Efficacy of Tocilizumab Therapy in Different Subtypes of COVID-19 Cytokine Storm SyndromeCOVID-19 사이토 카인 폭풍 증후군의 상이한 아형에서 토 실리 주맙 요법의 효능Article Published on 2021-06-032022-09-01 Journal: Viruses [Category] MERS, 진단, [키워드] 95% CI ARDS C-reactive protein calcitonin contributed COVID-19 CRS cytokine Cytokine release syndrome Cytokine storm Cytokine storm syndrome D-dimer diagnosed Diagnostic Criteria examined ferritin fibrinogen groups heterogenous Hypofibrinogenemia increased mortality Inflammation interleukin interleukin-6 Macrophage macrophage activation syndrome monoclonal antibodies Mortality mortality rate Pancytopenia Patient patients patients with COVID-19 patients with SARS-CoV-2 Pneumonia reduced Retrospective study SARS-CoV-2 pneumonia Sepsis Serum ferritin significantly higher storm subtype tested the patient therapy three group three groups Tocilizumab tocilizumab therapy Treatment treatment results was used were assessed [DOI] 10.3390/v13061067 PMC 바로가기 [Article Type] Article
Description and Analysis of Cytokine Storm in Registered COVID-19 Clinical Trials: A Systematic ReviewSystematic Review Published on 2021-06-022022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Biomarker Biomarkers Characteristics clinical clinical trial clinical trial registry clinical trials COVID-19 COVID-19 patient COVID-19 patients criteria CRP CRS Cutoff cutoff value Cytokine release syndrome Cytokine storm D-dimer Definition description elevated ferritin Fever high variability hospitalized patient IL-6 Inflammatory biomarker LDH Lymphocyte count medication medications radiologic required review searched storm systematic review Tocilizumab Trial Variability was measured [DOI] 10.3390/pathogens10060692 PMC 바로가기 [Article Type] Systematic Review
Biomarkers of Cardiac Stress and Cytokine Release Syndrome in COVID-19: A ReviewCOVID-19에서 심장 스트레스 및 사이토카인 방출 증후군의 바이오마커: 검토Review Published on 2021-06-012022-09-11 Journal: Current heart failure reports [Category] MERS, SARS, 바이오마커, [키워드] absence acute COVID-19 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Biomarkers BNP cardiac Cardiac biomarkers cardiac injury cardiac troponin clinical benefit concerning Coronary artery Coronary artery disease coronavirus Coronavirus 2019 correlated COVID-19 CRS cytokine cytokine release Cytokine release syndrome Cytokines defined Dexamethasone elevated etiology Evidence global pandemic IL-6 Illness severity increased mortality Injury marker myocardial injury myocarditis Obstructive Patient patients hospitalized patients with COVID-19 pattern peptide recent reduce referred to Release Remdesivir respiratory respiratory virus review risk SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown Stress syndrome therapy troponin while [DOI] 10.1007/s11897-021-00505-2 PMC 바로가기 [Article Type] Review
Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2Brief Communication Published on 2021-05-262022-10-04 Journal: Nature Medicine [Category] MERS, SARS, 변종, [키워드] administration adverse event anti-PD1 association blockade BNT162b2 Cancer Cancer immunotherapy Colon cancer Colorectal cancer coronavirus disease COVID-19 COVID-19 vaccination COVID-19 vaccine CRS cytokine level Cytokine release syndrome Diagnosis elevated evidenced favor Immune checkpoint inhibitors include inflammatory markers monotherapy mRNA mRNA vaccine mRNA vaccines occurred Patient Patients with cancer Pfizer-BioNTech raised reported RNA vaccines Support syndrome vaccination [DOI] 10.1038/s41591-021-01387-6 PMC 바로가기 [Article Type] Brief Communication
Off-label tocilizumab and adjuvant iron chelator effectiveness in a group of severe COVID-19 pneumonia patients: A single center experience중증 COVID-19 폐렴 환자 그룹에서 오프라벨 토실리주맙 및 보조제 철 킬레이터 효과: 단일 센터 경험Observational Study Published on 2021-05-072022-09-12 Journal: Medicine [Category] SARS, 임상, 진단, [키워드] acute respiratory syndrome adjuvant analyzed antibody Better center Chinese Comorbidities Comorbidity consecutive patients contribute Control coronavirus disease Coronavirus-2 corticosteroid therapy COVID-19 Critical Critical case Critically ill CRS Cytokine release syndrome death defined effective Effectiveness Emergency enrolled Evolution female ferritin Glucose had no hospital Hydroxychloroquine IL-6 receptor Invasive mechanical ventilation less male monoclonal Noninvasive ventilation occurred off-label outcome oxygen oxygen saturation Patient Pneumonia prevention rapid increase Romania SARS-CoV-2 SARS-COV-2 infection selected serum serum ferritin level Serum level Severe COVID-19 pneumonia severe pneumonia Side effect single center standard care TCZ Tocilizumab treated younger patients [DOI] 10.1097/MD.0000000000025832 PMC 바로가기 [Article Type] Observational Study
