Discovery of Novel and Highly Potent Inhibitors of SARS CoV-2 Papain-Like Protease Through Structure-Based Pharmacophore Modeling, Virtual Screening, Molecular Docking, Molecular Dynamics Simulations, and Biological EvaluationPharmacology Published on 2022-02-212022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Analysis anti-viral drug antiviral immune responses approach Biological carried complexes Compound compounds conducted COVID-19 database Dynamics dysregulation effective Host identify indicated Inflammation inhibitor inhibitory activity Interaction key amino acid maturation MD simulation modeling molecular docking molecular dynamics novel Papain-like protease pharmacophore pharmacophore modeling PLPro positive control potent predicted protease SARS CoV-2 Screening stability Treatment virus was used [DOI] 10.3389/fphar.2022.817715 PMC 바로가기 [Article Type] Pharmacology
Biophysical and Biological Tools to Better Characterize the Stability, Safety and Efficacy of a Cosmeceutical for Acne-Prone Skin여드름 피부를위한 우주의 안정성, 안전성 및 효능을 더 잘 특성화하기위한 생물 물리학 적 및 생물학적 도구Article Published on 2022-02-132022-08-31 Journal: Molecules [Category] COVID19(2023년), MERS, SARS, 치료제, [키워드] Cutibacterium acnes 3D model 3D models Acne acne-prone skin affecting anti-inflammatory activity antimicrobial antimicrobial effectiveness Better biofilm Biological Care caused cell line Compliance Corneal cosmeceutical COVID-19 pandemic criteria cytotoxicity defined disease Effectiveness evaluate evaluated extrusion Formulation greater HaCaT human reconstructed 3D models keratinocytes Masks microbial preservative system pro-inflammatory problem proliferation Quality assurance reconstructed reference standard Result rheological properties Rheology Safety serum skin skin care skin disease stimulate Treatment widespread [DOI] 10.3390/molecules27041255 PMC 바로가기 [Article Type] Article
AutoPlate: Rapid Dose-Response Curve Analysis for Biological AssaysAutoPlate: 생물학적 분석을 위한 신속한 용량 반응 곡선 분석Immunology Published on 2022-02-102022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] accelerate analysed Analysis Biological biological assay COVID-19 Curve Data analysis develop Dose-response effective ELLA example immune correlate immunoassays IMPROVE Influenza Laboratory pseudotype pseudotype neutralization pseudovirus Rapid Safe SARS-C0V-2 SARS-CoV-2 Scientific community time-consuming Vaccine virus [DOI] 10.3389/fimmu.2021.681636 PMC 바로가기 [Article Type] Immunology
Potential COVID-19 Drug Candidates Based on Diazinyl-Thiazol-Imine Moieties: Synthesis and Greener Pastures Biological StudyDiazinyl-Thiazol-Imine 모이어티에 기반한 잠재적인 COVID-19 약물 후보: 합성 및 더 친환경적인 목초지 생물학 연구Article Published on 2022-01-132022-09-10 Journal: Molecules [Category] 치료제, [키워드] Amino acid amino acid residues approved drugs aryl binding affinity binding score binding scores Biological biological activity calculated candidate characterized Compound condensation conditions COVID-19 cytotoxicity determine docking study drug Elemental free energy greener pastures hydrophobic hydrophobic interaction hydrophobic interactions imines-tethered thiazoles in silico molecular docking indicated Ligand ligands M pro molecular molecular docking molecules molnupiravir Pass Pasture PDB phenyl Potential potential therapeutic agent potential therapeutic agents receptor Remdesivir Research statistical analysis suggested synthesis therapeutic agents were used [DOI] 10.3390/molecules27020488 PMC 바로가기 [Article Type] Article
The European Bioinformatics Institute (EMBL-EBI) in 2021AcademicSubjects/SCI00010 Published on 2022-01-072022-10-31 Journal: Nucleic Acids Research [Category] COVID-19, [키워드] bioinformatics Biological BioModel contributed COVID-19 European Bioinformatics Institute function highlight Image improvement include integration introduced maintain molecular data Pfam resource resources training UniProt [DOI] 10.1093/nar/gkab1127 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
