Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructuresSARS-CoV-2 스파이크 단백질과 DNA-펩티드 나노구조의 결합 상호작용 특성 규명Article Published on 2022-07-272022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome Amino acid amino acid sequence analyte angiotensin angiotensin converting enzyme Beta binding binding interaction binding interactions binding modes capture characterization complement concentrations Corona virus DNA ELISA enzyme full-length spike protein geometric hACE2 immunosorbent inactivated increase in Interaction investigated moiety mono peptide Protein binding quantified Quantitative RBD receptor SARS-CoV-2 SARS-CoV-2 spike protein sequence Severe acute respiratory syndrome Severe Acute Respiratory Syndrome Corona Virus shown Spike protein Spike proteins subunit subunits tested the spike protein trimeric trivalent variant variations virus virus strain viruses while wild type [DOI] 10.1038/s41598-022-16914-9 PMC 바로가기 [Article Type] Article
Modulating Fingolimod (FTY720) Anti-SARS-CoV-2 Activity Using a PLGA-Based Drug Delivery SystemArticle Published on 2022-07-182022-10-04 Journal: ACS applied bio materials [Category] COVID19(2023년), SARS, 신약개발, [키워드] activity Anti-SARS-CoV-2 Activity Antiviral antiviral activity cell line Combination concentrations confocal microscopy COVID-19 COVID-19 case Cytometry death delivery develop Disease progression drug Drug repurposing encapsulation exhibit fingolimod Flow FTY720 less Lysosomes macropinocytosis nanoparticle Nanotechnology occur pathway PLGA PLGA-based nanoparticles reduce Safe System therapy for COVID-19 Toxicity Treatment Vaccine viral infection Viral transmission [DOI] 10.1021/acsabm.2c00349 PMC 바로가기 [Article Type] Article
Mid-regional proadrenomedullin, C-terminal proendothelin-1 values, and disease course are not different in critically ill SARS-CoV-2 pneumonia patients with obesity Research Published on 2022-07-152022-10-05 Journal: International journal of obesity (2005) [Category] COVID19(2023년), SARS, 바이오마커, 임상, [키워드] 28-day mortality acute respiratory syndrome Admission affected baseline Blood BMI body mass index C-reactive protein C-terminal caused changed chronic inflammation Clinical outcome collected Concentration concentrations coronavirus Coronavirus disease 2019 Critically ill Critically ill patient CRP disease course higher risk ICU Inflammatory biomarker intensive care investigated marker mechanisms MR-proADM Netherland no significant difference not different obesity Observational cohort study outcome Patient patients with obesity PCT procalcitonin Result retrospective SARS-CoV-2 SARS-CoV-2 pneumonia significantly suggested the disease ventilator WBC [DOI] 10.1038/s41366-022-01184-2 [Article Type] Research
The Chilean Maternal-Infant Cohort Study-II in the COVID-19 Era: A Study ProtocolArticle Published on 2022-07-142022-10-05 Journal: Frontiers in Public Health [Category] 임상, [키워드] age assessment association biochemical Breast Chilean clinical Cohort collected concentrations consequence COVID-19 COVID-19 pandemic Critical developmental dietary intake gestation Glucose growth growth factor Health hemoglobin Infant infant growth infant health infant nutrition information insulin lactation Maternal Maternal Health Mental mental health mental health problem mother Neonatal nutrition nutritional status Observatory Obstetric offspring Pregnancy pregnant women preliminary finding public health measure public health system recruited recruitment Trial [DOI] 10.3389/fpubh.2022.904668 PMC 바로가기 [Article Type] Article
Potent neutralization by monoclonal human IgM against SARS-CoV-2 is impaired by class switchSARS-CoV-2에 대한 단일 클론 인간 IgM에 의한 강력한 중화는 클래스 전환에 의해 손상됩니다Article Published on 2022-07-052022-09-12 Journal: EMBO Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated Anti-viral antibodies antibody Antigen B cell B cells binding cell sorting class switch concentrations Donor expected explain human cells IgA IgG IgM IgM antibodies infected with SARS-CoV-2 MACACS membrane membrane antigen. monoclonal neutralization parents potent SARS-CoV-2 the antibody Virus neutralization [DOI] 10.15252/embr.202153956 PMC 바로가기 [Article Type] Article
