CD4+ T cells – Page 5 – Communicable Diseases Research

SARS-CoV-2-specific T cell responses and correlations with COVID-19 patient predisposition

SARS-CoV-2-특이 T 세포 반응 및 COVID-19 환자 소인과의 상관관계

Clinical Trial

Published on 2020-12-012022-08-31
Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 바이오마커, 임상, 치료법,

Divergent SARS-CoV-2-specific T- and B-cell responses in severe but not mild COVID-19 patients

Clinical Trial

Published on 2020-12-012023-07-12
Journal: European Journal of Immunology [Category] SARS,

[키워드] Antibody Response CD4+ T cells COVID-19 IgG SARS-CoV-2
[DOI] 10.1002/eji.202048908 [Article Type] Clinical Trial

Thymosin Alpha 1 Reduces the Mortality of Severe Coronavirus Disease 2019 by Restoration of Lymphocytopenia and Reversion of Exhausted T Cells

티모신 알파 1은 림프구 감소증의 회복과 소진된 T 세포의 회복을 통해 심각한 코로나바이러스 질병 2019의 사망률을 감소시킵니다

Article

Published on 2020-11-192022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] (PD-1 Alpha benefit Blood CD4+ T cell CD4+ T cells CD4+ T-cell CD8+ CD8+ T cell CD8+ T cells circulation clinical benefit clinical benefits Clinical outcome clinical outcomes conditions COVID-19 COVID-19 patient COVID-19 patients domain elderly patients expression flow cytometry hospital immune immune reconstitution immune response Immunoglobulin Infection less lymphocytopenia marker mechanism mononuclear cell mononuclear cells Mortality mucin Patient PD-1 Peripheral blood Peripheral blood mononuclear cells protein 3 reduced respiratory restoration restored reversed reversion SARS-CoV-2 Severe acute respiratory syndrome severe COVID-19 severe COVID-19 patient severe COVID-19 patients significantly T cell T cells T-cell T-cell exhaustion T-cell receptor thymosin thymosin alpha 1 Treatment treatment for COVID-19 Viral viral infection viral infections was measured Wuhan Wuhan, China
[DOI] 10.1093/cid/ciaa630 PMC 바로가기 [Article Type] Article

CD4 and CD8 Lymphocyte Counts as Surrogate Early Markers for Progression in SARS-CoV-2 Pneumonia: A Prospective Study

CD4 및 CD8 림프구는 SARS-CoV-2 폐렴의 진행을 위한 대리 조기 마커로 계산: 전향적 연구

Article

Published on 2020-11-092022-09-10
Journal: Viruses [Category] SARS, 바이오마커,

[키워드] Admission appear Area association AUC best bilateral pneumonia CD3+CD4+ CD3+CD8+ CD4 CD4+ CD4+ T cells CD8 Complete count COVID-19 criteria Critical Curve decrease demographics disease dysregulation evaluate Evolution Factor Follow-up high correlation Hospital admission hospital discharge involved IQR Laboratory tests Linear regression model linear regression models lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes median medical history parameter pathophysiology Patient patients with SARS-CoV-2 Pneumonia Predictive Predictive value predictive values Prospective prospective cohort study receiver receiver operating characteristic recruited ROC ROC Curve ROC curves SARS-CoV-2 SARS-COV-2 infection severe disease severity subset suggested surrogate T cell T cells Treatment were recorded were used
[DOI] 10.3390/v12111277 PMC 바로가기 [Article Type] Article

Systematic Analysis of Coronavirus Disease 2019 (COVID-19) Receptor ACE2 in Malignant Tumors: Pan-Cancer Analysis

