A Deep Look Into COVID-19 Severity Through Dynamic Changes in Blood Cytokine Levels혈액 사이토카인 수치의 동적 변화를 통한 COVID-19 심각성 심층 조사Immunology Published on 2021-11-092022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] Analysis can be used change chemokine comprehensive analysis Course COVID-19 COVID-19 patient cytokine cytokine release Cytokines deep disease disease severity dynamic excessive inflammatory response expand FIVE G-CSF GM-CSF groups Growth factors help hyperinflammation ICU identify IFN-α2 IL-10 IL-6 Immunity initial intensive care IP-10 large cohort Level longitudinal M-CSF marker MIG Mortality nine Patient patients with COVID-19 performed Peripheral blood predictor required SARS-CoV-2 severity severity predictors significantly higher significantly increased Stage symptom onset the disease therapy thought TNF-α two group [DOI] 10.3389/fimmu.2021.771609 PMC 바로가기 [Article Type] Immunology
The application framework of big data technology in the COVID-19 epidemic emergency management in local government—a case study of Hainan Province, ChinaResearch Published on 2021-11-042022-10-28 Journal: BMC Public Health [Category] COVID-19, MERS, SARS, [키워드] adopted Analysis Application framework Big data technology China comprehensive analysis country COVID-19 COVID-19 epidemic Data analysis data management Emergency management Epidemic Evidence feasibility Government Hainan Hainan Province include lifecycle limitations Local local government management measure mechanism Migration provide Region Result SARS epidemic semistructured interview Spread stages Support supported [DOI] 10.1186/s12889-021-12065-0 PMC 바로가기 [Article Type] Research
Development of T-cell immunity in a liver and hematopoietic stem cell transplant recipient following coronavirus disease 2019 infection2019년 코로나바이러스 감염에 따른 간 및 조혈모세포 이식 수혜자의 T세포 면역 발달Case Reports Published on 2021-11-012022-09-12 Journal: Cytotherapy [Category] MERS, SARS, 진단, [키워드] 229E affected Allogeneic antibody Antigen antigens Cell cellular immunity CMV comparable comprehensive analysis coronavirus disease Coronaviruses COVID-19 COVID-19 infection development EBV HCoV HCoVs healthy donor High-risk patients highlight HKU1 human coronavirus immunological protection Immunosuppression Immunotherapy in vitro Infection initial less liver Liver transplantation membrane Mild NL63 OC43 organ Organ transplant outbreak Patient patients with comorbidities Peripheral blood Post-infection reactivity recipient Reinfection responses against retained risk stratification robust SARS-CoV2 SCT spike survivor T cell T cell assay T cell memory T cells T-cell immunity the patient Transplant umbilical upper respiratory symptom viruses [DOI] 10.1016/j.jcyt.2021.05.005 PMC 바로가기 [Article Type] Case Reports
Immune characterization of a Colombian family cluster with SARS-CoV-2 infectionSARS-COV-2 감염을 가진 콜롬비아 가족 군집의 면역 특성Case Reports Published on 2021-10-152022-09-01 Journal: Biomédica [Category] MERS, SARS, 바이오마커, 진단, [키워드] acute phase alteration anti-SARS-CoV-2 antibodies antibodies, neutralizing antibody Antibody Response anticuerpos neutralizantes células asesinas naturales CD107a CD38 CD56 CD8+ T cell CD8+ T cells Cell cells characterized clinical feature Clinical features Cluster co-expression comprehensive analysis Coronavirus infections COVID-19 cytokine Cytokines described ELISA evaluate evaluated exhibited flow cytometry Frequency functional granzyme B hallmark healthy controls HLA-DR IL-10 immune change immune changes immune marker immunofluorescence Immunotherapy indirect immunofluorescence infecciones por coronavirus infected individual infected individuals inflamación Inflammation killer cells, natural linfocitos T marker material NK cell NK cells outcome peptides perforin phenotype phenotypic plaque reduction neutralization proinflammatory cytokines Proinflammatory response reduced required RT-PCR SARS- CoV-2 SARS-COV-2 infection stimulated T cell T cells T-cell T-cells T-lymphocytes the antibody response viral peptide viral peptides were assessed [DOI] 10.7705/biomedica.5976 PMC 바로가기 [Article Type] Case Reports
COVID-ONE-hi: The One-stop Database for COVID-19-specific Humoral Immunity and Clinical ParametersCOVID-ONE-hi: COVID-19 특정 체액 면역 및 임상 매개변수에 대한 원스톱 데이터베이스Article Published on 2021-10-012022-09-12 Journal: Genomics, Proteomics & Bioinformatics [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] addition Analysis caused clinical clinical feature clinical parameter collected comprehensive analysis Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical database defined groups Humoral immunity immune response Immunity information Interpretation mortality rate One-stop tool parameters Patient peptide populations Protein protein microarray provide response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein serum sample Shiny. Spike protein Symptom variety [DOI] 10.1016/j.gpb.2021.09.006 PMC 바로가기 [Article Type] Article