Serum Free Zinc Is Associated With Vaccination Response to SARS-CoV-2무혈청 아연은 SARS-CoV-2에 대한 예방 접종 반응과 관련이 있습니다Article Published on 2022-06-302022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Analysis antibody association Biomarker Cohort Concentration concentrations Course COVID-19 deficiency diagnostic value diagnostics diagnostics, free zinc, COVID-19 vaccination dose elevated expected Free Health care worker highest humoral humoral immune response immune response immune system Immunoglobulin indicate indicated infection risk neutralizing antibody observed correlation positive correlation provided resolved response response to vaccination SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 vaccination second dose serum serum sample severe disease course the antibody response time Total Trace element Vaccine was determined while Zinc [DOI] 10.3389/fimmu.2022.906551 PMC 바로가기 [Article Type] Article
Insights to estimate exposure to regulated and non-regulated disinfection by-products in drinking water Research Published on 2022-06-292022-10-05 Journal: Journal of Exposure Science & Environmental Epidemiology [Category] 바이오마커, [키워드] activated Activated carbon analyzed Barcelona Chlorate collected Concentration concentrations correlated DBP Effect epidemiological studies explained filtered finding Health Impact information insight Linear model Linear regression Linear regression model machine learning models median multivariate number of sample objective Occurrence participant predict Predictive Predictive model quantified Questionnaires reduced regulated Replication Result Significance Spain study population tap THM total variance Urine validation variable [DOI] 10.1038/s41370-022-00453-6 [Article Type] Research
Immunometabolic analysis shows a distinct cyto-metabotype in Covid-19 compared to sepsis from other causesResearch article Published on 2022-06-242022-10-05 Journal: Heliyon [Category] 바이오마커, 치료기술, [키워드] accompanied Analysis cause CD14+ CD14+ monocyte CD8+ T cells change characteristic Cohort concentrations controls correlated COVID-19 Critical cytokine Cytokine release syndrome Disease progression disease severity expression flow cytometry greater healthy control Hypothesis immune checkpoint immune response immunometabolism involved Lipid mechanism metabolic derangement metabolic risk factor metabolism monocytopenia mononuclear cell multiplex pandemic Pathway analysis Patient PBMC PBMCs PD-L1 Peripheral blood Phosphatidylcholine plasma plasma concentration recruited reduced reflect Result Sepsis serum severe cases severity shown SOFA score Support systemic inflammatory response the disease Treg Tryptophan unique was increased was performed [DOI] 10.1016/j.heliyon.2022.e09733 [Article Type] Research article
Humoral and Cellular Immune Response After a 3-Dose Heterologous SARS-CoV-2 Vaccination Using the mRNA-BNT162b2 and Viral Vector Ad26COVS1 Vaccine in Hemodialysis Patients혈액 투석 환자에서 mRNA-BNT162b2 및 바이러스 벡터 Ad26COVS1 백신을 사용한 3회 용량 이종 SARS-CoV-2 백신 접종 후 체액 및 세포 면역 반응Observational Study Published on 2022-06-232022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] Ad26COVS1 age anti-SARS-CoV-2 antibody approach BNT162b2 booster booster dose Cellular immune response chronic hemodialysis patient Concentration concentrations COVID-19 dose eight evaluated females Hemodialysis Heterologous humoral Humoral immunity immune response IMPROVE interferon-γ median mRNA vaccination neutralizing antibody Patient patients positive regimen response SARS-CoV-2 SARS-CoV-2 spike seroconversion rate spike IgG Stimulating T-cell Response vaccination Vaccine vaccine platform vector [DOI] 10.3389/fimmu.2022.907615 PMC 바로가기 [Article Type] Observational Study
Surface plasmon resonance biosensor with laser heterodyne feedback for highly-sensitive and rapid detection of COVID-19 spike antigenCOVID-19 스파이크 항원의 고감도 및 신속한 검출을 위한 레이저 헤테로다인 피드백이 있는 표면 플라즈몬 공명 바이오센서Article Published on 2022-06-152022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] amplification anti-SARS-CoV-2 Antigen biological samples biosensor can be used change changes in Concentration concentrations convert COVID-19 diagnosing Diagnostic method dynamic range exhibited FIVE high resolution intensity lAbel Label free approach Laser Laser feedback linear magnitude monoclonal antibodies Optical biosensor outbreak pandemic Prevention and control refractive index Refractive index sensing repeatability respond SARS-CoV-2 SARS-CoV-2 spike antigen sensitivity surface plasmon surface plasmon resonance [DOI] 10.1016/j.bios.2022.114163 PMC 바로가기 [Article Type] Article