Lipidomic alteration of plasma in cured COVID-19 patients using ultra high-performance liquid chromatography with high-resolution mass spectrometryOmics Published on 2021-03-262022-10-28 Journal: Bioscience Reports [Category] COVID-19, [키워드] addition age alterations Analysis automated Biological functions changes in cholesteryl ester Compound conducted consolidation COVID-19 COVID-19 group COVID-19 patient cured Differential analysis discharged patient dyslipidemia Elderly patient group groups High-resolution high-resolution mass spectrometry knowledge Lipid Lipidomics marker Mild mild symptoms multivariate novel coronavirus disease pandemic pathogenesis of COVID-19 Patient physiological change plasma potential therapeutic target prognostic provide public health crisis Research resource SARS-CoV-2 severe symptom signaling pathways Symptoms symptoms of COVID-19 therapy Treatment Triglyceride undergo viral infection was performed was used were used [DOI] 10.1042/BSR20204305 PMC 바로가기 [Article Type] Omics
Network Pharmacology and bioinformatics analyses identify intersection genes of niacin and COVID-19 as potential therapeutic targets네트워크 약리학 및 생물정보학 분석을 통해 니아신과 COVID-19의 교차 유전자를 잠재적 치료 표적으로 식별Article Published on 2021-03-222022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, [키워드] Analysis Anti-inflammatory BCL2L1 binding bioinformatics biological function Biological functions cellular Clinical characteristics Colorectal cancer colorectal neoplasms Computational biology coronavirus coronavirus disease COVID-19 COVID-19 patients Cytoprotection effective enhancement evaluate FIVE functional functions Genes help identify IFNg IL1B indicated infected with COVID-19 inflammatory reaction inflammatory reactions Intersection measurement mechanism microenvironment molecular docking analysis molecular function network network pharmacology niacin pandemic Pathways Patient pharmacological target Pharmacology potential therapeutic target Prognosis PTGS2 Regulation SERPINE1 signaling pathway survival rate susceptible targets therapeutic therapy Treatment Vitamin [DOI] 10.1093/bib/bbaa300 PMC 바로가기 [Article Type] Article
Changes in 25-(OH) Vitamin D Levels during the SARS-CoV-2 Outbreak: Lockdown-Related Effects and First-to-Second Wave Difference—An Observational Study from Northern ItalyArticle Published on 2021-03-192022-10-28 Journal: Biology [Category] COVID-19, [키워드] 25-hydroxy vitamin D addition age allergy approach area of interest association Biological functions change changes in Concentration Daily dose Effect excluded experimental evidence feature First wave group groups Health hospital individual investigated Italy less Level lockdown obesity pandemic Patient protective role recorded reduced risk Respiratory tract infections SARS-COV-2 infection SARS-CoV-2 positivity second wave severity of COVID-19 simple sun exposure susceptibility sustained the SARS-CoV-2 variable Vitamin D vitamin D level Vitamin D status Vitamin D supplementation was obtained Wave [DOI] 10.3390/biology10030237 PMC 바로가기 [Article Type] Article
Elucidating the tunability of binding behavior for the MERS-CoV macro domain with NAD metabolitesArticle Published on 2021-01-272022-10-04 Journal: Communications Biology [Category] 치료제, [키워드] addition ADP-ribose approaches base bind binding binding ability binding affinity binding pocket biochemical biological function Biological functions chromatin co-crystallized conditions DNA repair domain domains genomic highlight in viral investigated involved Ligand MERS-CoV metabolism metabolite metabolites Middle East nicotinamide adenine dinucleotide NMR spectroscopy observation physiological temperature provide recognize Replication Small molecules stability variety viral infection Viral proteins X-ray crystallography [DOI] 10.1038/s42003-020-01633-6 PMC 바로가기 [Article Type] Article
A Global Review on Short Peptides: Frontiers and Perspectives †Review Published on 2021-01-152022-10-30 Journal: Molecules [Category] COVID-19, [키워드] altered peptide ligands ant/super/agonists Aptamers bilayer interactions Biological functions Cancer cell-penetrating peptides constrained amino acids and peptide (bio)mimetics cosmeceuticals cross diketopiperazine Diseases disorders domain drug design and drug/gene delivery feature improvement in silico include independent information Insulin therapy interactions interfere Ligand limitations membranes methodology molecular overcome peptide peptide-based peptides problem Protein researcher review SARS-CoV-2 short peptides Signaling SWOT analysis synthesis targets therapy unique Vaccines [DOI] 10.3390/molecules26020430 PMC 바로가기 [Article Type] Review