International Nonproprietary Names (INN) for novel vaccine substances: A matter of safety새로운 백신 물질에 대한 INN(International Nonproprietary Names): 안전성 문제Review Published on 2022-01-032022-09-11 Journal: Vaccine [Category] SARS, 변종, [키워드] applicability assigned Biological Biological Standardization Committee COVID-19 COVID-19 pandemic criteria ENhance exchange expert explain facilitate Health Organization inactivated information ingredient International Nonproprietary Names live-attenuated vaccine live-attenuated vaccines mRNA vaccines name novel Novel vaccine substances novel vaccines nucleic acid nucleic acids patient safety pharmacovigilance recipients Recombinant protein recombinant proteins Safe SARS-CoV-2 SARS-CoV-2 vaccine the WHO Traditional unique Vaccine Vaccines Viral vector vaccines virus variant virus variants WHO World Health Organization [DOI] 10.1016/j.vaccine.2021.11.054 PMC 바로가기 [Article Type] Review
Learning From Biological and Computational Machines: Importance of SARS-CoV-2 Genomic Surveillance, Mutations and Risk Stratification생물학 및 전산 기계에서 배우기: SARS-CoV-2 게놈 감시, 돌연변이 및 위험 계층화의 중요성Cellular and Infection Microbiology Published on 2021-12-242022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Algorithm approach best Biological blood urea breathlessness C-reactive protein C-reactive protein (CRP characteristic Clinical data clinically Cohort coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation cough country COVID-19 dataset demonstrated develop diagnostic disease manifestation disease severity Evolution feature FIVE Frequency functional genomic Genomic analysis genomic mutations genomic sequencing Genomic surveillance healthcare highlight Importance India information learning leukocyte machine learning management ML model ML models Mutation Observing pandemic parameter parameters pathogen Patient patient severity performed physical symptoms predict Probability receiver operating characteristic resource respiratory respiratory rate Respiratory Support risk Risk assessment risk stratification ROC SARS-CoV-2 SARS-CoV-2 genomic surveillance severe acute respiratory syndrome Coronavirus severe COVID-19 severe disease Severe patient significantly singular statistical statistical analysis Symptom tested the patient urea variants variants of concern variants of interest virus VOCs VOIs [DOI] 10.3389/fcimb.2021.783961 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Skin Manifestations in Psoriatic and HS Patients in Treatment with Biologicals during the COVID-19 PandemicReview Published on 2021-12-132022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acne inversa affected Biological biologics changed coronavirus COVID-19 COVID-19 outbreak COVID-19 pandemic cutaneous manifestation Dermatology Diseases global public health hidradenitis suppurativa Immune-mediated less manifestation Manifestations pandemic Patient patients psoriasis SARS-CoV-2 skin skin manifestations subset Treatment [DOI] 10.3390/jcm10245841 PMC 바로가기 [Article Type] Review
The military as a neglected pathogen transmitter, from the nineteenth century to COVID-19: a systematic reviewReview Published on 2021-12-102022-10-31 Journal: Global Health Research and Policy [Category] COVID-19, SARS, [키워드] affected Analysis Biological conditions Contaminated country COVID-19 Critical database described disease Diseases distribution driving Evidence exacerbate feature Frequency generate global public health Global public health policy groups Health health systems impacted impair inclusion criteria increasingly Infectious disease information living condition mechanism mechanisms Military as transmission vector Military civilian transmission of infectious disease outbreak Pandemics pathogen performed poor compliance populations provided public health reported researcher Result risk searched selected supplementary material systematic review Transmission unhygienic unique vaccination while [DOI] 10.1186/s41256-021-00232-0 PMC 바로가기 [Article Type] Review
What a Pandemic Has Taught Us About the Potential for Innovation in Rural Health: Commencing an Ethnography in Canada, the United States, Sweden, and AustraliaPublic Health Published on 2021-12-072022-10-31 Journal: Frontiers in Public Health [Category] Coronavirus, SARS, [키워드] Antifragility approach Biological Canada Capacity Care Community condition COVID-19 COVID-19 pandemic defined Ethnography example flexible Health health systems highlight hospital identify implementation include initial Innovation Local organization pandemic Potential Practitioner question rapid response required Research respond response rural stability Stress suggested The United States Virtual care [DOI] 10.3389/fpubh.2021.768624 PMC 바로가기 [Article Type] Public Health