Genome-wide association study of resistance to Mycobacterium tuberculosis infection identifies a locus at 10q26.2 in three distinct populationsMycobacterium tuberculosis 감염에 대한 내성에 대한 게놈 차원의 연관성 연구는 3개의 별개 집단에서 10q26.2의 유전자좌를 확인합니다Research Article Published on 2021-03-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 95%CI activating ADAM12 allele Analysis association C10orf90 characterized chromosome Cluster Cohort Contact decreased expression defined Diagnosis ENCODE Endemic enrolled epidemiological Evidence exposure to France French Genome-wide association study genome-wide significant genotyped household contact household contacts identify IFN-γ independent individual infected individual infected individuals Infection inter-individual interferon Interferon-gamma intronic region lead locus Lymphocytes monocyte Monocytes Mycobacterium tuberculosis natural history outcome p53 patients performed Population populations positive proportion Protective Release replicated selected shown skin Skin test South Africa subject Suppressor gene Test Th17 transcription factor TST Tuberculin tuberculin skin test Tuberculosis Tumor tumor suppressor tumor suppressor gene ubiquitin ligase upstream Variability variant variants [DOI] 10.1371/journal.pgen.1009392 PMC 바로가기 [Article Type] Research Article
A genomic region associated with protection against severe COVID-19 is inherited from Neandertals심각한 COVID-19에 대한 보호와 관련된 게놈 영역은 네안데르탈인에게서 유전됩니다419 Published on 2021-03-022022-08-13 Journal: Proceedings of the National Academy of Sciences of [Category] 유전자 메커니즘, [키워드] activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 association chromosome coronavirus described ENCODE enzyme Enzymes Eurasia Frequency Genetic genetic association genetic risk factor genetics genomic region GenOMICC Haplotype Human genome increase Infection intensive care moderate Neandertals New OAS1 occur Protective Protein reduction in Region Relative risk respiratory risk RNA viruses SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe COVID-19 severe disease shown Significance virus with COVID-19 [DOI] 10.1073/pnas.2026309118 PMC 바로가기 [Article Type] 419
The impact of global and local Polynesian genetic ancestry on complex traits in Native Hawaiians하와이 원주민의 복잡한 형질에 대한 전 세계 및 지역 폴리네시아 유전 조상의 영향Research Article Published on 2021-02-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adjust Affect association binary trait Biomarkers BMI Cancer cancers capture captures cardiometabolic cardiometabolic traits cardiovascular disease cardiovascular diseases chromosomal chromosome Cohort Community complex covariate Culture diabete diabetes Diabetic disease disease risk disparity driven by epidemiological studies European evaluated Factor Genetic genetic factors genetic information genetic risk factor genetic risk factors genetic susceptibility genomic Hawaiian Islands Health heart failure identify increase in increased risk independent individual individuals Local mechanism Native obesity Perspective populations prevalent proportion Quantitative Questionnaires reducing replicate Replication risk risk factor Risk factors Samoa small sample size SNP T2D tested type-2 diabetes variant while [DOI] 10.1371/journal.pgen.1009273 PMC 바로가기 [Article Type] Research Article
Genetic variants are identified to increase risk of COVID-19 related mortality from UK Biobank dataUK Biobank 데이터에서 유전적 변이가 COVID-19 관련 사망 위험을 증가시키는 것으로 확인되었습니다.Primary Research Published on 2021-02-032022-09-10 Journal: Human Genomics [Category] MERS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 associations bronchial epithelial cell cardiovascular disease cardiovascular diseases caused chromosome chromosomes CLUAP1 coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mortality dataset death deaths DES DNAH7 downregulated gene dysfunction ENhance epithelial cells ethnic group Ethnic groups Factors Genetic genetic factors Genetic variant genetic variants Genome-wide association study genome-wide significant GWAS heterogeneous Host Host genetic factors human bronchial epithelial cells identify increased risk infected case infecting innate immune system interactions male mitochondrial mitochondrial dysfunction molecular Mortality pathogenesis of COVID-19 power Replication reported respiratory Result risk factor risk of COVID-19 risk of death SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity significantly SPEG STXBP5 supplementary material susceptibility susceptibility loci the patient therapeutic options thromboembolic thromboembolic disease TOMM7 Traditional UK biobank UK Biobank data variant WSB1 [DOI] 10.1186/s40246-021-00306-7 PMC 바로가기 [Article Type] Primary Research
