Recent Experience: Corticosteroids as a First-line Therapy in Children With Multisystem Inflammatory Syndrome and COVID-19-related Myocardial Damage최근 경험: 다기관 염증 증후군 및 COVID-19 관련 심근 손상이 있는 어린이의 1차 요법으로서의 코르티코스테로이드Article Published on 2021-11-012022-09-11 Journal: The Pediatric Infectious Disease Journal [Category] MERS, SARS, 바이오마커, 진단, [키워드] 95% confidence interval acute respiratory syndrome added afebrile age albumin albumin level albumin levels Analysis average C-reactive protein C-reactive protein (CRP cardiovascular cardiovascular complications children children with MIS-C Complication coronavirus Corticosteroid CRP damage declined dysfunction Ejection fraction faster Fever ICU Immunoglobulin In-hospital independent risk factor Infection Inflammatory interquartile range Intravenous immunoglobulin IQR IVIG Laboratory MIS-C myocarditis normalization Odds ratio Patient patients recent reported respiratory retrospective cohort study severe acute respiratory syndrome Coronavirus significantly sodium syndrome therapeutic strategy treated Treatment treatment failure ventricular [DOI] 10.1097/INF.0000000000003260 PMC 바로가기 [Article Type] Article
Drug delivery systems as immunomodulators for therapy of infectious disease: Relevance to COVID-19감염성 질환 치료를 위한 면역조절제로서의 약물 전달 시스템: COVID-19와 관련성Review Published on 2021-11-012022-09-11 Journal: Advanced drug delivery reviews [Category] MERS, 신약개발, 진단, 치료제, [키워드] Activation adaptive approach approaches blocking agents cellular Coagulation complement complex complex interplay COVID-19 damage drug delivery system drug delivery systems endothelial Endothelium global pandemic identify immune Immune cell immune cells Immune suppression immunomodulator immunomodulatory IMPROVE improvement Inflammasome inflammasomes Inflammation Interaction involved limit moderate to severe molecular nanomedicine not limited outcome pathogen clearance pathology pathophysiology Patient patients with moderate Prognosis Relevance SARS-CoV-2 severe COVID-19 survival rates Therapeutic approach therapeutic approaches therapeutic option therapy tissue damage [DOI] 10.1016/j.addr.2021.113848 PMC 바로가기 [Article Type] Review
Is Ferroptosis a Key Component of the Process Leading to Multiorgan Damage in COVID-19?Review Published on 2021-10-252022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] affecting Cell cell death component contributing to COVID-19 cytoplasm damage erastin Fatty acid Ferroptosis Glutamate GPX4 GSH GSH-GPX4 axis inactivation inducer inhibit Intervention iron kidney leading lipid peroxides Manifestations metabolism molecular mechanism Multiorgan Multiorgan damage multiple organs Myocardial myocarditis oxidative stress pathology Polyunsaturated precursor Process programmed cell death promoted reactive oxygen specy reduce reported SARS-CoV-2 SARS-COV-2 infection Shock upregulation [DOI] 10.3390/antiox10111677 PMC 바로가기 [Article Type] Review
Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell TherapyCOVID-19에서 다기관 실패의 분자 메커니즘과 줄기 세포 치료의 잠재력Review Published on 2021-10-252022-09-11 Journal: Cells [Category] MERS, SARS, 임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 blood-brain-barrier caused Cell therapy confirmed case confirmed cases coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients damage death failure Health major organ mesenchymal molecular mechanism molecular mechanisms multi-organ failure organ system organ systems oxidative stress Potential regenerative respiratory respiratory distress SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe respiratory distress STEM stem cell Stem cell therapy stem cells systemic damage Therapeutics treating COVID-19 [DOI] 10.3390/cells10112878 PMC 바로가기 [Article Type] Review
Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2중증 급성 호흡기 증후군 코로나 바이러스로 감염된 노인 햄스터의 비정상적인 혈액 응고 및 신장 손상 2Article Published on 2021-10-222022-09-01 Journal: Viruses [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] abnormality acute kidney acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition age aged Syrian hamster animal model animal models Blood coagulation cause Coagulation coagulation factor Coagulation factors Consumption coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 research damage demonstrated disease stages groups hamster Infection Inflammatory response Inflammatory responses intranasal intravascular coagulation investigated kidney kidneys lack lung Lungs male mesangial matrix Mortality Pathogenesis Patient patients Pneumonia prothrombin Prothrombin time proximal respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity Symptom systemic systemic symptoms tissue damage Urinary tract Viral viral replication [DOI] 10.3390/v13112137 PMC 바로가기 [Article Type] Article