A Chinese host genetic study discovered IFNs and causality of laboratory traits on COVID-19 severityResearch article Published on 2021-10-012022-10-05 Journal: iScience [Category] 변종, 유전자 메커니즘, [키워드] Analysis association Biological sciences caused Chinese cholesterol clinical assessment comprehensive analysis contribute COVID-19 diagnosis COVID-19 pandemic COVID-19 severity current death disease disease severity explain functional gene gene-based analysis Genetic genetic mechanism genetic study genetics GSEA GWAS Host IFN Infection Innate immunity interferon Laboratory mendelian randomization MHC complex MR study Pathways Patient Receptor binding risk factor SARS Coronavirus traits Treatment type I interferon Virology WBC [DOI] 10.1016/j.isci.2021.103186 [Article Type] Research article
Multi-species single-cell transcriptomic analysis of ocular compartment regulonsArticle Published on 2021-09-282022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] addition adult stem cells Cell cell types ciliary comprehensive analysis directional disease disorder Factors ganglion cell ganglion cells Gene Expression Gene regulation Health identify include Interaction involved KLF7 maturation neural retina ocular populations probe Research Retina single-cell Single-cell RNA sequencing single-cell transcriptomic analysis stem cell tissue transcription factor transcriptomic transcriptomics unique various tissue Vertebrate zebrafish [DOI] 10.1038/s41467-021-25968-8 PMC 바로가기 [Article Type] Article
Demographic, Clinical and Immunogenetic Profiles of a Greek Cohort of COVID-19 PatientsArticle Published on 2021-09-272022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] allele association Characteristics clinical Clinical characteristics Clinical management Comorbidities comprehensive analysis controls Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient COVID-19 patients cross-sectional demographic disease epidemiological female Frequency healthy control healthy controls Hospitalized hospitalized patient human leucocyte antigens Immunogenetics immunology increase in Laboratory male marker Mild mild COVID-19 patient Older Patient positive profile profiles SARS-CoV-2 Stage statistical significance statistically significant Subgrouping susceptibility [DOI] 10.3390/life11101017 PMC 바로가기 [Article Type] Article
Uncertainty quantification and sensitivity analysis of COVID-19 exit strategies in an individual-based transmission modelResearch Article Published on 2021-09-172022-10-28 Journal: PLoS Computational Biology [Category] Coronavirus, SARS, [키워드] Care catastrophic comprehensive analysis country COVID-19 COVID-19 epidemic COVID-19 transmission Curve distribution Efficacy flattening Health implementation infected individuals input parameter intensive care Intermittent Intervention intrinsic knowledge measure opening pandemic parameter predict prevalent quantification question raising reduction in Safe sensitivity sensitivity analysis severity Spread Stratification subject Support the epidemic tracing Transmission Transmission model Uncertainty Variability virus [DOI] 10.1371/journal.pcbi.1009355 PMC 바로가기 [Article Type] Research Article
Variability in Codon Usage in Coronaviruses Is Mainly Driven by Mutational Bias and Selective Constraints on CpG Dinucleotide코로나 바이러스에서 코돈 사용의 가변성은 주로 CPG 디 뉴클레오티드의 돌연변이 바이어스 및 선택적 제약에 의해 주도된다.Article Published on 2021-09-102022-09-10 Journal: Viruses [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptation avoidance Bia breadth codon codon usage Codon usage bias comprehensive analysis Coronaviridae family coronavirus coronavirus disease Coronavirus disease 2019 coronavirus genome coronavirus genomes Coronaviruses COVID-19 CpG Critical dependent on dinucleotide Endemic enrichment explain Frequency Host host switch hosts human coronavirus human coronaviruses humans identify infecting mammalian mutational bia Mutational bias Neutral Orthocoronavirinae pandemic primary host respiratory risk SARS-CoV-2 SARS-CoV2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 synonymous the Coronaviridae total variation Usage Variation virus Virus evolution viruses zoonotic [DOI] 10.3390/v13091800 PMC 바로가기 [Article Type] Article