Complement activation – Page 5 – Communicable Diseases Research

Markers of Polyfunctional SARS-CoV-2 Antibodies in Convalescent Plasma

회복기 혈장 내 다작용성 SARS-CoV-2 항체 마커

Research Article

Published on 2021-04-202022-09-10
Journal: mBio [Category] MERS, SARS, 변종, 진단,

COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune Functions

COVID-19 중증도는 차등 항체 Fc 매개 선천 면역 기능과 관련이 있습니다

Observation

Published on 2021-04-202022-09-10
Journal: mBio [Category] MERS, SARS, 바이오마커, 진단,

[키워드] Activation ADCC ADCD ADCP Anti-RBD antibodies Anti-RBD antibody Anti-S1 anti-SARS-CoV-2 antibodies binding antibody antibody-dependent cell-mediated cytotoxicity antibody-dependent complement deposition Cell-mediated cytotoxicity complement Complement activation contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients COVID-19 severity COVID-19 therapeutics cytotoxicity Efficacy and safety elicit elicited Fc receptor Fc receptors Fc-mediated functions feature function hospitalized COVID-19 patient hospitalized COVID-19 patients hyperinflammation immune functions induce Inflammation Innate innate immune function neutralization pathogen pathogen clearance pathophysiological mechanism pathophysiological mechanisms phagocytosis SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines severity specific antibody systemic inflammation tested understanding vaccine-induced antibody
[DOI] 10.1128/mBio.00281-21 PMC 바로가기 [Article Type] Observation

Inflammatory stress in SARS-COV-2 associated Acute Kidney Injury

SARS-COV-2 관련 급성 신장 손상의 염증성 스트레스

Review

Published on 2021-04-102022-09-10
Journal: International Journal of Biological Sciences [Category] MERS, SARS, 유전자 메커니즘,

[키워드] (Tocilizumab) Activation Acute kidney injury AKI AMY-101 Angiotensin II antibody C-reactive protein cardiovascular disease clinical evidence complement Complement activation COVID-19 COVID-19 infection COVID-19 patients Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients CRP CRRT cytokine Cytokine storm Cytokines diabetes Ethnicity history of smoking hypertension IL-6 Increasing Infection Inflammation Inflammatory inflammatory pathway inhibitor interleukin interleukin-6 mechanisms monoclonal antibody Older age Pathogenesis pathway Pathways patients with COVID-19 risk factor SARS-COV-2 infection severity of COVID-19 Signaling smoking Stress TGF-β therapy Tocilizumab Treatment Trigger
[DOI] 10.7150/ijbs.58791 PMC 바로가기 [Article Type] Review

SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation

SARS-CoV-2는 JAK1/2 종속 국소 보체 과활성화를 유도합니다.

Research Articles

Published on 2021-04-072022-09-12
Journal: Science Immunology [Category] MERS, SARS, 진단,

[키워드] ACE activated Activation affecting Alternative pathway angiotensin angiotensin converting enzyme Antiviral blocked Bronchoalveolar lavage C3 convertase C3a Cell cell lines clinical manifestation Combination combination therapy complement Complement activation Complement C3 complement component complement system convertase coronavirus disease Coronavirus disease 2019 COVID-19 disease severity disease-causing driver drug entry receptor epithelial cell epithelial cells expressed expression Genes Gut Hyperactivation implicated induce infected cells inhibited inhibitor interferon JAK inhibitor jak inhibitors JAK1 kidney kidneys liver Local lung epithelial Lung epithelial cells Lungs lymphoid normalized not affect pathway Pathways patients processing produced Protein Remdesivir respiratory epithelial cell respiratory epithelial cells ruxolitinib SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Signaling Stat1 the disease tissues transcript Transcription underlie virus
[DOI] 10.1126/sciimmunol.abg0833 PMC 바로가기 [Article Type] Research Articles

Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection

보완 과잉 활성화 및 소비는 SARS-CoV-2 감염의 병원 내 사망률을 예측합니다

Clinical Trial

Published on 2021-03-252022-08-13
Journal: Frontiers in Immunology [Category] SARS, 임상,

[키워드] 95% CI accompanied Activation advanced disease analyzed anaphylatoxin anaphylatoxin C3a C-reactive protein C3a/C3 caused characteristic classical pathways clinical complement Complement activation complement activation and consumption complement inhibitory drug complement inhibitory drugs complement profile complement system Consumption coronavirus coronavirus disease coronavirus disease (COVID-19) covariate COVID-19 COVID-19 related mortality COVID-19 severity Cox model decrease enzyme-immunoassays Evidence Factors ferritin hemolytic hemolytic titration hospital Hospital stay Hospitalized hospitalized COVID-19 patients implicated In-hospital in-hospital mortality Increased Inflammation interleukin interleukin-6 marker Mortality objective Ordinal Scale outcome Outpatient overactivation Pathogenesis patients died PCR-confirmed COVID-19 predictor Primary outcome prospective cohort study Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus secondary outcome severity severity of COVID-19 significantly Support the disease the WHO Thromboinflammation Treatment treatment of COVID-19 turbidimetry uncontrolled were measured WHO ordinal scale
[DOI] 10.3389/fimmu.2021.663187 PMC 바로가기 [Article Type] Clinical Trial

Seroconversion stages COVID19 into distinct pathophysiological states

혈청전환은 COVID19를 별개의 병태생리학적 상태로 단계화합니다.