Role of Vitamin K-Dependent Factors Protein S and GAS6 and TAM Receptors in SARS-CoV-2 Infection and COVID-19-Associated ImmunothrombosisReview Published on 2020-09-282022-10-31 Journal: Cells [Category] COVID-19, [키워드] AXL Biological functions Cancer Coagulation complications consequence COVID-19 COVID-19 patients Endothelium Factor GAS6 immune response immune system immunothrombosis infect cells Inflammation inflammatory disease involved kinase MERTK Pathologies pathology progression PROS1 protein S receptor reported Respiratory failure role SARS-CoV-2 SARS-COV-2 infection Signaling Stage TAM the disease Treatment TYRO3 tyrosine tyrosine kinase receptor Vascular Vascular function viral infection Vitamin [DOI] 10.3390/cells9102186 PMC 바로가기 [Article Type] Review
Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines199 Published on 2020-09-232022-10-29 Journal: Open Biology [Category] COVID-19, SARS, [키워드] Biological functions cellular component changes in characterized coronavirus Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 disease severity Critical cytokine cytokine level cytokine levels disease distress hallmark heart failure highlight Hyperinflammatory IFN-γ IL-6 immune response interferons interleukin Liver damage modulate morbidity and mortality multi-organ failure Necrosis pandemic pathology potential therapy pro-inflammatory cytokine Prognosis renal SARS Shock syndrome the cytokine storm the disease TNF-α type I [DOI] 10.1098/rsob.200160 PMC 바로가기 [Article Type] 199
Advances in RNA cytosine-5 methylation: detection, regulatory mechanisms, biological functions and links to cancerRNA 시토신-5 메틸화의 발전: 탐지, 조절 메커니즘, 생물학적 기능 및 암과의 연관성Review Published on 2020-09-142022-08-07 Journal: Biomarker Research [Category] Biochemistry, [키워드] 5-methylcytosine accumulating advance approach biological function Biological functions Cancer cancer pathogenesis cancer treatment catalytic cellular distribution cellular processe Detection techniques disadvantage Disadvantages distribution Epitranscriptome Evidence functional consequence functional consequences mechanism mechanisms Modification molecular mRNAs posttranscriptional modification progression Regulatory RNA RNA methylation RNA modification RNAs rRNA rRNAs single-nucleotide substrates Transcriptome tRNAs tumorigenesis vault RNAs Viral Viral RNA viral RNAs [DOI] 10.1186/s40364-020-00225-0 PMC 바로가기 [Article Type] Review
Functional diversification accompanies gene family expansion of MED2 homologs in Candida albicans기능적 다양화는 칸디다 알비칸스에서 MED2 상동체의 유전자 패밀리 확장을 수반합니다Research Article Published on 2018-04-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 3’ end accompany addressed affected aggregation biological function Biological functions buffer Candida Candida albican Candida albicans Cell Combination commensal complex component conserved contribute contributed correlated did not produce difficulty domain duplication Effect entire gene example expansion expression facilitate family members function functional functions Gene duplication gene families gene family generate Genes genetic diversity greater growth homolog identify INDEL individual gene individual genes induced Infection influence involved killing Macrophage mapped mechanism mediator Mutation natural selection neofunctionalization occurred opportunistic pathogen organism overlap pathogen pathogenic phenotype Phenotypes phenotypic phenotypic effect polymorphic site Positive selection promoter provide question regulate regulated Regulation Regulatory repeated selective pressure sequence sequence similarity Specific strain Strains subfunctionalization subunit sucrose traits transcriptional transcriptional regulator unique Variability variant virulence were assessed yeast [DOI] 10.1371/journal.pgen.1007326 PMC 바로가기 [Article Type] Research Article
Digital Genotyping of Macrosatellites and Multicopy Genes Reveals Novel Biological Functions Associated with Copy Number Variation of Large Tandem RepeatsMacrosatellites 및 Multicopy 유전자의 디지털 유전형 분석은 대규모 직렬 반복의 복사 수 변화와 관련된 새로운 생물학적 기능을 나타냅니다.Research Article Published on 2014-06-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accompanied accumulation accumulations Analysis approach approaches association Biological Biological functions changes in copy copy number correlation Digital DNA methylation DNA methylation levels Effect Effects eukaryotic Evolution example expansion extreme FIVE focus fraction function functional Gene Expression Genes Genome genome assembly Genome-wide association study genomes genomic Genotype GWAS hallmark hallmarks human population human populations humans identify include information lead Local loci majority mechanism modulating non-human primates novel nucleotide number Organisms phenotypic diversity Population Previous studies Repeat repeated selective selective pressure sequence significantly single nucleotide single nucleotide variation SNP SNPs suppression tandem tandem repeat tandem repeats transgenic utility Variability variant variants Variation variations [DOI] 10.1371/journal.pgen.1004418 PMC 바로가기 [Article Type] Research Article