Manufacturing and Management of CAR T-Cell Therapy in “COVID-19’s Time”: Central Versus Point of Care Proposals"COVID-19 시대"의 CAR T-세포 치료제 제조 및 관리: 중앙 대 진료 현장 제안Review Published on 2020-10-152022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단, [키워드] administration adoptive cell immunotherapy affected antigen receptor attenuate CAR caused Cell cell therapies chimeric antigen receptor COVID-19 pandemic criteria curative treatment cytokine Cytokine release syndrome focus good manufacturing practice Health Service Health services hematologic hospital hospitalized patients Infection Intervention malignancies manufacturing process neurotoxicity Patient patient selection pharmaceutical industry Point Prevent Prophylactic reduction resource respiratory Safe SARS-CoV-2 SARS-CoV-2 coronavirus saturation Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 supply chains T-cell T-cells Therapies therapy Tocilizumab Treatment [DOI] 10.3389/fimmu.2020.573179 PMC 바로가기 [Article Type] Review
Recommendations for screening, monitoring, prevention, and prophylaxis of infections in adult and pediatric patients receiving CAR T-cell therapy: a position paperReview Published on 2020-09-262023-08-30 Journal: Infection [Category] E형 간염, [키워드] B-cell acute lymphoblastic leukemia Bacterial infections chimeric antigen receptor diffuse large B-cell lymphoma fungal infections viral infections [DOI] 10.1007/s15010-020-01521-5 PMC 바로가기 [Article Type] Review
Clinical characterization and risk factors associated with cytokine release syndrome induced by COVID-19 and chimeric antigen receptor T-cell therapy Research Published on 2020-09-172022-10-05 Journal: Bone marrow transplantation [Category] SARS, 임상, 치료법, [키워드] CAR-T CAR-T therapy chimeric antigen receptor clinical Clinical characteristics Complication coronavirus disease correlated COVID-19 COVID-19 group CRS Cytokine release syndrome Cytokines demonstrated diagnose Disease progression dramatic increase evaluated excessive immune response GRADE had more hypertension IFN-γ IL-10 IL-2 IL-6 independent risk factor induce Inflammatory response intensity life-threatening management patients Retrospective study risk factor severe COVID-19 significantly higher significantly more T-cell therapy TNF-α Treatment Viral load [DOI] 10.1038/s41409-020-01060-5 [Article Type] Research
IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome530 Published on 2020-09-082022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS, [키워드] accompanied Activation acute respiratory distress ARDS Bacteria Bacterial Bacterial infection Bacterial sepsis blockade Burn causes chimeric antigen receptor Clinical efficacy clinical manifestation coagulation cascade COVID-19 COVID-19 patient Critical CRS cytokine cytokine production Cytokine release syndrome diagnosed dysfunction elevated endothelial Endothelial cell Endothelial dysfunction endotheliopathy exhibited highlight Human monoclonal antibody Hyperinflammatory hyperinflammatory responses IL-10 IL-6 IL-6 signaling IL-8 Immunotherapy in vitro data indicate induce infections Inflammation involved life-threatening MCP-1 molecular mechanism monocyte chemotactic protein-1 Pathogenesis Patient Proinflammatory cytokine promoted robust Sepsis severe COVID-19 patient severe COVID-19 patients Signaling Significance syndrome systemic inflammatory response T cell therapy Tocilizumab trans-signaling Treatment vascular endothelial cell [DOI] 10.1073/pnas.2010229117 PMC 바로가기 [Article Type] 530
Harnessing Memory NK Cell to Protect Against COVID-19Pharmacology Published on 2020-08-202022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] adaptive adaptive NK cell addition Against Allogeneic antiviral activity approach Cell chemokine chimeric antigen receptor coronavirus disease COVID-19 cytotoxicity early stage effective antiviral treatment Evidence exhibit function globe HCMV Human Cytomegalovirus hyper inflammation immune system immunization immunopathology Immunotherapy imperative Infection infections Inflammatory cytokine innate immune system Interaction lung tissue memory memory NK cell MERS natural NK cell NK cells offer pathogen-specific Perspective Prevalence progression Proinflammatory cytokine protective role public health crisis residue respiratory infection Responder responses SARS-CoV-2 severe lung pathology subset suppresse therapeutic potential Treatment vaccination Vaccine vaccine-induced immune response viral infections virus viruses [DOI] 10.3389/fphar.2020.01309 PMC 바로가기 [Article Type] Pharmacology
CAR T-cell treatment during the COVID-19 pandemic: Management strategies and challengesReview article Published on 2020-08-012022-10-05 Journal: Current research in translational medicine [Category] SARS, 치료법, [키워드] acute respiratory syndrome affecting CAR CAR-T CAR-T therapy CAR-T treatment caused chimeric antigen receptor Chimeric antigen receptor T-cells coronavirus coronavirus disease COVID-19 COVID-19 pandemic Cytokine release syndrome Disease progression Factor healthcare service hematologic Hematological malignancies Immunocompromised Infection malignancies pandemic Patient Prevent Protective Relapsed/refractory hematological malignancies SARS-CoV-2 T-cell T-cells therapy Treatment [DOI] 10.1016/j.retram.2020.06.003 [Article Type] Review article
Evaluation of a Fully Human, Hepatitis B Virus-Specific Chimeric Antigen Receptor in an Immunocompetent Mouse ModelArticle Published on 2019-05-082023-06-16 Journal: Molecular therapy : the journal of the American So [Category] B형 간염, Fulltext, [키워드] AAV CAR chimeric antigen receptor HBV immunocompetent mice Immunotherapy rejection scFv expression. T cell therapy [DOI] 10.1016/j.ymthe.2019.02.001 PMC 바로가기
CAR T Cells for Solid Tumors: New Strategies for Finding, Infiltrating, and Surviving in the Tumor MicroenvironmentReview Published on 2019-02-052023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] adoptive T cell immunotherapy chimeric antigen receptor engineered T cells solid tumors T cell [DOI] 10.3389/fimmu.2019.00128 PMC 바로가기 [Article Type] Review
Engineering CAR-T cellsCAR-T 세포 공학Review Published on 2017-06-242022-08-07 Journal: Biomarker Research [Category] Biochemistry, [키워드] Antigen antigen receptor antigen receptors B cell Blood CAR-T CAR-T cell CAR-T cells cells chimeric chimeric antigen receptor Chimeric antigen receptor redirected T cells donors Engineering Evolution Hematologic malignancy investigated malignancies outcome Patient patients Production receptor receptors resolved solid tumors Structure T cell T cells tumors Viral vector widespread [DOI] 10.1186/s40364-017-0102-y PMC 바로가기 [Article Type] Review