Continuous renal replacement therapy with the addition of CytoSorb cartridge in critically ill patients with COVID-19 plus acute kidney injury: A case-seriesCOVID-19와 급성 신장 손상이 있는 중환자에서 CytoSorb 카트리지를 추가하여 지속적인 신대체 요법: 사례 시리즈Article Published on 2021-05-012022-09-11 Journal: Artificial organs [Category] MERS, SARS, 바이오마커, [키워드] 95% CI acute kidney Acute kidney injury acute respiratory distress acute respiratory distress syndrome addition Admission AKI Analysis analyzed Antibiotics anticoagulation APACHE ARDS arterial pressure assessment body mass body mass index C-reactive protein cartridge chronic Concentration Continuous Continuous renal replacement therapy continuous renal replacement therapy with cytosorb COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients Critically ill patient CRRT CRS cutoff point Cytokine release syndrome Cytosorb D-dimers Duration enrolled ferritin function Hospital mortality Hydrocortisone hyperinflammation ICU ICU admission in-hospital mortality inflammatory biomarkers intensive care interferon interferon beta Interferon beta-1b interleukin interleukin-6 Lactate lactate dehydrogenase life-threatening lymphocyte Lymphocyte count lymphocyte counts male mechanical ventilation Mortality nonsurvivors organ function oxygen Oxygenation PaO Patient Physiology predicted prone positioning Prophylactic prophylactic anticoagulation provided Pulmonary emboli renal replacement therapy replacement therapy respiratory distress Respiratory distress syndrome retrospective ribavirin Safe Sepsis Septic shock Shock Side effect SOFA SOFA scores survivor Survivors syndrome therapy Thromboembolism Ventilation were recorded with COVID-19 [DOI] 10.1111/aor.13864 PMC 바로가기 [Article Type] Article
Shared inflammatory pathways and therapeutic strategies in COVID-19 and cancer immunotherapyCOVID-19 및 암 면역 요법에서 공유된 염증 경로 및 치료 전략Article Published on 2021-05-012022-09-12 Journal: Journal for immunotherapy of cancer [Category] SARS, 진단, [키워드] acute respiratory distress adverse event Allogeneic anti-inflammatory drug Anti-inflammatory therapy antibody Antigen approach ARDS benefit Cancer immunotherapy caused Cell cells characterized chimeric circulating cytokines clinical trial Complication coronavirus COVID-19 CRS cytokine disease drug drugs Effect elevated Endothelial dysfunction exaggerated immune response Graft-versus-host disease help Hospitalization immune system Immunotherapy infection with SARS-CoV-2 Inflammation Inflammation mediators Inflammatory inflammatory pathway inhibiting interleukin-6 interstitial involved mechanism monoclonal antibody Mortality pathogenesis of COVID-19 pathway performed preliminary evidence reducing reduction in SARS-COV-2 infection stimulate suppress syndrome systematic review systemic manifestation therapeutic strategy therapy toxicities Toxicity Treatment trials triggered viral infection [DOI] 10.1136/jitc-2021-002392 PMC 바로가기 [Article Type] Article
The effectiveness of continuous renal replacement therapy in critical COVID-19 patients with cytokine release syndrome: a retrospective, multicenter, descriptive study from Wuhan, ChinaResearch Paper Published on 2021-04-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, MERS, SARS, [키워드] Acute kidney injury Adsorption AKI C-reactive protein consolidation Continuous Continuous renal replacement therapy convalescent plasma COVID-19 COVID-19 patient critical COVID-19 patient CRRT CRS cytokine release Cytokine release syndrome D-dimer death decrease develop dialysis disease Effectiveness elevated evaluated Factors Fatality rate filtration hospital Inflammation Inflammatory cytokine Inflammatory marker kidney LASSO Lung CT multicenter neutrophil count neutrophil counts organ Patient Protective reduced renal replacement therapy Respiratory failure Result retrospective risk factor severe complication significantly Spread syndrome the patient Wuhan Wuhan, China [DOI] 10.18632/aging.202838 PMC 바로가기 [Article Type] Research Paper
Newly Diagnosed Acute Myeloid Leukemia in a Patient With Severe SARS-CoV-2 InfectionInfectious Disease Published on 2021-04-142022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute myeloid leukemia administration AML Anemia applied Bone marrow Chemotherapy clinical condition Clinical course cough COVID-19 CRS Cytokine release syndrome diagnosed Diagnosis died Dyspnea Fever flow cytometry Hematologic malignancy Hospitalization implementation Infection intensive care leukemia male multi-organ failure myeloid Pandemics Patient Peripheral blood proportion re-evaluation Respiratory failure SARS-CoV-2 SARS-COV-2 infection Sepsis suffered supportive care the patient tissue plasminogen activator Tocilizumab was performed worsened [DOI] 10.7759/cureus.14480 PMC 바로가기 [Article Type] Infectious Disease
Clinical trial enrollment at a rural satellite hospital during COVID-19 pandemicResearch Article Published on 2021-04-082022-10-30 Journal: Journal of Clinical and Translational Science [Category] COVID-19, [키워드] accelerated activating black canakinumab CCT clinical clinical centers clinical trial college Controlled clinical trial coronavirus disease COVID-19 COVID-19 pandemic CRS Cytokine release syndrome enrolled Enrollment female Guidance Hill hospital interquartile range lack Local median age Memorial multicenter pandemic participant pathology Patient Patient care patients with COVID-19 remote monitoring resource resources Safety SARS-CoV-2 South Telemedicine the patient Treatment Trial Virginia [DOI] 10.1017/cts.2021.777 PMC 바로가기 [Article Type] Research Article