treatment Viral pneumonia virus was obtained Whale WOA Wolf X-ray [DOI] 10.1016/j.asoc.2021.107238 [Article Type] Research article
Supplementary research on K150del variant of activated protein C활성화된 단백질 C의 K150del 변이체에 대한 추가 연구Research Paper Published on 2021-05-152022-09-10 Journal: Aging (Albany NY) [Category] MERS, SARS, 변종, [키워드] 2019 coronavirus disease activated activated protein C activities administration alteration anti-apoptotic Anti-inflammatory Anti-inflammatory effects Anticoagulant APC apoptotic auxiliary Cell clinician Concentration coronavirus coronavirus disease COVID-19 cytoprotective activity differentially expressed gene Differentially expressed genes disease risk Effects functional HEK 293T help in viral infections Inflammatory lung tissue mutant performed predict Protein protein C reduced repeated Research restored signaling pathways therapeutic Transcriptome transcriptome analysis treated variant Viral viral infections virus virus defense [DOI] 10.18632/aging.202904 PMC 바로가기 [Article Type] Research Paper
The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infectionAccelerated Communication Published on 2021-05-072022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, [키워드] ACE2 ACE2 expression ACE2, angiotensin-converting enzyme 2 Activation acute respiratory syndrome Analysis angiotensin-converting enzyme 2 antibody antiviral treatments auxiliary binding block Cell cells chaperone combination therapy complex coronavirus COVID-19 Critical depleting domain Endoplasmic reticulum Factor global pandemic GRP78 GRP78, 78-kDa glucose-regulated protein hMAb159, humanized monoclonal antibody Host host receptor humanized monoclonal antibody Infection Interaction knocked down Loss lung epithelial cell marker molecular docking pathogen Protein RBD RBD, receptor-binding domain recent reduced Safe SARS-2-S SARS-2-S, SARS-CoV-2-Spike protein SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 selected spike Spike protein the RBD the receptor-binding domain the SARS-CoV-2 unfolded protein response VeroE6-ACE2, VeroE6 cells overexpressing ACE2 viral entry virus viruses [DOI] 10.1016/j.jbc.2021.100759 PMC 바로가기 [Article Type] Accelerated Communication
A multi‐class COVID‐19 segmentation network with pyramid attention and edge loss in CT imagesOriginal Research Paper Published on 2021-05-042022-10-30 Journal: Iet Image Processing [Category] COVID-19, [키워드] Accuracy assist Automatic auxiliary coefficient consolidation contagiousness Convolution COVID‐19 dataset diagnose Diagnosis effective evaluated experiment feature ground glass opacities IMPROVE include Infection information interstitial lung Novel coronavirus outperform positive powerful tool promote severity similarity Symptom the disease [DOI] 10.1049/ipr2.12249 PMC 바로가기 [Article Type] Original Research Paper
Effectiveness of hydrogen peroxide as auxiliary treatment for hospitalized COVID-19 patients in Brazil: preliminary results of a randomized double-blind clinical trialRandomized Controlled Trial Published on 2021-05-012022-10-04 Journal: Epidemiology and Health [Category] 임상, [키워드] acute respiratory syndrome adverse effect asked auxiliary clinical trial control group coronavirus coronavirus disease coughing COVID-19 double-blind Dyspnea effective Effectiveness evaluate evaluated Evidence experimental group Fisher exact test group Hospital stay hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hydrogen peroxide Mild moderate MOST mouthwashes nasal Nasal Sprays no significant difference Patient polymerase chain positive Randomized randomly divided reduction in reported Safe SARS-CoV-2 severity Student test Symptom Symptoms tested the patient Treatment were recorded were used [DOI] 10.4178/epih.e2021032 PMC 바로가기 [Article Type] Randomized Controlled Trial
A Review of the Current Status of Clinical Management of COVID-19 in the Elderly고령자 코로나19 임상관리 현황 고찰Review Published on 2021-04-092022-09-11 Journal: Medical science monitor : international medical jo [Category] SARS, 치료제, [키워드] addition Adults antiviral therapy approval auxiliary Biology chronic disease Chronic diseases clinical comprehensive evaluation COVID-19 COVID-19 patients COVID-19 vaccines Critically ill current Effect effective elderly Elderly patient elderly patients Epidemic global pandemic immune regulation Isolation lack management measure Novel coronavirus present Psychological problems respiratory therapy review SARS-CoV-2 SARS-COV-2 infection severity sick status susceptible the disease the epidemic therapy Treatment treatment for COVID-19 treatment of COVID-19 variety with COVID-19 [DOI] 10.12659/MSM.930278 PMC 바로가기 [Article Type] Review
Examining the Hand in the Video Consultation영상 상담에서 손 검사Article Published on 2021-04-012022-09-11 Journal: Zeitschrift für Orthopädie und Unfallchirurgie [Category] SARS, 치료기술, [키워드] absence auxiliary both hands can not carried complement confidence interval consultation Contact COVID-19 COVID-19 pandemic deficit deviation direct contact English evaluated Examining Fach feasibility Feasibility study feasible fingers Good Gut hand hand surgery high correlation joints less medical history motion movement Patient care range of motion sensitivity social distancing strength Support Symptoms telediagnosis the patient [DOI] 10.1055/a-1304-3593 PMC 바로가기 [Article Type] Article
High expression of SARS-CoV-2 entry factors in human conjunctival goblet cells인간 결막 잔 세포에서 SARS-CoV-2 진입 인자의 높은 발현Review Published on 2021-04-012022-09-11 Journal: Experimental eye research [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 auxiliary cell type cell types cellular protease co-expressed conjunctival Conjunctival goblet cell COVID-19 expression of SARS-CoV-2 Factor goblet Goblet cell goblet cells help Immunity involved molecular mechanism priming protease receptor SARS-CoV-2 cell SARS-COV-2 infection SARS‐CoV‐2 Sequencing Serine serine 2 shown single-cell TMPRSS2 transmembrane transmembrane protease serine 2 virus entry was performed [DOI] 10.1016/j.exer.2021.108501 PMC 바로가기 [Article Type] Review