Research Progress of Genetic Structure, Pathogenic Mechanism, Clinical Characteristics, and Potential Treatments of Coronavirus Disease 2019Pharmacology Published on 2020-08-272022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 acute respiratory distress acute respiratory syndrome Affect angiotensin converting enzyme 2 ARDS binding biogenesis cardiovascular system caused Cell clinical Clinical characteristics Coronavirus disease 2019 Coronavirus-2 COVID-19 Cytokine storm digestive system enzyme global pandemic Infectious disease Injury multiple organ failure pathogenesis of SARS-CoV-2 pathogenic mechanism pathogenic mechanisms Potential Potential treatment Progress receptor Respiratory system resulting SARS-CoV-2 severe acute respiratory syndrome coronavirus-2 Structure syndrome systemic inflammatory response Treatment urinary system [DOI] 10.3389/fphar.2020.01327 PMC 바로가기 [Article Type] Pharmacology
Caveolae and Lipid Rafts in Endothelium: Valuable Organelles for Multiple FunctionsReview Published on 2020-08-212022-10-28 Journal: Biomolecules [Category] Coronavirus, [키워드] adipocytes Angiogenesis biogenesis caused caveolae caveolin cavin Cell cell type cholesterol COVID-19 endocytosis Endothelial cell endothelial cells Extracellular fatty acids function functions heterogeneous human disease increase in invagination involved Lipid lipid composition Lipid rafts living cells marker mechanism membrane metabolism Microscope Migration molecular Multiple organelle plasma membrane platform proliferation Protein raft saturated sphingomyelin unique Vascular virus entry [DOI] 10.3390/biom10091218 PMC 바로가기 [Article Type] Review
The Role of Extracellular Vesicles as Allies of HIV, HCV and SARS VirusesReview Published on 2020-05-222022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] Ally biogenesis caused Cell Coronaviruses EVs Exosomes Extracellular Extracellular vesicles functional HCV HIV in viral Infection Intercellular communication knowledge nucleic acid Other pathogen Pathogens pathological conditions physiological plasma membrane Protein released respiratory role SARS virus SARS viruses therapeutic strategy Vesicle viral infection virus viruses [DOI] 10.3390/v12050571 PMC 바로가기 [Article Type] Review
Genome-wide identification of short 2′,3′-cyclic phosphate-containing RNAs and their regulation in aging짧은 2',3'-사이클릭 인산염 함유 RNA의 게놈 전체 식별 및 노화 조절Research Article Published on 2019-11-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulated adapter ligation adenosine advent aging Analysis biogenesis can not capture characterized cleavage cytidine cytoplasmic Degradation Determination effort event Evolution expressed expression expression level expression levels functional hidden identify ligation reaction mRNAs ncRNAs next-generation sequencing technology non-coding RNA Non-coding RNAs pathway phosphate physiological produced random reduction regulated Regulation remained ribonuclease RNA RNA molecule RNA molecules RNA-Seq RNAs rRNAs sequence standard RNA tissues Transcriptome tRNAs [DOI] 10.1371/journal.pgen.1008469 PMC 바로가기 [Article Type] Research Article
Genes involved in mitochondrial biogenesis and function may not show synchronised responses to mitochondria in shell gland of laying chickens under infectious bronchitis virus challengeResearch Article Published on 2019-04-012022-10-27 Journal: BMC Molecular and Cell Biology [Category] Coronavirus, [키워드] ATPase biogenesis bronchitis cause Chicken oviduct coactivator complex control group DNA down-regulated Egg expression expression level IBV Infection Infectious bronchitis Infectious Bronchitis Virus involved Laying chicken lesion mitochondrial Mitochondrial function Nuclear DNA encoded genes oviduct Protein receptor reduced Region response Result SDHA significantly higher significantly lower subunit variant virus virus multiplication [DOI] 10.1186/s12860-019-0190-7 PMC 바로가기 [Article Type] Research Article