Chromosome 3 cluster rs11385942 variant links complement activation with severe COVID-19염색체 3 클러스터 rs11385942 변이체 링크는 심각한 COVID-19로 활성화를 보완합니다Article Published on 2021-02-012022-09-11 Journal: Journal of autoimmunity [Category] 변종, 유전자 메커니즘, [키워드] ABO ABO group Activation association Blood Group C5a carried carrier carriers cascade chromosome chromosome 3 circulating Cluster complement Complement activation Complement cascade COVID-19 COVID-19 patients COVID-19 severity disease severity European GA variant. gene cluster genetic data genetic susceptibility Genetic variation hospitalized patient increased risk mechanism Patient plasma Plasma levels remained risk risk allele rs11385942 G> SC5b-9 severe COVID-19 severity terminal complement complex upper airway upper airways variant Variation Viral Viral load with COVID-19 [DOI] 10.1016/j.jaut.2021.102595 PMC 바로가기 [Article Type] Article
Clinical Practice Guidelines for Prenatal Aneuploidy Screening and Diagnostic Testing from Korean Society of Maternal-Fetal Medicine: (2) Invasive Diagnostic Testing for Fetal Chromosomal AbnormalitiesPractice Guideline Published on 2021-01-252023-06-12 Journal: Journal of Korean medical science [Category] B형 간염, [키워드] Amniocentesis Chorionic Villus Sampling chromosome CVs Invasive Prenatal Diagnostic Testing Microarray [DOI] 10.3346/jkms.2021.36.e26 PMC 바로가기 [Article Type] Practice Guideline
Shorter telomere lengths in patients with severe COVID-19 disease중증 코로나19 환자의 텔로미어 길이 감소Research Paper Published on 2021-01-152022-09-10 Journal: Aging (Albany NY) [Category] 유전자 메커니즘, [키워드] age aging Cell cell types chromosome contribute COVID-19 COVID-19 patient disease higher risk highest impair incidence increase individual infect limit Lymphocytes maintain manifestation mechanism molecular Mortality older patient older patients Pathologies pathway Patient Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes Protective regeneration regenerative SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus severe COVID-19 severe COVID-19 disease severe manifestations of COVID-19 severity severity of COVID-19 Structure telomere telomeres the disease tissue tissue homeostasis tissues Trigger [DOI] 10.18632/aging.202463 PMC 바로가기 [Article Type] Research Paper
Genetic Dissection of the Regulatory Mechanisms of Ace2 in the Infected Mouse LungImmunology Published on 2021-01-082022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] ACE2 ACE2 sequence acute lung injury Analysis analyzed approaches Bayesian Body weight loss BXD family caused chromosome core Coronaviruses defined disease disease risk disease severity Dissection enzyme epithelial cells expression expression level function gene co-expression network gene product H1N1 Hierarchical Host host response identify include Infection Influenza influenza A virus lung Lung infection Lung injury MAPK membrane-bound MERS-CoV mice modulate molecular morbidity and mortality mouse mRNA level network analysis outcome parental participated potential therapeutic target primary human airway Protein pulmonary quantified respiratory diseases RNA-Seq SARS-CoV SARS-CoV-2 Sepsis severity signaling pathways significantly strain TNF transcript Transcriptome variant viral infection viral infections Viral load viremia network weight loss WGCNA [DOI] 10.3389/fimmu.2020.607314 PMC 바로가기 [Article Type] Immunology
A bacterial artificial chromosome (BAC)-vectored noninfectious replicon of SARS-CoV-2SARS-CoV-2의 박테리아 인공 염색체(BAC) 벡터 비감염성 복제Article Published on 2021-01-012022-09-11 Journal: Antiviral Research [Category] SARS, 치료제, [키워드] Antiviral antiviral agent Antiviral agents antiviral protein BAC Bacterial bacterial artificial chromosome biosafety biosafety level cell lines chromosome COVID-19 pandemic daclatasvir desired mutation desired mutations envelope facilitate hepatitis C hepatitis C virus IFN-α in viral In-vitro inhibitor Interferon alpha membrane nCoV overexpression Plasmid Protein Remdesivir replicated Replication replicon reporter reporter gene RNA SARS-CoV-2 secreted sofosbuvir structural genes subgenomic mRNA transfection Viral viral subgenomic mRNA Virus-host interactions ZAP Zinc [DOI] 10.1016/j.antiviral.2020.104974 PMC 바로가기 [Article Type] Article
Elementary Laboratory Assays as Biomarkers of Ageing: Support for Treatment of COVID-19?노화의 바이오마커로서의 기초 실험실 분석: COVID-19 치료 지원?Review Published on 2021-01-012022-09-11 Journal: Gerontology [Category] MERS, 바이오마커, [키워드] ABO blood type Adolescence age Ageing Analysis approach best Biomarker blood type C5a cause causes changes in chromosome chronological age Cluster death disease fitness focus Health status healthy Infection information laboratory assay laboratory assays large cohort life Life expectancy Medical laboratory Metrics multitude network performed plasma Plasma levels risk risk factor SARS CoV-2 SARS CoV-2 infection senescence Stage statistical the stage timeline with COVID-19 Youth [DOI] 10.1159/000517659 PMC 바로가기 [Article Type] Review