The Remarkable Evolutionary Plasticity of Coronaviruses by Mutation and Recombination: Insights for the COVID-19 Pandemic and the Future Evolutionary Paths of SARS-CoV-2돌연변이 및 재조합에 의한 코로나 바이러스의 현저한 진화 가소성 : Covid-19 Pandemic과 SARS-Cov-2의 미래 진화 경로에 대한 통찰력Review Published on 2022-01-022022-09-10 Journal: Viruses [Category] SARS, 변종, 신약개발, 치료제, [키워드] addition Affect B.1.1.529 birds coronavirus CoV CoV protein CoV proteins COVID-19 COVID-19 pandemic CoVs deletions Epidemics Evolution FIVE focus Future Health highlight homologous Human insertions insight mammal molecular molecular evolution mutations non-homologous omicron pandemic path point mutations positive-sense single-stranded RNA positive-sense single-stranded RNA viruses Recombination recombination event SARS-CoV-2 SARS-CoV-2 pandemic spike strain Transmissibility Vaccine Vaccines viruses zoonotic origin [DOI] 10.3390/v14010078 PMC 바로가기 [Article Type] Review
Influenza viruses and coronaviruses: Knowns, unknowns, and common research challenges인플루엔자 바이러스 및 코로나바이러스: 알려진 것, 알려지지 않은 것 및 일반적인 연구 과제Review Published on 2021-12-302022-09-10 Journal: PLoS Pathogens [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome coronavirus adaptation approach Biology coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 CoVs crisis determinant disease severity effective vaccine global pandemic highlight humans IMPROVE Influenza Influenza virus influenza viruses knowledge mechanism molecular Multidisciplinary Approaches pandemic physiological Research respiratory respiratory virus respiratory viruses Safe SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Viral viral outbreak virus viruses [DOI] 10.1371/journal.ppat.1010106 PMC 바로가기 [Article Type] Review
A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targetsShort Reports Published on 2021-12-282022-10-28 Journal: PLoS Biology [Category] COVID-19, SARS, [키워드] approved approved drugs autophagy cell cultures cell line clinically Compound conducted conserved coronavirus coronavirus 2 Coronavirus replication coronavirus target CoV CoV replication CoVs demonstrated dependent on dose-dependent inhibition effective effective therapy epithelial Factor FKBP8 Genes genome-wide CRISPR screen HCoV-229E Health highlighting highly pathogenic Host Huh7 human coronavirus identify independent Infection inhibitor MERS-CoV Middle East MINAR1 nasal over pathway Protein Replication required respiratory SARS-CoV SARS-COV-2 infection Support survival target therapeutic intervention Tmem41b Treatment virus replication viruses [DOI] 10.1371/journal.pbio.3001490 PMC 바로가기 [Article Type] Short Reports
Ecological surveillance of bat coronaviruses in Sarawak, Malaysian BorneoResearch Note Published on 2021-12-202022-10-27 Journal: BMC Research Notes [Category] Coronavirus, COVID-19, [키워드] Amplicon bat bat coronavirus bat-CoV bats Bayesian posterior Betacoronavirus bootstrap cave clade collected Consensus coronavirus CoV CoVs Epidemic event Guano human coronaviruses island Lineage Malaysia maximum-likelihood Nature objective PCR primer phylogenetically preserved Probability RdRP reserve Result RNA-dependent RNA polymerase Sample Sanger method Sarawak screened sequenced specimen Surveillance transported unique Viral transport medium wind zoonotic [DOI] 10.1186/s13104-021-05880-6 PMC 바로가기 [Article Type] Research Note
Ecological surveillance of bat coronaviruses in Sarawak, Malaysian BorneoResearch Note Published on 2021-12-202022-10-27 Journal: BMC Research Notes [Category] COVID-19, [키워드] Amplicon bat bat coronavirus bat-CoV bats Bayesian posterior Betacoronavirus bootstrap cave clade collected Consensus coronavirus CoV CoVs Epidemic event Guano human coronaviruses island Lineage Malaysia maximum-likelihood Nature objective PCR primer phylogenetically preserved Probability RdRP reserve Result RNA-dependent RNA polymerase Sample Sanger method Sarawak screened sequenced specimen Surveillance transported unique Viral transport medium wind zoonotic [DOI] 10.1186/s13104-021-05880-6 PMC 바로가기 [Article Type] Research Note