The Role of Epithelial Damage in the Pulmonary Immune Response폐 면역 반응에서 상피 손상의 역할Review Published on 2021-10-152022-09-12 Journal: Cells [Category] MERS, SARS, 진단, [키워드] Acute inflammation cell death cell type cellular senescence Chronic diseases chronic obstructive chronic obstructive pulmonary disease (COPD) contributing to COPD coronavirus Coronavirus Disease (COVID)-19 COVID-19 damage damage-associated molecular pattern damage-associated molecular patterns (DAMPs) DAMPs disease pathogenesis dysregulation epithelial epithelial cell epithelial damage fibroblast hallmark highlight idiopathic pulmonary fibrosis (IPF) Immune cell immune response Inflammatory Injury innate immune response IPF lung necroptosis Necrosis necrotic cell death pathway promote pulmonary pulmonary disease pulmonary fibrosis Respiratory disease response responsible role senescence subsequent tissue wound healing [DOI] 10.3390/cells10102763 PMC 바로가기 [Article Type] Review
SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In VitroSARS – COV – 2 스파이크는 DNA 손상 복구를 손상시키고 V (D) J J 재조합을 억제합니다.Article Published on 2021-10-132022-09-01 Journal: Viruses [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Adaptive immunity affecting BRCA1 cell line clinical Clinical outcome clinical outcomes Clinical studies coronavirus coronavirus disease Coronavirus disease 2019 damage DNA DNA damage DNA damage repair DNA repair effective full-length immune immune responses Immunity impede in vitro indicated Infection influence inhibit mechanism nucleus pandemic Patient patients potential molecular Protein public health Recombination recruitment repair required respiratory SARS–CoV–2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Side effect significantly spike Spike protein spike-based vaccines the spike protein V(D)J recombination Vaccine [DOI] 10.3390/v13102056 PMC 바로가기 [Article Type] Article
A Vimentin-Targeting Oral Compound with Host-Directed Antiviral and Anti-Inflammatory Actions Addresses Multiple Features of COVID-19 and Related Diseases숙주 지향적 항바이러스 및 항염 작용이 있는 Vimentin 표적 경구 화합물은 COVID-19 및 관련 질병의 여러 특징을 다룹니다Research Article Published on 2021-10-122022-09-10 Journal: mBio [Category] MERS, 변종, 치료제, [키워드] Action affected Anti-inflammation anti-inflammatory actions Antiviral Bleomycin cellular cellular processe complications Compound COVID-19 cultured cells damage disease symptom Diseases drug effective Efficacy endosomal trafficking Factor fibrosis filaments focus function host immune responses host-directed antiviral human ACE2 hyperinflammation identify immune responses Infection inhibited late-stage disease lung damage Lung injury macrophages mechanism mice Multiple oral outcome overactive pathogen pathogen clearance Patient physical physical properties Protein RATs reduced reducing regulatory T cells Safe SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus small molecule Spike protein T cells targets the SARS-CoV-2 the SARS-CoV-2 virus therapeutic agent therapeutic agents therapeutic potential treating COVID-19 triggered unique vimentin Viral Viral load Viral mutations [DOI] 10.1128/mBio.02542-21 PMC 바로가기 [Article Type] Research Article
Effect of Vitamin D Supplementation on Muscle Status in Old Patients Recovering from COVID-19 InfectionCOVID-19 감염에서 회복 중인 노인 환자의 근육 상태에 대한 비타민 D 보충제의 효과Randomized Controlled Trial Published on 2021-10-092022-09-12 Journal: Medicina [Category] MERS, SARS, 임상, 진단, [키워드] 6MWT addition Alanine alanine aminotransferase Aldolase aspartate Aspartate aminotransferase biochemical parameter Biochemical parameters Biochemistry blood count carried center cholecalciferol conducted contribute cortisol COVID-19 creatine creatine kinase damage decrease decreases double-blind trial Effect Elderly patient elderly patients exercise Glucose health center Health status hematological homeostasis hormone Improvements Infection involved Lactate lactate dehydrogenase life material men metabolism muscle Myoglobin objective pathology Patient physical physical fitness pilot study Placebo protective role Protein Quality of life reported Respiratory function Respiratory function tests Result returned SARS-CoV-2 serum spirometry status suffered Testosterone total protein transaminase two group two groups urea uric acid Vitamin Vitamin D Vitamin D supplementation was used [DOI] 10.3390/medicina57101079 PMC 바로가기 [Article Type] Randomized Controlled Trial
Sphingolipids in Lung Pathology in the Coronavirus Disease Era: A Review of Sphingolipid Involvement in the Pathogenesis of Lung DamagePhysiology Published on 2021-10-082022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] “cytokine storm” antagonistic anti-apoptotic cascade cause Cell ceramide ceramide synthase change chronic lung disease contribute COVID COVID-19 Cytokine storm damage de novo Diseases Efficacy effort endothelial epithelial Evidence fibrosis Hyperinflammatory implicated indicate Inflammation inflammatory effects inflammatory process Inflammatory response initiate investigated involved Involvement Lipid lung lung cancer lung damage Lung disease Lung injury novel coronavirus disease PAH Pathogenesis Pathologies pathway pro-apoptotic produced proliferation proliferative pulmonary arterial hypertension pulmonary fibrosis recent receptor Regulation review S1P pathway SARS-CoV-2 shown Signaling sphingolipid sphingolipids sphingosine survival therapeutic option Treatment [DOI] 10.3389/fphys.2021.760638 PMC 바로가기 [Article Type] Physiology