Molecular Biosciences

Published on 2020-10-232022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

[키워드] ACE2 ACE2 expression ACE2 gene Affect Analysis analyzed B cell breast cancer patients Cancer cancer cell lines cancer patient cancer type cancers carried CD4+ T cells CD8+ T cells China Clinical prognosis conducted Coronavirus disease 2019 correlated correlation COVID-19 COX dendritic cells determine DNA elevated evaluated expressed expression expression level Frequency Functional enrichment analysis global pandemic GSEA HLA gene immune immune infiltration indicated infiltrating investigated Kaplan-Meier lung Macrophage macrophages malignant malignant tumor medium mismatch Mutation Neutrophils not correlated observational study organ Pan-cancer analysis pathway patients with pneumonia positive correlation Prognosis receptor regression analysis repair reported Result risk factor SARS-CoV-2 significantly Spread survival systematic analysis TCGA tested the SARS-CoV-2 virus tissues TMB Tumor tumors with COVID-19
[DOI] 10.3389/fmolb.2020.569414 PMC 바로가기 [Article Type] Molecular Biosciences

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

Research

Published on 2020-09-302022-10-05
Journal: Nature [Category] 유전자 메커니즘, 임상, 치료기술, 치료제,

[키워드] acute respiratory syndrome Adults age antibody Antibody Response BNT162b1 CD4+ CD4+ T cell CD4+ T cells CD8+ CD8+ T cell Cohort Concentration coronavirus disease Coronavirus-2 COVID-19 COVID-19 vaccine cytokine response dose effective elicit elicited ENCODE fraction geometric mean healthy immune response individual individuals mechanisms MOST mRNA vaccine neutralized non-randomized nucleoside-modified mRNA observer-blinded Open-label pandemic participant placebo-controlled produced PROTECT pseudovirus RBD RBD-binding IgG Receptor binding domain reported response responses robust SARS-CoV-2 SARS-CoV-2 spike variants sera serum Spread T cell T cell response T helper the SARS-CoV-2 titre Tolerability Trial vaccination Vaccine vaccine trial
[DOI] 10.1038/s41586-020-2814-7 [Article Type] Research

Association of Peripheral Lymphocyte and the Subset Levels With the Progression and Mortality of COVID-19: A Systematic Review and Meta-Analysis

Medicine

Published on 2020-09-252022-10-31
Journal: Frontiers in Medicine [Category] COVID-19,

Immunological and inflammatory profiles in mild and severe cases of COVID-19

Article

Published on 2020-07-082022-10-04
Journal: Nature Communications [Category] SARS, 치료기술, 치료법,

[키워드] Activation Acute inflammation CD4+ T cells CD8+ T cell clinical expression COVID-19 COVID-19 patient cytotoxicity defined distribution dysregulation epidemiological Express expression fatality feature hospitalized patient Immune cell Immune profile Immunophenotyping Infection infiltration Inflammatory inhibitory lung tissue lymphopenia macrophages management marker Mild Mortality NK cells occur outcome Pathogenesis pathogenesis of SARS-CoV-2 Patient patients with COVID-19 profile SARS-CoV-2 RNA selective Severe case severe COVID-19 disease severe COVID-19 patients severe disease subset T cell T-cell T-cell activation target therapeutic intervention Treatment viral infection Virological with COVID-19 with mild disease
[DOI] 10.1038/s41467-020-17240-2 PMC 바로가기 [Article Type] Article

Immunologic dysfunction contributes to the otitis prone condition

article

Published on 2020-06-302024-09-01
Journal: The Journal of infection [Category] 폐렴구균 감염증,

[키워드] acute otitis media Adaptive immunity antibody antigen presenting cells B cells CD4+ T cells Haemophilus influenzae Innate immunity Moraxella catarrhalis Otitis prone Streptococcus pneumoniae
[Article Type] article

Nasal Pneumococcal Density Is Associated with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens

비강 폐렴구균 밀도는 미세 흡인 및 세균 병원체에 대한 인간 폐포 대식세포의 반응성 증가와 관련이 있다.

Article

Published on 2020-02-012024-08-24
Journal: American Journal of Respiratory and Critical Care Medicine [Category] 폐렴구균 감염증,

[키워드] Alveolar macrophages CD4+ T cells interferon-γ microaspiration. Streptococcus pneumoniae nasopharyngeal colonization