Targeting the SARS-CoV2 nucleocapsid protein for potential therapeutics using immuno-informatics and structure-based drug discovery techniques면역 정보학 및 구조 기반 약물 발견 기술을 사용하여 잠재적 치료제를 위한 SARS-CoV2 뉴클레오캡시드 단백질 표적화Article Published on 2020-12-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 치료법, 치료제, [키워드] Analysis antigens approach B-cell B-cell epitope B-cell epitopes bioinformatics candidate complex coronavirus Coverage COVID-19 Critical docking Drug discovery epitope Epitope-based vaccine Epitopes help identify IFN-γ Immunity Immuno-informatics induce inhibitor leucocyte life cycle molecular dynamics Molecular dynamics simulation N protein N-protein N-terminal domain non-allergenic non-toxic nucleocapsid nucleocapsid protein Occurrence Protein ribonucleoprotein SARS-CoV2 SARS-CoV2 infection sequence Stage Structure T-cell epitope T-cell epitopes targeting the N protein therapeutic intervention therapeutic interventions therapeutic option therapeutic options Vaccine Viral viral genome viral life cycle zidovudine zidovudine triphosphate [DOI] 10.1016/j.biopha.2020.110914 PMC 바로가기 [Article Type] Article
An Immunoinformatics Study to Predict Epitopes in the Envelope Protein of SARS-CoV-2Research Article Published on 2020-11-252022-10-31 Journal: The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien des Maladies Infectieuses et de la Microbiologie Médicale [Category] COVID-19, [키워드] affected Analysis analyzed B-cell epitope binding energy Bioinformatics analysis carried caused Cell-mediated immune responses complementary computational method coronavirus Coverage COVID-19 CTL CTL epitope disease docked elicit envelope envelope protein epitope evaluated HLA allele HTL humoral IEDB Immune Epitope Database immune system in vitro in vivo NCBI database overlapped peptide peptide-based vaccine predict predicted retrieved SARS-CoV-2 sequence suggested Support T-cell epitopes Vaccine vaccine for COVID-19 virus was determined was performed [DOI] 10.1155/2020/7079356 PMC 바로가기 [Article Type] Research Article
Design of novel multiepitope constructs-based peptide vaccine against the structural S, N and M proteins of human COVID-19 using immunoinformatics analysis면역정보학 분석을 이용한 인간 코로나19의 구조적 S, N, M 단백질에 대한 새로운 다중 에피토프 구조 기반 펩타이드 백신 설계Research Article Published on 2020-10-152022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, [키워드] 3D structure acute respiratory syndrome adopted allergen Analysis analyzed approach B-cell B-cell epitope B-cell epitopes BepiPred Betacoronavirus binding calculated candidate Candidates causative agent cellular immune responses center China CDC Chinese clade cleavage contribute Control Coronaviridae Coverage COVID-19 CTL CTL epitope demonstrated develop disease control domain Efficiency elicit Ellipro epitope Epitopes GalexyPepDock highest HTL HTL epitopes humoral Hypothesis I-TASSER identify IEDB immune responses immunodominant immunoinformatics in silico in vivo Interaction linear MHC multiepitope vaccine N and M NCBI database NetCTL NetMHCpan novel Betacoronavirus peptide predicted proteasomal Protein RBD Receptor-binding domain regions reported respiratory S protein S, N and M proteins SARS-CoV-2 SARS-CoV-2 peptide vaccine SARS-CoV-2 susceptibility sequence Severe acute respiratory syndrome strong interactions Tap transport/proteasomal cleavage These data TLR TLRs TLRs 2, 3 and 4 Transport Vaccination strategies Vaccine virus was obtained [DOI] 10.1371/journal.pone.0240577 PMC 바로가기 [Article Type] Research Article
Epitope-based peptide vaccines predicted against novel coronavirus disease caused by SARS-CoV-2Article Published on 2020-10-152023-07-11 Journal: Virus research [Category] SARS, [키워드] B-cell epitope Immune-informatics SARS-CoV-2 Spike protein T-cell epitope Vaccine design [DOI] 10.1016/j.virusres.2020.198082 PMC 바로가기
Determine the Potential Epitope Based Peptide Vaccine Against Novel SARS-CoV-2 Targeting Structural Proteins Using Immunoinformatics ApproachesMolecular Biosciences Published on 2020-10-152022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] Against Analysis analyzed antigenic epitope antigenic site approach B-cell epitope binding binding affinity caused China corona virus disease 2019 coronavirus CoV COVID-19 CoVs CTL cytotoxic diagnosed disease docking complex effective envelope epitope high mortality rate HLA Human immunoinformatics introduced mammal MHC-I new strain novel pathogenic virus peptide Peptide vaccines positive Potential predict predicted Replication RNA genome RNA virus SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus spike structural protein targeting unique Vaccine variety Wuhan [DOI] 10.3389/fmolb.2020.00227 PMC 바로가기 [Article Type] Molecular Biosciences