Longitudinal monitoring in Cambodia suggests higher circulation of alpha and betacoronaviruses in juvenile and immature bats of three species캄보디아의 종방향 모니터링은 3종의 어린 박쥐와 미성숙한 박쥐에서 알파 및 베타 코로나바이러스의 더 높은 순환을 시사합니다Article Published on 2021-12-172022-09-10 Journal: Scientific Reports [Category] SARS, 치료기술, 치료제, [키워드] age Alpha alphacoronavirus Analysis Asia Asian association bat bats Betacoronavirus China circulation coronavirus CoV CoV infection CoVs develop Diversity Ecological epidemiology examined exhibiting highlight Hipposidero immature IMPROVE indicate information lead literature review longitudinal occur PCR amplicon Phylogenetic analysis positive positive PCR test proportion public health recent reproduction reproduction cycle reproductive Result sampling SARS-CoV-2 virus sequence species Surveillance Virology virus viruses [DOI] 10.1038/s41598-021-03169-z PMC 바로가기 [Article Type] Article
Molecular Characterization of Infectious Bronchitis Virus Strain HH06 Isolated in a Poultry Farm in Northeastern ChinaVeterinary Science Published on 2021-12-162022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] Analysis bovine characterization characterized China clade clades coronavirus Coronaviruses CoV CoVs domain Epidemic Evolution explain farm Genetic Genome glycoprotein HCoV-OC43 Host IBV indicated Infectious Bronchitis Virus Isolated maintain mammalian MERS-CoV Molecular epidemiology motif Phylogenetic Phylogenetic relationship poultry protein sequence Recombination S gene S protein SARS CoV-2 SARS-CoV SARS-CoV-2 selected selection pressure sequence spike Spread strain variant virulent viruses zoonosis [DOI] 10.3389/fvets.2021.794228 PMC 바로가기 [Article Type] Veterinary Science
Impact of chemotherapy and immunotherapy on the composition and function of immune cells in COVID-19 convalescent with gynecological tumors부인과 종양과 코비드 -19 회복기에서 면역 세포의 조성 및 기능에 대한 화학 요법 및 면역 요법의 영향Research Paper Published on 2021-12-152022-09-01 Journal: Aging (Albany NY) [Category] SARS, 진단, [키워드] acute infection anti-viral activity B cells cancers caused Chemotherapy clonal expansion convalescent Convalescent patients coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CoVs effort ENhance facilitated functional phenotype healthy donor ICIs Immune cell immunological change Immunological memory Immunotherapy Impact molecular feature molecular features neutropenia NK cells pandemic Patient patients PBMC PBMCs performed Peripheral blood peripheral blood samples proportion PROTECT Reinfection resurgence SARS-CoV-2 virus single cell sequencing Single-cell RNA sequencing T and B cells T cell T cells Treatment Tumor tumors [DOI] 10.18632/aging.203739 PMC 바로가기 [Article Type] Research Paper
Indomethacin-based PROTACs as pan-coronavirus antiviral agents범 코로나바이러스 항바이러스제로서의 인도메타신 기반 PROTACArticle Published on 2021-12-152022-09-11 Journal: European journal of medicinal chemistry [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition anti-inflammatory drug Anti-SARS-CoV-2 Activity Antiviral antiviral activity antiviral agent Antiviral agents antiviral potency Chimera class coronavirus Coronavirus-2 CoVs demonstrated develop early stage example host protein human CoVs indicated indomethacin infected Vero E6 cells inhibit inhibit SARS-CoV-2 interact knowledge mechanism mechanism of action Nsp7 PGES-2 prostaglandin prostaglandin E PROTAC Protein proteolysis proteomic study Replication reported SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 strains Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Support synthesis targeting the SARS-CoV-2 Vero E6 VERO E6 cells [DOI] 10.1016/j.ejmech.2021.113814 PMC 바로가기 [Article Type] Article
Exploring the diversity of coronavirus in sewage during COVID-19 pandemic: Don’t miss the forest for the treesCOVID-19 전염병 동안 하수에서 코로나바이러스의 다양성 탐구: 나무를 위한 숲을 놓치지 마세요Article Published on 2021-12-152022-09-11 Journal: The Science of the total environment [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] analyzed animal coronavirus Animal host applied approach Characteristics circulation clinical samples contig Coronaviridae Coronaviridae family coronavirus CoV COVID-19 COVID-19 pandemic CoVs detect enrichment Genetic HCoV HCoV-OC43 infecting next generation sequencing NGS OC43 Occurrence pandemic protocol rodents SARS-CoV-2 sequenced Sequencing sewage Sewage virome specimen target Target enrichment sequencing typing Viral metagenomics. virus wake was obtained wastewater [DOI] 10.1016/j.scitotenv.2021.149562 PMC 바로가기 [Article Type] Article