Research Article

Published on 2021-03-162022-09-10
Journal: eLife [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] Activation Alpha Analysis antibodies Antibody titer Antibody titers B cell subsets Biomarker biosignature clinical trial complement Complement activation COVID19 COVID19 patient cross-sectional Cytokines D-dimer Depletion driving end-organ damage endothelial damage Hematopoiesis heterogeneous heterogenous Hospitalized Human hyperinflammation Hypoalbuminemia IFN Increases increases in interferons knowledge lack ligands Limited Lymphocytes marker molecular mechanism molecular mechanisms Neutrophils NK cells pathophysiological Patient Platelets populations SARS Seroconversion Stage T cell T cells therapeutic intervention thrombotic thrombotic microangiopathy
[DOI] 10.7554/eLife.65508 PMC 바로가기 [Article Type] Research Article

Severe COVID-19: A multifaceted viral vasculopathy syndrome

중증 코로나19: 다면적 바이러스성 혈관병증 증후군

Article

Published on 2021-02-012022-09-11
Journal: Annals of diagnostic pathology [Category] SARS, 유전자 메커니즘, 치료기술, 치료제,

[키워드] activate Activation alveolar macrophage Alveolar macrophages Autopsies basement membrane Beta blunting Brain capillary cascade caspase caspase 3 cellular characteristic circulating circulation coagulation cascade complement Complement activation COVID-19 COVID-19 infection cytokine Cytokine storm Cytokines death docked endocytosed endothelial Endothelial cell endothelial cells Endothelialitis eosin expression fat hematoxylin Hematoxylin and eosin Histopathology host response IL6 IL8 In situ Infection Infectious virus macrophages membrane microangiopathy pathophysiology predict prevalent procoagulant Protein pseudovirion pseudovirions reduplication Release removal response to therapies resulting SARS-CoV-2 septal serious COVID-19 severe COVID-19 spike Spike protein subcutaneous fat syndrome the cytokine storm therapy TNF alpha Viral viral capsid Viral load Viral protein Viral proteins Viral RNA viral spike protein zone
[DOI] 10.1016/j.anndiagpath.2020.151645 PMC 바로가기 [Article Type] Article

Chromosome 3 cluster rs11385942 variant links complement activation with severe COVID-19

염색체 3 클러스터 rs11385942 변이체 링크는 심각한 COVID-19로 활성화를 보완합니다

Article

Published on 2021-02-012022-09-11
Journal: Journal of autoimmunity [Category] 변종, 유전자 메커니즘,

Complement Activation in Kidneys of Patients With COVID-19

COVID-19 환자의 신장에서 보체 활성화

Immunology

Published on 2021-01-292022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술,

[키워드] activated Activation acute kidney failure acute respiratory syndrome affected Alternative pathway analyzed Antigen arteries Arterioles Artery Autopsy basement membrane biopsies biopsy C1q C3c C4d C5b-9 Capillaries capillary Cell classical pathway cleavage clinical setting Coagulation collateral tissue collectin complement Complement activation Complement pathway complement system complement—immunological term complex controls COVID-19 COVID-19 patients Critically ill Critically ill patient critically ill patients CTRL deregulated develop Disseminated intravascular coagulation dominant Endothelial cell endothelial injury Factor Frequency glomerular hemolytic uremic syndrome highest immune cell responses immune response immunohistochemistry In situ hybridization in some infection with COVID-19 Injury innate immune system intravascular coagulation investigated involved kidney Kidney failure kidneys lectin lectin pathway lectin pathway activation lung marker MASP-2 membrane Most patient Most patients nuclear occur opsonization organ pathway Patient patients with COVID-19 PCNA peritubular peritubular capillaries peritubular capillary plasma Platelet Platelets positive platelets Prevent proliferation Protein protocol renal renal arteries renal tissue respiratory SARS-CoV-2 Severe acute respiratory syndrome specimen specimens subsequent therapy Thrombus thrombus formation tissue tissue injury Transplant Treatment triggering uremic syndrome virus viruses with COVID-19 worsening
[DOI] 10.3389/fimmu.2020.594849 PMC 바로가기 [Article Type] Immunology

Complement activation and endothelial perturbation parallel COVID-19 severity and activity

보완 활성화 및 내피 교란은 COVID-19 심각도 및 활동과 병행합니다.

Article

Published on 2021-01-012022-08-31
Journal: Journal of autoimmunity [Category] MERS, SARS, 바이오마커,

[키워드] Activation animal animal models association Biomarker Biomarkers C5a cohort study complement Complement activation complement system contribute coronavirus coronavirus disease coronavirus disease-2019 correlated COVID-19 COVID-19 patients COVID-19 severity disease severity endothelial endothelial damage endotheliopathy Endothelium evaluate evaluated high plasma level high plasma levels Hospital admission hypercoagulability manifestation Mild moderate pathophysiology Patient patients with COVID-19 plasma progression Remission SC5b-9 selectin severe disease severity significantly significantly increased target the disease the patient therapy tissue injury von Willebrand factor were measured
[DOI] 10.1016/j.jaut.2020.102560 PMC 바로가기 [Article Type] Article