Reverse vaccinology assisted designing of multiepitope-based subunit vaccine against SARS-CoV-2Research Article Published on 2020-09-162022-10-29 Journal: Infectious Diseases of Poverty [Category] COVID-19, SARS, [키워드] acute respiratory syndrome alleles Amino acid Antigen antigenicity B-cell epitope binding binding affinity Cell computational approach coronavirus Coronavirus disease 2019 Coverage COVID-19 COVID-19 pandemic CTL cytotoxic T lymphocyte docking downloaded effective envelope epitope Escherichia coli functions GenBank glycoprotein highly antigenic HLA HTL humans immune response Immune simulation immunogenic immunoinformatics in silico In silico cloning increased expression Infection Interaction investigated K-12 leukocyte life-threatening linkers membrane glycoprotein MEV codon Multiepitope-based subunit vaccine non-allergenic pathogenic Pneumonia Prevent Protein responsible Result SARS-CoV-2 sequence structural protein subunit suggested surface T lymphocyte the SARS-CoV-2 TLR3 Vaccine vaccine candidate [DOI] 10.1186/s40249-020-00752-w PMC 바로가기 [Article Type] Research Article
Impact of glycan cloud on the B-cell epitope prediction of SARS-CoV-2 Spike proteinArticle Published on 2020-09-042022-10-04 Journal: NPJ Vaccines [Category] 진단, [키워드] Alter Analysis antibody antibody-based therapy B-cell epitope China diagnostics epitope flexible glycosylation pattern heterogeneous homogeneous identify Impact inaccessible N-glycosylation outbreak pandemic proportions Protein Receptor binding domain resulting S-protein S2 subunit SARS-CoV-2 spike spread to target the S1 subunit the Spike trimeric Vaccine Vaccine development Vaccines were used [DOI] 10.1038/s41541-020-00237-9 PMC 바로가기 [Article Type] Article
Epitope-based chimeric peptide vaccine design against S, M and E proteins of SARS-CoV-2, the etiologic agent of COVID-19 pandemic: an in silico approachBioinformatics Published on 2020-07-272022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] acute respiratory syndrome antigenic epitope applied approach average B-cell epitope binding bioinformatics candidate vaccine chimeric Chimeric Peptide Vaccine codon optimization coronavirus coronavirus disease Coverage COVID-19 Cytokines demonstrated docking E protein Ethnic groups expression IFN-γ IgG1 IgG2 IgM IL-2 Immune receptor immune response in silico Approach International mRNA Muti-epitope pandemic peptide predicted proliferation Proteins public health emergency SARS-CoV-2 secondary structure T-cell T-cell epitope T-helper cell TLR3 TLR4 Vaccine vaccine candidate Vaccine design WHO World Health Organization [DOI] 10.7717/peerj.9572 PMC 바로가기 [Article Type] Bioinformatics
Molecular Characterization of Porcine Epidemic Diarrhea Virus and Its New Genetic Classification Based on the Nucleocapsid GeneArticle Published on 2020-07-232022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] age antigenic antigenicity average B-cell epitope Bayesian cause characterization classification COE demonstrated detection rate epidemic diarrhea genetic mutation Host mutant N gene N1 and N2 New nucleocapsid nucleocapsid protein PEDV Phylogenetic analysis Porcine epidemic diarrhea virus S gene sequence significantly lower strain Strains the spike protein virus [DOI] 10.3390/v12080790 PMC 바로가기 [Article Type] Article
Identification and Analysis of Unstructured, Linear B-Cell Epitopes in SARS-CoV-2 Virion Proteins for Vaccine DevelopmentArticle Published on 2020-07-202022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] B-cell B-cell epitope B-cell epitopes bat coronavirus Consensus coronavirus COVID-19 cross-protection development Efficacy epitope Epitope prediction epitope switch event facilitate humans identification immune system immunoinformatics intermediate lack linear mutational processe N proteins nucleic acid-based vaccine overlap pandemic predictor previous study Protein reported SARS-CoV SARS-CoV-2 SARS-CoV-2 isolate secondary structure serum Stage Strains switching transfer translated unfolded protein response Vaccine Variability while zone [DOI] 10.3390/vaccines8030397 PMC 바로가기 [Article Type] Article