Exposure of Candida albicans β (1,3)-glucan is promoted by activation of the Cek1 pathwayCek1 경로의 활성화에 의해 칸디다 알비칸스 β(1,3)-글루칸의 노출이 촉진됩니다Research Article Published on 2019-01-312022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate activated Activation addition AIDS antigenic approach biogenesis bloodstream Cancer patients Candida Candida albican Candida albicans cascades cause Cdc42 Cell cell wall cell wall synthesis decrease detect disrupt Disruption downstream drug exhibit exposure Fungal infection fungal infections fungal pathogens glucan glycosylated GTPase homozygous Hyperactivation immune immune cells immune function immune system increase independent innate immune cell Innate immune cells Intracellular kinase kinases lab lead leads mannan MAPK masking mitogen Mortality mutant Mutation Pathogens pathway Patient Phosphatidylserine polysaccharide promoted protein kinase receptor receptors regulate remodeling responsible Signaling signaling cascade significantly increased synthesis the cell up-regulated upregulated upregulation upstream virulence virulence factor weakened were used wild-type wild-type cell wild-type cells [DOI] 10.1371/journal.pgen.1007892 PMC 바로가기 [Article Type] Research Article
A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery박테리아 세포 신장 기계에 의한 펩티도글리칸 중합의 활성화에서 PBP2의 중심 역할Research Article Published on 2018-10-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Actin activate activated Activation activation pathway activities activity Analysis antibiotic Author Bacteria bacterial cell biogenesis Cell Cell elongation cell wall cell wall synthesis changes in complex complexes component conserved Control control cell crosslinking cytokinesis cytoskeletal filament cytoskeletal filaments determine disrupt enzymatic activity enzyme Enzymes Escherichia coli Evidence exhibited Genetic genetic evidence glycan glycan polymerase glycan polymerases hyperactivate identify in vitro in vivo inactivated morphogenic MreB Mutation osmotic lysis pathway PBP PBP2 PBPs penicillin penicillin-binding protein penicillin-binding proteins polymerase Prevent promote PROTECT provide remained required Rod system RodA stimulate the cell uncrosslinked variant [DOI] 10.1371/journal.pgen.1007726 PMC 바로가기 [Article Type] Research Article
Cell envelope stress in mycobacteria is regulated by the novel signal transduction ATPase IniR in response to trehalose마이코박테리아의 세포 외피 스트레스는 트레할로스에 대한 반응으로 새로운 신호 전달 ATPase IniR에 의해 조절됩니다Research Article Published on 2017-12-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Activation activator Affect assembly ATPase Author BAC bacterial cell biogenesis cascade Cell cell envelope cell wall complex compounds damaged defect domain domains drug ethambutol experiment explain exposure to family Gram-negative bacteria homologue identify include induce inducer integrity involved isoniazid latter gene Lipid lipids locus mechanism Mutagenesis mutant mutants mutations mycobacteria mycobacterial Mycobacterium operon overexpression pathway promoter PROTECT regulated Regulation regulator Regulatory regulatory gene respond RNAseq shown signal Signal transduction Signaling Stress stress response sugar sugars the cell transcriptional regulator transposon trehalose Tuberculosis understanding unique [DOI] 10.1371/journal.pgen.1007131 PMC 바로가기 [Article Type] Research Article
Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA ReplicationResearch Article Published on 2017-11-212022-10-29 Journal: mBio [Category] Coronavirus, [키워드] acute respiratory syndrome Affect biogenesis cleavage coexpressed convoluted membranes coronavirus Coronaviruses cytoplasmic electron tomography element Endoplasmic reticulum eukaryote Evidence expressed Formation highlight Human in viral induce lethal infection maturation membrane structure membranes MERS-CoV Middle East MIMIC Mutagenesis nidovirus nidoviruses nonstructural protein nonstructural proteins Nsp3 nsp4 organelle pathogen Pathogens polyprotein positive precursor proliferation Protein proteolytic Replication replication complex replication organelle biogenesis replication structures required Research respiratory respiratory syndrome coronavirus RNA RNA synthesis RNA virus SARS-CoV similarity subunit suggested thought transmembrane transmembrane domains transmembrane protein Vesicle viral double-stranded RNA viral factory Viral protein [DOI] 10.1128/mBio.01658-17 PMC 바로가기 [Article Type] Research Article
Subcellular localization and interactions among rubber particle proteins from Hevea brasiliensisArticle Published on 2017-11-022023-08-30 Journal: Journal of experimental botany [Category] E형 간염, [키워드] Hevea biogenesis Endoplasmic reticulum Latex Particle plant rubber [DOI] 10.1093/jxb/erx331 PMC 바로가기