Cancer cells – Page 5 – Communicable Diseases Research

Immune Checkpoints in Viral Infections

Review

Published on 2020-09-212022-10-28
Journal: Viruses [Category] COVID-19,

Cytotoxic and Anti-Plasmodial Activities of Stephania dielsiana Y.C. Wu Extracts and the Isolated Compounds

스테파니아 디엘시아나 Y.C. 우 추출물 및 분리된 화합물의 세포독성 및 항말라리아 활성

Article

Published on 2020-08-182024-08-11
Journal: Molecules [Category] 말라리아,

[키워드] aporphine alkaloids Aurora kinase Cancer cells malaria Plasmodium falciparum Stephania dielsiana Y.C. Wu
[DOI] 10.3390/molecules25163755 PMC 바로가기 [Article Type] Article

Immunoglobulin M: An Ancient Antiviral Weapon – Rediscovered

Immunology

Published on 2020-08-112022-11-01
Journal: Frontiers in Immunology [Category] COVID-19,

[키워드] acquisition adaptive antibody Apoptosis asymmetric Cancer cells Cell Evolution host protein IgM IgM function IgM structure Immunity immunization immunodeficiency virus Immunoglobulin include Influenza virus inhibitor Macrophage monomer mucosal murine models non-human primates passive mucosal immunization with IgM pathogen invasion Pathogens Plasma cell preserved Prevent prevention of mucosal virus transmission by IgM produced promote raise recent recombinant monoclonal IgM released respond second shown Somatic hypermutation spleen thought Transmission Vaccine vaccine-induced long-lived IgM plasma cells vertebrates virus weapon
[DOI] 10.3389/fimmu.2020.01943 PMC 바로가기 [Article Type] Immunology

Drug repurposing against COVID-19: focus on anticancer agents

Review

Published on 2020-05-122022-10-29
Journal: Journal of Experimental & Clinical Cancer Research : CR [Category] COVID-19, MERS, SARS,

Neocentromeres Provide Chromosome Segregation Accuracy and Centromere Clustering to Multiple Loci along a Candida albicans Chromosome

네오센트로미어는 칸디다 알비칸스 염색체를 따라 여러 유전자좌에 염색체 분리 정확도 및 중심체 클러스터링을 제공합니다

Research Article

Published on 2016-09-232022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Accuracy adaptation addition approach assembly benefit Cancer cancer cell Cancer cells cancers Candida Candida albican Candida albicans caused Cell cell division centromere change Chemotherapy chromosome chromosome 5 chromosome segregation chromosomes Cluster Clustering complexes consequence Contact copy number de novo defined disease DNA DNA sequence drug resistance error rate exhibit function functional functions Gene Expression Genes Genome greater independent independent of instance kinetochore leads Like loci maintain mechanisms Multiple nuclear nucleus observation occur organism protein complex Proteins provide recent reduced Region reorganization required segregation speciation stability Support the cells three-dimensional structure Transcription yeast
[DOI] 10.1371/journal.pgen.1006317 PMC 바로가기 [Article Type] Research Article

Regulation of p53 and Rb Links the Alternative NF-κB Pathway to EZH2 Expression and Cell Senescence

p53 및 Rb의 조절은 대체 NF-κB 경로를 EZH2 발현 및 세포 노화에 연결합니다

Research Article

Published on 2014-09-252022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activated Activation alternative NF-κB pathway Analysis ANAPC1 c-Rel cancer cell Cancer cells CD40 CD40 ligand CD40L CDK4 CDK6 Cell cell cycle cell senescence cellular senescence ChIP chromatin immunoprecipitation chronic chronic lymphocytic leukemia classical complexes Crosstalk de-repression defined Degradation DEK dependent on Effect effector effectors expression EZH2 fibroblasts Hematological malignancies Hematological malignancy IKK IKKα induce inhibit investigated IκB IκBα knockdown leads Loss Lymphocytic leukemia mechanism microarray analysis microenvironment NEMO NF-κB NF-κB inducing kinase NF-κB pathway NF-κB2 NIK or canonical oxygen p100 p21WAF1 p52 p53 pathway patients phenotype Phosphorylation polycomb protein promote protein stability provide PSMA5 quantitative PCR RacGAP1 reactive oxygen species reactive oxygen specy regulate Regulation regulatory subunit RELA RelB repression retinoblastoma retinoblastoma protein ROS SASP senescence senescent siRNA solid tumors stability stimulated subset subunit subunits suppress suppression target gene Target genes the cell Tumor tumor suppressor tumorigenesis tumors tumour suppressor turn western blot Western blot analyses Western blot analysis wild type
[DOI] 10.1371/journal.pgen.1004642 PMC 바로가기 [Article Type] Research Article

A Mechanism of Gene Amplification Driven by Small DNA Fragments

작은 DNA 조각에 의한 유전자 증폭 메커니즘

Research Article

Published on 2012-12-132022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] amplification amplified amplify annealing Author Cancer cancer cell Cancer cells capture cause Cell chromosomal chromosomal DNA chromosomal region contribute copy number degenerative dependent on detected disorders DNA DNA amplification DNA fragment driving duplication Efficiency elevated event events expression Extracellular Factor favor found fragment Frequency gene amplification Genetic variation genomic homology Human increase independent independent of initiated involved loci mechanism molecular molecular mechanism molecular mechanisms nucleotide nucleotides occur oligonucleotide Organisms Patients with cancer polymorphism Rad1 Rad51 Rad52 regions S. cerevisiae Saccharomyces cerevisiae serum single-stranded stimulate Trigger triggered Variation yeast
[DOI] 10.1371/journal.pgen.1003119 PMC 바로가기 [Article Type] Research Article

Human Chitinases and Chitinase-Like Proteins as Indicators for Inflammation and Cancer

염증 및 암에 대한 지표로서의 인간 키티나제 및 키티나제 유사 단백질

Review

Published on 2007-05-032022-08-07
Journal: Biomarker Insights [Category] Biochemistry,

[키워드] a major Activation AMCase Arthritis Asthma atherosclerotic atherosclerotic plaques Biomarker C-terminal chitin-binding domain Cancer cells cell proliferation chitin chitinase chitinase-like protein chitinase-like proteins chitinases Chitotriosidase chondrocyte chondrocytes circulation cirrhosis contribute cytokine detected diagnostic diagnostic and prognostic marker enzymatic activity enzyme epithelial cells examination family fibrosis found Gaucher Disease glucocorticoid Glucocorticoid treatment Glucocorticoids Glyco_18 Domain Glyco_18 domain-containing protein hepatic fibrosis Human human diseases Human Glyco_18 domain-containing proteins hydrolyse hydrolytic activity IL-4 Indicator Inflammatory bowel disease inherited lysosomal storage involved lipid-laden macrophage lipid-laden macrophages Macrophage macrophage activation macrophages marker mechanism mediators Migration murine murine lectin neutrophil Neutrophils Non-invasive Osteoarthritis overproduced Pathogenesis Patient Prognostic marker progression Protein Proteins regulated rheumatoid arthritis sensitivity Serum level SI-CLP Side effect Side effects solid tumors synovial cells Th2 cytokine Th2 cytokine IL-4 Th2-environment the cell therapy tissue tissues Tumor tumors unique upregulated YKL protein YKL proteins YKL-39 YKL-40 YM1
PMC 바로가기 [Article Type] Review